 mir132 is a creb induced microrna involved in dendritic spine plasticity . 
 we observed that visual experience regulates histone post - translational modifications at a cre locus important for mir212/132 cluster transcription and mir132 expression in the visual cortex of juvenile mice . 
 monocular deprivation reduced mir132 expression in the cortex contralateral to the deprived eye . counteracting mir132 reduction with infusion of 
 chemically modified mir132 mimic oligonucleotides completely blocked ocular dominance plasticity ( odp ) . 
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