for the first time , the presented data suggest that a variant in the retn gene plays a significant role in acne pathogenesis .
we also demonstrate an excess transmission of mutant allele g at retn-420 from 130 trio families using tdt analysis .
therefore , we suggest that inherited variation in retn at -420 appears to be associated with heritable acne vulgaris .
 resistin ( retn ) , recently found to be relevant to inflammation and inflammatory disorders . 
 we , therefore , aimed to investigate the potential role of retn gene polymorphism in pathogenesis of acne vulgaris with familial history . 
 we investigated the retn-420c / g polymorphism in 180 patients with acne vulgaris and 180 healthy individuals in a case - control association analysis . in this study 
 , we also investigated the heritability of the retn susceptible allele from 140 trio families with acne affected offspring . 
 the genotyping was performed by polymerase chain reaction and direct dna sequencing . 
 the retn-420c / g polymorphism was significantly associated with acne in patients compared with healthy controls ( p=0.014 ) . 
 the minor allele g at -420 was more prevalent in cases vs. controls ( p=0.002 ) . 
 the retn-420c / g polymorphism was significantly associated with severity of acne vulgaris in patients ( p=0.0097 ) . 
 the results of a transmission disequilibrium test revealed a significant association between the retn-420c / g polymorphism and acne vulgaris ( p<0.001 ) . 
 for the first time in the literature , to our knowledge , we demonstrate a significant association of the retn-420c / g functional polymorphism with familial acne vulgaris . 
Conclusion