
 blue rubber bleb nevus syndrome ( brbns ) or bean s syndrome is a disorder characterized by distinctive vascular malformations that mostly involve cutaneous and gastrointestinal tract .occult bleeding and iron deficiency anemia ( ida ) are the most common clinical presentation of brbns but melena , hematochezia and involvement of internal organs has also been reported.1 , 
 2it is a very rare syndrome and only about 200 cases have been reported till 2012 . 
 
 here
, we report a case of brbns that present with ida . to the best of our knowledge

 a 22 years old man was referred to the gi clinic of afzalpour hospital for evaluation of ida .
history of abdominal pain , prolonged diarrhea and/or constipation , vomiting , flatulence and prolonged fever were negative .
he suffered from a vascular mass on right supraclavicular region at birth with gradual enlargement . at the childhood , surgical resection of the mass
was performed and histology showed irregular cavernous channels in both cutaneous and subcutaneous tissue compatible with venous malformation . at the age of 15 , oral iron intake was started because of ida . at about the same time , multiple bluish colored nodular lesions appeared on his lower extremities .
he was not drug abuser and drug history included only oral and intravenous iron supplementation since 7 years ago . in physical examination
these nodules measured from 0.5 to 1.5 cm and tended to refill after compression . scar of a previous incision was present on the right supraclavicular region ( figure2 ) .
upper and lower gastrointestinal endoscopy along with duodenal biopsy had been performed 4 years ago and was normal.serum immunoglobulin a(ig a ) and anti - tissue transglutaminase antibody ( ttg ) -ig a levels were also normal
. 
 
 in our center the patient underwent upper and lower gi endoscopy for second time . in upper endoscopy , a bluish vascular lesion with 10
mm diameter and wrinkled surface was seen in proximal part of duodenum ( figure3-a).colonoscopy also revealed a similar lesion in the descending part of colon ( figure3-b ) .
3-a ( left ) shows a bluish vascular lesion with wrinkled surface in proximal part of duodenum .

 important diseases that involve the skin and gastrointestinal tract with vascular malformations include brbns , mafucci s syndrome and osler - weber- rendu syndrome . however , rendu - osler - weber syndrome is an inherited autosomal dominant condition and these patients often experience recurrent episodes of epistaxis with telangiectasia in histologic examination   and patients with mafucci s syndrome also have bone malformations and chondrodysplasias . 
 

a diagnosis of brbns was made on the basis of the typical skin lesions which were rubbery discrete compressible blebs increasing in number over the years , multiple bluish nevi in duodenum and colon on gi endoscopy , and histological picture of venous malformation on skin biopsy .
brbns ( or bean s syndrome ) is a rare disorder that is characterized by multiple recurrent vascular malformations that primarily involve the skin and the gastrointestinal tract .the disease and its association with hemagniomas in the skin and gastrointestinal tract was first reported in 1860 by gascoyen.a century later in 1958 , william bean named it as brbns . 
 

skin lesions in brbns are often first noticed at birth or in the neonatal period , but can present later .the size ranges from a few millimeters to many centimeters .
three types of skin lesions have been described .the most common type is red to blue , nipple - like skin lesion that is easily compressible and refills slowly on release of pressure .
this is an important diagnostic sign .the skin lesions in this case were also small , bluish , soft and compressible , and they occurred in the upper and lower extremities ; these are the typical features of brbns . 
 

the gastrointestinal tract is the most common organ involved in this disorder , small bowel and distal colon are predominantly affected .
bleeding from vascular malformations in gasterointestinal tract often cause ida that is the most common clinical manifestation of brbns but rarely presented as melena or hematochezia.1 , 
 2 in endoscopy , the mucosal nodules are either flat , polypoid or have central bluish nipples.1 , 
 7 in our case , the gastrointestinal lesions were limited to two protuberant lesions with wrinkled surface in duodenum and distal part of colon . 
 
 rarely , involvement of other internal organs occurs and can result in hemothorax , hemopericardium , pulmonary hypertension and central nervous system symptoms . 
 

often , brbns develops sporadically , but sometimes is inherited as an autosomal dominant pattern and its association with chromosome 9p has already been established .our case seems to have developed sporadically because no family member had history of brbns . 
 
 in most cases ,
only asymptomatic skin lesions are present and patients have a normal life span without any malignant transformation .
gi bleeding and rarely , central nervous system involvement can befatal and skeletal lesions are able to cause functional and physical inability .
intussusceptions , volvulus , and bowel infarction should be considered in patient with brbns and abdominal pain . 
 

the treatment of brbns is mainly conservative . when the patient is asymptomatic and only has mild anemia , observation and iron supplements are adequate.1- 
 3 
 
 several therapeutic modalities have been attempted to date for treating brbns .
antiangiogenetic agents such as steroids , interferon -2a and octreotide have been applied to reduce the frequency and severity of bleeding episodes.unfortunately , in most cases , discontinuing administration of these medical treatments has led to recurrence of the disease . 
 

although endoscopic laser photocoagulation , sclerosis , band ligation and polypectomy have been successfully utilized , they may be dangerous in transmural lesions . 
 

laparatomy with intraoperative endoscopy may be the best approach for patients with refractory anemia and multiple lesions in gi tract especially small bowel.15- 
 20 in the largest study on treatment of brbns published so far , ten patients with brbns and ida with prior history of at least one blood transfusion , underwent whole gi endoscopy .
subsequent gastrointestinal bleeding recurred in only one patient who had received less extensive procedures . 
 

our patient was consulted about the natural history of the disease and the chronicity of the condition which is disabling but not fatal in majority of cases .
he did well during 2 years of follow up and his hemoglobin level was maintained without any need to transfusions .
long term follow up is required to evaluate the effect of conservative treatment with iron supplementation in this patient and determine surgical intervention will be necessary or not . 

 
 blue rubber bleb nevus syndrome is a rare disorder that is characterized by multiple recurrent vascular malformations of skin and gastrointestinal tract . 
 the affected patients may present with diverse manifestations including iron deficiency anemia . 

 
 we report this syndrome in a 22-year - old man that was referred to our hospital for iron deficiency anemia with unknown cause and vascular malformations in the skin and gastrointestinal tract . because of stable hemoglobin level 
 , we decided to treatment him by iron supplementation and close follow up . 
 we report this case along with a review of literature . 
 

INTRODUCTION


CASE REPORT


DISCUSSION


CONFLICT OF INTEREST
