burning mouth syndrome ( bms ) is a burning or itching sensation in the normal oral mucosa .
the pain is persistent , ranges from moderate to severe , and occurs particularly often in postmenopausal women .
the international association for the study of pain defines bms , which is also called stomatodynia , glossodynia , oral dysesthesia , and persistent idiopathic orofacial pain , as  any form of burning or stinging sensation in the mouth in association with a normal mucosa in the absence of local or systemic disease.1 in the literature , antidepressants and benzodiazepines have shown beneficial effects in the treatment of patients with bms.2,3 however , there has been no report on treatment with a dopamine partial agonist for bms . herein , we report a case of treatment - resistant bms successfully treated with low - dose aripiprazole .
a 66-year - old female with no systemic disease or trauma history visited our clinic after being referred by her family physician .
she complained of a chronic burning sensation in her tongue without taste alteration and dry mouth , which had lasted for 13 months .
at first , she went to her family physician and was evaluated by laboratory screening tests .
though antibiotics , topical dexamethasone , and kampo were administered at various clinics , the burning sensation was not ameliorated .
based on the medication effects , a candidal infection was excluded . at the first examination , she came to our clinic by herself .
no orientation disturbance or any verbal fluency problem was observed . no abnormality associated with the burning sensation
based on the clinical , laboratory , and anamnestic data , we established a diagnosis of bms . because she was anxious about several side effects of antidepressants , she was started on escitalopram at 5 mg / d .
however , the burning sensation was not reduced , even at 10 mg / d .
therefore , duloxetine was administered instead of escitalopram . though duloxetine was initiated at 20 mg / d and gradually increased to 40 mg / d , her burning sensation was aggravated .
the burning sensation was partially reduced at 7.5 mg / d , but dose escalation was not effective .
therefore , low - dose aripiprazole powder ( 1.0 mg / d ) was added to her treatment regimen .
a month later , she said that she almost always forgot about the burning sensation during the day .
six months later , the mirtazapine was stopped and there was no change for the worse .
two months later , the aripiprazole was also stopped , which resulted in recurrence of the burning sensation .
aripiprazole was restarted at 1.0 mg / d , and the burning sensation disappeared within a few days . with low - dose aripiprazole , she continued to live a healthy life without experiencing any side effect .
we report a case of bms that barely responded to antidepressants and was successfully treated with aripiprazole .
low - dose antidepressants , anticonvulsants , and benzodiazepines have been investigated and are the most accepted options for bms .
tricyclic antidepressants are the most commonly prescribed drugs for bms.4 additionally , it has been reported that serotonin  norepinephrine reuptake inhibitor5,6 and selective serotonin reuptake inhibitor7 are effective
recently , the effectiveness of atypical antipsychotics was reported in these patients.8,9 to our knowledge , there is no report on the effectiveness of aripiprazole for bms .
aripiprazole is an atypical antipsychotic that bears the properties of d2 and 5-ht1a partial agonists and is a potent antagonist of the 5-ht2a receptor.10 unlike other atypical antipsychotics that are dopamine d2 antagonists , aripiprazole has a unique effect on the dopamine system . because of its d2 partial agonist activity , some studies have mentioned that aripiprazole has a role as a dopamine system stabilizer .
recently , neurotransmitter positron emission tomography data indicated that hypofunction of the dopaminergic system within the basal ganglia was related to bms.11 one possible explanation is that the efficacy of aripiprazole in treating bms is partly caused by stabilization of these dopamine receptors within the basal ganglia . especially as this case did not have any response to a selective serotonin reuptake inhibitor ( escitalopram ) or a serotonin  norepinephrine reuptake inhibitor ( duloxetine ) , it is strongly suggested that the efficacy of aripiprazole is caused by dopamine stabilization . considering this dopaminergic hypothesis
, other treatments including other antipsychotic drugs and electroconvulsive therapy might be options of treatment for bms .
recently , the role played by the dopamine system of the brain in pain control has garnered attention .
kasahara et al12 reported four cases of refractory chronic pain that improved with a low dose of aripiprazole . in their paper
it is also believed that the dopamine and opioid systems interact in complex ways in the treatment of chronic pain .
this report suggests that low - dose aripiprazole may be effective for patients with treatment - resistant bms .
 we report a case of refractory burning mouth syndrome ( bms ) ameliorated with low dose of aripiprazole . 
 the patient was a 66-year - old female who had suffered from chronic burning pain in her tongue for 13 months . 
 no abnormality associated with the burning sensation was detected in the laboratory tests and the oral findings . 
 considering the clinical feature and the history together , we diagnosed the burning sensation as bms . 
 the bms pain was decreased by aripiprazole ( powder ) 1.0 mg / d , though no other antidepressants had satisfying pain relief . 
 it could be supposed that the efficacy of aripiprazole is caused by dopamine stabilization in this case , and bms might have a subtype that is reactive to aripiprazole . 
 further studies are needed to confirm the efficacy of aripiprazole for bms . 
Introduction
Case presentation
Discussion
Conclusion