collision cancers are malignancies in the same organ or anatomical site that comprises at least two different tumor components , with no mixed or transitional area between the two components .
, it is known that the prognosis of collision cancer is very poor even after radical resection .
herein , we present a case of coexisting neuroendocrine carcinoma and conventional adenocarcinoma ( collision tumor ) in the ampulla of vater , which has seldom been reported in literature .
a 51-year - old man was presented with a month history of jaundice , pruritis and choluria . he had no history on medical problems , but was paraplegic due to his car accident .
physical examination showed acutely ill appearances without fever , with generalized skin and mucosal jaundice also being observed , but otherwise , his overall symptoms were unremarkable . in laboratory findings , we found elevated serum levels of bilirubin ( 3.38 mg / dl ) , alkaline phosphatase ( 229 u / l ) , gamma - glutamyl transpeptidase ( 843 u / l ) , alanine aminotransferase ( 389 u / l ) , and aspartate aminotransferase ( 602 u / l ) .
all tumor markers , including serum carcino - embryonic antigen ( cea ) and carbohydrate antigen 19 - 9 ( ca 19 - 9 ) were within normal limits . abdominal computed tomography ( ct ) and magnetic resonance cholangiopancreatography ( mrcp ) disclosed about 1.91.8 cm sized heterogeneously enhancing mass in ampulla of vater , causing obstruction of distal common bile duct , and dilatation of biliary tree and wirsung duct .
1 ) . with the clinical diagnosis on tumor of the ampulla of vater , endoscopic retrograde cholangiopancreatography ( ercp ) was performed , which revealed huge prominent papilla and dilated common bile duct with asymmetrically irregular structures ( fig .
he underwent pylorus - preserving pancreaticoduodenectomy under the diagnosis of ampulla of vater cancer . in operation finding , there was about 21.5 cm sized hard mass on ampulla of vater .
several enlarged lymph nodes were found around periampullary region , and all of them were cleared .
the patient suffered from delayed gastric emptying during his recovery , probably because he was paraplegic and bed - ridden .
he recovered from delayed gastric emptying in 50 days after surgery , and was discharged on postoperative day 59 .
after discharge , he was re - admitted due to ongoing nausea , and was later expired due to tumor lysis syndrome on postoperative day 90 .
pathologically , routine haematoxylin and eosin stains through the sections on the ampulla of vater showed multiple nests of tumor cells displaying a prominent organoid pattern of growth and forming rosettes .
the tumor cells were large and had a moderate amount of eosinophilic cytoplasm , a low nuclear to cytoplasmic ratio , and round or oval nuclei of various sizes .
the tumor cells were immunoreactive for cd56 , neuron specific enolase ( nse ) and synaptophysin .
in addition , conventional ductal adenocarcinoma composed of infiltrating glands was seen . in this area ,
the immunochemical stain with cd56 , nse and synaptophysin was negative , and this area extended and collided with poorly differentiated neuroendocrine carcinoma ( fig .
thus , we finally diagnosed the condition as ' collision tumor ' of adenocarcinoma and neuroendocrine carcinoma in ampulla of vater .
the majority of neuroendocrine tumor ( net ) occurs in the gi tract ( 67.5% ) and in the bronchopulmonary system ( 25.3% ) . within the gi tract
, most nets occur in the small intestine ( 41.8% ) , rectum ( 27.4% ) , and stomach ( 8.7%).1 less than 1% of nets occur in the ampulla of vater.2 the who classification published in 2010 fundamentally divides net into 2 clinically distinct pathologic classes : well- and poorly differentiated.3 well - differentiated nets can be classified as either low or intermediate grade . well - differentiated grade 1 and grade 2 nets traditionally have been referred to as carcinoids , regardless of grade or site of origin .
poorly differentiated nets are high - grade , large cell and small cell carcinomas are characterized by rapid dissemination , resistance to treatment , and have a highly fatal course .
disease extent varies according to location of the primary tumor.4 patients with distant metastases ( well- and moderately differentiated ) have a median survival of 33 months.4 the median survival of patients with distant metastases who have anaplastic nets is only 5 months.4 across all types of nets , prognosis seems to be dependent on both the histology and extent of the disease .
well - differentiated grade 1 nets are generally associated with less - aggressive behaviors , grade 2 nets have a more variable clinical course , and poorly differentiated grade 3 nets are characterized by extremely aggressive tumor biology and poor prognosis.5 simultaneous coexistence of different tumor is assorted into two characteristics : collision tumor and composite tumor.6 a collision tumor is defined as the simultaneous coexistence of at least two independent tumors located in close proximity with no mixed or transitional areas in between .
nevertheless , composite tumor is formed by two or more neoplastic tissues with different histological characteristics developed from the same histological origin , as shown by transition area.7,8 collision tumors have occasionally been reported in the past , but recently , there has been an increasing number of emerging reports .
the overall prognosis of collision tumor around the periampullary region varies from its differentiation , but malignant collision tumor has dismal prognosis even after the radical resection .
this means that the malignant collision tumor is more malignant than the adenocarcinoma of periampullary region .
stomach and esophagus are the main sites of origin for collision tumor in the gastrointestinal tract . adenocarcinomas and other malignancies such as squamous cell carcinomas , carcinoid and neuroendocrine tumors are usually situated in these areas.9 - 11 however , occurrences of collision tumors in pancreas and periampullary regions are very rare
. only few reports on occurrences of collision tumors in periampullary regions have been published in english literature.2,8,12 - 18 preoperative diagnosis of collision tumors is difficult due to its lack of specific symptoms and radiologic features .
in addition , serum levels of tumor markers such as cea and ca 19 - 9 are not significantly different from the adenocarcinoma patients .
although it is difficult to diagnose collision tumors preoperatively , radical resection of tumor is still the reasonable treatment choice for resectable tumors .
nevertheless , some studies insisted that it is debatable whether surgical resection is a proper treatment , because of its dismal prognosis.19 chemotherapy using gemcitabine has been widely used for periampullary malignancies clinically , but there is no proven efficacy for collision tumors in periampullary region.19 this is probably due to the highly malignant nature of collision tumors and some unknown oncological features of collision tumor .
generally , neuroendocrine tumor has higher invasiveness and poorer prognosis than adenocarcinoma in collision tumor for ampulla of vater.20 therefore , it is reasonable to treat more aggressive tumors in collision tumors , such as the neuroendocrine tumor in this case . according to the who complementary notes on tnm staging of malignant tumors , if more than one tumor co - exists in one organ , the staging of the tumors
, we presented a case of coexisting neuroendocrine carcinoma and conventional adenocarcinoma in the ampulla of vater .
thus , principle therapeutic modalities are not available , such as the extent of resection , off - the - shelf chemo - regimen , and adjuvant therapeutic tools .
further investigations are required to determine the tumorigenesis of collision tumor , and to generate principle therapeutic modalities of collision tumor in ampulla of vater .
 herein , we present a case of coexisting neuroendocrine carcinoma and conventional adenocarcinoma ( collision tumor ) in the ampulla of vater , which has seldom been reported in the literature . a 51-year - old man presented with a month history of jaundice . 
 mrcp disclosed about 1.91.8 cm sized heterogeneously enhancing mass in ampulla of vater , causing obstructions of distal common bile duct . 
 he underwent pylorus - preserving pancreaticoduodenectomy under the diagnosis on ampulla of vater cancer . 
 pathologically , sections on the ampulla of vater showed conventional ductal adenocarcinoma extended and collided with poorly differentiated neuroendocrine carcinoma . in conclusion , we hereby presented a case of coexisting neuroendocrine carcinoma and conventional adenocarcinoma in the ampulla of vater . 
INTRODUCTION
CASE
DISCUSSION