these cysts are the most common type of developmental odontogenic cysts arising from the crowns of impacted , embedded , or unerupted teeth .
they constitute the second most common cystic lesion of the jaws , after radicular cysts .
tooth bearing. they are most frequently associated with the crowns of permanent teeth , though few rare cases are reported in association with the crowns of deciduous tooth , complex odontoma , and supernumerary teeth .
dentigerous cysts associated with supernumerary teeth constitute 5 - 6% of all dentigerous cysts and about 90% are associated with a maxillary mesiodens . the most reasonable theory to explain its pathogenesis appears to be that the cyst is the result of the accumulation of fluid between an unerupted tooth and the surrounding reduced enamel epithelium .
the mandibular third molar and maxillary canines are involved most often , followed by the mandibular premolars and the maxillary third molar .
dentigerous cyst associated with an ectopic tooth within the maxillary sinus is fairly rare , and only 20 cases had been reported in medline since 1980 including the 3 cases reported by buyukkurt et al . who reviewed the literature reports of this condition from 1980 to 2009 .
in the present paper , we report an additional case of dentigerous cysts associated with an ectopic third molar in the right maxillary sinus .
of oral medicine and radiology , with the chief complaint of pus discharge from upper right posterior region of jaw and right nostril since last 3 years .
detailed history revealed that it started as pus discharge from oral cavity 3 years back , for which he took medicines from a general physician for over a year .
but , no permanent relief was obtained , and condition further deteriorated when pus discharge from right nostril started 6 months back . later on , he consulted a dentist for the problem who prescribed medicines for a week . as there was no relief , he referred him to our dental college .
extra - oral examination revealed presence of diffuse , soft , tender swelling over right maxillary sinus [ figure 1 ] .
pus discharge was evident from distal aspect of upper right second molar , on application of pressure with finger in buccal vestibule in that region .
extra - oral photograph showing diffuse swelling over right maxillary sinus radiographic evaluation included iopa of the upper right second molar , opg , waters view , lateral cephalogram , and ct scan .
opg revealed upper right third molar in the maxillary sinus near its posterosuperior aspect [ figure 2 ] . on ct scan examination ,
a cystic expansile lesion was seen in the right maxillary sinus with the crown of an unerupted tooth within it .
bony defect was seen in its inferior wall allowing the cyst to communicate with the roof of the oral cavity .
opg showing impacted third molar in the right maxillary sinus near its posterosuperior aspect coronal ct image showing expansile cystic lesion surrounding crown of impacted molar in the right maxillary sinus incisional biopsy report was indicative of dentigerous cyst . patient was referred to maxillo - facial surgery department where enucleation of cystic lesion under ga was carried out via the caldwell - luc approach , and tissue was sent for histopathological examination , which confirmed the finding of incisional biopsy report [ figure 4 ] .
post - operative healing was uneventful , and patient was followed - up over a period of next 2 years and was asymptomatic [ figures 5 and 6 ] .
photomicrograph showing the cystic lesion lined by non - keratinized squamous epithelium post - operative photograph
ectopic teeth are those located in the jawbones or regions other than the alveolar arch .
ectopic eruption of a tooth is rare ; however , there have been few reports of tooth in the nose , mandibular condyle , coronoid process , and maxillary sinus , which is also the largest of the paranasal sinuses .
ectopic eruption may occur as a result of 1 of 3 distinct processes described below , or it may be idiopathic .
odontogenesis is a complex process , and abnormal tissue interactions between the oral epithelium and the underlying mesenchymal tissue during development may potentially result in ectopic tooth development and eruption .
it is believed that the displacement of tooth buds by the expansion of progressively growing dentigerous cysts results in the displacement of the tooth to other areas . in the present case ,
have mentioned a case of an iatrogenic displacement of the upper right third molar into the maxillary antrum in a 40-year - old female during the extraction of that tooth . though cases of dentigerous cysts are reported in children , they are usually present in the second or third decade of life and are rare in childhood . the incidence is higher in males than in females ( m : f-1.84 : 1 ) .
multiple and bilateral cysts have been reported in patients with syndromes such as basal cell nevus syndrome , mucopolysaccharidosis , and cleidocranial dysplasia as well as in a non - syndromic patient .
it can cause headache , obstruction of the sinus , epiphora due to nasolacrimal duct obstruction , recurrent sinusitis , purulent rhinorrhea , elevation of the orbital floor , and fractures .
impingement of this lesion on the orbital floor can cause diplopia and possibly even blindness .
on radiographic examination , dentigerous cysts appear as unilocular radiolucencies of varying sizes , with well - defined sclerotic borders , associated with the crown of an unerupted tooth . if a follicular space on radiography is more than 5 mm , an odontogenic cyst can be suspected .
water view , opg , and lateral cephalogram are simple and inexpensive projections for radiographic evaluation of an ectopic tooth in the maxillary sinus .
ct scan provides superior bony detail , help in determination of the size and extent of the lesion , and is useful to distinguish a maxillary lesion of antral origin from an extra - antral lesion .
studied 12 patients with teeth in the maxillary sinus by plain film radiography ( pfr ) and by ct with a dental software programme .
he found that ct was superior to pfr to determine proximity of the tooth to the sinus wall or its ankylosis , proper surgical planning ( crestal incision or caldwell - luc approach ) , as well as prediction of prognosis or complications .
ustuner et al . provided mri findings of the cystic lesion , which appears homogeneously hypointense on t1-weighted images and hyperintense on t2-weighted images .
chronic secretions , air , and acute hemorrhage in the sinus may also appear hypointense , but their central location in the sinus distinguishes them from tooth , which lies eccentrically in the cyst wall .
the differential diagnosis of a dentigerous cyst includes unicystic ameloblastoma , adenomatoid odontogenic tumor ( aot ) , early stages of gorlin cyst / calcifying epithelial odontogenic tumor ( ceot ) , ameloblastic fibroma , ameloblastic fibro - odontoma , and odontogenic keratocyst .
unicystic ameloblastoma is seen in persons under the age of 30 years , occurs equally in both genders , and has a tendency to occur in posterior mandible associated with the crown of an unerupted third molar .
aot is common in second decade , affects females twice as often as males , has a striking tendency to occur in the anterior maxilla and in about 74% of cases associated with the crown of an unerupted canine .
gorlin cyst is commonly found in the incisor and canine area ( 65% of cases ) .
approximately one third of cases are associated with an unerupted tooth , most often a canine .
ceot is an uncommon lesion , which is most often encountered between third to fifth decades , occurs equally in both genders , and has a tendency to occur in posterior mandible associated with an impacted third molar .
ameloblastic fibroma is an uncommon tumor , occurs in first two decades , more common in males , commonly found in posterior mandible , and is associated with an unerupted tooth in about 75% of cases .
however , the ameloblastic fibro - odontoma is rarely found within the maxillary sinus and usually occurs in persons under the age of 20 .
odontogenic keratocyst may be found in patients from infancy to old age , commonly found in posterior body and ascending ramus of mandible , and in 25% to 40% of cases , unerupted tooth is involved .
histologically , dentigerous cysts are lined by a layer of non - keratinized stratified squamous epithelium , with a surrounding wall of thin connective tissue containing odontogenic epithelial rests .
cases of ameloblastoma or epidermoid carcinomas developing from the lining epithelium of a dentigerous cyst are adequately documented , whereas mucoepidermoid carcinomas are less well - documented .
also , squamous cell carcinoma may develop from the lining epithelium of a dentigerous cyst .
the standard treatment for a dentigerous cyst is enucleation and extraction of the associated tooth via a caldwell - luc procedure . in large cysts , an initial marsupialization to diminish
the size of the osseous defect , followed by enucleation and tooth extraction , has been advocated .
endoscopic approach for its management is also described in the literature , which is associated with lesser operative as well as post - operative morbidity . in conclusion ,
occurrence of an ectopic tooth in the maxillary sinus and association of a dentigerous cyst with it is a rare phenomenon .
its presence may be asymptomatic initially with clinical manifestations , later on as adjacent structures are affected .
convention radiographs are sufficient for the diagnosis , but advanced imaging is useful for treatment planning .
odontogenesis is a complex process , and abnormal tissue interactions between the oral epithelium and the underlying mesenchymal tissue during development may potentially result in ectopic tooth development and eruption .
it is believed that the displacement of tooth buds by the expansion of progressively growing dentigerous cysts results in the displacement of the tooth to other areas . in the present case ,
during the extraction of the third molar , an iatrogenic displacement into the maxillary antrum can occur .
have mentioned a case of an iatrogenic displacement of the upper right third molar into the maxillary antrum in a 40-year - old female during the extraction of that tooth . though cases of dentigerous cysts are reported in children , they are usually present in the second or third decade of life and are rare in childhood . the incidence is higher in males than in females ( m : f-1.84 : 1 ) .
multiple and bilateral cysts have been reported in patients with syndromes such as basal cell nevus syndrome , mucopolysaccharidosis , and cleidocranial dysplasia as well as in a non - syndromic patient .
it can cause headache , obstruction of the sinus , epiphora due to nasolacrimal duct obstruction , recurrent sinusitis , purulent rhinorrhea , elevation of the orbital floor , and fractures .
impingement of this lesion on the orbital floor can cause diplopia and possibly even blindness .
on radiographic examination , dentigerous cysts appear as unilocular radiolucencies of varying sizes , with well - defined sclerotic borders , associated with the crown of an unerupted tooth . if a follicular space on radiography is more than 5 mm , an odontogenic cyst can be suspected .
water view , opg , and lateral cephalogram are simple and inexpensive projections for radiographic evaluation of an ectopic tooth in the maxillary sinus .
ct scan provides superior bony detail , help in determination of the size and extent of the lesion , and is useful to distinguish a maxillary lesion of antral origin from an extra - antral lesion .
studied 12 patients with teeth in the maxillary sinus by plain film radiography ( pfr ) and by ct with a dental software programme .
he found that ct was superior to pfr to determine proximity of the tooth to the sinus wall or its ankylosis , proper surgical planning ( crestal incision or caldwell - luc approach ) , as well as prediction of prognosis or complications .
ustuner et al . provided mri findings of the cystic lesion , which appears homogeneously hypointense on t1-weighted images and hyperintense on t2-weighted images .
chronic secretions , air , and acute hemorrhage in the sinus may also appear hypointense , but their central location in the sinus distinguishes them from tooth , which lies eccentrically in the cyst wall .
the differential diagnosis of a dentigerous cyst includes unicystic ameloblastoma , adenomatoid odontogenic tumor ( aot ) , early stages of gorlin cyst / calcifying epithelial odontogenic tumor ( ceot ) , ameloblastic fibroma , ameloblastic fibro - odontoma , and odontogenic keratocyst .
unicystic ameloblastoma is seen in persons under the age of 30 years , occurs equally in both genders , and has a tendency to occur in posterior mandible associated with the crown of an unerupted third molar .
aot is common in second decade , affects females twice as often as males , has a striking tendency to occur in the anterior maxilla and in about 74% of cases associated with the crown of an unerupted canine .
gorlin cyst is commonly found in the incisor and canine area ( 65% of cases ) .
approximately one third of cases are associated with an unerupted tooth , most often a canine .
ceot is an uncommon lesion , which is most often encountered between third to fifth decades , occurs equally in both genders , and has a tendency to occur in posterior mandible associated with an impacted third molar .
ameloblastic fibroma is an uncommon tumor , occurs in first two decades , more common in males , commonly found in posterior mandible , and is associated with an unerupted tooth in about 75% of cases .
however , the ameloblastic fibro - odontoma is rarely found within the maxillary sinus and usually occurs in persons under the age of 20 .
odontogenic keratocyst may be found in patients from infancy to old age , commonly found in posterior body and ascending ramus of mandible , and in 25% to 40% of cases , unerupted tooth is involved .
histologically , dentigerous cysts are lined by a layer of non - keratinized stratified squamous epithelium , with a surrounding wall of thin connective tissue containing odontogenic epithelial rests .
cases of ameloblastoma or epidermoid carcinomas developing from the lining epithelium of a dentigerous cyst are adequately documented , whereas mucoepidermoid carcinomas are less well - documented .
also , squamous cell carcinoma may develop from the lining epithelium of a dentigerous cyst .
the standard treatment for a dentigerous cyst is enucleation and extraction of the associated tooth via a caldwell - luc procedure . in large cysts , an initial marsupialization to diminish
the size of the osseous defect , followed by enucleation and tooth extraction , has been advocated .
endoscopic approach for its management is also described in the literature , which is associated with lesser operative as well as post - operative morbidity . in conclusion ,
occurrence of an ectopic tooth in the maxillary sinus and association of a dentigerous cyst with it is a rare phenomenon .
its presence may be asymptomatic initially with clinical manifestations , later on as adjacent structures are affected .
convention radiographs are sufficient for the diagnosis , but advanced imaging is useful for treatment planning .
 dentigerous cysts are the most common type of developmental odontogenic cysts arising from the crowns of impacted , embedded , or unerupted teeth . 
 they constitute about 20% of all epithelium - lined cysts of the jaws . 
 the teeth involved most often are mandibular third molar and maxillary canines . 
 about 70% of dentigerous cysts occur in the mandible and 30% in the maxilla . 
 dentigerous cysts associated with ectopic teeth within the maxillary sinus are fairly rare , and only 20 cases had been reported in medline since 1980 . in the present paper , 
 we report an additional case of dentigerous cysts associated with ectopic third molar in the right maxillary sinus . 
 also , pathogenesis of ectopic tooth , role of advanced imaging , differential diagnosis , and management are discussed . 
Introduction
Case Report
Discussion
Disturbance in tooth developmental
Pathological process
Iatrogenic activity: