 
 dna adducts derived from complex mixtures of polycyclic aromatic compounds emitted from tobacco smoke are compared to industrial pollution sources ( e.g. , coke ovens and aluminum smelters ) , smoky coal burning , and urban air pollution . 
 exposures to coke oven emissions and smoky coal , both potent rodent skin tumor initiators and lung carcinogens in humans , result in high levels of dna adducts compared to tobacco smoke in the in vitro calf thymus dna model system , in cultured lymphocytes , and in the mouse skin assay . 
 using tobacco smoke as a model in human studies , we have compared relative dna adduct levels detected in blood lymphocytes , placental tissue , bronchoalveolar lung lavage cells , sperm , and autopsy tissues of smokers and nonsmokers . 
 adduct levels in dna isolated from smokers were highest in human heart and lung tissue with smaller but detectable differences in placental tissue and lung lavage cells . 
 comparison of the dna adduct levels resulting from human exposure to different complex mixtures shows that emissions from coke ovens , aluminum smelters , and smoky coal result in higher dna adduct levels than tobacco smoke exposure . 
 these studies suggest that humans exposed to complex combustion mixtures will have higher dna adduct levels in target cells ( e.g. , lung ) as compared to nontarget cells ( e.g. , lymphocytes ) and that the adduct levels will be dependent on the genotoxic and dna adduct - forming potency of the mixture . 
 
 imagesfigure 1.figure 1.figure 2.figure 3.figure 3.figure 3.figure 3.figure 3.figure 3.figure 4 . 
Images