adenoid type of bcc is a rare histopathological variant which can morphologically present as pigmented and nonpigmented nodule or ulcer without predilection for any particular site .
it is more prevalent after the fourth decade of life and its peak incidence is at the 6 decade with male preponderance .
it is exclusively seen on sun exposed and hair bearing skin especially of the face .
about one - third of bcc occurs on sun protected area , suggesting factors other than solar exposure playing a role such as genetic susceptibility .
adenoid type of bcc is a rare histopathological variant which can morphologically present as pigmented and nonpigmented nodule or ulcer without any site predilection .
two females aged 56 and 60 years , presented with asymptomatic ulcer and a painful dark colored lesion on the lumbosacral area since 10 and two months respectively . in the first case ,
the lesion started as an asymptomatic raised lesion on a normal skin on the lower back evolving into a non - healing ulcer eventually over a period of 10 months .
the second case noticed a painful black colored nodule on the lower back that gradually increased in size to form a large plaque within two months .
there was no history of pre - existing skin condition , indigenous drug intake ( containing arsenic ) , exposure to irradiation and trauma at the affected site prior to appearance of lesions in both these cases . both the patients were residents of mumbai which has not reported high content of arsenic in potable water .
the examination of the first case revealed a single irregular ulcer measuring about 3  4 cm in diameter over the sacral area overlying the natal cleft with rolled out indurated edges and sloping margins [ figure 1a ] .
the ulcer was mobile and not adherent to the underlying structures . while in the second case
, there was a single well defined circular blackish 3  2.5 cm sized plaque on the lower back in right paramedian position about 4 cm above the natal cleft [ figure 1b ] .
single , irregular ulcer of 34 cm , over sacral area with rolled out indurated edges and sloping margins .
the floor shows healthy granulation tissue and serosanguinous discharge single circular plaque of 32.5 cm on lumbosacral area in right paramedian position .
overlying surface is irregular with brown black pigmentation laboratory investigations of both patients were normal except for anemia .
x - ray of lumbosacral region in both the cases did not reveal involvement of the underlying bones . there was no evidence of metastases in both the cases on radiological investigations .
biopsy from the lesion in both the cases revealed thinned out epidermis with masses of basaloid cells in the dermis and retracted spaces separating them from a strong stroma .
the masses of basaloid cells showed palisading at the periphery . at places , the cells showed tubular differentiation with the lumina showing granular material .
the cells arranged in intervening strands were suggestive of adenoid type of bcc [ figures 2a - c ] .
( h and e , 40 ) thinned out epidermis with masses of basaloid cells in the upper dermis , separated by stroma .
note the retraction spaces ( h and e , 40 ) the mid and lower dermis shows masses of tumor cells with tubular differentiation and granular material in the lumina , suggesting adenoid type of basal cell carcinoma ( bcc ) ( h and e , 40 ) tubular differentiation suggesting adenoid type of basal cell carcinoma ( bcc )
the role of solar exposure is well documented and contributes to its predilection for the head and neck region ( around 75 - 86% ) .
rest of the lesions appear on other areas and only 10% of all bccs are located on the trunk .
there is paucity of literature on exact incidence of adenoid bcc but bastiaens , et al .
it is often regarded as a low grade malignancy compared to other subtypes like nodular and morpheic form which are of high grade .
unusual location has been arbitrarily defined on the basis of percentage of incidence , an index referred to as anatomical incidence called the relative tumor density ( rtd ) index , which considers the ratio between the proportion of tumour in a certain location and the proportion of the surface area on the same location and ; the sites considered as such in the literature in agreement with the experts .
these sites are breasts , periungual region , palms , soles , glutei and intertriginous areas like axillae , groins , and genitals .
niwa , et al . reported five cases of bcc at axillae , groins , foot and pinnae .
sun exposure is suggested as the primary factor but these tumours are rarely seen on forearm , hands and lower limbs , despite significant sun exposure . regarding possible association of tumour location with histological subtypes
, some studies showed that unexposed areas like the trunk and the limbs display predominantly superficial type of bcc , while those on sun exposed areas show mainly nodular pattern .
scrivener , et al . found nose to be the common site for morpheaform bcc .
in basal cell nevus syndrome , the bcc lesions are also found on palms and soles .
adenoid bcc has been reported at various sites including axillae , back , leg , inner canthus of eye , chin and forehead and rarely even cervix and prostate .
both our cases and giant bcc reported by fresini , et al . had same location on the back and all three revealed same histology of adenoid type of bcc [ table 1 ] .
clinical features of reported cases of adenoid type of basal cell carcinoma ( bcc ) on histopathology histopathology of this rare variant shows arrangement of cells in the intertwining strands and radially around islands of connective tissue , resulting in a tumour with a lace like pattern .
the lumina may be filled with a colloidal substance or with an amorphous granular material , but the secretory activity of the cells lining the lumina can not be delineated even with histochemical methods .
present cases and review of reported cases adds the information that the adenoid type of bcc can have few unique features i.e. tendency to involve unexposed parts like back and axilla and larger size of the lesions .
 basal cell carcinoma ( bcc ) is almost exclusively seen in head - neck region with rare involvement of trunk and extremities . 
 the tumour is commonly seen on nose , eyelids , at the inner canthus of eyes and behind the ears . 
 adenoid type of bcc is one of the rare histopathological types of bcc which has not found to have any site predilection . 
 we report two cases of bcc occurring at an unusual site i.e. , lower back and both of them showed adenoid type of bcc on histopathology . 
 morphologically they were pigmented and ulcerative type of bcc respectively . 
Introduction
Case Report
Discussion