childhood cancer has an enormous impact on the lives of children and their families , forcing them to face stressful experiences , full of anguish , fear and suffering.1,2 generally , cancer involves a prolonged treatment that demands care and implies several changes , such as adaptations to new routines , new discourses , new situational settings regarding uncertainties about the treatment course , anxiety and fear of dying , changes in affective and emotional contexts , and concerns about financial welfare and family cohesion , bringing feelings of doubt and impotence.3 this context can lead the child and the relatives to depressive states , discouragement , hopelessness , confusion , and exaustion.2 receiving a cancer diagnosis is an intense personal experience , based on universal , cultural , and familiar meanings . to deal with the suffering caused by cancer , patients and their relatives use different coping strategies , and patients frequently use spirituality to cope with the disease.1,4,5 spirituality
is described in a broader sense than religion , being related to issues such as the meaning and purpose of life , and using spiritualistic beliefs to seek these answers.6 in 1988 , the world health organization ( who ) deepened investigations regarding spirituality , which was included in the who multidimensional definition of health . nowadays , spiritual welfare
is still considered a health dimension , among physical , psychic , and social dimensions.7 especially regarding cancer patients , spirituality seems to involve the search of the meaning and purpose of life , improving the quality of life of the child and his / her family .
scientific studies are being carried out to investigate possible influences of spirituality in human health .
spirituality has also been considered a dimension that must be included in a global care to the patient.8 the purpose of this study was to analyze the influence of spirituality in childhood cancer care , involving biopsychosocial aspects of the child , the family , and the health care team facing the disease .
, a search of the literature was conducted via national and international electronic databases ( scientific electronic library online [ scielo ] , pubmed , and latin american and caribbean health sciences literature [ lilacs ] ) using different combinations of medical subject headings ( mesh ) terms  spirituality ,   child psychology ,  
the title and abstracts of the retrieved articles were entirely read , and a matrix including title of journal / article , year of publication , subject , and type of publication was done . the search strategy and
inclusion criteria were as follows : ( a ) articles about spirituality in childhood cancer care ; ( b ) manuscripts written in english or portuguese ; ( c ) recent manuscripts regarding the subject ; ( d ) original articles with online accessible full text available in coordination of improvement of higher education personnel ( capes ) journal portal , a virtual library linked to brazil s ministry of education and subjected to content subscription;9 ( e ) prospective or retrospective observational ( analytical or descriptive , except case reports ) , experimental or quasi - experimental studies , and reviews of literature .
exclusion criteria were : ( a ) other designs , such as case reports and series of cases ; and ( b ) nonoriginal studies , including editorials , brief communication , and letters to the editor .
after carrying out the search strategies and analyzing title and abstract according to the eligibility criteria , 20 articles were retrieved and included in the final sample . from this total ,
ten ( 50.0% ) manuscripts1,1018 were found in pubmed database , four ( 20.0%)5,1921 retrieved in scielo database , one ( 5.0%)4 was found in lilacs database , and five ( 25.0%)2,7,8,22,23 manuscripts were found in the reference lists of the retrieved articles .
table 1 provides an overview of all studies included in the final sample and of all data elements used during the data analysis process .
the 20 studies were distributed in the previously determined two categories as follows : importance of spirituality to patients , their families and caregivers ; and strengthening of spirituality in the health care context .
the relation between spirituality and health has lately become a subject of growing interest among researchers , as a positive influence of spirituality in the people s welfare was noted .
the studies retrieved in the present review adopt a global view of health , dealing with subjects in their different dimensions and overcoming the biomedical model , which only highlights the physical aspect of the health  disease process and acts as a mechanistic idea of the body and its functions , being responsible for a fragmented treatment.22 an observational study by batista et al4 show that the patient s quality of life regarding peace aspects is higher the more the patient s level of spirituality .
this evidences that , more than only focusing on the disease , it is also important to consider the patient s subjective aspects , to transmit inner peace.4
they express their spirituality by a variety of behaviors , such as rite simulation and games involving creativity .
studies show that children who develop their spirituality and have spiritual care have more positive coping strategies , sharing resilience as a protection factor.15 the practice of spirituality in childhood cancer care involves not only the patient , but also the family of the pediatric patient .
schneider and mannell,13 in a study conducted among parents of children with cancer , demonstrated that there is a need for orientation by a spiritual counselor , highlighting the importance of spirituality to the family , in a situation of disease .
the majority of the parents find it difficult to deal with their faith when the child s health state worsens ; faith was also cited as a source of comfort and as an extremely personal issue . during difficult times
, some parents questioned their beliefs , but they did not have their faith shaken . in this sense , the health care professional can give support to the spiritual practices of the parents , volunteering to pray with them , if they feel at ease doing so.13 in cancer , suffering often becomes a part of the routine of the children and their families .
the experience of childhood cancer suffering has been described , highlighting the narratives of uncertainty related to the treatment process .
the impact of uncertainty to the family reflects in the moments of confusion , despair , worries , exhaustion , discouragement , that are peculiar to the suffering regarding the battle against cancer.2 another study , one that focused on the mothers needs while facing the difficulties of having a child with cancer , points out that it is important for the mother to have a place where she could feel comforted in the moments of fragility .
being able to cry far from the eyes of her son / daughter is a need and assures the mother of her own fragility and limitation , also giving her the conscience that she has to be strong so as to support her child.23 faria and cardoso1 highlight spirituality as a coping strategy for caregivers of children with leukemia .
the study assessed the level of stress of 20 caregivers , and pointed to spirituality , along with  problem solving  and  escape and avoidance ,  as a relief to the suffering resulting from a cancer diagnosis , where caregivers seek strength to deal with the situation and continue their caregiving function . in this context , most studies show that spirituality can act as a way of adaptation to stress in a health context.19 spirituality was found to be a source of comfort and hope and has helped to better accept the chronic condition by the child.20 there is enough evidence that spirituality rises as a striving factor of hope for children with cancer and their families , at the same time protecting them against despair and helping them to cope with difficulties.2
recent studies show that the health care team has become more sensitive to this specific dimension of care .
however , additional studies are still necessary to identify and to evaluate the adequate practices , to clarify concepts , and to contribute to professional improvement.16 the participation of the health care practitioner is hampered by a curriculum that does not adequately prepare him to deal with subjective dimensions that are not expressed in a rational and clear way .
that is why it is crucial for health care professionals to acknowledge their own spiritual language , assumptions , and experiences,17 so as to provide a broader care to children with cancer .
it is of note that the spirituality herein studied does not relate to a specific religious belief ; instead , it refers to the relation between the subject and the divine and the consequences of this relationship , such as attitudes , thoughts , feelings , and their manifestations in each individual .
it is a dimension that is beyond the limits of the universe and that is related to the search for a meaning for life.5,12 facing the importance of enabling health care professionals to adequately approach spirituality , the strategies in table 2 bring important findings on how the health care team must deal with the patients and the caregivers spirituality in the health context .
these strategies show that the health care team s work must overcome the strict objective of treating the disease , successfully creating an environment in which the pediatric cancer patient recognizes what happens to him / her , only then being able to understand the meaning of his / her disease and finding solutions to cope with this new life context.21 having this in mind , and also considering that children are spiritual beings whose expression of spirituality may be limited by the capacity of the adults to understand them , childhood cancer care might contemplate the child s particular world and stages in a holistic way , regarding the individual and his / her family , in an attempt to satisfy the child s
cancer , in itself , defies the child and his / her family . in this context , people ask themselves about faith and religiosity , and spiritual care may or may not be desired , depending on the way the families of children with cancer understand or recognize the meaning of their lives through spirituality .
this review was able to verify that spirituality is considered a source of comfort and hope and has helped in the better acceptance of the chronic condition of the children with cancer and their families . however , to achieve a better understanding regarding the subject , further studies are needed , exploring the impact of spirituality in the experience of pediatric cancer .
health care practitioners must also be better qualified , so as to identify the right moment to interfere and offer families of pediatric patients and patients themselves strategies that deal with spiritual care , providing the child with a fuller and more humanized care .
 to deal with the suffering caused by childhood cancer , patients and their families use different coping strategies , among which , spirituality appears a way of minimizing possible damage . in this context , the purpose of the present study was to analyze the influence of spirituality in childhood cancer care , involving biopsychosocial aspects of the child , the family , and the health care team facing the disease . to accomplish this purpose , a nonsystematic review of literature of articles on national and international electronic databases ( scientific electronic library online [ scielo ] , pubmed , and latin american and caribbean health sciences literature [ lilacs ] ) was conducted using the search terms  spirituality ,   child psychology ,   
 child ,  and  cancer ,  as well as on other available resources . after the search , 20 articles met the eligibility criteria and were included in the final sample . 
 our review showed that the relation between spirituality and health has lately become a subject of growing interest among researchers , as a positive influence of spirituality in the people s welfare was noted . 
 studies that were retrieved using the mentioned search strategy in electronic databases , independently assessed by the authors according to the systematic review , showed that spirituality emerges as a driving force that helps pediatric patients and their families in coping with cancer . 
 health care workers have been increasingly attentive to this dimension of care . however , it is necessary to improve their knowledge regarding the subject . 
 the search highlighted that spirituality is considered a source of comfort and hope , contributing to a better acceptance of his / her chronic condition by the child with cancer , as well as by the family . 
 further up - to - date studies facing the subject are , thus , needed . 
 it is also necessary to better train health care practitioners , so as to provide humanized care to the child with cancer . 
Introduction
Methods
Results
Discussion
Importance of spirituality to patients, their families, and their caregivers
Strengthening of spirituality in the health care context
Conclusion