it is a common discomfort making to the top ten list of complaints in ambulatory medical care , but our understanding of the epidemiology of headache disorders is still incomplete .
most of the recurrent headache cases are due to benign chronic primary headache disorders , such as tension headache and migraine .
less frequently , headache could be due to other underlying conditions such as infections , cerebral hemorrhage and brain lesions [ 5 , 6 ] .
the study of headache epidemiology can address a number of important questions such as variation in the occurrence and severity of headache in the population , and the relationship between headache and other medical disorders .
in addition , these studies may provide clues to abortive treatments and preventive strategies for headache .
it is well documented among adults that overuse of headache medication may contribute to the development of chronic headache [ 814 ] .
epidemiologic studies indicate that chronic headache ( > 15  days per month ) is common in the adult population with a 25% prevalence rate [ 1521 ] and a prevalence of chronic headache associated with medication overuse of about 1% [ 18 , 20 , 21 ] .
in general , self - medicating for headache is highly prevalent and self - care is likely to increase in the era of health - care reform [ 22 , 23 ] .
. chronic and inappropriate use of over - the - counter drugs such as analgesics , particularly nonsteroidal anti - inflammatory drugs ( nsaids ) , can lead to overuse syndromes and drug - induced headache [ 25 , 26 ] . in the present study
, we sought to estimate the association between analgesic use and headache among adults in a large sample of the jordanian population in relation to age , gender and headache frequency .
in this study , participants ( age range 1885 ) were approached at their work places , classes or homes .
, researchers asked every participant to nominate two other persons until the desired sample size was obtained .
the study was ethically approved by the institutional review board ( irb ) at jordan university of science and technology and was carried out in accordance with the principles described in the declaration of helsinki , including all amendments and revisions .
the study was conducted in various regions of jordan during the period from january 2007 to november 2008 .
the questionnaire was distributed , in person , by the researchers , and was completed in the presence of the researcher .
each participant was provided with a full explanation of the study and how to complete the questionnaire .
participants were informed that the researcher would be available for any required assistance during scoring of the questionnaire .
for the small group of participants who were illiterate , the questionnaire was administered by the researcher in the form of an interview .
data were aggregated into groups and only the authors and the investigator were allowed access to the collected data .
the questionnaire gathered information that included demographic data , frequency and type of headache , and its impact on everyday activities , analgesic use , consultation of a doctor or pharmacist on the use , increase or decrease in the frequency of headache after painkiller usage , increase or decrease in painkiller dose and family history of headache .
every person who was 18  years or older was allowed to complete the survey .
retest reliability , 50 subjects were selected randomly ; they answered the questionnaire twice with a 1-week interval . test 
for each item , correlation coefficients ranged from 0.79 to 0.86 , suggesting that the questionnaire was reliable .
the data were coded using the statistical package for the social sciences , version 15.0 ( spss inc .
the data were summarized using frequency tables and means and standard deviation for continuous variables .
to estimate the prevalence of headache among adults in jordan , a sample of participants ( 4,836 participants ; mean age 27    0.4  years , and male : female ratio of 59:41 ) was allowed to complete a self - conducted screening questionnaire . as shown in table  1 , about half of the participants ( 49.2% ) were university students and 78.3% were jordanian citizens . moreover ,
70.7% participants were single and 47.4% were smokers.table  1the demographic data of the study samplevariablen ( % ) gender  male2,870 ( 59.4 )  female1,966 ( 40.6)age  1829  years3,572 ( 73.95 )  3039  years506 ( 10.46 )  4049  years402 ( 8.32 )  50  years356 ( 7.37)education  illiterate83 ( 1.7 )  elementary school65 ( 1.3 )  secondary school213 ( 4.4 )  high school610 ( 12.6 )  diploma344 ( 7.1 )  university student2,378 ( 49.2 )  bachelor901 ( 18.6 )  masters181 ( 3.7 )  ph.d.61 ( 1.3)nationality  jordanian3,787 ( 78.3 )  arab ( non - jordanian)841 ( 17.4 )  foreign208 ( 4.3)marital status  single3,422 ( 70.8 )  married1,304 ( 27.0 )  divorced55 ( 1.14 )  other55 ( 1.14)monthly income  low ( < or = 400  jd)257 ( 5.3 )  medium ( > 400  jd to < or = 1,000  jd)3,831 ( 79.2 )  high ( > 1,000  jd)748 ( 15.5)smoking  smoker2,294 ( 47.4 )  non - smoker2,542 ( 52.6)1  jd is equivalent to about 1.4 us dollars the demographic data of the study sample 1  jd is equivalent to about 1.4 us dollars of the 4,836 participants , 82.3% complained of headache at least once per year .
for both the 1829 and the 3039-year - old groups , the yearly prevalence of headache was found to be the same ( 82.8% ) , while it was 79.9 and 81.7% for the 4049 and older than 50-year - old groups , respectively . among the participants , 17.2% had daily headache attacks ,
while 25.7% had fewer than daily to weekly headaches , 21.6% had headaches on fewer than weekly up to monthly basis , 17.8% complained of headaches on a fewer than monthly basis and 17.7% of all participants did not experience headache attacks .
moreover , 38.4% of the headache complainers did not know the exact type of headache they were experiencing , 36.9% complained of tension type headache and only 7.7% were diagnosed with migraine headache ; 51.6% of complainers thought that headache affected their daily activities .
a large number of participants stated that one or more of their family members complained of headache as well ( table  2).table  2frequency , type , and family history of headachevariablen ( % ) headache frequency  daily832 ( 17.2 )  fewer than daily to weekly1,243 ( 25.7 )  fewer than weekly to monthly1,043 ( 21.6 )  fewer than monthly to 1  year860 ( 17.8 )  no headache858 ( 17.7)type of headache  migraine372 ( 7.7 )  tension1,749 ( 36.1 )  unknown1,857 ( 38.4 )  no headache858 ( 17.7)headache affects daily activities ( if any )  yes2,051 ( 51.6 )  no1,927 ( 48.4)other family members complaining from headaches  father327 ( 6.8 )  mother545 ( 11.3 )  brothers or sisters552 ( 11.4 )  other relatives558 ( 11.5 )  more than one family member860 ( 17.8 )  none1,994 ( 41.1 ) frequency , type , and family history of headache of the migrainers , 37.7% ( n  =  140 ) complained of daily headache , 35.6% ( n  =  132 ) had fewer than daily up to weekly headaches , and 18.1 ( n  =  67 ) and 8.6% ( n  =  32 ) complained of headaches on a fewer than weekly up to monthly basis , and on fewer than monthly basis , respectively .
additionally , about 75% ( n  =  279 ) of migrainers thought that migraine adversely affected their daily activities .
concerning tension type headache , 20.3% ( n  =  348 ) complained of daily headache , 34.7% ( n  =  594 ) had fewer than daily up to weekly headaches , and 24.1% ( n  =  413 ) and 20.8 ( n  =  356 ) complained of headaches on fewer than weekly up to monthly basis , and fewer than monthly basis , respectively .
moreover , about 53% ( n  =  907 ) indicated that tension type headache affected their daily activities .
the stratified prevalence for both migraine and tension type headache according to age group and gender are shown in table  3.table  3stratified prevalence of migraine and tension - type headache according to age group and genderheadache typetension - type headachemigrainegendermale n ( % ) female n ( % ) male n ( % ) female n ( % ) age category ( years )  1829652 ( 31.6)586 ( 39.0)158 ( 7.7)97 ( 6.5 )  3039120 ( 36.1)73 ( 43.7)34 ( 10.2)11 ( 6.7 )  404972 ( 31.7)68 ( 39.1)17 ( 7.5)18 ( 10.3 )  50 and above92 ( 37.3)49 ( 40.8)28 ( 11.3)8 ( 6.7)total936 ( 32.6)776 ( 39.5)237 ( 8.3)134 ( 6.8 ) stratified prevalence of migraine and tension - type headache according to age group and gender only 17.3% of participants sought medical care for their headaches .
the percentage of participants using analgesics on a weekly basis was 24.5% , less than monthly but more than weekly was 24.8% , monthly usage was 22.5% , and the percentage of participants who never use a analgesics was 14.6% .
participants who used analgesics on the advice of a physician were 15.3% , while those who used analgesics on a pharmacist advice compromised 13.6% .
those who used analgesics based on the experience of a family member or others were 34.8 and 47.4% , respectively ( table  4 ) .
in addition , 13.1% of participants complained of increased headache severity or frequency on medication use .
results also revealed that 22.0% of participants had increased their analgesic dose and 78.0% did not change their regimen .
the most frequently used analgesic among participants was acetaminophen ( 78.00% ) , and to a lesser extent ibuprofen ( 7.49% ) and aspirin ( 5.58% ) ( table  5).table  4approach to medication use among patients with headachevariablen ( % ) seeking medical help for headaches  yes688 ( 17.3 )  no3,290 ( 82.7)advice on using analgesics  physician609 ( 15.3 )  pharmacist541 ( 13.6 )  family1,383 ( 34.8 )  others ( friends , co - workers , neighbors , etc.)1,887 ( 36.3)frequency of analgesics usage  daily606 ( 15.2 )  fewer than daily to weekly974 ( 24.5 )  fewer than weekly to monthly985 ( 24.8 )  fewer than monthly to 1  year829 ( 22.4 )  no analgesics584 ( 14.6)increase in headache frequency after analgesic use  yes520 ( 13.1 )  no3,458 ( 86.9)increase analgesic dose used over time  yes877 ( 22.0 )  no3,101 ( 78.0)some participants have sought the advice of more than one categorytable  5frequency of analgesics use among headache patientsname of the analgesic usedn ( % ) acetaminophen3,103 ( 78.0)ibuprofen298 ( 7.5)aspirin222 ( 5.6)diclofenac sodium64 ( 1.6)naproxen25 ( 0.6)metamizole11 ( 0.3)mefenamic acid10 ( 0.3)ergotamine10 ( 0.3)others137 ( 3.5)note that some patients used more than one medication approach to medication use among patients with headache some participants have sought the advice of more than one category frequency of analgesics use among headache patients note that some patients used more than one medication
in this study , we report for the first time an overall 1-year period prevalence of headache among adults in jordan . a sample ( 4,836 ) of participants
were requested to complete a self - conducted screening questionnaire . as much as 82.3% of participants reported that they complained of headache at least once per year .
this is much higher than the average global prevalence of headache ( 46% ) [ 27 , 28 ] .
similar percentages were obtained from two studies conducted in other middle eastern countries namely oman   and qatar , and from other developing   and developed countries [ 3234 ] . on the other hand ,
one study conducted in oman showed a prevalence of headache of about 45% , however , that study was among university medical students and not the general population . in nearby saudi arabia , the prevalence of primary headaches ranged from 8 to 13% [ 30 , 36 , 37 ] , which is much lower than that reported in all other studies from the middle east area .
the higher prevalence of headache in jordan indicates that it is one of the major health problem .
tension - type headache was found to be the most prevalent among other types of headaches ( 36.9% compared to 7.7% for migraine ) .
the prevalence of tension - type headache , in this study , falls within the prevalence range previously reported from studies conducted in the middle east area ( 1139% ) [ 29 , 35 , 38 , 39 ] . additionally , the reported prevalence for tension - type headache , in this study , is lower than its global prevalence ( about 42% ) , which seems to be the case for the whole middle east area .
studies on migraine headache from other arab countries reported prevalence that ranged from 10 to 12.2% [ 29 , 39 , 40 ] , which is higher than the migraine prevalence in our studied sample .
as in the case of tension type headache , both the global migraine prevalence ( about 11% ) , and the migraine prevalence in western europe ( about 14% )   is higher than that in jordan . therefore , jordan seems to have lower migraine prevalence than many other parts of the world .
a recent study from nearby qatar reported a migraine prevalence of about 8.0% , which is very similar to the prevalence reported in the current study .
the effect of headache on everyday activities was obvious in our study where a significant percentage ( 51.6% ) of participants ascertained that headache adversely affected their daily activities .
our results showed that 82.7% of participants did not seek medical attention for their headaches . in agreement with other s findings [ 29 , 39 ] , 75.6% of our population used analgesics and acetaminophen was the most popular ( 78.0% ) .
the popularity of acetaminophen over other analgesics could be related to its availability as an over - the - counter medication , low price , and because it is known to be safe to the gastrointestinal tract .
previous studies from jordan and surrounding countries reported smoking prevalence of about 2648% , depending on the gender , age and the specific population group studied [ 4144 ] . worldwide
, the overall prevalence of smoking among adult males and females was estimated to ranges from 21 to 37% in the high - income countries , and 8.9 to 49% in low to middle income countries .
therefore , the percentage of smokers obtained in this study is comparable to previous studies from the region and to low to middle income countries all over the world . according to data obtained form the jordanian department of statistics , about 38% of jordanian adult population falls into the age range of 1929  year , which is considered a high percentage of young adults . in this study , however , 74% of the studied sample falls within the range of 1829  years , and 47% of them were college students .
therefore , the studied sample appears to be not population based , which is one limitation of the current study .
another limitation is the fact that the sensitivity and specificity of the questionnaire was not tested . in summary
, headache is a major health problem in jordan , where 82.3% of participants experienced troublesome headache attacks at least once per year .
analgesic overuse without seeking medical advice is regarded as potential for development of chronic headache .
these results indicate the need for public education to ensure safe practices and to make the use and selling of analgesics more stringent .
 here , we investigated the prevalence of headache among adults in jordan . 
 the study was conducted from january 2007 to november 2008 . 
 a sample of 4,836 participants were permitted to complete a self - conducted screening questionnaire . as much as 82.3% of participants complained from headache at least once per year . 
 36.1% were tension - type headache and 59% of the participants had other family members who suffered from headache . 
 headaches affected everyday activities in 51.6% of the participants ; 82.7% of participants did not seek medical attention for their headaches . among those who used analgesics ( 75.6% ) , acetaminophen was the most common ( 91.43% ) . in conclusion , headache and overuse of analgesics 
 were prevalent in a significant part of the society . 
 thus , there is a need to educate the public to ensure safe practices and to make the use and selling of analgesics more stringent . 
Introduction
Methods
Results
Discussion