the complexity of choosing a particular treatment for an individual patient while keeping her informed about the relevant options and considerations keeps increasing as personal genetic information becomes more commonly available .
this is leading clinicians and patients to question their role in the decision - making process .
for example , what role should patients take in choosing between alternative treatment options , in particular when the benefits and risks of each option are not crystal clear ?
to what extent should clinicians share their own hesitations about the best treatment choice , exposing their patients to the incomplete knowledge about each alternative ?
how should clinicians take such decisions without exposing patients to superfluous stress when current knowledge about the advantages and drawbacks of available therapy options is far from complete ?
these questions , and the doctor 's dilemma , have long been the topic of public discourse .
over 800 years ago , maimonides , a prominent jewish philosopher and practicing physician , wrote that ' the risk of a wrong decision is preferable to the terror of indecision ' .
although this remains as true as ever , should we not be asking what role patients have in taking a treatment decision - even when current knowledge is incomplete ? such questions seem to be more pertinent as we enter the age of personal genomes , when an individual 's pharmacogenomic data may affect their choice between treatment options [ 1 - 3 ] .
can patients comprehend complex diagnostic information and act on it when they face a choice between alternative therapeutic options , based on their personal genomic data ?
in other words , should patients be made aware of the fine details of current medical knowledge , including the gaps in it , when crucial treatment decisions have to be made ?
inevitably , some of those decisions may later turn out to have been the wrong ones for them .
wendy lorizio and colleagues   have examined this charged issue in a real - world personalized medicine scenario by following the treatment choices of 235 breast cancer patients currently taking or planning to take tamoxifen for prevention of cancer recurrence and who were offered the cyp2d6 genotyping test . their study is a fine example of our current knowledge limitations : at the time of conducting their cyp2d6 genotyping and follow - up patients survey ( march 2008 to may 2010 ) , most published studies , based on retrospective data , indicated that individuals having a cyp2d6 poor metabolizer genotype ( predictive of complete lack of the enzyme activity ) were less likely to benefit from tamoxifen for the prevention of breast cancer recurrence . however , more recent meta - analysis and studies cast doubt about the relevance of cyp2d6 genotypes for breast cancer recurrence in tamoxifen - treated patients .
thus , it could well be that a similar study taking place today would find other results , namely that patients would be less likely to change from tamoxifen to another drug following genotyping .
as long as no consensus has been reached on the effect of cyp2d6 genotypes on the efficacy of tamoxifen for preventing breast cancer recurrence , monitoring the serum level of endoxifen , its active metabolite , seems the most appropriate biomarker for adjusting tamoxifen dosages . including this biomarker as a decision making tool in breast cancer therapy seems to be justified at our currently incomplete state of knowledge .
moreover , it will remain a valuable biomarker once endoxifen itself , currently in clinical trials , is eventually approved as a drug .
the study by lorizio et al .   found that 46% ( 6 of 13 ) of the breast cancer patients prescribed tamoxifen and genotyped as poor cyp2d6 metabolizers elected to change their medication to another drug within the following 6 months .
this crucial treatment decision , while obviously taken along with their attending physicians , must have been affected by their participation in the informational session held by the researchers before the genetic testing , in which the results of studies examining the effects of cyp2d6 genotypes on breast cancer recurrence were presented .
notably , the authors   found that about half the patients had previous knowledge about the relevance of cyp2d6 genotypes for tamoxifen therapy , with the source of this knowledge being their nurses or clinicians , the medical literature or the general media ( internet , tv and newspapers ) .
yet it seems that performing the genotyping tests and learning about their results in a medical setting affected the decision on switching treatment .
this study   does not examine the extent to which the decision about changing the medication was driven by the patients or their clinicians .
the genotyping results were transferred to patients through their attending physicians , who did not receive specific recommendations along with the laboratory results .
it would have been of interest to also interview the clinicians and find out about their role and considerations in taking this decision ; however , this would require a larger study , as in this one only 13 patients of the 235 who were genotyped were found to be cypd6 poor metabolizers .
however , this study   illustrates that when genotyping relevant to drug response is carried out in a clinical setting along with informing patients about the test implications in advance of the testing , a decision about medication change followed for about half the patients whose test results indicated ( at that time ) that they were unlikely to benefit from tamoxifen .
this study conveys important insights for moving personalized medicine forward : offering patients pharmacogenetic testing in the clinical setting along with an educational session on the test relevance for their medication choices is an effective route for taking informed treatment decisions .
. the challenge will be to keep medicine participatory and patients fully informed when medicine and personal genomes meet - which may not be as far away as it seemed just a decade ago .
 informing patients about risks and benefits of alternative treatment options and choosing between them is becoming a bigger challenge as knowledge about the relationship between the individual 's genetic profile and the efficacy and safety of available medications accumulates . 
 putting personalized medicine into practice requires new modes of information sharing and decision making by patient and physician . 
 this is illustrated by a case study on treatment choices of breast cancer patients following genotyping for cyp2d6 , recently published in genome medicine.see research article : http://genomemedicine.com/content/3/10/64 
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A real-world example
Moving towards personalized medicine
Competing interests