from march 2001 to february 2005 , we performed us in 58 patients , mri in 24 patients , and both mri and us in 10 patients for a total of 72 patients ( 63 women and 9 men , age range : 19 - 70 years , average age : 50 years ) who were clinically suspected of having morton neuroma . by review of the pathologic and surgical reports on the medical records ,
the final study group of this report was comprised of twenty confirmed morton neuromas in 17 patients among the 72 patients : 12 neuromas ( in 11 patients ) were pathologically confirmed by partial neurectomy ; the remaining eight neuromas ( in 6 patients ) were confirmed by gross inspection at the time of surgery , and these were remedied by neurolysis .
all the surgery was performed by one experienced orthopedic surgeon . the surgical decision for surgery
was based on the clinical findings and the pre - operative mri and/or us reports .
patients were asked to access their satisfaction with the operation results according to the system advocated by johnson et al . ( 14 ) as follows : 1 ) completely satisfied ( essentially pain free , no restrictions in activity and only minor restrictions in footwear ) , 2 ) satisfied with minor reservations ( occasional mild pain , minor restrictions in activity and minor restrictions in foot wear ) , 3 ) satisfied with major reservations ( mild or moderate pain , moderate restrictions in activity and major restrictions in footwear , but overall improvement ) , 4 ) dissatisfied ( no improvement in pain or worse pain , major restrictions in activity and footwear , or worse symptoms ) .
the grades of the patients ' satisfaction and the difference of the grades according to the methods of treatment were analyzed .
the us evaluation was performed by one of four experienced musculoskeletal radiologists with using 9-mhz linear array transducers ( hdi 5000 , advanced technology laboratories , bothell , wa ) .
the us images were obtained from the plantar aspect of the foot in the transverse and longitudinal planes , relative to the metatarsal shafts , with each patient in a sitting position with their feet in slight plantar flexion . the diagnostic criterion for morton neuroma , as assessed by us , was a well - defined , round or ovoid , hypoechoic ( relative to the adjacent muscle ) mass located just proximal to the metatarsal heads in the plantar aspect of the intermetatarsal space ( 5 ) .
all the mr imaging studies were performed on a 1.5-t scanner ( signa horizon , ge medical systems , wi ) .
the patients were examined in the supine position with the foot placed in plantar flexion within a transmit - receive extremity coil . the imaging protocol consisted of a t1-weighted spin - echo sequence ( t1wi ;
tr / te , 550/9 ) , a fast spin echo ( fse ) t2-weighted sequence ( t2wi ; tr / te , 4000/96 ) and a t1-weighted fat - suppressed spin - echo sequence ( contrast - enhanced fat - saturated [ cefs ] t1wi ; tr / te , 617/12 ) that was obtained after the intravenous injection of 0.2 ml / kg gadopentetate ( magnevist , schering , berlin , germany ) .
the imaging plane was oblique coronal , and this was perpendicular to the metatarsal bones .
the section thickness was 3 - 5 mm without an intersection gap , the image matrix was 256  192 or 256  256 and the field of view was 10 - 14 cm ( mostly 12 cm ) ; this resulted in in - plane resolution of 0.220 - 0.292 mm ( pixel size ) .
the diagnostic criterion for mr imaging was a well - demarcated ovoid or dumbbell - shaped intermetatarsal mass at the plantar aspect near the metatarsal heads , and the mass had intermediate to low signal intensity on both t1wi and t2wi ( 1 , 15 , 16 ) .
the comparison of the us and mr imaging findings was performed retrospectively by a consensus of two experienced radiologists , and then each image was correlated with the surgical and pathologic findings .
the size of the lesion was measured as the largest transverse diameter on both us and mri .
the fluid between the metatarsal bones ( the inter - metatarsal bursa ) was excluded during the measurement of the lesion on mri .
in addition , we compared the t1wi with the cefs t1wi for lesion conspicuity and for detecting morton neuroma .
from march 2001 to february 2005 , we performed us in 58 patients , mri in 24 patients , and both mri and us in 10 patients for a total of 72 patients ( 63 women and 9 men , age range : 19 - 70 years , average age : 50 years ) who were clinically suspected of having morton neuroma . by review of the pathologic and surgical reports on the medical records ,
the final study group of this report was comprised of twenty confirmed morton neuromas in 17 patients among the 72 patients : 12 neuromas ( in 11 patients ) were pathologically confirmed by partial neurectomy ; the remaining eight neuromas ( in 6 patients ) were confirmed by gross inspection at the time of surgery , and these were remedied by neurolysis .
all the surgery was performed by one experienced orthopedic surgeon . the surgical decision for surgery
was based on the clinical findings and the pre - operative mri and/or us reports .
patients were asked to access their satisfaction with the operation results according to the system advocated by johnson et al .
( 14 ) as follows : 1 ) completely satisfied ( essentially pain free , no restrictions in activity and only minor restrictions in footwear ) , 2 ) satisfied with minor reservations ( occasional mild pain , minor restrictions in activity and minor restrictions in foot wear ) , 3 ) satisfied with major reservations ( mild or moderate pain , moderate restrictions in activity and major restrictions in footwear , but overall improvement ) , 4 ) dissatisfied ( no improvement in pain or worse pain , major restrictions in activity and footwear , or worse symptoms ) . the grades of the patients ' satisfaction and the difference of the grades according to the methods of treatment were analyzed .
the us evaluation was performed by one of four experienced musculoskeletal radiologists with using 9-mhz linear array transducers ( hdi 5000 , advanced technology laboratories , bothell , wa ) .
the us images were obtained from the plantar aspect of the foot in the transverse and longitudinal planes , relative to the metatarsal shafts , with each patient in a sitting position with their feet in slight plantar flexion . the diagnostic criterion for morton neuroma , as assessed by us , was a well - defined , round or ovoid , hypoechoic ( relative to the adjacent muscle ) mass located just proximal to the metatarsal heads in the plantar aspect of the intermetatarsal space ( 5 ) .
all the mr imaging studies were performed on a 1.5-t scanner ( signa horizon , ge medical systems , wi ) .
the patients were examined in the supine position with the foot placed in plantar flexion within a transmit - receive extremity coil . the imaging protocol consisted of a t1-weighted spin - echo sequence ( t1wi ; tr / te , 550/9 ) , a fast spin echo ( fse ) t2-weighted sequence ( t2wi ; tr / te , 4000/96 ) and a t1-weighted fat - suppressed spin - echo sequence ( contrast - enhanced fat - saturated [ cefs ] t1wi ; tr / te , 617/12 ) that was obtained after the intravenous injection of 0.2 ml / kg gadopentetate ( magnevist , schering , berlin , germany ) .
the imaging plane was oblique coronal , and this was perpendicular to the metatarsal bones .
the section thickness was 3 - 5 mm without an intersection gap , the image matrix was 256  192 or 256  256 and the field of view was 10 - 14 cm ( mostly 12 cm ) ; this resulted in in - plane resolution of 0.220 - 0.292 mm ( pixel size ) .
the diagnostic criterion for mr imaging was a well - demarcated ovoid or dumbbell - shaped intermetatarsal mass at the plantar aspect near the metatarsal heads , and the mass had intermediate to low signal intensity on both t1wi and t2wi ( 1 , 15 , 16 ) .
the comparison of the us and mr imaging findings was performed retrospectively by a consensus of two experienced radiologists , and then each image was correlated with the surgical and pathologic findings .
the size of the lesion was measured as the largest transverse diameter on both us and mri .
the fluid between the metatarsal bones ( the inter - metatarsal bursa ) was excluded during the measurement of the lesion on mri .
in addition , we compared the t1wi with the cefs t1wi for lesion conspicuity and for detecting morton neuroma .
among the 20 neuromas ( in 17 patients ) , 12 neuromas ( 12/20 , 60% ) were found in the third intermetatarsal space and the other eight neuromas ( 8/20 , 40% ) were in the second intermetatarsal space ( table 1 ) upon operation .
therapeutic success was assessed at the post - operative 2-month follow - up in 13 patients because four patients who underwent excision were unfortunately lost during follow up .
eleven out of the 13 patients ( 11/13 , 85% ) had near complete relief from pain , two ( 2/13 , 15% ) had moderate improvement with some remaining pain , and none of the patients became worse .
complete relief or marked improvement of the pain was seen in six patients ( 6/7 , 86% ) treated by excision and in five patients ( 5/6 , 83% ) treated by neurolysis ( table 1 ) . among the confirmed 20 morton neuromas ( in 17 patients ) ,
us was performed for 14 neuromas ( 11 patients ) , mri was performed for 17 neuromas ( 15 patients ) , and both us and mri were performed for 11 neuromas ( 9 patients ) .
the typical appearance of morton neuroma on the us and mr images is shown in figure 1 .
us depicted 11 out of 14 neuromas correctly , but the remaining three neuromas were not detected .
on the other hand , mri detected 13 out of 17 neuromas correctly , but the remaining four neuromas were not detected .
hence , the detection rate of mri for morton neuroma was 76% ( 13/17 ) .
figure 2 shows the true positive and false negative lesions in the patients who underwent both us and mr imaging .
us demonstrated a mass in only the third intermetatarsal space , while the mr imaging revealed a mass in only the second intermetatarsal space .
three patients had false negative results on the us imaging analysis , and four patients had false negative results on the mri analysis ( table 1 ) . among them
figure 3 shows the case confirmed by excision and pathologically proven , but it was false negative on mr . on us ,
the mean size of the measured neuromas was 4.9  1.45 mm ( range : 4 - 9 mm ) . on mri ,
the mean size of the neuroma was 5.1  1.32 mm ( range : 3 - 8 mm ) .
most of the neuromas were 5 mm or less ( 10 of the 14 neuromas [ 71% ] detected on us and 10 of the 17 neuromas [ 59% ] detected on mri ) .
the maximum difference in size for the same masses measured by us and mr imaging was less than 1 mm .
of the 13 neuromas depicted by mr imaging , three were visualized only on t1wi , while one was noted only on the cefs t1wi .
accordingly , the neuromas detected on t1wi ( 12/13 , 92% ) outnumbered those on the contrast - enhanced images ( 10/13 , 77% ) ( table 1 ) .
among the 20 neuromas ( in 17 patients ) , 12 neuromas ( 12/20 , 60% ) were found in the third intermetatarsal space and the other eight neuromas ( 8/20 , 40% ) were in the second intermetatarsal space ( table 1 ) upon operation .
therapeutic success was assessed at the post - operative 2-month follow - up in 13 patients because four patients who underwent excision were unfortunately lost during follow up .
eleven out of the 13 patients ( 11/13 , 85% ) had near complete relief from pain , two ( 2/13 , 15% ) had moderate improvement with some remaining pain , and none of the patients became worse .
complete relief or marked improvement of the pain was seen in six patients ( 6/7 , 86% ) treated by excision and in five patients ( 5/6 , 83% ) treated by neurolysis ( table 1 ) .
among the confirmed 20 morton neuromas ( in 17 patients ) , us was performed for 14 neuromas ( 11 patients ) , mri was performed for 17 neuromas ( 15 patients ) , and both us and mri were performed for 11 neuromas ( 9 patients ) .
the typical appearance of morton neuroma on the us and mr images is shown in figure 1 .
us depicted 11 out of 14 neuromas correctly , but the remaining three neuromas were not detected .
hence , the detection rate of us was 79% ( 11/14 ) . on the other hand , mri detected 13 out of 17 neuromas correctly , but the remaining four neuromas were not detected .
hence , the detection rate of mri for morton neuroma was 76% ( 13/17 ) .
figure 2 shows the true positive and false negative lesions in the patients who underwent both us and mr imaging .
us demonstrated a mass in only the third intermetatarsal space , while the mr imaging revealed a mass in only the second intermetatarsal space .
three patients had false negative results on the us imaging analysis , and four patients had false negative results on the mri analysis ( table 1 ) . among them , five patients underwent neurolysis and only one patient underwent excision .
figure 3 shows the case confirmed by excision and pathologically proven , but it was false negative on mr . on us ,
the mean size of the measured neuromas was 4.9  1.45 mm ( range : 4 - 9 mm ) . on mri ,
the mean size of the neuroma was 5.1  1.32 mm ( range : 3 - 8 mm ) .
most of the neuromas were 5 mm or less ( 10 of the 14 neuromas [ 71% ] detected on us and 10 of the 17 neuromas [ 59% ] detected on mri ) .
the maximum difference in size for the same masses measured by us and mr imaging was less than 1 mm .
of the 13 neuromas depicted by mr imaging , three were visualized only on t1wi , while one was noted only on the cefs t1wi .
accordingly , the neuromas detected on t1wi ( 12/13 , 92% ) outnumbered those on the contrast - enhanced images ( 10/13 , 77% ) ( table 1 ) .
morton neuroma was first described by thomas morton in 1876 as " a peculiar and painful affection of the fourth metatarsophalangeal articulation " ( 17 ) .
however , subsequent studies have shown that the third and second spaces are the more common sites for neuroma ( 5 ) .
our study has also demonstrated that the third space is the most common site of involvement .
it is generally accepted that the development of morton neuroma may be induced by repetitive compression of the plantar nerve against the deep transverse intermetatarsal ligament , with subsequent perineural fibrosis ( 18 ) .
a tentative diagnosis of morton neuroma can be made at the time of clinical assessment , but imaging correlation is required for the exact localization of neuroma and for the detection of multiple lesions , and especially when the clinical findings are indeterminate .
this can prevent patients from undergoing rather avoidable surgical exploration at the wrong sites , which may lead to inadvertent complications ( 5 , 17 ) .
in addition , other causes of metatarsalgia can also be excluded via imaging modalities . the possible clinical differential diagnoses that can cause metatarsalgia include intermetatarsal bursitis , stress fractures , necrosis of the sesamoid bones , synovitis of the metatarsophalangeal joint , infection and true neoplasm ( 3 , 8) .
these include intermetatarsal bursitis , ganglion cyst , synovial cyst , giant cell tumor ( gct ) of the adjacent tendon sheath , fibromatosis , nodular fasciitis , pigmented villonodular synovitis and physiologic fluid distention of the intermetatarsal bursa when examining by using us and mri ( 4 , 17 ) .
an investigation using us suggested that if a mass in the interdigital space is greater than 20 mm in length , then it is an abnormality other than neuroma such as a ganglion cyst , a synovial cyst or a gct of the adjacent tendon sheath ( 17 ) .
several sonographic study results have disclosed a prospective sensitivity of 95 - 98% for morton neuromas and a retrospective sensitivity of up to 100%
( 5 , 6 , 9 ) . however , a recent study by quinn et al .
( 17 ) revealed that 85% of neuromas with an average width of 6 mm , an average height of 9 mm and an average length of 13 mm were identified prospectively .
analysis by us in our study showed a relatively low detection rate ( 79% ) of morton neuroma .
sonography is a very operator - dependent technique , for instance , the sonographer 's experience is quite important , and so erroneous detection does factor into us examinations .
the size of the morton neuroma is considered as another factor contributing to the variability of detection .
the diameter of the normal plantar digital nerve is 1 - 2 mm at the level of the intermetatarsal heads and the normal nerve is not readily identifiable on sonography ( 5 , 9 ) . in our study , the mean sizes of the masses were 4.9 mm with using us and 5.1 mm with using mri , and these values were smaller than those reported in a previous study ( 6.5 mm for us and 7.4 mm for mri ) ( 11 ) .
mr imaging is a highly sensitive modality ( 87% ) for the detection of morton neuroma ( 1 ) .
our mr imaging evaluation ( detection rate : 76% ) did not show a better detection result than that expected at the beginning of the study .
two neuromas were as small as 4 mm in transverse diameter ( one of these is the case presented in figure 2 ) .
that these lesions were missed was possibly due to their smaller size , and it was possibly due to the surgeon 's subjective diagnosis in the cases of surgical neurolysis in our study
. we should again consider the matter of the lesions ' size . in our study , most of the neuromas that were operated upon were 5 mm or less .
there was no lesion less than 3 mm detected by either the us or mri modalities . in this aspect ,
the size of the lesions that were operated in our study was relatively smaller as compared with previous studies ( 1 , 3 , 7 , 17 ) . the measurement of morton neuroma on the transverse mr image is dependent on the placement of the foot in the scanner .
in addition , the size of the morton neuroma is significantly larger in the prone position with plantar flexion of the ankle than in the supine and upright weight - bearing positions , in which the ankle is dorsiflexed ( 15 ) .
our study was done with the foot placed in the supine position , which possibly caused a decreased diameter of the neuroma , although plantar flexion was applied to the ankle .
the transverse diameter can be affected by the patient 's position or by the compression pressure during sonography .
previous studies have demonstrated that neuromas larger than 5 mm in diameter are more symptomatic than the smaller ones ( 3 , 5 , 6 ) .
( 7 ) showed that a more favorable clinical outcome can be expected after surgical intermetatarsal neurectomy when a morton neuroma has a transverse measurement larger than 5 mm on mri scans ; 77% of the patients in that study had a good outcome when the neuroma was greater than 5 mm , compared with only 17% of the patients had a good outcome when their neuromas measured 5 mm or less .
( 11 ) demonstrated that symptoms were not dependent on the size of the neuroma .
moreover , the mr imaging diagnosis of morton neuroma does not always imply symptomatology ; thus , careful correlation between the clinical and mr imaging findings is mandatory ( 4 ) .
the fluid distention of the intermetatarsal bursa may mimic that of neuromas , but it may not manifest symptoms and it is typically less than 3 mm in transverse dimension ( 3 ) .
there are different opinions regarding the best mr imaging sequences for detecting morton neuroma ( 12 , 15 , 16 ) .
erickson et al . ( 16 ) reported that t1wi was the most useful sequence because neuromas with decreased signal intensity were well demarcated from the adjacent fat tissue . on the other hand , zanetti et al .
( 3 ) suggested that t2wi was beneficial in order to exclude other diseases that mimic neuroma , such as intermetatarsal bursitis , because the latter revealed high signal intensities .
terk et al . ( 12 ) stressed that sequences with fat - suppression and contrast - enhancement were reliable sequences for showing high - contrast images , and their study revealed that t1wi alone failed to demonstrate the presence of 50% ( 3 of 6 ) of the neuromas . in our study , the t1wi revealed better results for the detection of morton neuroma than the cefs t1wi did .
in particular , the rarely enhanced neuroma cases shown in figures 1 and 3 were better discriminated on t1wi than on cefs t1wi . however , the opposite was also true in figure 2 when the neuroma was well enhanced .
we think that cefs t2wi is not obligatory for the purpose of detection alone , although it can be necessary for differentiation of neuroma from other possible lesions .
the falsepositive and true - negative rates could not be obtained because our study group consisted of only surgically proven morton neuromas ( including cases of neurolysis that might have been related to the surgeon 's subjectivity ) .
in addition , performing surgical exploration in the asymptomatic intermetatarsal spaces in clinical settings is not ethically possible whether or not a suspected morton neuroma is found on imaging studies .
the second limitation is the retrospective analysis of the us findings , is that , sonography is an operator - dependent method .
the third limitation is that the double lesions in one patient were not separately evaluated in the clinical outcome . in summary ,
us and mr imaging are compatible modalities for the evaluation of morton neuroma , and both modalities have relatively high detection rates .
both imaging studies can provide information on the location and size of the neuroma prior to surgery .
in addition , the contrast enhanced sequence does not seem essential for the detection of neuroma .
 objectivethe purpose of this study was to compare the diagnostic accuracy of both ultrasonography ( us ) and magnetic resonance imaging ( mri ) for the assessment of morton neuroma.materials and methodsour study group was comprised of 20 neuromas from 17 patients , and the neuromas were confirmed on surgery following evaluation with us , mri , or both us and mri . 
 the diagnostic criterion for morton neuroma , as examined by us , was the presence of a round or ovoid , well - defined , hypoechoic mass . 
 the diagnostic criterion , based on mr imaging , was a well defined mass with intermediate to low signal intensity on both the t1- and t2-weighted images . 
 the retrospective comparison between the sonographic and mr images was done by two experienced radiologists working in consensus with the surgical and pathologic correlations.resultsthe detection rate of morton neuroma was 79% for 14 neuromas from 11 patients who had undergone us followed by an operation . 
 the detection rate was 76% for 17 neuromas from 15 patients who had undergone mri and a subsequent operation . 
 the mean size of the examined neuromas was 4.9 mm on the us images and it was 5.1 mm on the mri studies . 
 ten neuromas ( 71% ) were 5 mm or less as measured by us , and three neuromas were not detected , whereas on the mri analysis , 10 neuromas ( 59% ) were 5 mm or less and four neuromas were not visualized . among the patients examined during postoperative follow - up , 
 symptoms were completely relieved in 85% and the symptoms were partially relieved in 15%.conclusionus and mr imaging are comparable modalities with high detection rate for the evaluation of morton neuroma . 
MATERIALS AND METHODS
Patients
Surgical Data and Assessing the Therapeutic Outcome
Imaging Protocols, Diagnostic Criteria and Analysis of the Imaging Findings
RESULTS
Surgical Data and Assessment of the Therapeutic Outcome
General Information and the Result of Imaging Analysis
DISCUSSION