 in a preliminary study , 12 male and 12 female weanling sherman strain rats were given a single dose of 1000 mg polybrominated biphenyls ( pbbs ) firemaster ff1 lot 7042 kg / body weight as a 5% solution in corn oil . 
 three male and three female weanling rats were given corn oil . 
 one day after dosing pbb blood levels ranged from 78 to 162 ppm and 42 days later they ranged from 1.1 to 2.99 ppm . 
 the liver was the only organ with pathological changes . in a long - term recovery study groups of 20 male and female rats , 2 months old , were given 0 or 1000 mg pbbs / kg body weight as a single dose in peanut oil . 
 five rats per group killed 2 , 6 , 10 , and 14 months after dosing had pronounced liver pathology , including hepatic porphyria in the female rats and neoplastic nodules also mainly in female rats . 
 chemical analyses of blood , liver , and adipose tissue for ppbs 10 and 14 months after dosing gave the following mean results 
 . blood levels in females were 2.9 and 2.92 ppm , respectively , and males 0.94 and 1.34 ppm , respectively . 
 adipose tissue levels in females were 1202 and 783 ppm and in males 713 and 866 ppm , respectively . 
 the liver levels in females were 37 and 22 ppm and in males 60 and 63 ppm , respectively.imagesfigure 4.figure 5.figure 6.figure 7.figure 8 . 
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