patients symptoms manifest mainly as axial mechanical lower back pain . magnetic resonance imaging ( mri )
findings include decreased disc height , loss of t2-weighted signal within the disc , and disc bulging .
ideally , symptoms are managed non - operatively but in some patients pain management fails and patients are significantly disabled and/or require high narcotic pain medications .
a couple of recent food and drug administration ( fda ) investigational device exemption ( ide ) studies demonstrated the effectiveness of lumbar total disc replacement ( tdr ) in the treatment of degenerative disc disease in adults .
older patients ( age > 60 ) are not considered good candidates for tdr because of associated facet arthropathy and other degenerative changes .
the authors report their initial experience with 2 children who underwent tdr at their institution .
the pain was fairly constant and worsened on sitting down but was relieved on lying down with occasional radicular pain .
she failed non - operative management including epidural steroid injections and courses of various medications .
mri revealed overall good alignment with disc degeneration appreciated at l4 - 5 [ figure 1 ] .
the patient eventually had a lumbar discectomy at l4 - 5 at an outside hospital at the age of 15 years .
she had no improvement with a lumbar discectomy and presented to us again with lower back pain interfering with her ability to participate in school and requiring regular narcotic pain medication .
the patient underwent a l4-l5 artificial lumbar disc replacement through a left anterior retroperitoneal approach .
the patient did remarkably well with almost complete resolution of her back pain from a pre - operative vas score of 9/10 to 1/10 at 6 months follow - up after the surgery .
mri showing overall good alignment with disc degeneration at l4 - 5 level with low signal intensity on t2-weighted imaging and diffuse central bulge slightly off to the right side post - operative x - ray revealing good disc placement a 17-year - old teenager secondary to complains of back and right lumbar radicular leg pain underwent a l5-s1 microdiscectomy at another institute . though the leg pain improved after surgery , he continued having axial lower back pain requiring regular narcotic pain medications with interference in activities of daily living and participation in sports .
mri showed disc degeneration involving l5-s1 level with no evidence of any significant disc herniation [ figure 3 ] .
he failed trials of multiple epidural injections , physical therapy , pain medications and other conservative measures .
the patients pain usually worsened while sitting down and improved with changes in position appearing to be discogenic in nature .
after careful pre - operative counseling and discussion of treatment options with the family , the patient underwent l5-s1 disc replacement .
unfortunately , he did not had much improvement after surgery with reduction in pain from a pre - operative vas score 9/10 to 5/10 despite post - operative x rays at 6 months follow - up showing well - placed implant with preserved motion at the operated level [ figure 4 ] .
mri showing disc degeneration involving l5-s1 level with no evidence of any significant disc herniation post - operative x - rays done at 6 months follow - up showing a well - placed implant with preserved motion at the operated level
the pain was fairly constant and worsened on sitting down but was relieved on lying down with occasional radicular pain .
she failed non - operative management including epidural steroid injections and courses of various medications .
mri revealed overall good alignment with disc degeneration appreciated at l4 - 5 [ figure 1 ] .
the patient eventually had a lumbar discectomy at l4 - 5 at an outside hospital at the age of 15 years .
she had no improvement with a lumbar discectomy and presented to us again with lower back pain interfering with her ability to participate in school and requiring regular narcotic pain medication .
the patient underwent a l4-l5 artificial lumbar disc replacement through a left anterior retroperitoneal approach .
the patient did remarkably well with almost complete resolution of her back pain from a pre - operative vas score of 9/10 to 1/10 at 6 months follow - up after the surgery .
mri showing overall good alignment with disc degeneration at l4 - 5 level with low signal intensity on t2-weighted imaging and diffuse central bulge slightly off to the right side post - operative x - ray revealing good disc placement
a 17-year - old teenager secondary to complains of back and right lumbar radicular leg pain underwent a l5-s1 microdiscectomy at another institute . though the leg pain improved after surgery , he continued having axial lower back pain requiring regular narcotic pain medications with interference in activities of daily living and participation in sports .
mri showed disc degeneration involving l5-s1 level with no evidence of any significant disc herniation [ figure 3 ] .
he failed trials of multiple epidural injections , physical therapy , pain medications and other conservative measures .
the patients pain usually worsened while sitting down and improved with changes in position appearing to be discogenic in nature .
after careful pre - operative counseling and discussion of treatment options with the family , the patient underwent l5-s1 disc replacement .
unfortunately , he did not had much improvement after surgery with reduction in pain from a pre - operative vas score 9/10 to 5/10 despite post - operative x rays at 6 months follow - up showing well - placed implant with preserved motion at the operated level [ figure 4 ] .
mri showing disc degeneration involving l5-s1 level with no evidence of any significant disc herniation post - operative x - rays done at 6 months follow - up showing a well - placed implant with preserved motion at the operated level
lumbar disc herniation occurs in pediatric population with a much lower incidence than in adults .
it presents with lumbar radiculopathy and back pain in both adults and in the pediatric population .
microdiscectomy has been reported to be safe and effective in management of pediatric patients with lumbar disc herniation who fail conservative management .
children may also present with back pain predominantly discogenic similar to degenerative disc disease symptoms common in the adult population .
cases where radiculopathy is not the predominant symptom may not benefit from discectomy as happened in one of our patients who underwent a failed discectomy at some other hospital .
lower back pain is reported by less than 1% of 7-year - olds but by the age of 16 , 18% of children report some lower back pain .
kjaer , et al . showed about a 3 of 439 13-year - olds undergoing mris for back pain had mri abnormalities .
salminen , et al . followed 40 15-year - old patients reporting lower back pain for 9 years prospectively .
their study noted significant number of 15-year - old patients who developed chronic lower back pain in their 20s .
long - term chronic back pain was associated with disc degenerative changes on initial mri scans in the 15-year - olds .
these studies show the degenerative disc cascade probably starts in the adolescent years in many patients.[810 ] management remains controversial .
mri scans in up to a third of 20-year - olds show some degenerative changes .
disagreement exists regarding the localization of the disc as the cause of pain in adults .
diagnosis is somewhat easier in younger patients because multi - level degenerative mri changes are not normally seen in the younger age group .
other cause of lower back pain in the younger age group should also be excluded including psychological disease , viral myalgia , sickle cell disease , infection , spinal deformity , fracture , or urological disease .
fusion surgery for back pain in a pediatric spine exposes patients to a larger overall risk of adjacent segment degeneration which is well described in adults considering their longer expected life span .
this probably explains the reluctance among spine surgeons to fuse children or adolescents with back pain as the predominant symptom in the absence of radiculopathy .
availability of tdr theoretically might help such patients who generally have single degenerated disc and can be treated with lumbar disc replacement bypassing the problems associated with fusion at an early age . though the exact role of discography is controversial , it can be of help in pin - pointing the cause of back pain to a single disc in patients with multilevel disc degeneration which generally is uncommon in children .
several prospective randomized trials in carefully selected adult patients demonstrated arthroplasty as an effective treatment for degenerative disc disease .
the fda ide studies for the charite and prodisc artificial lumbar disc showed that about two thirds of carefully selected patients improved with surgery .
five - year follow - up in the charite group show over 55% of patients with long - term improvement in symptoms as defined by the fda success criteria .
there have been no studies or reports of technical feasibility and outcome following tdr in children .
selection of younger patients for tdr surgery should be carefully considered and all other options should be exhausted prior to surgery .
our small experience shows results similar to adult tdr surgery with one patient showing improvement while the others demonstrating no significant improvement despite a technically successful surgery .
though there are studies reporting good outcomes with maintenance of range of motion up to 10 years after disc replacement in adults , similar data in pediatric age group is lacking due to rarity of such procedures in children which at the best should be avoided .
the short follow - up in this report represents a significant shortcoming and leaves unanswered the long - term outcome of tdr in pediatric patients .
also the unpredictable nature of the outcome reported in this series further highlights the complex nature of back pain with multifactorial etiology which can not be fully addressed with motion preservation alone .
another consideration is the performance of the artificial disc in pediatric population who are more active and athletic than the general adult population raising the possibility of early implant wear and failure .
decision - making in management of degenerative disc disease back pain in children can be challenging .
the availability of artificial lumbar disc and the technical possibility of performing it in the adolescent age group as described in this paper may widen the treatment options and can be clinically important for this subgroup of patients .
though technically not difficult , successful surgery with motion preservation may not be synonymous with good outcome and role of tdr in pediatric patients needs to be proven in further studies with long term follow - up .
 management of painful lumbar disc degeneration is one of the most common conditions treated by spine surgeons . 
 several recent prospective multicenter trials have demonstrated the effectiveness of artificial lumbar disc replacement in treating discogenic lower back pain . though data on the safety and effectiveness has gradually been accumulated in adults , 
 there is a lack of published data on the effectiveness and feasibility of lumbar artificial disc replacement in adolescents . 
 the authors share their initial clinical experience with lumbar disc replacement in a couple of adolescents . 
Introduction
Case Reports
Case 1
Case 2
Discussion
Conclusions