a 65-year - old man with a medical history of stage iii nasopharyngeal cancer , end - stage renal disease treated with dialysis , hyperthyroidism , type 2 diabetes mellitus , hypertension , atrial fibrillation , and secondary hyperparathyroidism presented at the oral medicine clinic of the college of dentistry , university of florida for dental evaluation prior to the start of radiotherapy .
intraoral radiographs were taken using a cs2000 intraoral x - ray system ( carestream dental llc , atlanta , ga , usa ) with # 2 soredex optime ( soredex , charlotte , nc , usa ) photo - stimulable phosphor ( psp ) sensors at 70 kvp , 7 ma , and a 0.142-second exposure time , using a standard bitewing technique . a panoramic image was obtained using an orthopantomograph  op100 d digital panoramic x - ray unit ( instrumentarium dental , tuusula , finland ) with exposure factors of 70 kvp with 12 ma for 17.6 seconds .
the panoramic and bitewing radiographs revealed multiple tortuous vascular calcifications in the soft tissue of the neck and cheek bilaterally , with a dense " rail track " pattern of linear calcifications within the facial artery . based upon the radiographic presentation and the patient 's known medical history ,
multiple radiopaque entities were also noted in the soft tissue of the neck , more on the left than on the right , consistent with a diagnosis of carotid atherosclerosis ( figs . 1 and 2 ) .
positron emission tomography / computed tomography ( pet / ct ) scans were performed using a philips gemini gxl 16 pet / ct system with 5 mm thickness .
the acquired data were reviewed by a medical radiologist , and " pipe - stem " calcifications were observed in the bilateral , lingual , and facial arteries ( fig .
calcifications may occur in several locations in the cardiovascular system , including the intima and media of vessels .
intimal arterial calcification is associated with atherosclerosis , and vascular plaques form within the intima of the involved vessel.3 however , in mnckeberg arteriosclerosis , the calcific deposits are located entirely within the medial layer of the arterial wall and both the internal and external elastic membranes are spared.712 in a recent study , the prevalence of mnckeberg arteriosclerosis in the population was found to be 13.3% for males and
6.9% for females , and it is a well - recognized age - related phenomenon.1112 medial artery calcification can lead to vascular stiffness , resulting in increased vascular resistance , reduced compliance of the artery , and an inability to properly vasodilate in the setting of increased stress.13 medial calcinosis contributes to significant adverse cardiovascular outcomes in patients with chronic kidney disease and diabetes , where higher levels of medial artery calcification are a risk factor for amputation.14 the affected artery may not demonstrate evidence of a pulse .
the exact pathogenic mechanism of medial calcinosis is not well understood . however , degenerative processes leading to the apoptosis or necrosis of medial smooth muscle cells and osteogenic processes leading to formation of bone - like structures are two distinct pathologic mechanisms that have been suggested for mnckeberg arteriosclerosis.15 meema et al.8 have suggested the possibility that two clinically and histologically different types of medial calcifications may exist . the first type is a benign , slowly progressive , essentially asymptomatic form with thin medial calcifications and little or no narrowing of the arterial lumen .
in contrast , the second type is defined as a malignant , rapidly progressive form , in which massive and extensive medial calcifications may displace the internal elastica toward the lumen , causing luminal narrowing.78 mnckeberg initially described medial calcinosis as primarily affecting the arteries of the lower limbs , and occasionally affecting the peripheral arteries of the upper extremities
. however , the process rarely affects the intraabdominal arteries , with the exception of the renal and splenic arteries.7 some reports in the literature have described mnckeberg arteriosclerosis . in 1977 , lachman et al.7 described the involvement of coronary , peripheral , and visceral arteries with mnckeberg calcification . a case of mnckeberg arteriosclerosis involving the aorta ,
pelvic , and lower limb arteries was reported by lanzer in 1998.16 the nonvascular involvement of soft tissue ( pharynx and larynx ) with mnckeberg sclerosis was reported by couri et al.6 in this report , we described a diabetic patient with end - stage renal disease on dialysis , who had advanced and previously undiagnosed mnckeberg medial calcinosis of the facial and lingual arteries .
knowledge of the radiographic appearance of this calcification is clinically useful in developing a differential diagnosis .
the proper interpretation of radiographic images presupposes a thorough knowledge of the anatomy , distribution , number , size , and shape of the calcifications .
the calcified vessel appears as a parallel pair of thin , radiopaque lines that may have a straight course or a tortuous path , showing a pattern of blood vessels that looks like railroad tracks.511 carotid artery calcifications and phleboliths are calcifications that can be seen in the same location on a panoramic radiograph .
carotid artery calcifications radiographically appear as curvilinear irregular parallel radiopacities in the soft tissues of the neck at or below the third and fourth cervical vertebrae , and inferior and lateral to the hyoid bone.1718 phleboliths can be seen on a panoramic radiograph as round or oval in shape with a homogeneously radiopaque center , giving phleboliths a " target " appearance.19 mnckeberg sclerosis is listed among the primary diseases of vessels that can be visualized on panoramic radiographs . to the best of our knowledge ,
our report describes the first known case of medial calcification in the facial artery on the panoramic radiograph of a diabetic patient with end - stage renal disease .
soft tissue calcifications in the maxillofacial area are relatively common and can occur as the result of physiologic or pathologic mineralization , and generally correspond to radiographic findings in routine examinations , such as panoramic radiographs .
a comprehensive review and thorough interpretation of all conventional and routine dental radiographs , especially beyond the region of interest , is necessary , and dental practitioners should be aware of the various calcified structures seen on panoramic radiographs , especially those associated with systemic diseases . a proper knowledge of radiographic features , however subtle they may be , assists the clinician in following up and further managing the patient , including appropriate referrals .
 mnckeberg sclerosis is a disease of unknown etiology , characterized by dystrophic calcification within the arterial tunica media of the lower extremities leading to reduced arterial compliance . 
 medial calcinosis does not obstruct the lumina of the arteries , and therefore does not lead to symptoms or signs of limb or organ ischemia . 
 mnckeberg sclerosis most commonly occurs in aged and diabetic individuals and in patients on dialysis . 
 mnckeberg arteriosclerosis is frequently observed in the visceral arteries , and it can occur in the head and neck region as well . 
 this report describes a remarkable case of mnckeberg arteriosclerosis in the head and neck region as detected on dental imaging studies . to the best of our knowledge , 
 this is the first case that has been reported in which this condition presented in the facial vasculature . 
 the aim of this report was to define the radiographic characteristics of mnckeberg arteriosclerosis in an effort to assist health care providers in diagnosing and managing this condition . 
Case Report
Discussion