 a practical catalytic 
 method for enantioselective addition 
 of an allene unit to aldimines is disclosed . 
 transformations are promoted 
 by an in - situ - generated b - based catalyst that is derived from a simple , 
 robust , and readily accessible ( in multigram quantities ) chiral aminoalcohol . 
 
 a range of aryl- , heteroaryl- , and alkyl - substituted homoallenylamides 
 can be obtained in 6691% yield and 84:16 to > 99:1 enantiomeric 
 ratio through reactions performed at ambient temperature and in the 
 presence of 0.13.0 mol% of the chiral catalyst and a commercially 
 available allenylboron reagent . 
 the catalytic protocol does not require 
 strict anhydrous conditions , can be performed on gram scale , and promotes 
 highly selective addition of an allenyl unit ( vs a propargyl group ) . 
 
 the utility of the approach is demonstrated through development of 
 succinct approaches to syntheses of anisomycin and epi - cytoxazone . 
Supplementary Material