while india has achieved the goal of elimination of leprosy as a public health problem , defined as < 1 case per 10,000 population , at the national level in december 2005 , leprosy still persists in certain high endemic districts .
a total of 125,785 new cases were detected during the year 201415 , which gives annual new case detection rate of 9.73 per 100,000 population .
a total of 88,833 cases are recorded as on april 1 , 2015 , giving a prevalence rate of 0.69 per 10,000 population . due to the decreasing prevalence of leprosy , the clinical suspicion for diagnosing the same has reduced .
we report an unusual presentation of multibacillary leprosy which was diagnosed on slit skin smear examination from the lesion .
a 21-year - old man , working as a priest , presented with a history of generalized raised nodular lesions for 2 years .
the patient was apparently asymptomatic 2 years back when he started developing reddish raised small lesions over the right knee .
the lesions gradually increased in size and then ruptured with blood - stained purulent discharge .
similar lesions gradually developed over other sites such as left knee , both elbows , and ears .
other symptoms , such as joint pain , swelling of joints , or fever , were absent .
this biopsy report was suggestive of fungal infection ; hence , the patient was treated with itraconazole and amoxicillin - clavulanic acid but without any relief .
no acid - fast bacilli ( afb ) staining was done . on clinical examination ,
multiple erythematous nodules and plaques of varying sizes ranging from 3 mm to 3 cm in diameter were seen on bilateral ear pinna and bony prominences of the extremities , i.e. , elbows , knees , malleoli , and dorsal aspect of bilateral feet [ figure 1 ] .
nodular lesions on the right leg the blood parameters were within normal limits . slit skin smears and biopsy from multiple lesions were collected and processed for bacterial and fungal culture since a provisional diagnosis of subcutaneous mycoses was considered .
. a bacterial index of 4 + ( 10 afb per oil immersion field ) was recorded .
histopathological examination of skin biopsy showed an unremarkable epidermis with underlying dermis showing a diffuse polymorphous inflammatory infiltrate coexisting with foamy histiocytes , neutrophils , plasma cells , and lymphocytes , extending from dermis to subcutis [ figure 3 ] .
standard nerve stimulation test was done which showed evidence of mild axonal sensory mononeuritis multiplex in bilateral upper limbs and axonal sensory polyneuropathy affecting bilateral lower limbs with bilateral greater auricular , ulnar , common peroneal nerves showing thickening .
acid - fast bacilli in large numbers , grouped together in cigar - bundle appearance . stained with modified ziehl 
neelsen staining , 100 dermis showing diffuse polymorphous inflammatory infiltrate with foamy histiocytes , neutrophils , plasma cells , and lymphocytes ; stained with h and e , 100 fite - faraco stain demonstrating acid - fast bacilli , 100 based on zn stain results and histopathological report , the patient was considered as a case of lepromatous leprosy and started on multidrug therapy ( mdt ) .
two months after commencement of mdt , the patient showed improvement with reduction of the nodular lesions .
on clinical examination , multiple erythematous nodules and plaques of varying sizes ranging from 3 mm to 3 cm in diameter were seen on bilateral ear pinna and bony prominences of the extremities , i.e. , elbows , knees , malleoli , and dorsal aspect of bilateral feet [ figure 1 ] .
. slit skin smears and biopsy from multiple lesions were collected and processed for bacterial and fungal culture since a provisional diagnosis of subcutaneous mycoses was considered .
. slit skin smear received for detection of mycobacterium leprae was stained by modified ziehl 
examination of stained smear revealed characteristic afb in large numbers [ figure 2 ] . a bacterial index of 4 + ( 10 afb per oil immersion field ) was recorded .
histopathological examination of skin biopsy showed an unremarkable epidermis with underlying dermis showing a diffuse polymorphous inflammatory infiltrate coexisting with foamy histiocytes , neutrophils , plasma cells , and lymphocytes , extending from dermis to subcutis [ figure 3 ] .
standard nerve stimulation test was done which showed evidence of mild axonal sensory mononeuritis multiplex in bilateral upper limbs and axonal sensory polyneuropathy affecting bilateral lower limbs with bilateral greater auricular , ulnar , common peroneal nerves showing thickening .
acid - fast bacilli in large numbers , grouped together in cigar - bundle appearance . stained with modified ziehl 
neelsen staining , 100 dermis showing diffuse polymorphous inflammatory infiltrate with foamy histiocytes , neutrophils , plasma cells , and lymphocytes ; stained with h and e , 100 fite - faraco stain demonstrating acid - fast bacilli , 100 based on zn stain results and histopathological report , the patient was considered as a case of lepromatous leprosy and started on multidrug therapy ( mdt ) .
two months after commencement of mdt , the patient showed improvement with reduction of the nodular lesions .
recent reports from india indicate that leprosy continues to be transmitted within the community despite advances in multidrug therapy . continued findings of childhood leprosy cases ranging from 9.6% ( 2015 ) to 11.43% ( 2009 ) corroborate this theory as persistently high childhood proportion signifies ongoing transmission in general population .
leprosy presents as a wide spectrum of clinical manifestations , varying from polar tuberculoid to polar lepromatous disease .
variable clinical presentations of leprosy , depending on an increasing bacterial load and loss of m. leprae - specific cellular immunity , make it difficult to arrive at an accurate diagnosis , thereby emphasizing the need for appropriate investigations in every suspect case .
mild symptoms in early stages of leprosy may be overlooked by the patient leading to a delay in seeking medical attention .
lack of clinical suspicion and appropriate investigation on the part of the health care professional may lead to a missed diagnosis and further delay in instituting appropriate therapy .
given that the patient exhibited nodular lesions and lack of sensory loss , he was misdiagnosed as a case of subcutaneous fungal infection at the primary point of therapy .
the specimen obtained from the patient did not show any fungal element on microscopy and culture and there was no response to empiric antifungal therapy which helped to rule out fungal etiology .
leprosy should therefore be considered as a differential diagnosis for atypically presenting skin lesions not improving on empiric treatment . with histopathological examination ,
leprosy presents as granulomatous inflammation that may mimic other granulomatous diseases including tuberculosis , sarcoidosis , leishmaniasis , and subcutaneous fungal infections .
special stains such as fite  faraco stain have an added advantage in demonstrating m. leprae in histopathogical examination but may show negative results in tuberculoid leprosy cases where the lesions are paucibacillary in nature .
this is a rare case of lepromatous leprosy presenting as nodular lesions without obvious sensory loss . in the current scenario ,
when the disease is considered as eliminated in india and patients coming with typical signs have become a rarity , a high index of clinical suspicion is necessary so as to not miss out on cases with atypical presentation .
however , slit skin smear from selective sites , which is a relatively minor procedure , should always be done in suspected leprosy cases .
 despite india achieving the goal of elimination of leprosy as a public health problem , leprosy is still being transmitted in india . however , due to decreased clinical suspicion of leprosy and atypical case presentations , such cases may be not be diagnosed . 
 we present a case report of an unusual presentation of multibacillary leprosy which presented as nodular lesions . 
 this case report indicates that atypical presentations of leprosy may be missed out by primary care physicians . 
INTRODUCTION
CASE REPORT
In our hospital
Laboratory investigations
DISCUSSION
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