a total of 81 consecutive adult patients with physician diagnosed asthma were recruited from the asthma clinic of obafemi awolowo university teaching hospital ile - ife osun state nigeria .
the diagnosis of asthma was confirmed on symptoms consistent with asthma and a chart evidence of bronchodilator reversibility test of fev115% with at least 200 ml , 20 min after inhalator of 400 microgram of b2-agonist ( salbutamol ) .
the patients were clinically stable with no exacerbation or hospital admission and no change in medication dosage or frequency in the last 4 weeks in order to avoid any bias in patients opinion about their health status .
patients with other comorbidity conditions like copd and hypertensive heart disease and those with pre - existing recognized psychopathology were excluded .
eligible patients were interviewed by a team of researchers led by the second author in a prepared room in the clinic . ethical clearance for the study was obtained from the institutions ethical committee . after the purpose of the study was explained , each patient gave a written consent before being included .
the participant completed sociodemographic questionnaires that capture variables such as the age , sex , occupational status , and clinical variables such as duration of symptoms .
each patient completed the mini - asthma quality of life questionnaire ( 11 ) and hospital anxiety and depression scale ( 12 ) .
the lung function was assessed by peak expiratory flow meter ( micro medical ltd , rochester , uk ) after due explanation of the procedure and accompanied demonstration .
mini - asthma quality of life questionnaire ( mini - aqlq ) ( 11 ) : the original asthma quality of life questionnaire is a disease specific instrument with 32-items that was designed to measure functional impairments that are most troublesome to adult asthma patients ( 13 ) .
it has four domains : symptoms ( 12 items ) , activity limitation ( 11 items ) , emotional function ( 5 items ) , and environmental stimuli ( 4 items ) , validation studies have shown that it has good evaluative and discriminative properties ( 13 , 14 ) .
the mini - aqlq was developed by the same author with the aim of having a measure with the same specification as the original aqlq , but short and easy to complete .
the mini - aqlq has 15 items that are divided into four domains , these are symptoms domain ( 5 items ) , activity domains ( 4 items ) , emotional domain ( 3 items ) , and environmental domain ( 3 items ) .
the questionnaire is analyzed directly from the scores recorded and expressed as the mean score per item for each domain thus the score ranges from 1 to 7 for each domain , and for the overall quality of life score that is the mean score of all the items .
the internal consistency test done showed a cronbachs alpha coefficient of 0.8469 , while the alpha for each domain and the overall aqol ranged from 0.74540 8332 . on the mini - aqol , for this study a score of mean + /-
fair , a score < mean -1 standard deviation is graded poor quality of life , while > mean + 1 standard deviation is graded good quality of life hospital anxiety and depression scale [ hads ] ( 12 ) : the hospital anxiety and depression scale has been widely used to detect anxiety and depressive symptoms in general medical outpatient populations .
the fourteen ( 14 ) items are rated on a 4-point scale ranging from absence of symptom , or the presence of a positive feature ( scoring 0 ) to maximum symptomatology or absence of positive features that scores 3 ( 10 ) .
the instrument has been widely used and standardized among nigerians where a minimum score of eight ( 8) on each of the subscales has been observed to indicate the presence of significant symptoms ( 15 ) .
statistics : all data were analyzed using the statistical package for the social sciences ( version 11 ) , chicago , il .
descriptive statistics were used and the test of association was done using chi squared test for proportions and student 
pearson 's correlation was also used , while regression analysis was used to assess the predictive values of some variables .
a total of 81 consecutive adult patients with physician diagnosed asthma were recruited from the asthma clinic of obafemi awolowo university teaching hospital ile - ife osun state nigeria .
the diagnosis of asthma was confirmed on symptoms consistent with asthma and a chart evidence of bronchodilator reversibility test of fev115% with at least 200 ml , 20 min after inhalator of 400 microgram of b2-agonist ( salbutamol ) .
the patients were clinically stable with no exacerbation or hospital admission and no change in medication dosage or frequency in the last 4 weeks in order to avoid any bias in patients opinion about their health status .
patients with other comorbidity conditions like copd and hypertensive heart disease and those with pre - existing recognized psychopathology were excluded .
eligible patients were interviewed by a team of researchers led by the second author in a prepared room in the clinic . ethical clearance for the study was obtained from the institutions ethical committee . after the purpose of the study was explained , each patient gave a written consent before being included .
the participant completed sociodemographic questionnaires that capture variables such as the age , sex , occupational status , and clinical variables such as duration of symptoms .
each patient completed the mini - asthma quality of life questionnaire ( 11 ) and hospital anxiety and depression scale ( 12 ) .
the lung function was assessed by peak expiratory flow meter ( micro medical ltd , rochester , uk ) after due explanation of the procedure and accompanied demonstration .
mini - asthma quality of life questionnaire ( mini - aqlq ) ( 11 ) : the original asthma quality of life questionnaire is a disease specific instrument with 32-items that was designed to measure functional impairments that are most troublesome to adult asthma patients ( 13 ) .
it has four domains : symptoms ( 12 items ) , activity limitation ( 11 items ) , emotional function ( 5 items ) , and environmental stimuli ( 4 items ) , validation studies have shown that it has good evaluative and discriminative properties ( 13 , 14 ) .
the mini - aqlq was developed by the same author with the aim of having a measure with the same specification as the original aqlq , but short and easy to complete .
the mini - aqlq has 15 items that are divided into four domains , these are symptoms domain ( 5 items ) , activity domains ( 4 items ) , emotional domain ( 3 items ) , and environmental domain ( 3 items ) .
the questionnaire is analyzed directly from the scores recorded and expressed as the mean score per item for each domain thus the score ranges from 1 to 7 for each domain , and for the overall quality of life score that is the mean score of all the items .
the internal consistency test done showed a cronbachs alpha coefficient of 0.8469 , while the alpha for each domain and the overall aqol ranged from 0.74540 8332 . on the mini - aqol , for
fair , a score < mean -1 standard deviation is graded poor quality of life , while > mean + 1 standard deviation is graded good quality of life hospital anxiety and depression scale [ hads ] ( 12 ) : the hospital anxiety and depression scale has been widely used to detect anxiety and depressive symptoms in general medical outpatient populations .
the fourteen ( 14 ) items are rated on a 4-point scale ranging from absence of symptom , or the presence of a positive feature ( scoring 0 ) to maximum symptomatology or absence of positive features that scores 3 ( 10 ) .
the instrument has been widely used and standardized among nigerians where a minimum score of eight ( 8) on each of the subscales has been observed to indicate the presence of significant symptoms ( 15 ) .
statistics : all data were analyzed using the statistical package for the social sciences ( version 11 ) , chicago , il .
descriptive statistics were used and the test of association was done using chi squared test for proportions and student 
pearson 's correlation was also used , while regression analysis was used to assess the predictive values of some variables .
the mean age of respondents was 35.22 ( sd14.36 ) , with a male female ratio of 1:1 , mean duration of asthma symptom 17.9 ( sd14.49 ) ( table 1 ) .
twelve ( 14.8% ) have had two or more hospital admissions due to asthma symptoms in the past one year , other clinical variables are shown in table 2 . 
 
sociodemographic characteristics of respondents clinical , psychological and mini - aqol variables the mean quality of life in the various domains of the mini - aqol were symptoms domain 3.6 ( sd1.34 ) , emotion domain 4.0 ( sd1.90 ) , environment domain 3.0 ( sd2.20 ) , activity domain 4.5 ( sd1.48 ) and the mean overall aqol was 3.58 ( sd1.78 ) .
variables significantly associated with the overall quality of life included the presence of anxiety symptoms ( =7.9 , p=.02 ) , depressive symptoms ( =6.45 , p=.04 ) , the number of hospital admissions because of asthma in the past year ( =9.6 , p=.05 ) , number of asthma attacks in the past month ( =15.7 , p=.003 ) , low educational status ( =6.6 , p=.04 ) , smoking ( =10.96 , p=.004 ) , and alcohol use ( =23.47 , p=.001 ) .
there is also a significant negative correlation between the overall quality of life and patient 's age , peak expiratory flow ( pef ) , anxiety symptoms , depressive symptoms , and asthma attacks ( table 3 ) .
regression analysis using overall asthma quality of life score as dependent variable showed that anxiety ( t=0.27 , p=.01 ) , low educational status ( t=2.75 , p=.007 ) , and female gender ( t=2.37 , p=.02 ) all significantly predicted low quality of life . 
 
correlation between mini - aqol domains scores and other variables ( pearsons ) r - pearsons correlation values .
asthma is a disease that can result in varying degrees of restrictions affecting the physical , emotional , and social spheres of a patient 's life , thus affecting patient 's quality of life . in this study ,
the presence of psychological symptoms resulted in low quality of life scores in all the domains of the asthma quality of life questionnaire ; adam et al . (
10 ) had reported that people with both asthma and psychological distress have poorer quality of life .
mancuso et al . ( 16 ) also reported that asthmatics reporting the presence of depressive symptoms have worse health related quality of life than asthma patients with similar disease activity but fewer depressive symptoms .
reports have also shown that psychological factors may influence asthma management in many ways , for example , depression is associated with decreased problem solving ability ( 17 ) , memory ( 18 ) , and attention span ( 19 ) , this may slow decision making and affect asthma management .
thus as in other studies ( 10 , 16 ) , this study suggests that the comorbidity of asthma and psychological symptoms affect the quality of life of asthmatics .
other factors that were significantly associated with quality of life in our sample of asthmatics include the number of asthma attacks in the past month and the number of hospital admissions related to asthma in the past year .
this is not surprising since the presence of asthma symptoms affect quality of life , while improvement in symptoms result in improvement in patients perceived quality of life ( 11 ) .
the educational status of the patients was also significantly associated with asthma quality of life .
sociodemographic factors such as socioeconomic status , level of education , and others had been reported as important independent factors that influence quality of life among asthmatics ( 20 ) , our results corroborates these findings .
there was also an inverse relationship between the peak expiratory flow ( pef ) rate and overall asthma quality of life ( aqol ) .
the peak expiratory rate ( pef ) , which is an indication of lung function and may indicate disease severity , confirms that the more severe the patients diseased condition the worse the patient 's quality of life .
regression analysis also indicates that both psychological symptoms and sociodemographic variables are important predictors of quality of life among asthmatics .
the presence of anxiety , which is an indication of distress , along with a low educational level and female gender are all important predictors of low quality of life among asthmatics .
physicians caring for this group of patients will do well to take note of this group of patients with a view to improving their quality of life .
limitation to this study included the fact that assessment was done only once thus change in patients diseased state and quality of life could not be assessed .
the instrument used was also not compared to another instrument thus its effectiveness can not be fully assessed .
this study has shown that psychological and sociodemographic factors apart from disease specific variables are important determinants of quality of life among asthmatics .
the authors have not received any funding or benefits from industry or elsewhere to conduct this study .
 backgroundassessment of health related quality of life ( hrql ) has become central to assessing the self - perceived impact of physical and mental impairment on patient 's health . 
 studies have reported a high rate of psychological disturbances among asthmatics ; however , the impact of these psychological factors on hrql remains unexplored.objectivesto assess the health related quality of life among a sample of asthmatics and to identify the psychological and clinical variables that affect quality of life among asthmatics.methoda total of 81 patients attending the clinic were assessed using the mini - asthma quality of life questionnaire ( mini - aqlq ) , and the hospital anxiety and depression scale ( hads ) . 
 sociodemographic and clinical variables were also obtained from the patients , the lung function was assessed using peak expiratory flow rate ( pefr).resultsmean age of all the patients was 35.22 ( sd14.36 ) with a mean duration of asthma symptoms of 17.5 ( sd14.4 ) years . 
 mean peak expiratory flow was 336 l / min ( sd74.12 ) . 
 anxiety was present in 44.4% of respondents , while 40% of respondents reported the presence of depressive symptoms , 48.1% of the respondents reported low scores on the asthma quality of life questionnaire . 
 poor quality of life was associated with the presence of psychological symptoms , female sex , and lower educational level.conclusionpsychosocial variables are just as important as clinical variables as determinants of health related quality of life among asthmatics . 
Methods
Subjects
Study design
Instruments
Results
Discussion
Conclusion
Conflict of interest and funding