cancer occurrence is highly influenced by environment , genetic , gender , age , race , socioeconomic status , education , culture , obesity , and all life style related factors which might result in incidence rate change of these cancers in every population ( 1 , 2 ) . main gynecologic cancers ( ovary , endometrium and cervix ) besides breast cancer are responsible for 1.6% of total human cancers in the world ( 3 ) .
breast , endometrium and ovary are cancers with high incidence in the developed and western countries , north europe and north america .
lower incidence in the less developed regions including asian countries is observed ( 35 ) . there are suggestions regarding different survival of ovarian cancer , adjusted by available diagnostic and therapeutic modalities .
more attention to confounding factors are needed , for instance undiag - nosed late stage ovarian cancer cases leading to dead affect involved diagnosed cancer population into more early stage and lower age population ( 6 ) .
cervical cancer incidence is among the 3 most common female cancers in 90% of the countries in the world ( 7 ) .
breast and gynecologic cancer incidence rates are the consequence of many factors . a common well known etiology for breast , ovarian and endometrial cancer is parity , with lower incidence in mul - tiparous women ( 811 ) .
risk factors of ovarian cancer include age , white race , nulliparity , positive family history of ovarian , endometrial and breast cancer ( 1214 ) .
cervical cancer is more common in the regions with low socioeconomic status ( 15 ) .
study of incidence trend might clarify epidemio - logic and clinical points to be studied more and used as and documented background for decision making and necessary interventions . in the present study change of incidence rate in breast , ovarian , endometrial and cervical cancer in a 4 - 5 year period of time in different countries including iran
data of 2004 national cancer registry of iran , published by the iranian ministry of health regarding all reported breast , ovarian , endometrial and cervical cancers were included in this comparative study ( 16 ) .
iranian national cancer registry report , as pathology based registry has presented crude incidence rates .
these data are not standardized by population in 2004 , so comparing it with those of the other countries is not possible . from 2008 ,
so , in the first step , results of breast , ovarian , endometrial and cervical cancer patients were standardized with standard world population .
all reported female cancers of breast , cervix , ovary , and endometrium were included in the analysis .
since other gynecologic cancers are rare their crude incidence rates were not included in the study .
data of each of cancers in 2004 was separately proceeded to age- standard incidence rate according to the world standard population of the same year . in the second step ,
results of age- standard incidence rates ( asr ) of the 4 above mentioned cancers in iran , 2004 besides asr of 6 other countries including usa , australia , japan , india , africa and thailand , 2004 were compared to asr reports of all above mentioned cancers in 2008 , globocan database .
the main variables are asr of breast , ovarian , endometrial and cervical cancer cases in different countries which are presented in two time cutoff ( 2004 and 2008 ) , in order to clarify the trend of disease in these time periods in different regions .
cancer registry data of iran is pathology based which include 80% of cancer cases ( 16 ) .
published data of the iranian ministry of health and care is ethically available for study and private data of patients is not included .
about 24498 female cancer patients were reported in 2004 iran , including 1923 ( 7.8% ) gynecologic cancer patients ( ovary , endometrium , uterus , cervix , vagina , vulva , placenta and other female genital organ ) , 16310 ( 66.6% ) non - gynecologic patients and 6265 ( 25.6% ) breast cancer cases .
that is , breast and gynecologic cancer patients cover 33.42% of all site female cancer cases in 2004 .
age groups of patients ( all female ) are shown in table 1 as demographic picture .
the number and frequency of breast and gynecologic female cancer patients according to age - groups in iran , 2004 the percentages of cancer patients in iran 2008 was 8.1% gynecologic , 69.9% non - gynecologic , 22% breast cancer based on globocan , 2008 database ( 17 ) .
the depiction of comparing iranian female cancers 2004 and 2008 percentage in non - gynecologic , breast , ovarian , cervix and endometrial subgroups are presented in fig.1 .
compared asr of iranian female gynecologic and breast cancer cases in 2004 and 2008 trend are presented in table 2 .
asr trend of gynecologic and breast cancer cases in iran , 2004 and 2008 comparison of the 4 mentioned cancers and asr trends of each cancer between iran and 6 other countries , in 2004 and 2008 are presented in table 3 .
percentage of female cancer cases ( categorized based on gynecologic , non - gynecologic and breast ) in iran , 2004 and 2008 comparison of standard incidence rate and its trend ( 2004 to 2008 ) , in breast , cervical , endometrial and ovarian cancer patients in different countries
we noticed in this study that in iran the incidence trend of breast and endometrium are decreasing , besides increasing trend of ovary and cervix .
most of breast and gynecologic female cancer patients occur in 40 - 59 age group ( table 1 ) .
this distinct the disease burden in terms of considering the high probable diagnosis and anticipating therapy for this age group .
the frequency of occurrence for different cancers in iran has been shown in fig . 1 through the percentages of non gynecologic cancers and gynecologic cancers along with breast cancer in 2004 and 2008 .
as it is shown , breast cancer is the most common female cancers among iranian women . among the gynecologic cancer cases , ovary is the most common .
this marks the burden of gynecologic cancer in iranian female population through 2004 - 2008 ( fig.1 ) .
compared asr of iranian female gynecologic and breast cancer cases , 2004 - 2008 shows that the incidence of ovarian , cervical and endometrial cancer has not changed significantly , although the asr of breast cancer has decreased from 24.93 in 100,000 population in 2004 to 18.4 in 100,000 population in 2008 ( table 2 ) .
this decreasing trend needs more evaluation . the lower occurrence and the younger age population in iran
might explain the mentioned trend ( 17 ) . a brief comparison of breast and gynecologic cancer asr of iran and those of the other countries are presented below .
the most common cancer in the world among 4 under study cancers is breast cancer followed by cervix , endometium and ovary ( table 2 ) .
breast cancer in all of the compared six countries revealed the highest incidence rate cancer .
the highest age standard incidence rate ( asr ) of breast cancer is observed in usa and australia with a decreasing trend . in iran and uganda
there is a higher asr in comparison to iran , thailand and uganda and lower in comparison to western countries , decreasing trend is like iran . in india and thailand , asr is lower with a rising trend ( table 3 ) .
several risk factors are associated with breast cancer including smoking , late child bearing , nuliparity , early menarche and late menopause , low breast - feeding , post - menopausal estrogen- progesterone replacement therapy , low physical activity , high bmi in older age , alcohol consumption , diet and the old age ( 1820 ) .
these risk factors are an area of more study in the future to clarify causes of any increasing or decreasing trends in each country .
iran is a low incidence area of breast cancer like other asian countries and inverse to western countries ( 17 ) . in iran in older age and after menopause slope of increasing breast cancer incidence by age exhibit slow rise in contrast to usa with continuous increase after menopause ( 21 ) .
trend of breast cancer in usa has increased 26% within 1980s and with lower speed within 1990s ( 22 ) . a 3.5% decrease in breast cancer asr
is observed from 2001 to 2004 which might be due to decreasing practice of hormone replacement therapy ( 23 ) .
as observed in table 3 trend of breast cancer asr from 2004 to 2008 in usa has been decreasing .
increase of breast cancer incidence rate observed in the data of the present study , in thailand and india might be the result of adoption of some aspects of western life style such as lower activity , more fast food usage , trend to obesity , later marriage , lower parity and so on .
the most common gynecologic cancer in the world is cervical cancer ( table 3 ) . in africa
the most common gynecologic cancer in japan , india , uganda , africa and thailand is cervical cancer , as well .
cervical cancer incidence in usa and australia is relatively low and trend is in favor of decrease . in countries such as uganda , africa and thailand incidence is high and trend is increasing ( table 3 ) . in iran ,
asr of cervical cancer is low ( the lowest asr of cervical cancer among the compared countries ) but trend is increasing ( table 2 ) . hpv infection as a sexually transmitted infection is regarded as the main factor influencing cervical cancer development ( 25 ) .
other risk factors are as follows : multiple partners , early age intercourse , smoking , socioeconomic status , and multiparty ( 26 , 27 ) .
proper screening ( pap smear and hpv testing ) results in cervical cancer asr decrease , which is observed in developed countries ( 2830 ) .
this matter might explain the observed decreasing trend of cervical cancer asr in usa and australia from 2004 - 2008 ( table 3 ) .
the most common gynecologic cancer in iran is ovary , although asr of ovarian cancer is lower in comparison to other countries ( table 3 ) .
trend of ovarian cancer asr in iran is increasing such as africa and india which are increasing , as well .
in western countries such as usa and australia , ovarian cancer asr is higher with a decreasing trend .
other studies report high rates of ovarian cancer in developed and western countries with a platue in asr and a lower rate in developing and asian countries including iran with increasing trend as observed in the present cancer data ( 4 , 5 ) .
main risk factors of ovarian cancer are nuliparity , low parity , obesity , white race , high fat diet and inactivity .
in contrast breast feeding , multiparity and oral contraceptive pill consumption are protective factors ( 5 , 31 , 32 ) .
it seems reasonable that a trend to western lifestyle , that influence diet , obesity and lower parity is lead to increase in trend of ovarian cancer asr which is observed in the present data ( table 3 ) .
the most common gynecologic cancer in usa and australia is endometrial cancer ( table 3 ) .
in contrast to japan and india where endometrial cancer incidence is lower with increasing trend , in iran endometrial cancer asr is low and the trend is decreasing ( table 2 ) one of the main limitations of comparative asr studies is different management of data gatherings .
more careful organized cancer registry may simulate higher asr , and vice versa is true as well .
data of iranian cancer registry might be in improvement curve and not in maximum clarify specially due to its pathologic basis .
main risk factors of endometrial cancer are old age , nuliparity , early menarche , late menopause and obesity ( 33 ) .
trend of developing countries to obesity and higher life expectancy might explain the increasing trend of endometrial cancer incidence in these countries .
probable causes of the decreasing trend in endometrial cancer in developed countries might be studied more in the future .
two main limitations of the study are as follows . at first , underestimate of cancer incidence especially in 2004 is probable due to new organization of cancer registry and pathology based method .
second point is the wide range of causes , risk factors , epidemiologic parameters in different regions and for each of 4 studied gynecologic cancers .
so , authors seriously feel the need of several step by step studies for more definite clinical discussion followed by decision in practice .
the most common cancer in the world among 4 under study cancers is breast cancer followed by cervix , endometium and ovary ( table 2 ) .
. the highest age standard incidence rate ( asr ) of breast cancer is observed in usa and australia with a decreasing trend . in iran and uganda
there is a higher asr in comparison to iran , thailand and uganda and lower in comparison to western countries , decreasing trend is like iran . in india and thailand , asr is lower with a rising trend ( table 3 ) .
several risk factors are associated with breast cancer including smoking , late child bearing , nuliparity , early menarche and late menopause , low breast - feeding , post - menopausal estrogen- progesterone replacement therapy , low physical activity , high bmi in older age , alcohol consumption , diet and the old age ( 1820 ) .
these risk factors are an area of more study in the future to clarify causes of any increasing or decreasing trends in each country .
iran is a low incidence area of breast cancer like other asian countries and inverse to western countries ( 17 ) . in iran in older age and after menopause slope of increasing breast cancer incidence by age exhibit slow rise in contrast to usa with continuous increase after menopause ( 21 ) .
trend of breast cancer in usa has increased 26% within 1980s and with lower speed within 1990s ( 22 ) . a 3.5% decrease in breast cancer asr is observed from 2001 to 2004 which might be due to decreasing practice of hormone replacement therapy ( 23 ) . as observed in table 3 trend of breast cancer asr from 2004 to 2008 in usa has been decreasing .
increase of breast cancer incidence rate observed in the data of the present study , in thailand and india might be the result of adoption of some aspects of western life style such as lower activity , more fast food usage , trend to obesity , later marriage , lower parity and so on .
the most common gynecologic cancer in the world is cervical cancer ( table 3 ) . in africa
the most common gynecologic cancer in japan , india , uganda , africa and thailand is cervical cancer , as well .
cervical cancer incidence in usa and australia is relatively low and trend is in favor of decrease . in countries such as uganda , africa and
thailand incidence is high and trend is increasing ( table 3 ) . in iran ,
asr of cervical cancer is low ( the lowest asr of cervical cancer among the compared countries ) but trend is increasing ( table 2 ) .
hpv infection as a sexually transmitted infection is regarded as the main factor influencing cervical cancer development ( 25 ) .
other risk factors are as follows : multiple partners , early age intercourse , smoking , socioeconomic status , and multiparty ( 26 , 27 ) .
proper screening ( pap smear and hpv testing ) results in cervical cancer asr decrease , which is observed in developed countries ( 2830 ) .
this matter might explain the observed decreasing trend of cervical cancer asr in usa and australia from 2004 - 2008 ( table 3 ) .
the most common gynecologic cancer in iran is ovary , although asr of ovarian cancer is lower in comparison to other countries ( table 3 ) .
trend of ovarian cancer asr in iran is increasing such as africa and india which are increasing , as well .
in western countries such as usa and australia , ovarian cancer asr is higher with a decreasing trend .
other studies report high rates of ovarian cancer in developed and western countries with a platue in asr and a lower rate in developing and asian countries including iran with increasing trend as observed in the present cancer data ( 4 , 5 ) .
main risk factors of ovarian cancer are nuliparity , low parity , obesity , white race , high fat diet and inactivity .
in contrast breast feeding , multiparity and oral contraceptive pill consumption are protective factors ( 5 , 31 , 32 ) .
it seems reasonable that a trend to western lifestyle , that influence diet , obesity and lower parity is lead to increase in trend of ovarian cancer asr which is observed in the present data ( table 3 ) .
the most common gynecologic cancer in usa and australia is endometrial cancer ( table 3 ) .
in contrast to japan and india where endometrial cancer incidence is lower with increasing trend , in iran endometrial cancer asr is low and the trend is decreasing ( table 2 ) one of the main limitations of comparative asr studies is different management of data gatherings .
more careful organized cancer registry may simulate higher asr , and vice versa is true as well .
data of iranian cancer registry might be in improvement curve and not in maximum clarify specially due to its pathologic basis .
main risk factors of endometrial cancer are old age , nuliparity , early menarche , late menopause and obesity ( 33 ) .
trend of developing countries to obesity and higher life expectancy might explain the increasing trend of endometrial cancer incidence in these countries .
probable causes of the decreasing trend in endometrial cancer in developed countries might be studied more in the future .
two main limitations of the study are as follows . at first , underestimate of cancer incidence especially in 2004 is probable due to new organization of cancer registry and pathology based method .
second point is the wide range of causes , risk factors , epidemiologic parameters in different regions and for each of 4 studied gynecologic cancers .
so , authors seriously feel the need of several step by step studies for more definite clinical discussion followed by decision in practice .
in countries such as usa and australia asr of breast , ovary and endometrium are higher in comparison with other countries including iran and the trend is decreasing .
the incidence of cervical cancer is lower and trend is in favor of more decrease .
in contrast in countries , such as africa , thailand , india and iran , although asr of breast , ovary and endometrium is lower in comparison with western countries , the trend is in favor of increase , except of breast in iran with a decreasing trend .
changes in lifestyle towards western pattern might explain increase trend of breast , ovary and endometrial cancer in the globe .
the first one probable reason is change of sexual behavior towards western lifestyle and the second , is lack of organized preventative screening programs resulting in increase in cervical cancer asr .
more studies focusing on epidemiologic patterns and the causes including risk factors for each cancer besides more attention to continuation of the present study trend in the future might clarify and suggest preventative interventions in public health planning and clinical decision making regarding cancer .
ethical issues ( including plagiarism , informed consent , misconduct , data fabrication and/or falsification , double publication and/or submission , redundancy , etc . ) have been completely observed by the authors .
 abstractbackgroundfemale cancer , especially breast and gynecologic cancers are considered multistage disease , highly influenced by risk and protective factors and/or screening preventive modalities . 
 consequences of all these factors result in the trend of change over time.methodsin this comparative study , based on data of national cancer registry of iran 2004 published by iranian ministry of health , age  standard incidence rate ( asr ) according to the world population was calculated in all reported gynecologic and breast cancers . 
 source of all subjects are pathologic based . in the next step , 
 the calculated asr of iran and those of the other countries in 2004 were compared to globocan asr reports of 2008.resultsin iran asr of breast cancer 2004 ( 24.93 ) changed to 18.4 in 2008 . 
 ovarian cancer asr of 2004 , 3.07 was 3.1 in 2008 . 
 endometrial cancer asr in 2004 ( 2.29 ) was 1.7 in 2008 . 
 cervical cancer asr of 1.71 in 2004 was 2.2 in 2008.conclusionsin iran incidence trend of breast and endometrium are decreasing in the same direction of usa and australia . increasing trend of ovary and cervix asr in iran 
 is in the inverse direction of usa and australia which are decreasing . 
 future studies to find out the same trend or any changes , might develop these findings and improve consequent practical decisions based on results of this study and complementary future studies . 
Introduction
Materials and Methods
Results
Discussion
Breast cancer
Cervical cancer
Ovarian cancer
Endometrial cancer
Conclusion
Ethical considerations