according to the korean society for the study of obesity , about 30% of the korean population is classified as overweight or obese , which has been linked to the development of various malignant diseases , including colorectal cancer and breast cancer . according to data from the korea central cancer registry in 2008 , the onset of prostate cancer has been sharply increasing since 1999 . in 2008 ,
a ratio of 26.1 new cases of prostate cancer per 100,000 persons was reported , and by virtue of developments in diagnostic methods such as prostate - specific antigen ( psa ) and transrectal ultrasonography , the onset rate is rapidly increasing .
a recent epidemiologic study reported that obesity may be protective against the development of early stage prostate cancer . on the contrary
, other studies have shown that obesity may be associated with an increased risk of advanced disease and death from prostate cancer .
.   reported higher rates of positive surgical resection margins and biochemical recurrence in obese patients with localized prostate cancer undergoing radical prostatectomy than in normal - weight patients .
that report is considered to be a representative example of an association between obesity and localized prostate cancer .
as aforementioned , most studies on the relationship between body mass index ( bmi ) and the prognosis of prostate cancer patients have focused on localized prostate cancer . to our knowledge , studies are lacking on the relation between bmi and castration - resistant prostate cancer ( crpc ) .
thus , we proposed to analyze the prognostic value of bmi in korean patients with crpc .
a retrospective study was conducted of 55 patients who were diagnosed with prostate cancer and who received hormonal therapy for local or distant metastasis .
all patients received docetaxel chemotherapy owing to the development of crpc between january 2003 and december 2009 at our institution .
this study was approved by the institutional review board of seoul national university bundang hospital .
crpc was defined as cases of an increased psa level despite a serum testosterone level in the castrate range , a psa level that increased 3 consecutive times despite interruption of administrating antiandrogen agents for 4 to 8 weeks or despite secondary hormonal treatment owing to advancement of the metastatic lesion , or the new development of a measurable metastatic lesion as assessed by imaging or an increase in size .
bmi was calculated by dividing body weight ( kg ) by the square of height ( m ) , which was measured before docetaxel treatment . according to the world health organization asian - pacific obesity guidelines , patients with a normal or lower bmi ( < 23 kg / m )
were categorized as group i and patients with an overweight or greater bmi ( 23 kg / m ) were categorized as group ii . by use of the medical records of the patients , age , time from the diagnosis of prostate cancer , follow - up period , serum psa level ,
gleason score , eastern cooperative oncology group ( ecog ) performance status , serum alkaline phosphatase level , serum creatinine level , metastasis to the internal organs , radiation treatments , and performance of radical prostatectomy were investigated retrospectively .
the primary clinicopathological outcomes according to bmi were compared by using mann - whitney u test and chi - square test .
cancer - specific survival was estimated by the kaplan - meier method , and differences between the groups were tested by using the log - rank test .
the effect of bmi on cancer - specific survival was examined by using a cox proportional hazards regression model , and hazard ratios ( hrs ) and 95% confidence intervals ( cis ) were computed .
all p - values were two - sided , and values < 0.05 were considered to indicate statistical significance .
analyses were performed by using the pasw ver . 18.0 ( ibm co. , armonk , ny , usa ) .
on the basis of bmi , 27 patients ( 49.1% ) belonged to group i ( bmi<23 kg / m ) and 28 patients ( 50.9% ) belonged to group ii ( bmi23 kg / m ) .
mean follow - up periods were 30 months and 34.2 months , respectively ( p=0.381 ) .
when subjects were categorized according to bmi , those with a higher bmi had a higher gleason score ( 71.4% vs. 59.3% , p=0.343 ) and lower psa ( 285.7536.9 vs. 135.5267.3 , p=0.233 ) , but the differences were not significant .
in addition , there was no significant difference between the two groups in terms of age , ecog performance status , hemoglobin level , alkaline phosphatase level , metastasis to the internal organs , radiation treatments , or performance of radical prostatectomy ( p>0.05 ) ( table 1 ) .
of 55 patients , 16 patients had died at the time of last follow - up of the current analysis , and the median follow - up among surviving patients was 24.7 months ( 95% ci , 19.9 to 29.4 months ) .
the median survival times were 17.8 months ( 95% ci , 12.3 to 23.2 months ) for men with a normal bmi and 33.2 months ( 95% ci , 27.9 to 38.6 months ) for overweight men . in the normal - weight group ,
14 patients died of prostate cancer . in the overweight group , only 2 patients died of prostate cancer , thus showing a higher prostate cancer - specific death rate in the normal bmi group than in the overweight group ( p=0.001 ) ( fig .
1 ) . in the univariate analysis for predicting prostate cancer - specific survival rates , bmi ( p=0.005 ; hr , 0.121 ) , logpsa ( p=0.044 ; hr , 2.878 ) , and alkaline phosphatase level
( p=0.039 ; hr , 8.582 ) were significant factors for prediction . in the multivariate analysis , bmi ( p=0.005 ;
hr , 0.55 ) , logpsa ( p=0.008 ; hr , 7.836 ) , gleason score ( p=0.018 ; hr , 6.434 ) , hemoglobin ( p=0.006 ; hr , 0.096 ) , alkaline phosphatase level ( p=0.005 ; hr , 114.1 ) , and metastasis to the internal organs ( p=0.028 ; hr , 5.195 ) were significant factors for prediction ( table 2 ) .
according to the medical check - up data in 2008 from the national health insurance corporation , 3.24 million persons had a bmi>25 kg / m , comprising 32.8% of a total of 9.88 million people who received the exam .
high bmi is a problem not only of korea , which is experiencing rapid industrialization , but also of most industrialized countries , including europe and america . in the united states ( us ) , about 48 to 66 billion us dollars
the severity of obesity is its association with various systemic diseases , such as hypertension , diabetes , circulatory diseases , and eye diseases , as reported in many studies [ 11 - 13 ] . in this study , high bmi
was observed to positively affect the patients with crpc who received docetaxel treatment . in the multivariate analysis ,
improvement in the cancer - specific survival rate was observed in the group of patients with bmi23 kg / m .
in addition , logpsa , gleason score , hemoglobin level , alkaline phosphatase level , and metastasis to internal organs were reported as significant prognostic factors .
the above results contradict those of a previous study that reported an adverse clinical effect of obesity on localized prostate cancer .
magheli et al .   reported worse pathological results of obese patients compared with normal - weight patients in a study of 1,877 patients who underwent radical prostatectomy .
irani et al .   reported that obesity not only raised the onset of prostate cancer with an odds ratio of 2.47 but significantly increased the prevalence rate in the resection area in the case of radical prostatectomy . according to rodriguez et al .
. adams et al .   reported a linear relationship between bmi increase and the prostate cancer - specific death rate . according to the study conducted by freedland et al .   using shared equal access regional cancer hospital data targeting a total of 1,106 patients , obesity raised biochemical recurrence rates after radical prostatectomy .
of a total of 1,226 patients with crpc , the overall survival rate and cancer - specific survival rate of overweight and obese patients were higher than those of the normal - weight patients , which agrees with the results of the present study .
moreover , a similar correlation was reported between obesity and biochemical failure in 939 patients treated with external beam radiotherapy .
on the basis of this study , we examined the correlation between obesity and the survival rate of patients with crpc who received docetaxel treatment .
many studies have been reported on the correlation between bmi and prostate cancer in korean men .
however , most studies have focused on the effects of bmi on the prognosis of localized prostate cancer . to our knowledge , there have been no studies of the relation between bmi and crpc in korean men .
in contrast with previously published studies on men with an earlier stage of disease , our results revealed a protective effect of an elevated bmi in patients with crpc . a hypothesis that thin people are vulnerable to cancer cachexia , thus resulting in a poor prognosis , has been suggested .
cancer cachexia is considered a poor response to rapid progression and treatment of cancer . in the present study ,
normal - weight patients showed lower hemoglobin levels and ecog performance status and higher psa levels than did overweight patients , even though the difference was not significant . in comparison ,
high - bmi patients are considered to accumulate more protein and calories than thin patients and , accordingly , are more efficient in enduring the cancer - cachetic - producing effect .
some studies have suggested that energy restriction appears to decrease cellular proliferation by ceasing progression through the cell cycle and enhancing apoptosis of cancer cells . in previous studies , various hypotheses
have been presented to explain the correlation between prostate cancer and obesity [ 22 - 24 ] .
first , obesity , especially abdominal obesity , is associated with insulin resistance and hyperinsulinemia , which contributes to a high serum insulin level and insulin - like growth factor - i level facilitating the development of cancer .
moreover , obesity - associated high leptin levels adversely affect the survival of prostate cancer patients .
recently , adiponectin , a major adipose cytokine that decreases in circulation in obesity and ameliorates obesity , was identified as an inhibitor of prostate cancer cell growth .
the results of the present study showed that the survival rate was significantly high in the crpc group having a bmi23 kg / m .
as a retrospective study , a limitation of the present study is the sample size of 55 , which is small compared with other studies . despite this limitation , the present study is the first such study in this field in korea . in the future ,
prospective and large - scale multi - institutional studies on the pathology of the correlation are expected to be conducted .
the findings from the current study suggest that bmi as well as other prognostic factors are independent prognostic factors in patients with crpc who receive docetaxel treatment . with higher bmi ,
the cancer - specific survival rate was observed to improve more , in contrast with the correlation in earlier stages of prostate cancer .
in addition , logpsa , gleason score , hemoglobin level , alkaline phosphatase level , and metastasis to internal organs were significant prognostic factors . a large - scale
, prospective study will be needed to elucidate the exact association between bmi and crpc .
 purposewe investigated the correlation between body mass index ( bmi ) and the prognosis of castration - resistant prostate cancer ( crpc ) in patients who received docetaxel treatment.materials and methodsa retrospective study was conducted of 55 patients who were diagnosed with crpc and received docetaxel treatment between 2003 and 2009 at our institution . 
 patients with a normal or lower bmi ( < 23.0 kg / m2 ) were categorized as group i and patients with an overweight or greater bmi ( 23.0 kg / m2 ) were categorized as group ii . 
 clinicopathological features and survival rates were evaluated by using the kaplan - meier method and cox proportional hazards models.resultson the basis of bmi , 27 patients ( 49.1% ) belonged to group i and 28 ( 50.9% ) patients belonged to group ii . 
 mean follow - up periods were 30 months and 34.2 months , respectively ( p=0.381 ) . 
 there were no significant differences between the two groups in terms of age , prostate - specific antigen ( psa ) , gleason score , eastern cooperative oncology group performance status , hemoglobin level , alkaline phosphatase level , distant metastasis , radiation treatments , or performance of radical prostatectomy ( p>0.05 ) . in the univariate analysis for predicting survival rates , bmi ( p=0.005 ; hazard ratio [ hr ] , 0.121 ) , logpsa ( p=0.044 ; hr , 2.878 ) , and alkaline phosphatase level 
 ( p=0.039 ; hr , 8.582 ) were significant factors for prediction . in the multivariate analysis , bmi 
 ( p=0.005 ; hr , 0.55 ) , logpsa ( p=0.008 ; hr , 7.836 ) , gleason score ( p=0.018 ; hr , 6.434 ) , hemoglobin ( p=0.006 ; hr , 0.096 ) , alkaline phosphatase level ( p=0.005 ; hr , 114.1 ) , and metastasis to the internal organs ( p=0.028 ; hr , 5.195 ) were significant factors for prediction.conclusionsbetter effects on the cancer - specific survival rate were observed in cases with higher bmi . 
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
CONCLUSIONS