 the effects of inhaled zinc oxide / hexachloroethane smoke ( 11,580 mg x min / m3 ) and intratracheally instilled zinc chloride ( 2.5 mg / kg body weight ) have been studied in rat lung . 
 the effects of subsequent treatment with 70% oxygen have been studied after both procedures . 
 both the inhalation of the smoke and instillation of zinc chloride produced similar effects that included pulmonary edema , alveolitis and , at a later stage , some fibrosis . 
 after zinc chloride instillation , the pathological changes largely spared the periphery of the lung , while following smoke inhalation they were more diffuse . 
 subsequent oxygen administration had little effect on the development or progression of the pathological changes.imagesfigure 5.figure 6.figure 7.figure 8 . 
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