the mucosal folds in the body of the stomach are usually less than 1 cm thick .
occasionally these folds , also referred to as rugae , may thicken and enlarge , a condition known as hypertrophic gastropathy . while mntrier 's disease is most commonly associated with hypertrophic gastric folds , a variety of other diseases have also been associated .
these include zollinger - ellison syndrome , gastric lymphoma , diffuse gastric cancer , polyposis and eosinophilic gastroenteritis . rarely , infections with human cytomegalovirus ( cmv ) or helicobacter pylori ( hp ) may cause enlargement of the gastric folds [ 3 , 4 ] . although awareness of these mimics of mntrier 's disease is crucial , it may have an important bearing on patient management and outcome .
we report a patient with hypertrophic gastropathy caused by hp who showed dramatic response to therapy .
a 52-year - old man undergoing screening for gastric cancer was found to have grossly enlarged gastric mucosal folds ( fig .
there was no history of upper abdominal pain , vomiting , anorexia or significant weight loss .
laboratory testing revealed hemoglobin 15.1 g / dl , total protein 6 g / dl , serum albumin 3.9 g / dl , total leucocyte count 9,320/l , eosinophils 5.8% , serum gastrin 87 iu / ml and lactate dehydrogenase 155 u / l .
upper gastrointestinal endoscopy showed marked thickening of the gastric folds in the gastric proximal body ( fig .
contrast - enhanced computed tomography ( cect ) was performed mainly to investigate if other intra - abdominal lesions such as neuroendocrine tumor , lymphadenopathy or metastatic disease might be responsible for the thickened gastric folds . except for the thickened upper body of the stomach ,
endoscopic ultrasonography ( eus ) was performed to determine the origin of the thickened gastric mucosal folds and whether the layers of the gastric wall were preserved .
eus showed that the thickening in the proximal body was confined to the mucosal layer and that the muscularis propria and serosal layers were normal .
whole - body gallium scan for the presence of neoplastic lesions was normal . since gastric lymphoma ,
especially mucosa - associated lymphoid tissue lymphoma , was considered in the differential diagnosis , the interleukin 2 receptor serum level was measured and found to be mildly elevated at 783 u / ml ( normal < 520 u / ml ) .
significant neutrophilic infiltration was seen in the mucosa , and there was no evidence of malignancy or cmv infection ( fig .
the ratio of gastric crypts to glands was not determined because that assessment required a deeper biopsy .
the absence of symptoms and the finding of normal serum albumin indicated that mntrier 's disease was unlikely , and the diagnosis of hypertrophic gastropathy associated with hp infection was considered .
the patient received hp eradication therapy consisting of 1 week of treatment using lansoprazole , amoxicillin and clarithromycin .
he underwent a barium examination 5 months later , which revealed normal gastric mucosal folds ( fig .
gastroscopy showed that the thickened gastric mucosal folds previously seen in the proximal body were normal ( fig .
a repeat mucosal biopsy was negative for hp organisms , and the neutrophilic infiltration seen on the initial biopsy was minimal ( fig .
infection with hp is common , with about half of the world 's population harboring this bacterium in their stomach .
since hp infection is associated with important clinical diseases such as peptic ulcer disease , gastric lymphoma and gastric carcinoma , therapy is warranted for its eradication .
other conditions sometimes linked with hp infection include idiopathic thrombocytopenic purpura , iron deficiency anemia , scleroderma , idiopathic urticaria and migraine .
eradication therapy is generally recommended only for idiopathic thrombocytopenic purpura and unexplained iron deficiency anemia because evidence for association with hp is weak for the other conditions .
recently , hypertrophic gastropathy associated with hp has been proposed as an indication for treatment .
the dramatic improvement in gastric fold morphology and histology that was seen after eradication therapy in our patient provides additional support that patients with hp - associated hypertrophic gastropathy should be treated .
these patients may be at increased risk of gastric cancer , which underlines the importance of prompt treatment .
since hypertrophic gastric mucosal folds can be associated with many conditions , a thorough clinical and diagnostic evaluation is required to exclude other causes .
patients with mntrier 's disease are usually symptomatic and present with epigastric pain , vomiting , weight loss and low serum albumin level as a result of loss of proteins from the stomach .
patients with lymphoma and carcinoma commonly have anorexia and weight loss . in patients with zollinger - ellison syndrome
, the serum gastrin levels may be very high , multiple ulcers may be seen on gastroduodenoscopy , and abdominal imaging may show a tumor . hence , serum albumin level , total and differential leukocyte count ( eosinophilia in hypereosinophilic disorders ) , serum gastrin level , cmv serology and abdominal imaging ( cect , eus ) play an important role in the evaluation of patients with hypertrophic gastropathy .
our patient was asymptomatic , had a normal serum albumin and was tumor - free on imaging , which indicated that the conditions considered in the differential diagnosis were less likely .
the definitive diagnosis is derived from histological examination of the gastric mucosa , and therefore biopsy , preferably using a sufficiently large forceps to obtain a deep sample , is crucial .
mntrier 's disease is characterized by foveolar hyperplasia and scanty parietal cells , lymphoma and carcinomas manifest infiltration by neoplastic cells , inclusion bodies may be seen with cmv infection , and eosinophilic gastroenteritis shows infiltration with eosinophils .
evidence of hp infection by itself may not be sufficient to establish a cause - effect relationship with hypertrophic gastric folds .
the significant neutrophilic infiltration of the mucosa , exclusion of other causes and the resolution of thickened gastric mucosal folds and inflammation after bacterial eradication therapy in our patient strongly suggested that hp was the cause of his hypertrophic gastropathy .
there are also a few case reports describing the association of hp with lymphocytic and granulomatous gastritis , indicating that hp can cause non - neoplastic enlarged gastric folds [ 11 , 12 ] .
bacterial components may induce a distinct cytokine profile that may promote cellular proliferation and enlargement of the gastric folds .
one report suggested that increased production of interleukin-1 beta and hepatocyte growth factor during hp infection may result in gastric fold thickening .
the mutagenicity of gastric juice is increased in patients with hp infection and enlarged gastric folds , which may explain the increased risk of cancer in these patients . in conclusion , hp infection should be considered in the differential diagnosis of patients with hypertrophic gastropathy because the infection is easy to treat and the outcome is gratifying .
 infection with helicobacter pylori ( hp ) is common in many parts of the world . while most patients are asymptomatic , it causes peptic ulcer disease and malignancy in some of them . 
 other rare conditions have occasionally been reported in association with this infection . 
 we report a case of hypertrophic gastropathy caused by hp in a 52-year - old asymptomatic patient . 
 he was found to have marked enlargement of the gastric mucosal folds on radiological imaging and endoscopy . 
 a gastric mucosal biopsy showed hp colonization associated with neutrophilic inflammation . 
 after exclusion of neoplasia , other infections and infiltrative disorders , hp was thought to be the cause of the gastric fold hypertrophy . 
 the patient responded well to hp eradication therapy , with normalization of the gastric mucosal folds . 
 hp infection should be considered in the differential diagnosis of hypertrophic gastropathy and treated accordingly . 
Introduction
Case Report
Discussion