a 45-year - old iranian woman was referred to the private clinic in the city of hamadan for implant consultation .
her past medical history was not notable , and there was no evidence of systemic disease .
she had no history of trauma to the mandible . in the extra - oral examination ,
intra - oral examination revealed normal oral mucosa , the absence of soft tissue expansion , and teeth of a normal color .
all of the teeth were asymptomatic , with no pain or tenderness on percussion or palpation .
the involved teeth were vital in an electric stimulation test . for assessment before implant insertion , cbct had been ordered . during evaluation of the implant insertion areas on promax3d cbct ( planmeca oy , helsinki , finland ) , a radiolucent - radiopaque mixed lesion located on the apices of the lower incisors was observed . on the axial , sagittal , and coronal
cbct images , the extension of the lesion was observed from the mesial side of the right mandibular lateral incisor to the distal side of the left mandibular lateral incisor .
it was a multifocal lesion in which solitary lesions were reached together and made a larger lesion .
the total dimension of the lesion was about 16.6 mm in the mesiodistal direction and 6.9 mm in the longest superior - inferior direction . on the panoramic reconstructed cbct image ,
the lesion associated with the left mandibular lateral incisor was radiolucent , whereas the lesion on the apex of the left central incisor was mixed radiolucent - radiopaque and the lesion associated with the right central incisor was radiopaque with a radiolucent rim around the lesion of this tooth ( fig .
the state of the lesion relative to the buccal and lingual cortical plates could be assessed , which might not be possible on the conventional radiographs . on the axial image ,
one of them was located at the mesial side of the right canine and the other between the left central and lateral incisors ( fig .
cross - sectional images , the discontinuity of the lingual cortex was found at the area between the two central incisors on several consecutive sectional images ( fig .
this cortical discontinuity was more obvious on the three - dimensional ( 3d ) cbct images ( fig .
however , it should be considered that the cortical bone could be seen to have destruction on 3d images , even though it would have been thin without discontinuity on the cross - sectional images . on the digital periapical radiograph that was taken for
periodontal ligament space widening was found , especially around the root of the left lateral incisor .
based on the patient clinical and radiographic findings , a diagnosis of multifocal periapical cemento - osseous dysplasia was made .
pcod is a specific lesion within this group of conditions that usually occurs in middle - aged black women.4 a systematic review of the literature on cod indicated an ethnic distribution of 59% , 37% , and 3% for blacks , asians ( japanese , chinese , and korean ) , and caucasians including indian cases , respectively , in case reports.8 zegarelli et al reported the incidence of pcod in the general population to be 2 - 3/1000.9 periapical cemento - osseous dysplasia generally does not cause cortical bone expansion or perforation.9 - 12 alsufyani and lam reviewed the clinical and radiographic characteristics of 118 patients with cod.13 they showed that 71.6% of 118 patients had no cortical expansion , 76% had intact lamina dura , and 93% had a normal periodontal ligament space .
modern advances in imaging help the dentist to use the cbct with the appropriate field of view and spatial resolution ; therefore , the internal mineralized structure of the pathologic lesions can be investigated with a low radiation dose.14 axial cbct images clearly demonstrate the location and extension of the lesion .
the expansion and perforation of the cortical plates can be evaluated on cbct even if they are slight .
this report showed the discontinuity of the lingual cortex on some axial and cross - sectional cbct images .
this characteristic of the lesion was an unusual feature among the cases of pcod reported up to now that may be due to its large size and needed to be checked in further regular follow - ups .
this feature also could be found in an exaggerated fashion on the 3d cbct images .
although 3d imaging could help the radiologist in diagnosing the lesion for the first look , it should be noted that it is not a reliable viewing modality for assigning the real status of the lesion in relation to its surrounding bone structures . in many cod cases that have been misdiagnosed and/or mismanaged ,
the lesions were identified in their early stages as a periapical rarefying osteitis such as periapical abscess , granuloma , or cyst , and unnecessary endodontic treatment was performed . therefore , vitality tests are especially important for differential diagnosis . in the radiolucent - radiopaque mixed stage and the radiopaque stage , the differential diagnosis might include chronic sclerosing osteomyelitis , cementoossifying fibroma , odontoma , cementoblastoma , and osteoblastoma.13 periapical cemento - osseous dysplasia is usually detected on routine radiological examinations . however , the differential diagnosis of our case could be calcifying cystic odontogenic tumor and cemento - ossifying fibroma . by using cbct discrimination of pcod from these lesions that exhibit similar internal calcification on conventional radiography
high density mass in pcod which is centered in low density area is different from findings of calcifying cystic odontogenic tumor in which calcification is observed at or near the cyst wall.15 also , cemento - ossifying fibroma has more obvious concentric buccolingual expansion on multiplanar cbct image . unless pcod is symptomatic ,
treatment is usually not needed because development and maturation of the lesion is self - limiting .
intervention may cause secondary infection of the cementum - like radiopacities , which may in turn induce osteomyelitis in these lesions.13 however , if pcod demonstrates unusual changes or becomes symptomatic , surgical intervention would then be needed.7 this case was considered as no treatment with only periodic follow - up check .
 periapical cemento - osseous dysplasia ( pcod ) is a subtype of cemento - osseous dysplasia that usually occurs in middle - aged black women . 
 this report described a case of a 45-year - old iranian woman who was diagnosed with pcod on the basis of cone beam computed tomographic ( cbct ) findings . 
 cbct enabled detailed visualization of the bone changes . 
 this report described the special radiographic characteristics of pcod , including discontinuity of the lingual cortex on the cbct sectional and three - dimensional images . 
Case Report
Discussion