the online version of this article ( doi:10.1007/s13555 - 015 - 0088-z ) contains supplementary material , which is available to authorized users .
dermoscopy is a valuable noninvasive technique that increases diagnostic accuracy in melanoma and non - melanoma skin cancer [ 1 , 2 ] . recently , its use as an aid in the monitoring of topical treatment response has also been described [ 24 ] .
basal cell carcinoma ( bcc ) is the most frequent type of skin cancer in humans .
surgical excision is still considered the  gold - standard  of treatment . however , a number of topical therapies are now available for the treatment of different types of basal cell carcinoma . despite the fact that bcc is associated with a low mortality and
very rarely gives rise to metastatic disease , delays in its correct diagnosis and treatment prolong patient morbidity and increase the cost of care .
dermoscopy has also shown to be useful in the assessment of early recurrence or tumor persistence .
dermoscopic criteria such as pigmented structures , ulceration and arborizing vessels have been suggested to predict the presence of residual disease ( residual disease - associated dermoscopic criteria ) [ 4 , 5 ] .
this case report exemplifies the usefulness of dermoscopy in the assessment of residual disease after incomplete surgical excision and also in the monitoring of topical treatment response .
an otherwise healthy , 92-year - old woman was seen for the evaluation and treatment of a  long - standing  nodular lesion on the tip of her nose .
the lesion was characterized as a solitary , 5  mm , smooth , nodular , pearly tumor with telangiectasia ( fig .  1 ) .
dermoscopy confirmed the diagnosis of nodular bcc because of the presence of telangiectasia and arborizing vessels ( fig .  2 ) .
the wound healed by secondary intention with daily topical application of a pirfenidone gel ( fig . 
3 ) ( kitoscell - q , cell therapy and technology , s.a . de c.v . , mexico ) .
histopathologic examination revealed a neoformation arising from the epidermis proliferating into the papillary and reticular dermis .
it was constituted by an epithelial tumor with basaloid - appearing cells disposed in palisade at the periphery of the tumor nests .
the tumoral nests were surrounded by a lymphocytic inflammatory infiltrate and a fibromyxoid stroma with stromal retraction artifact in certain areas .
the tumor extended into the deep margins where tumoral nests were smaller , with angular shapes and interspersed by a more fibrous stroma .
histology confirmed the diagnosis of infiltrating nodular bcc and remains of tumoral cells within the wound bed and deep margins ( fig . 
six weeks after the incomplete surgical excision , the esthetic result was acceptable ( fig . 
however , dermoscopy confirmed the persistence of the tumor characterized by a large arborizing vessel ( fig . 
for this reason and due to the ease of at - home application , daily topical treatment with 5% imiquimod cream for 8  weeks was started ( fig . 
clinically and dermoscopically the patient revealed an appropriate response to the topical treatment characterized mainly by erythema and mild ulceration ( fig . 
four weeks after the end of treatment , the clinical esthetic result was acceptable ( fig . 
9 ) . at 12  months after the end of treatment dermoscopy confirmed the absence of any signs of recurrence ( fig . 
the patient was last seen 23  months after the end of treatment without any signs of recurrence and dermoscopy confirmed the eradication residual disease ( fig . 
all procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation ( institutional and national ) and with the helsinki declaration of 1964 , as revised in 2013 .
1the lesion on the nose was characterized as a solitary , 5  mm , smooth , nodular , pearly tumor with telangiectasiafig . 
2dermoscopy confirmed the diagnosis of nodular basal cell carcinoma because of the presence of telangiectasia and arborizing vesselsfig . 
3wound healed by secondary intention with daily topical application of a pirfenidone gelfig .  4 
 a ( 10 , 20 ) and b ( 40 ) .
histology confirmed the diagnosis of infiltrating nodular basal cell carcinoma and remains of tumoral cells within the wound bed and deep marginsfig . 
6dermoscopy confirmed the persistence of the tumor characterized by a large arborizing vesselfig .  7 
 a , b daily topical treatment with 5% imiquimod cream was startedfig . 
8 
 a  f clinically and dermoscopically the patient revealed an appropriate response to the topical treatment characterized mainly by erythema and mild ulcerationfig . 
9four weeks after the end of 5% imiquimod treatment the clinical esthetic result was acceptablefig . 
dermoscopy shows no signs of tumor recurrence and confirms eradication of residual disease the lesion on the nose was characterized as a solitary , 5  mm , smooth , nodular , pearly tumor with telangiectasia dermoscopy confirmed the diagnosis of nodular basal cell carcinoma because of the presence of telangiectasia and arborizing vessels wound healed by secondary intention with daily topical application of a pirfenidone gel 
 a ( 10 , 20 ) and b ( 40 ) .
histology confirmed the diagnosis of infiltrating nodular basal cell carcinoma and remains of tumoral cells within the wound bed and deep margins six weeks after the incomplete surgical excision the esthetic result was acceptable dermoscopy confirmed the persistence of the tumor characterized by a large arborizing vessel 
 a , b daily topical treatment with 5% imiquimod cream was started 
 a  f clinically and dermoscopically the patient revealed an appropriate response to the topical treatment characterized mainly by erythema and mild ulceration four weeks after the end of 5% imiquimod treatment the clinical esthetic result was acceptable one year later the patient had no signs of recurrence confirmed by dermoscopy clinical and dermoscopic appearance 23  months after the end of treatment .
basal cell carcinoma is the most frequent cancer of the skin and its incidence is increasing worldwide .
surgery , including mohs micrographic surgery , is considered the  gold standard  of treatment and the most effective in terms of recurrence rates .
incomplete excision has been associated with various recurrence rates ranging from 26% to 67% and 50% of recurrences occur within the next 612  months .
certain anatomic locations such as the nose and inner canthus , as well as certain histologic subtypes such as infiltrative and multifocal , have been associated as predictive factors for incomplete excision . in cases where the surgical intervention is unable to completely remove the tumor , adjuvant therapy such as a second surgical procedure , radiotherapy , photodynamic therapy and topical immunotherapy are used .
imiquimod is a toll - like receptor-7/8 ( tlr-7/8 ) agonist that acts as a topical immune response modifier and has been reported as a non - surgical alternative for the treatment of bcc , particularly for the superficial subtype [ 7 , 8 ] .
topical imiquimod 5% cream promotes a th-1 immune response aimed at enhancing the removal of neoplastic cells .
recently , imiquimod 5% cream has been described as a novel alternative to reduce deregulated hedgehog ( hh)/gli signal , independent of tlr signaling .
small molecule targeting of hh signaling by inhibiting the essential pathway effector smoothened has proven exceptionally efficient for the treatment of advanced and metastatic basal cell carcinoma . however , severe side effects , limited response rates , and rapid development of drug resistance may limit the therapeutic success of smo antagonists .
this reflects the need for the identification of alternative and additional strategies repressing oncogenic hh signaling .
imiquimod 5% may be one of such alternatives as a topical , safe and relatively easy to use drug for the treatment of different bcc subtypes as adjuvant or neoadjuvant therapy .
our case report exemplifies that dermoscopy is a valuable diagnostic aid that also serves to assess tumor recurrence / residual disease and to monitor topical treatment response .
it also adds further evidence to the use of imiquimod as an important topical neoadjuvant or adjuvant therapy for the treatment of bcc and residual disease in cases with incomplete surgical excision [ 10 , 11 ] .
all procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation ( institutional and national ) and with the helsinki declaration of 1964 , as revised in 2013 .
this article is distributed under the terms of the creative commons attribution - noncommercial 4.0 international license ( http://creativecommons.org/licenses/by-nc/4.0/ ) , which permits any noncommercial use , distribution , and reproduction in any medium , provided you give appropriate credit to the original author(s ) and the source , provide a link to the creative commons license , and indicate if changes were made .
 introductiona relatively novel application for dermoscopy is its use in the monitoring of topical treatment response for non - melanoma skin cancer . 
 basal cell carcinoma ( bcc ) is the most frequent type of skin cancer in humans . 
 surgical excision is still considered the  gold - standard  of treatment . 
 however , a number of topical therapies are now available for the treatment of different types of basal cell carcinoma.case reportthis case report exemplifies the usefulness of dermoscopy in the monitoring of residual disease after incomplete surgical excision and also in the monitoring of topical treatment response . 
 imiquimod 5% cream acts as a topical immune response modifier promoting a th-1 immune response enhancing the removal of neoplastic cells and has proven to reduce deregulated hedgehog ( hh)/gli signal strength independent of toll - like receptor signaling , which makes it a valuable adjuvant topical therapy for the treatment of basal cell carcinoma.conclusionimiquimod 5% cream is a valuable adjuvant therapy for the treatment of incompletely excised bcc . 
 this case report adds further evidence to the usefulness of dermoscopy in the assessment and monitoring of treatment outcome.electronic supplementary materialthe online version of this article ( doi:10.1007/s13555 - 015 - 0088-z ) contains supplementary material , which is available to authorized users . 
Electronic supplementary material
Introduction
Case Report
Discussion
Conclusion
Electronic supplementary material
Disclosures
Compliance with ethics guidelines
Open Access