common bile duct ( cbd ) cancer is a relatively rare but increasing malignancy worldwide that arises from biliary epithelium , known as a cancer with chemoresistance and poor prognosis .
complete resection is the most effective and the only potentially curative treatment.1 however , at the time of diagnosis most patients are presented with advanced diseases.2 even the patients who had undergone curative resection show high recurrence rates .
thus systemic chemotherapy is the mainstay of the treatment but cbd cancer is highly resistant to most chemotherapeutic agents.3 currently , there is no standard chemotherapeutic regimen established for cbd cancer .
gemcitabine appears to be the most effective single agent.4 target therapy to avoid multidrug resistance is now under investigation . here
, we report a case of unresectable cbd cancer with liver metastasis , which completely responded to combination chemotherapy of gemcitabine and s-1 . to our knowledge
, this is the first case reporting a patient with advanced cbd cancer which showed pathologic complete remission after chemotherapy .
a 65-year - old male was admitted for abdominal pain and fever , which started 2 weeks ago .
laboratory finding demonstrated white blood cells 12.310/l , hemoglobin 11.6 g / dl , platelets 30910/l , total bilirubin 0.7 mg / dl , alkaline phosphatase 117 iu / l , aspartate aminotransferase 26 iu / l , alanine aminotransferase 33 iu / l , high sensitivity c - reactive protein 22.1 mg / dl , carcinoembryonic antigen 2.0 ng / ml , carbohydrate antigen 19 - 9 7.6 u / ml , and alphafetoprotein 1.3 ng / ml . hepatitis b surface antigen was negative and hepatitis c virus antibody was positive .
abdominal computed tomography ( ct ) showed about 9 cm lobulating low attenuating mass with peripheral rim enhancement in the left lobe of the liver , which was thought to be mature pyogenic liver abscess ( fig .
he started antibiotics therapy with ceftriaxone and metronidazole , and underwent percutaneous drainage tube insertion using 10.2 fr pigtail catheter into the liver abscess .
two days later fever subsided and a week later he was discharged with oral antibiotics .
one month later , follow - up liver ct scan showed 1.5 cm enhancing lesion in distal cbd with progression of biliary dilatation , suggesting distal cbd cancer ( fig .
additional ct scan ( fig . 5 ) and magnetic resonance imaging ( mri ) ( fig .
6 ) showed multiple small nodules in right hepatic lobe and metastatic adenocarcinoma was confirmed from frozen slide of sono - guided liver biopsy ( fig .
since the patient was inoperable , he underwent combination chemotherapy with gemcitabine 1,600 mg intravenous infusion on day 1 and s-1 ( tegafur+gimeracil+oteracil ) 500 mg twice a day for 14 days with 1-week rest as one course .
serial ct scans checked every three cycles showed gradual regression of the metastatic nodules in liver ( fig . 8) .
grossly the resected cbd showed a 11 cm sized gray solid mass infiltrating into adjacent soft tissue .
microscopically there were no residual tumor but chronic active cholangitis with multifocal erosion and subepithelial fibrosis in the resected cbd ( fig .
then , 22 days after the operation he was discharged without any complication . for 3 months of follow - up , he did not develop any signs of recurrence and no evidence of recurrence was found in the 3-month postoperative ct scan ( fig .
although radical surgery is the most effective therapy for cure in patients with cholangiocarcioma , only 20% of patients are diagnosed with resectable diseases.5 patients with unresectable cholangiocarcinoma have dismal prognosis with median survival of 6 to 12 months6 and 5-year survival rate of less than 5%.7 for these patients palliative therapy is important in terms of quality of life as well as the survival rate . the role of chemotherapy
however chemotherapy has been reported to be more beneficial than the best supportive care.8 gemcitabine has shown to be an effective therapy for cholangiocarcinoma in phase ii trials.9,10 fluorouracil also has shown activity in combination with gemcitabine.11 s-1 is a novel oral fluoropyrimidine agent containing tegafur , gimeracil and oteracil potassium .
gimeracil is a competitive inhibitor of dihydropyrimidine dehyrogenase , which achieves higher concentrations of 5-fluorouracil in plasma and tumor tissues.12 yoshizawa et al.13 tested the combination of s-1 with other anticancer drugs ( gemcitabine , cisplatin , irinotecan , mitomycin c , adriamycin , and paclitaxel ) and reported that synergistic effect was most evident in gemcitabine / s-1 combination .
a recent review reported phase ii trials supporting the following combinations : gemcitabine / cisplatin , gemcitabine / oxaliplatin , gemcitabine / capecitabine , and 5-fluorouracil in unresectable or metastatic cholangiocarcinoma.14 also there have been phase ii trials of gemcitabine and s-1 combination chemotherapy showing a promising survival benefit with acceptable toxicity in patients with advanced biliary tract cancer.15,16 in our case , we used gemcitabine combined with s-1
. gemcitabine was chosen for its extensively evaluated data supporting effectiveness in advanced cbd cancer .
s-1 was selected as an alternative to 5-fluorouracil for its convenience of administration and less toxicity .
so far , several cases have been reported , in which advanced cholangiocarcinoma was completely treated with gemcitabine chemotherapy in japan,17 - 20 although only one of them has shown complete remission histopathologically.14 in our case , the metastatic lesion disappeared radiologically and primary tumor was confirmed to have disappeared histopathologically after the chemotherapy .
thus there are chances to have radiologically invisible remnant malignant cells in hepatic tissue and potential risk of recurrence .
however , the 3-month postoperative follow - up ct scan showed no evidence of recurrence .
it is remarkable that the combination chemotherapy intended for palliation played a role of curative treatment . in conclusion , we experienced a case of advanced cbd cancer with liver metastasis completely responded to combination chemotherapy with gemcitabine and s-1 .
after 12 cycles of chemotherapy , surgical resection for primary tumor was performed because the metastatic lesion had completely disappeared , from which no remnant cancer cells were found .
 common bile duct ( cbd ) cancer is a relatively rare malignancy that arises from the biliary epithelium and is associated with a poor prognosis . here , we report a case of advanced metastatic cbd cancer successfully treated by chemotherapy with gemcitabine combined with s-1 ( tegafur+gimeracil+oteracil ) . a 65-year - old male presented with pyogenic liver abscess . 
 after antibiotic therapy and percutaneous drainage , follow - up computed tomography ( ct ) showed an enhanced nodule in the cbd . 
 biopsy was performed at the cbd via endoscopic retrograde cholangiopancreatography , which showed adenocarcinoma . 
 additional ct and magnetic resonance imaging showed multiple small nodules in the right hepatic lobe , which were confirmed as metastatic adenocarcinoma by sono - guided liver biopsy . 
 the patient underwent combination chemotherapy with gemcitabine and s-1 . 
 after nine courses of chemotherapy , the hepatic lesion disappeared radiologically . 
 pylorus - preserving pancreaticoduodenectomy was performed , and no residual tumor was found in the resected specimen . 
 three weeks after the operation , the patient was discharged with no complications . through 3 months of follow - up , no sign of recurrence was observed on ct scan . 
 gemcitabine combined with s-1 may be a highly effective treatment for advanced cholangiocarcinoma . 
INTRODUCTION
CASE REPORT
DISCUSSION