atrial septal defect ( asd ) is a form of congenital heart defect that enables blood flow between two compartments of the heart called the left and right atria . normally , the right and left atria are separated by a septum called the interatrial septum .
if this septum is defective or absent , then oxygen - rich blood can flow directly from the left side of the heart to mix with the oxygen - poor blood in the right side of the heart , or vice versa.1 asd is one of the most common congenital cardiac defects and accounts for approximately 610% of all congenital cardiac defects.2 young children with asd are usually asymptomatic and could wait for elective surgical or catheter - based closure for 3 years or more.34 shunts from asd are usually detected in childhood or young adulthood .
the defect is generally well tolerated in infants and young children , but symptoms of mild fatigue , poor growth or dyspnoea on exertion may be present.5 therefore , early closure could be beneficial for such infants . if the asd is small , it may not require any intervention , or it may close on its own .
asd , and therefore the shunt , tends to increase with age , and repair usually takes place when asd is diagnosed.5 in asymptomatic patients with a large left - to - right shunt , surgical closure should be performed between 2 and 5 years of age.6 asd is not without morbidity .
about 40% of such patients may present with cryptogenic stroke at adulthood ; paradoxical embolism has also been reported.7 surgical repair of asd is a well - established procedure and is very safe , with a negligible mortality rate.8 transcatheter occlusion of an asd was first described by king and colleagues in 1976.9 although satisfactory results have been reported with transcatheter occlusion of these defects with a number of devices , only one of them has received food and drug administration ( fda ) approval : the amplatzer atrial septal occluder ( aga medical corporation ; golden valley , minn10 ) .
this study is carried out to determine the pattern and clinical profile of children with asd .
it is also aimed at determining the different types of interventions done for these patients and their complications .
the study was conducted at a paediatric cardiac centre , innova heart hospital , hyderabad , india , established in 2007 .
the hospital records showed that from april 2007 to june 2011 , a total of 69 patients underwent surgical closure of asd .
chinese duct occluder manufactured by shanghai shape memory alloy material co. , ltd,11 which consists of metal mesh woven by nitinol wires with shape memory function , supper elasticity and polyethylene filled mesh .
the occluder device has specifications of 4/6 , 6/8 , 8/10 , 10/12 , 12/14 , 14/16 and 16/18 mm ( diameter of  waist  pulmonary arterial end / diameter of aortic end ) , with lengths between 7 and 8 mm .
the delivery system consists of loading sheath , delivery sheath and control wire , on the top of which there are screw threads .
the diameter of outer sheath is 6 - 10 f. other duct occluders also included 4 .
the ado12 received fda approval with the specific indication for nonsurgical closure of patent ductus arteriosus .
this device is a self - expandable device made from a nitinol wire mesh and polyester fabric .
as the occluder is implanted , it expands outward , and the wires push against the rims of the asd .
the operation was performed after puncture and systemic heparinisation ( 100 iu / kg ) .
intra - operative , intravenous administration of antibiotics was started and continued for 24 hours to prevent infection .
for infants , the operation was performed under general anaesthesia , whereas for older children , it was done under courteous sedation .
record showed that 69 patients presented with asd and underwent interventional closure of the defect during the study period . forty ( 58% ) patients were females while 29 ( 42% ) patients were males , giving a male to female ratio of 1:1.4 .
their age ranged from 3.2 to 19 years , with a median age of 9.0 years .
their weight ranged from 7.5 to 39.0 kg , whereas median weight was 31.5 kg .
five patients ( 7.2% ) were young children aged between 3 and 5 years [ table 1 ] .
forty - four ( 63.8% ) of these children presented with symptoms of heart failure , whereas 47 ( 68.1% ) of the cases repaired were large - sized asd .
the majority had large - sized asd , whereas small asd accounted for 1.4% of cases .
clinical profiles of asd and procedures used for repair the device used for the procedure was further shown to have a success rate of 88.4% , as shown in table 2 .
the most common interventional closure procedures done were searcare heart and amplatzer technique with a highest success rate obtained in 2010 [ table 3 ] .
this is in keeping with other studies.1314 the reason for this preponderance could be genetic .
, a common genetic variation near a gene called msx1 is strongly associated with the risk of asd , and females with asd may have more of this variation near msx1 than their male counterpart.15 we noted that majority of our patients with asd presented with symptoms of heart failure .
majority of young children with asd are usually asymptomatic and could wait for elective surgical or catheter - based closure for 3 years or more .
however , some infants with asd who suffer from congestive heart failure , frequent respiratory infection , failure to thrive and progressive moderate - to - severe pulmonary hypertension do so because of late presentation.16 a good number of our patients had a large - sized asd , which explains why we have so many symptomatic patients in our study .
it is the degree of shunting that predisposes to increased pulmonary flow and subsequent cardiac decompensation .
the aso is a self - expanding double - disc device with a central connection waist to stent the asd .
preliminary human experience regarding its safety and efficiency in closing asd has been very encouraging.171819 the aso is one of the most frequently used devices to close asd and has been proven to be highly effective and safe in the short term .
previous reports have confirmed that transcatheter closure of asd with the aso achieved comparable efficacy and safety to that of surgical closure .
it has some additional advantages , which include less complication rate , requirement of a shorter hospital stay and avoidance of a permanent scar.20 this is true because we had little or no complications in our patients and their hospital stay was short .
the procedure is done in the hybrid theatre or cardiac catheterisation laboratory and requires a team that includes an interventional radiologist or interventional cardiologist .
the capital outlay may be more expensive than that in open surgical programme , thereby making the unit cost of interventional treatment higher on the average .
asd is a common congenital heart disease with a high success rate for those who underwent surgery .
the use of aso percutaneous closure devices has become the procedure of choice for closure of asd in suitable patients .
 background : atrial septal defect ( asd ) is a congenital heart defect that leads to shunting of blood between left and right atria 
 . it may be asymptomatic and sometimes may present with heart failure . 
 surgical repair is definitive , but currently non - surgical procedure is used to close the defect.materials and methods : it is a retrospective study of patients who underwent transcatheter closure of asd at innova heart hospital , hyderabad , india . 
 echocardiography was repeated at intervals of 24 hours , then at 1 , 3 and 6 months after the procedure to assess complications . 
 the morphological characteristics of the asd , including its diameter , location , shape and the width of surrounding septal margins , were also evaluated.results:from april 2007 to june 2011 , 69 consecutive children ( 29 males , 40 females ) with a median age of 9.0 years ( range = 3.219 years ) registered with diagnosis of asd . 
 the median weight was 31.5 kg ( range = 7.539.0 kg ) . 
 five patients ( 7.2% ) were young children aged 35 years . 
 forty - four ( 63.8% ) of these children presented with symptoms of heart failure , whereas 47 ( 68.1% ) of the cases repaired with device were large - sized asd . 
 the most common interventional procedures done were searcare heart and amplatzer technique with a highest success rate obtained in 2010.conclusions:asd is a common congenital heart disease with a high success rate for those who undergo intervention . 
INTRODUCTION
MATERIALS AND METHODS
Data Analysis: Statistic analysis
RESULTS
DISCUSSION
CONCLUSION