the most common causes of hypercalcemia are malignancies , particularly solid tumors , in hospitalized patients1 and primary hyperparathyroidism in non - hospitalized patients.2 the most common cause of primary hyperparathyroidism is a solitary parathyroid adenoma.2 neck ultrasound and dual - phase tc-99 m sestamibi ( mibi ) scan are generally used as first - line tools in the diagnosis of primary hyperparathyroidism.35 neck ultrasound is the least invasive and most inexpensive method to accurately localize hyperfunctioning parathyroid , but its efficacy is related to the operator experience and may be reduced in the presence of concomitant nodular goiter.3 mibi is a lipophilic monovalent cation showing increased uptake in epithelial cells rich in mitochondria such as hyperfunctioning parathyroid cells .
mibi scan shows high sensitivity ( 71%93% ) and specificity ( 90% ) in localizing hyperfunctioning parathyroid.35 reported sensitivity and specificity of mibi plus spect for solitary adenomas vary from 92% to 97% and from 96% to 99% , respectively.37 mibi retention is not parathyroid - specific and is also observed in hypermetabolic thyroid nodules ; blood vessels esophagus , longus colli muscle , and enlarged lymph nodes may represent other rare sources of false - positive results.3,8,9 hypercalcemia occurs in 2%63% of patients with sarcoidosis ; hypercalciuria is about three times more common ( 30%50% of cases).1,10 hypercalcemia in sarcoidosis is due to the uncontrolled synthesis of 1,25-dihydroxyvitamin d3 by macrophages .
1,25-dihydroxyvitamin d3 leads to an increased absorption of calcium in the intestine and to an increased resorption of calcium in the bone.1,10,11 primary hyperparathyroidism can coexist with sarcoidosis.11,12 less well - recognized is the ability of sarcoidosis itself to masquerade as a parathyroid adenoma.13 we report a case of cervical lymph node sarcoidosis misdiagnosed as parathyroid adenoma .
accumulation of mibi in hilar lymph nodes and in pulmonary interstitial fibrosis in sarcoidosis has been reported previously;1416 other cases of sarcoidosis have been misinterpreted as primary hyperparathyroidism before the mibi was introduced into clinical practice.12,13 a case of active sarcoid mimicking a mediastinal parathyroid adenoma on mibi scan was previously described by klieger.17 to our knowledge this is the first reported case of neck lymph node misdiagnosed as parathyroid adenoma on mibi scan and second case described in literature considering other localizations.17
she had a history of hypothyroidism caused by hashimoto s thyroiditis and treated with l - thyroxine .
serum investigation revealed increased calcium of 10.5 mg / dl ( normal range ( nr ) : 8.610.2 ) and a parathyroid hormone ( pth ) of 162 pg / ml ( normal range 1265 ) .
serum phosphorus was 3.5 mg / dl ( nr : 2.74.5 ) , urinary calcium was 152 mg/24 h ( nr : 50250 ) , and urinary phosphorus was 1298 mg/24 h ( nr : 8003000 ) .
vitamin d 25-oh was 21 ng / ml ( nr : 20100 ) . serum creatinine was 1.25 mg / dl ( nr : 0.61.1 ) , the estimated glomerular filtration rate ( egfr ) was 90 ml / min/1.73 m ( nr : 90120 ) , creatinine clearance ( ccr ) was 85 ( 85130 ml / min ) .
calcium clearance / creatinine clearance ratio was 0.02 and diagnosis of familial hypocalciuric hypercalcemia ( fhh ) was excluded .
primary hyperparathyroidism was suspected and a neck ultrasonography was performed , revealing a paratracheal hypoechoic mass of 15 mm of maximum diameter with peripheral vascularization located near the lower pole of the right lobe of the thyroid ( compatible with lower right parathyroid ) .
mibi scan and spect / ct identified a mibi - positive area corresponding to the paratracheal nodule detected by ultrasonography ( us ) , suggesting a lower right parathyroid adenoma ( fig .
being concordant us and mibi scan , a right inferior parathyroid adenoma was suspected and the patient underwent surgical exploration .
the indication for parathyroidectomy was based on the suspicion of parathyroid adenoma while the indication for thyroidectomy , after informed consent of the patient , was based on the thyroid volume , the volume and the characteristics of the thyroid nodules , and the fact that the thyroid and the nodules volume were in constant growth .
measurement of intraoperative pth was made : basal pth was 152 pg / ml , pth 10 minutes after excision was 211 pg / ml , while pth 20 minutes after excision was 152 pg / ml . the bilateral exploration of the neck was negative for the presence of other pathological parathyroid glands .
pathologic examination confirmed the preoperative diagnosis of hashimoto s thyroiditis associated with hyperplastic nodular goiter , but did not confirm the diagnosis of parathyroid adenoma , the mass being a granulomatous lymph node consistent with active sarcoidosis ( fig .
no other sarcoidosis lesions or related findings were found , the neck lymph node being the only visible lesion .
the patient has begun therapy for sarcoidosis with corticosteroids and is currently well 5 years after surgery .
we report a case of cervical lymph node sarcoidosis misdiagnosed as parathyroid adenoma on neck ultrasonography and mibi scan .
difficulty in us and mibi scan interpretation with high rate of false - positive images ( 15%20% ) has been described in the presence of hypermetabolic thyroid nodules ; blood vessels , esophagus , longus colli muscle , and enlarged lymph nodes may represent other rare sources of false - positive results.3,8,9 hypercalcemia can occur in sarcoidosis , its prevalence being approximately 20%;11 the relation between sarcoidosis and hypercalcemia was first noted in 1939.10,18 risk factors for development of hypercalcemia in patients with sarcoidosis include renal insufficiency , increased dietary vitamin d , dehydration , increased uptake of oral calcium and/or decreased calcium excretion , and increased sunlight exposure.10,18 our patient had mild renal insufficiency . in our case , postoperative exams and follow - up allowed to exclude the presence of a primary hyperparathyroidism , sarcoidosis thus being the only cause of hypercalcemia .
the presence of a mild renal insufficiency may have been the cause of the increase in pth . as with other lipophilic cations ,
the precise uptake mechanism in sarcoidosis is unknown.15 lymph nodes with sarcoid involvement are found in 23% to 37% of patients with sarcoidosis.13 accumulation of mibi in hilar lymph node and in pulmonary interstitial fibrosis in sarcoidosis has been reported previously.1416 it is a rare to observe other lymph nodes outside the chest showing increased uptake.14 before the introduction of mibi scanning into clinical practice , cases of sarcoidosis misinterpreted as primary hyperparathyroidism have been described.12,13 to our knowledge , the only case of active sarcoid mimicking a parathyroid adenoma on mibi scan was previously described by klieger,17 but in that case the disease was localized in the mediastinum .
our case was particularly interesting because it s the second case described in the literature of lymph node sarcoidosis mimicking a parathyroid adenoma on mibi scan ; the first case in involved a lymph node localized to the neck .
preoperative imaging studies ( us , mibi , scan and spect / ct ) were concordant and preoperative diagnosis of parathyroid adenoma was made .
intraoperative measurement of pth gave discordant results for which it was carried out a bilateral exploration of the neck : no pathological parathyroid was found .
fortunately , the suspicion of parathyroid adenoma was not the only indication for surgery , being present a large multinodular goiter associated with a thyroiditis .
only histological examination revealed the correct diagnosis of sarcoidosis which was subsequently treated . in conclusion
, sarcoidosis should be taken into account as a cause of unexplained hypercalcemia and the differential diagnosis of hypercalcemia , even in presence of mibi uptake , must include sarcoidosis localized in an isolated cervical lymph node .
 we report a case of cervical lymph node sarcoidosis misdiagnosed as parathyroid adenoma . 
 this is the second case described in the literature in which lymph node sarcoidosis was misdiagnosed as parathyroid adenoma on tc-99 m sestamibi ( mibi ) scan , the first case localized in the neck . a 64-year - old woman presented with a hypercalcemia . 
 neck ultrasonography revealed a paratracheal hypoechoic mass of 15 mm with peripheral vascularization . 
 mibi scan and spect / ct identified a mibi - positive area corresponding to the nodule detected by ultrasonography suggestive for a lower right parathyroid adenoma . a mass interpreted as the lower parathyroid was excised associated to a total thyroidectomy . 
 pathologic examination revealed a granulomatous lymph node consistent with active sarcoidosis . 
 sarcoidosis should be suspected as a cause of unexplained hypercalcemia and the differential diagnosis of hypercalcemia , even in presence of mibi uptake , must include sarcoidosis localized in an isolated cervical lymph node . 
Introduction
Case Report
Discussion