drug hypersensitivity syndrome ( dhs ) refers to a severe , potentially life - threatening , drug reaction . to better individualize this drug reaction ,
the term , drug rash with eosinophilia and systemic symptoms ( dress ) syndrome  has recently been used .
the most frequently involved organ is the liver , followed by the kidney and lungs .
the pathophysiology of dress syndrome remains unclear , but a defect in detoxification of causative drug , immunologic imbalance , and viral infections have been suggested .
the overall mortality in dress is about 10% and occurs in patients with severe multiorgan involvement . here ,
we present a case of a 10-year - old girl who developed dress syndrome after taking phenobarbital and ultimately died of multiorgan involvement with , acute respiratory distress syndrome ( ards ) , pneumomediastinum and acinetobacter sepsis .
a 10-year - old girl presented with high - grade intermittent fever with cough for 20 days and a generalized rash for 15 days following ingestion of phenobarbital for 6 weeks .
there was h / o seizures with fever from the age of 18 months , but the severity and frequency of seizures started increasing , occurring even without fever for which she was put on oral phenobarbital . on admission
, we found that the girl was toxic , febrile , icteric , with tachypnea , tachycardia , conjunctival congestion , stomatitis , and cervical , axillary and inguinal lymph node enlargement .
there was a diffuse erythematous , maculopapular rash without vesiculation or blistering [ figure 1 ] .
diffuse rash with oral involvement initial investigations showed leukocytosis , eosinophilia ( absolute eosinophil count : 1586/dl ) , high bilirubin , elevated liver enzymes , microscopic hematuria and minimal pyuria .
imaging studies revealed hepatomegaly with features of hepatitis , mild pericardial effusion on echocardiography , and features of diffuse pneumonitis .
dexamethasone ) was added on persistence of fever and dyspnea , following which there was a short period of improvement .
but after a few days , the girl again complained of sudden onset exacerbation of respiratory distress and we found that she had developed subcutaneous emphysema and pneumomediastinum [ figure 2 ] .
a repeat blood culture showed growth of acinetobacter baumanii and we switched over to sensitive antibiotics .
but the general condition deteriorated and the patient developed ards for which she was ventilated .
a systemic allergic reaction to anticonvulsant therapy was first described in 1950 and was named 
it has since been known as drug hypersensitivity syndrome and is now more often referred to as dress syndrome which is a specific , severe , idiosyncratic drug reaction characterized by skin rash with fever , facial edema , lymphadenopathy , and visceral involvement ( hepatitis , pneumonitis , myocarditis , nephritis , and colitis ) .
the diagnosis can be difficult because many of the clinical features can be nonspecific , and the syndrome often mimics infectious , neoplastic , or rheumatologic conditions .
the diagnosis of dress syndrome involves three criterias : 
 drug - induced skin eruptioneosinophillia , absolute eosinophil count > 1500/dl , or atypical lymphocytesat
least one of the following systemic abnormalities : enlarged lymph nodes at least 2 cm in diameter , hepatitis , interstitial nephropathy , interstitial lung disease , or myocardial involvement . 
 
drug - induced skin eruption eosinophillia , absolute eosinophil count > 1500/dl , or atypical lymphocytes at least one of the following systemic abnormalities : enlarged lymph nodes at least 2 cm in diameter , hepatitis , interstitial nephropathy , interstitial lung disease , or myocardial involvement .
anticonvulsants such as phenytoin , phenobarbital sodium , or carbamazepine , are the most common causes of dress syndrome
. other drugs like lamotrigine , valproic acid , allopurinol , sulfasalazine , nonsteroidal anti - inflammatory drugs , nevirapine and vancomycin have also been associated with this syndrome .
an association between human herpesvirus 6 infection and the development of dress syndrome has been suggested in susceptible patients .
life - threatening multiorgan failure has been documented in dress syndrome ; it carries a mortality rate of about 10% , especially in patients who have liver involvement . but
the pathogenesis is believed to be a drug - induced hypersensitivity caused by abnormalities in the production and detoxification of its active metabolites .
a genetic predisposition may also exist , as evidenced by an increased risk in patients with a family history of dress syndrome .
the syndrome may be related to epoxide hydrolase deficiency , which leads to accumulation of toxic metabolites , known as arene oxides , which may trigger an immunologic response .
phenobarbital - induced fulminant hepatic failure in the setting of dress syndrome has been described . to our knowledge , this is the first instance wherein pneumomediastinum , ards and sepsis together have been reported to develop in phenobarbital associated dress syndrome .
the recovery from this condition has been reported to be slow , lasting several weeks to months ; recurrences have also been reported .
glucocorticoids remain the most widely used agents for treatment of dress syndrome and can result in clinical improvement , although well - controlled clinical trials are lacking .
immuneglobulin in nevirapine - induced dress syndrome has been reported , as well as n - acetylcysteine in a patient with sulfasalazine - induced dress syndrome .
 drug rash with eosinophilia and systemic symptoms ( dress ) syndrome reflects a serious hypersensitivity reaction to drugs , and is characterized by skin rash , fever , lymph node enlargement , and internal organ involvement . 
 so far , numerous drugs such as sulfonamides , phenobarbital , sulfasalazine , carbamazepine , and phenytoin have been reported to cause dress syndrome . 
 we report a case of a 10-year - old girl who developed clinical manifestations of fever , rash , lymphadenopathy , hypereosinophilia , and visceral involvement ( hepatitis and pneumonitis ) after taking phenobarbital for seizures , with subsequent development of sepsis , acute respiratory distress syndrome ( ards ) and spontaneous air leak syndrome ( pnemothorax and pneumomediastinum ) . 
 she was put on steroids and various antibiotics and was ventilated , but ultimately succumbed to sepsis and pulmonary complications . 
Introduction
Case Report
Discussion