there are only four reported cases in the medical literature describing typical bronchial carcinoids metastasizing to the brain .
little is known about the pathogenesis and presentation of this disease due to the very small patient population .
a 67-year - old hispanic female presented to our hospital with a three - week history of right arm numbness and poor coordination . computed tomography ( ct ) with intravenous contrast of the brain and subsequent magnetic resonance imaging demonstrated multiple enhancing nodular densities throughout the brain .
ct with intravenous contrast of the chest , abdomen , and pelvis revealed a left hilar mass and a medial left upper lobe mass .
although metastases to the central nervous system are very frequent with small cell carcinomas , their presence is very uncommon in well - differentiated neuroendocrine tumors such as the one we present here .
this case raises questions about whether these tumors contain biomarkers that might predict a more aggressive behavior and if these patients might benefit from aggressive interventions similar to those taken in small cell carcinomas , such as prophylactic cranial radiation .
accounting for approximately 12% of all lung malignancies in adults and roughly 2030% of all carcinoid tumors , bronchial carcinoids are neuroendocrine tumors made up of peptide and amine - producing cells originating from the embryologic neural crest [ 1 , 2 , 3 , 4 ] .
carcinoids originate most commonly from the gastrointestinal tract , but can also originate from the lung , thymus , and ovary .
bronchial carcinoids are broken down into typical and atypical tumors based on their pathologic tumor grade .
typical bronchial carcinoids are slow growing tumors that rarely metastasize , whereas atypical tumors metastasize early to the hilar or mediastinal nodes and are associated with a higher recurrence rate [ 5 , 6 ] .
the average age of adults diagnosed with typical and atypical bronchial carcinoid tumors is 45 and 55 years , respectively [ 7 , 8 , 9 ] .
typical and atypical bronchial carcinoids have five - year survival rates ranging from 87100 to 3095% , respectively [ 7 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17,18,19,20,21,22,2324 ] .
bronchial carcinoids occur in 0.22 per 100,000 individuals per year , with a higher incidence among women and caucasians [ 1,2,3 , 25 , 26 ] .
a major risk factor for tumor development is smoking , which accounts for up to half of all bronchial carcinoids   and an even greater percentage of atypical carcinoids [ 5 , 30 ] . patients with the autosomal dominant syndrome of multiple endocrine neoplasia type 1 ( men1 ) are also at increased risk for bronchial carcinoid tumor development .
we report a case of a patient who presented with a typical carcinoid that metastasized to her brain .
a 67-year - old hispanic female presented to the emergency department complaining of a 3-week history of right arm numbness and poor coordination , during which eating , putting on makeup , and combing her hair had become increasingly difficult . her past medical history was significant for well - controlled essential hypertension and recently diagnosed behet 's syndrome .
she smoked one pack a day for 37 years , quitting 15 years prior to the onset of symptoms . on admission ,
physical examination revealed right hand paresis and abnormal cerebellar function , as seen with the finger - to - nose test .
all laboratory results were within normal limits . computed tomography ( ct ) with intravenous contrast of the brain and subsequent magnetic resonance imaging demonstrated multiple enhancing nodular densities throughout the brain , measuring up to 1.3 cm in maximum diameter ( fig .
1 ) . ct with intravenous contrast of the chest , abdomen , and pelvis revealed a 2.5  2.7  3.5-cm left hilar mass encasing the left upper lobe apical segmental artery ( fig .
2 ) and a 2.1  2.1  2.7-cm medial left upper lobe mass abutting the anterior mediastinum .
bronchoscopic evaluation confirmed the findings of imaging studies and endobronchial biopsy reported typical carcinoid histology ( fig .
3 ) , with stains positive for cd56 , synaptophysin , ttf-1 , and napsin , and negative for p63 , ck5 , and chromogranin .
a ct - guided percutaneous lung biopsy was performed on the hilar site to confirm the diagnosis given the rarity of central nervous system metastasis with this histology .
this report , in addition to a report from a second opinion tissue sample referral center , concurred with the diagnosis .
the patient was placed on steroid taper and her metastatic brain lesions were treated with stereotactic radiosurgery ( 16 gy at 60% isodense ) with complete improvement of neurologic symptoms .
surgical evaluation deemed the patient unresectable and plans were made to start concurrent chemotherapy and radiation .
written informed consent was obtained from the patient for publication of this paper and accompanying images .
a copy of the written consent form is available for review by the editor - in - chief of this journal .
there are only four reported cases in the medical literature describing typical bronchial carcinoids metastasizing to the brain .
the patients were reported in japan , israel , and germany , and their ages ranged from 45 to 76 years .
neuroendocrine tumors of the lung exist as a continuum from well - differentiated typical carcinoids to atypical carcinoids to extremely poorly differentiated small cell carcinomas . according to the 2004 who criteria for the diagnosis of neuroendocrine tumors ,
there are specific pathological criteria that need to be met when describing each subset of tumor   ( table 1 ) .
although metastasis of small cell carcinomas has been well described , little is known about the pathogenesis and presentation of typical bronchial carcinoid metastasis due to the very small patient population .
in addition to exploring the tumor 's genetics and clinical tendencies , we must also understand the treatment modalities for this malignancy in order to ultimately improve patient survival .
researchers have suggested several mechanisms to explain bronchial carcinoids ability to metastasize , including dendritic cell apoptosis , deletions of 11q   and 4q25 , dna methylation , and aneuploidy dna content .
other signals or genes that have been implicated include cell cycle inhibitor rb1 , drs tumor suppressor gene , phospholipase c beta 3 , and apoptosis signal caspase-8 .
markers for malignant bronchial carcinoid tumor transformation include gastrin - releasing peptide , bcl-2 , p53 , pou factor brn3adel , and tyrosine kinase receptors c - kit , pdgfr alpha / beta , and egfr [ 46 , 47 ] .
additionally , cd44 , nm23 , and ki-67 have all been shown to have prognostic significance for this tumor [ 46 , 47 ] . although the most common metastatic site of all carcinoid tumors is the liver , extrathoracic metastatic disease with bronchial carcinoid tumors is very rare , with one study citing a rate of 5% in a sample of 525 patients .
symptomatic patients can have hemoptysis from tumor hyper - vascularity or cough with recurrent pneumonia due to proximal airway obstruction . about three - fourths of bronchial carcinoids
are centrally located and have a pink to red vascular mass appearance with intact bronchial epithelium .
bronchial carcinoids , in addition to merkel cell carcinomas , pheochromocytomas , medullary thyroid carcinomas , and pancreatic neuroendocrine tumors , arise from neuroendocrine cells and have the capacity to secrete biologically active neuroamines and neuropeptides . despite the fact that less than 5% of patients exhibit hormonally related symptoms , typical and atypical bronchial carcinoids have the potential to cause carcinoid syndrome and cushing 's syndrome through ectopic production of serotonin   and adrenocorticotropic hormone [ 48,49 , 50,51 ] , respectively .
60% of atypical tumors express somatostatin receptors and can be imaged with radiolabeled octreotide [ 11 , 52 , 53 , 54,55 ] .
although this scan can image the entire body and identify metastatic disease outside the lung very easily , it has a very low specificity for disease detection [ 55 , 56 ] .
currently , there are no screening guidelines for bronchial carcinoid tumors and their presence can only be identified and confirmed through the use of radiographic studies and follow - up biopsy with immunohistological staining of the secreted products synaptophysin , neuron - specific enolase , and chromogranin . in terms of treatment modalities , surgical resection with lymph node dissection offers the only chance of a cure from these tumors .
consensus guidelines from the national comprehensive cancer network suggest the use of chemotherapy and radiation for resected stage ii or iii atypical carcinoids , but not for typical carcinoids .
although randomized trials have revealed only minimal activity , metastatic bronchial carcinoid patients are often treated with small cell carcinoma - related regimens including prophylactic cranial radiation with cisplatin plus etoposide with or without paclitaxel or single agent temozolomide .
although metastases to the central nervous system are very frequent with small cell carcinomas , their presence is very uncommon in well - differentiated neuroendocrine tumors such as the one we present here .
this case raises questions about whether these tumors contain biomarkers that might predict a more aggressive behavior and if these patients might benefit from aggressive interventions similar to those taken in small cell carcinomas , such as prophylactic cranial radiation .
additionally , more data will need to be collected on metastatic typical bronchial carcinoid patients in order to better characterize the optimal radiographic and laboratory screening tests and the subsequent treatment modalities that will result in the best overall outcomes .
 introductiontypical bronchial carcinoid tumors are known for their relatively indolent behavior . 
 there are only four reported cases in the medical literature describing typical bronchial carcinoids metastasizing to the brain . 
 little is known about the pathogenesis and presentation of this disease due to the very small patient population.case presentationa 67-year - old hispanic female presented to our hospital with a three - week history of right arm numbness and poor coordination . computed tomography ( ct ) with intravenous contrast of 
 the brain and subsequent magnetic resonance imaging demonstrated multiple enhancing nodular densities throughout the brain . 
 ct with intravenous contrast of the chest , abdomen , and pelvis revealed a left hilar mass and a medial left upper lobe mass . 
 histopathological findings were consistent with a neuroendocrine neoplasm of bronchial origin.conclusionalthough metastases to the central nervous system are very frequent with small cell carcinomas , their presence is very uncommon in well - differentiated neuroendocrine tumors such as the one we present here . 
 this case raises questions about whether these tumors contain biomarkers that might predict a more aggressive behavior and if these patients might benefit from aggressive interventions similar to those taken in small cell carcinomas , such as prophylactic cranial radiation . 
Introduction
Case Presentation
Conclusion
Introduction
Case Presentation
Discussion
Conclusion
Disclosure Statement