, the prevalence of overweight children and adults has also increased , and diet choices affect both development of caries and contribute to weight gain .
recent prevalence data estimate that overweight among children has more than tripled since 1970 and affects 32% of all children and adolescents [ 27 ] .
excess body fat is the product of ingesting too many calories and reduced physical activity .
but , the consumption of high - sugar , low - nutrient foods is of particular concern [ 911 ] .
it is generally accepted that sugars and prepared starches in the diet are significant contributors to these two health issues [ 1218 ] .
frequency of exposure to the teeth and food retention are important considerations when evaluating the caries potential of food products .
sucrose , fructose , and maltose are sugars commonly used in beverages and food products and add about 4 calories per gram .
consumption in developed countries is reported to be 4060  kg / person / year .   
dentists and other oral health professionals have been active in counseling their patients regarding general health issues , such as monitoring blood pressure , smoking and alcohol cessation , and detection of child abuse / neglect .
in addition , dentists have collaborated with medical colleagues in drafting guidelines for referring children with early childhood caries for definitive care , application of fluoride varnish and sedation .
it has now been suggested that the oral health provider become an active participant in screening their patients , especially children , for signs of overweight / obesity and offer appropriate counseling / referral .
other measurement tools , such as waist circumference , may be more accurate indicators of obesity , but the body mass index ( bmi ) is the most convenient screening means [ 20 , 21 ] . this clinical tool measures body weight
the ideal product would have few or no calories , be noncarcinogenic or mutagenic , be economical to produce , and would not be heat degradable but would provide sweetness and have no unpleasant aftertaste .
numerous nonnutritive sweetening agents have been developed , but none have possessed all of the preferred properties .  
patients and parents / care givers of children often ask oral health professionals about common dietary sugars and alternative sweeteners .
the purpose of this paper is to provide the dental professional information that will be helpful in counseling these individuals on diet , caries prevention , and weight control .
  currently , the food and drug administration ( fda ) of the united states has evaluated the data and other information and approved under the conditions of its use only aspartame , acesulfame potassium , saccharin , sucralose , and neotame as noncaloric sweeteners as  food additives ,  figure 1 .
however , the fda can also approve an agent under gras ( generally recognized as safe ) . for approval under gras , supporting data must have been provided and evaluated by qualified experts , and there is consensus that the substance is safe under the conditions of its intended use .  
initially granted gras status , saccharin is now approved as an additive to food and beverages .
it is 300 times as sweet as sucrose by weight , non - cariogenic and noncaloric but can have a slightly bitter or metallic aftertaste .
it is available as a tablet , powder , or liquid form and is widely used in food products including diet sodas , pharmaceuticals , and cosmetics .
saccharin has been approved for use in more than 100 countries world - wide . in high doses
, saccharin has been found to be associated with an increase frequency of bladder cancer in a strain of male rats .
however , a relationship between saccharin consumption and health risk in humans , at normal consumption amounts , has not been demonstrated and it is not considered to be a carcinogen .  
aspartame was initially approved by the fda in 1981 for limited use as a table top sweetener and for use in breakfast cereals , gelatins , and puddings .
but in 1983 , approval was extended to a larger group of food agents , including carbonated beverages . in 1996 , the fda approved aspartame as a general purpose sweetener for use in all foods and beverages .
aspartame is the most widely utilized non - cariogenic artificial sweetener and is 160220 times more sweet than sucrose .
it is often the manufacturer 's sweetener of choice in formulation of diet soft drinks , yogurt , puddings , gelatin , and snack foods .
prior to approval of aspartame by the fda , a number of significant issues were raised by concerned individuals relative to aspartame 's potential undesirable effects with long term consumption on growth , glucose homeostasis , neurotoxic effects in animals , behavioral reactions , seizure susceptibility and liver functions but these concerns have been largely addressed [ 2631 ] .
aspartame is claimed to be safe for type 2 diabetics but should be avoided by people with phenylketonuria as they can not metabolize phenylalanine , a component of aspartame .   
acesulfame potassium , a calorie - free , non - cariogenic , nonnutritive artificial sweetener , was initially approved by the fda in 1988 for use as a sweetener in dry food products . in 1994 ,
yogurt , refrigerated desserts , syrups , and baked goods were added to the approved list , and in 2002 it was accepted as a general purpose sweetener .
more than thirty countries have approved the product to be used in foods , beverages , cosmetics , and pharmaceutical products . like saccharin , acesulfame potassium ,
has a slightly bitter aftertaste and is often blended with other sweeteners to mask this property .
acesulfame potassium is stable at high cooking / baking temperatures , even under moderately acidic or basic conditions , which permits it to be used in baking or in products requiring a long shelf life .
although considered safe by the fda for general consumption in food , there have been some concerns raised relative to dose - dependent cytogenetic toxicity [ 32 , 33 ] .  
it was first accepted by the fda as an eating table - top sweetener in 1998 and followed by acceptance as a general purpose sweetener in 1999 .
sucralose is considered safe for use by diabetics and has been shown not to be metabolized into acids by oral microbiota .
it is heat stable during cooking and baking and is widely used in many food products such carbonated and noncarbonated beverages , as a tea and coffee sweetener , and in baked goods , chewing gum and frozen desserts . to date
no health issues have been established concerning the general dietary use of sucralose [ 34 , 35 ] .  
it received fda approval in 2002 for use as a general purpose sweetener in selected food products ( except not in meat and poultry ) and flavor enhancer .
neotame is an intense nonnutritive sweetener that is not fermentable by the oral microbiota and possesses a crisp , clean taste with no detectable aftertaste .
it is reported to be greater than 7,000 times more potent than sucrose on a weight basis depending on the food product and how it is prepared [ 36 , 37 ] .
neotame is a derivative of a dipeptide and has a similar chemical structure to aspartame .
it is also heat stable in baking applications and can be safely used by diabetics and pregnant women .
neotame is stable in carbonated soft drinks , powdered soft drinks , yellow cake , yogurt , and hot - packed still drinks .
  the fda has approved as  generally recognized as safe  ( gras ) several additional nonnutritive non-/low caloric calorie sweeteners , figure 2 .  
although rather expensive to manufacturer , sorbitol is often used as a  bulk  sweetener in a variety of food substances such as chewing gum , chocolates , cakes and cookies , toothpaste , and mouthwash . on a weight basis , sorbitol is only half as sweet as sucrose .
it is generally considered non - cariogenic , but sorbitol can be fermented slowly into acid by s. mutans .
research has shown sorbitol to possess mild cariogenic potential when used over an extended period of time by patients with reduced salivary gland function , and it normally supports the formation of dental plaque and the growth of mutans streptococci .
sorbitol is not easily digested or absorbed from the gastrointestinal tract , and diarrhea is a potential side effect if ingested in large quantities .  
xylitol , a five - carbon naturally occurring , nonfermentable , sugar alcohol , was first discovered in 1890 in birch and other hardwood tree chips , in wheat and oat straw in 1891 , and later in various fruits and vegetables [ 42 , 43 ] .
xylitol is as sweet as sucrose and possesses a pleasant taste but is relatively expensive to manufacture .
although not as calorie heavy as sucrose , xylitol does possess a calorie burden when consumed and has some potential for increasing blood glucose .
it is used primarily in mints , chewing gum , and toothpaste but is also available for table use .
studies have suggested that the regular use of xylitol containing chewing gum reduces the quantity of dental plaque , significantly reduced s. mutans levels , and increases saliva production [ 44 , 45 ] .
reduction of caries incidence and remineralization of caries lesions have been reported in caries susceptible individuals when chewing gum containing xylitol was regularly used [ 4650 ] .
xylitol has also been shown to inhibit cytokine expression by a lipopolysaccharide from one of the suspected periodontal pathogen bacteria , porphyromonas gingivalis .
thus , its regular use could possibly aid in preventing periodontal disease and gingival inflammation .
xylitol has been credited in lowering the risk of cariogenic bacteria transmission from mother to infant when compared to chlorhexadine and fluoride varnish treatments and reducing the incidence of ear infections among children at day - care centers [ 5255 ] . however
, excessive use of xylitol can aggravate symptoms of crohn 's disease and irritable bowel syndrome resulting in diarrhea [ 56 , 57 ] .  
erythritol , a four - carbon sugar alcohol , has similar characteristics of sorbitol , mannitol , and xylitol .
but , it is only slightly more than half as sweet ( 70% ) as sucrose and does not dissolve in water as well , but has significantly fewer calories by weight ( 0.2 calories per gram versus 4 calories per gram ) .
erythritol has been used in japan since 1990 as a component of candies , soft drinks , chewing gum , jams , and yogurt .
erythritol is heat stable and can be used in baking and as a sweetener in low carbohydrate / calorie diets .
it is almost completely absorbed by the small intestine ( and excreted unchanged in the urine within 24 hours ) , has shown no toxic or carcinogenic effects , and is considered safe for consumption by diabetics .
however , the daily use of erythritol has been shown to reduce mutans streptococci levels in plaque and saliva .
erythritol does not cause bloating , flatulence , or diarrhea at normal consumptions levels but may have a laxative effect in both children and adults if consumed in excess .  
tagatose , a low - calorie natural sugar , has all the good qualities of erythritol plus it has about the same ( 92% ) sweetness as sucrose , performs better in cooking , and has been shown to actually improve blood sugar control in diabetics .
it was granted gras status in 2001 and is used in a variety of drugs , foods such as chocolates , chewing gum , cakes , ice cream and frosted cereals , beverages , and dietary supplements .
tagatose has been shown to have benefits treating noninsulin - dependent type 2 diabetes as it attenuates the rise of serum glucose after oral glucose intake .
no significant adverse health effects have been associated with the ingestion of this product when consumed in reasonable amounts .
stevia , a heat stable sweetener with little or no aftertaste , is an extract from the herb stevia rebaudiana bertoni .
the herb is native to central and south america and has been used by the indigenous peoples of this area for centuries as a sweetener .
it has been used extensively in china , brazil , and japan , and to a lesser extent in germany , malaysia , and israel , for many years as a sweetener in numerous food categories .
originally banned by the fda , the use of stevia was approved in 1995 , as a dietary supplement but not as an additive . the argument to approve stevia
as a food additive was heated , and it remained approved only as a food supplement for an extended period of time .
however , in december 2008 , the fda responded favorably to gras status for the chemically refined derivative of stevia , the extract rebaudioside a ( rebiana ) , to be used as a general purpose sweetener .
rebiana is also available in combination with dextrose and as an extract from stevia leaves .
stevia has been shown to be safe for use by diabetics and has not been shown to be mutagenic [ 66 , 67 ] .
  new nonnutritive sweeteners have been introduced into human diets over the past few decades .
oral health care professionals are often called upon to provide knowledgeable advice regarding the importance of diet and the role of sugars and nonnutritive sweeteners in caries formation and weight control . as such
, they must be familiar with alternatives to sugar and the types of food products that are available with substitute non-/low caloric , non - cariogenic sweetening agents .
an excellent literature review of the caries incidence and remineralization properties of the sugar alcohols ( xylitol , erythritol , sorbitol ) has been written by mkinen .
although nonnutritive sweeteners do not generally promote dental caries , a program to prevent dental decay and promote oral health must also include good oral hygiene habits , regular dental professional care , and exposure to fluoride [ 69 , 70 ] .
whether the use of nonnutritive sweeteners has a positive impact on weight loss by consumers remains controversial [ 7175 ] .
it has been postulated that nonnutritive sweeteners encourage sugar craving and dependency because of their sweet nature , and flavor preference occurs with repeated exposures to sweet tasting foods and beverages .
several studies have shown an increase in bmi with consumption of nonnutritive sweeteners [ 77 , 78 ] .
but , others have found the evidence less compelling and more equivocal [ 7981 ] . whether nonnutritive sweetener use has a role in the current obesity and diabetes epidemic , whether beneficial , neutral , or not remains undetermined . in addition ,
consumption of two or more servings of nonnutritive sweetened sodas has been associated with a 2-fold increased odds for kidney function decline in women as measured by the egfr ( estimated glomerular filtration rate ) .
however , it is well established that a reduction of fermentable sugars and carbohydrates in the diet coupled with good oral hygiene practices will reduce the incidence of dental decay .  
while it is difficult to totally avoid sugar in the diet , as it is often added to processed food to enhance the taste , reducing the amount and frequency of dietary exposure to sugar is an important adjunct in preventing caries and reducing calorie intake although not without some potential health concerns as previously described [ 8385 ] .
however , nonnutritive sweeteners offer an attractive alternative to sugar in caries prevention and a possible adjunct in weight control when used appropriately and in concert with a balanced diet and exercise .
the identification of safe , palatable , heat stable , non-/low - caloric , nonnutritive / non - cariogenic sweetener substitutes for the more dental decay promoting and calorie heavy sugars such as sucrose , glucose , fructose , and maltose continues to be actively pursued .  
in addition to annually updating the health history , dental professionals should determine annually the bmi percentile of their patients and refer those on unhealthy trajectories to their physician or a dietitian for additional counseling .
it also behooves the dental professional to stay attuned to current information relative to alternative sweetener products that exist or are being developed and approved for dietary consumption by the fda and be prepared to be a source of counseling for their patients and families as they relate to reducing the incidence of caries and possible overweight [ 87 , 88 ] .
 caries and obesity are two common conditions affecting children in the united states and other developed countries . 
 caries in the teeth of susceptible children have often been associated with frequent ingestion of fermentable sugars such as sucrose , fructose , glucose , and maltose . increased 
 calorie intake associated with sugars and carbohydrates , especially when associated with physical inactivity , has been implicated in childhood obesity . 
 fortunately , nonnutritive artificial alternatives and non-/low - caloric natural sugars have been developed as alternatives to fermentable sugars and have shown promise in partially addressing these health issues . 
 diet counseling is an important adjunct to oral health instruction . 
 although there are only five artificial sweeteners that have been approved as food additives by the food and drug administration ( fda ) , there are additional five non-/low caloric sweeteners that have fda gras ( generally recognized as safe ) designation . given the health impact of sugars and other carbohydrates , 
 dental professionals should be aware of the nonnutritive non-/low caloric sweeteners available on the market and both their benefits and potential risks . 
 dental health professionals should also be proactive in helping identify patients at risk for obesity and provide counseling and referral when appropriate . 
1. Introduction
2. FDA Approved Nonnutritive Sweeteners as Additives
3. FDA GRAS Approved Nonnutritive Sweeteners
4. Discussion