controlled induced hypotension is a common procedure during anaesthesia applied to patients undergoing , among others , endoscopic sinus interventions .
decreased blood pressure allows reduction of bleeding in the surgical field , minimization of blood loss , better visibility and therefore , it increases the surgeon s comfort , reduces the surgery time and prevents complications emerging from blurred vision caused by coverage of the camera lens with blood .
studies have shown a variety of methods reducing bleeding in the surgical field through : lowering the mean arterial pressure ( map ) , lowering hr , local anemization with adrenaline , preoperative use of steroids ( which reduce the inflammatory reaction , damage to the blood vessels , edema , and adrenergic receptors activation ) , and reversing the trendelenburg position , which reduces blood supply in the surgical field .
magnesium , nitroglycerin , acei ( angiotensin converting enzyme inhibitors ) , calcium channel blockers , beta - blockers , sodium nitroprusside , clonidine , and large doses of inhalational anaesthetics have all been used to achieve the target map .
drug - induced vasodilatation is only beneficial if the cardiac output ( co ) is reduced .
it can be achieved through the administration of labetalol , a short - acting beta - blocker , which stabilizes the hr at 60 bpm and simultaneously reduces the map . taking into consideration the co values as an index of both perfusion and bleeding , it is reasonable to stabilize it within lower normal range values [ 26 ] .
additionally , remifentanil ( rfn ) , an ultrashort - acting opioid and  receptor agonist , also plays an important part in endoscopic surgery of paranasal sinuses .
it enables easy adjustment of the depth of anaesthesia and reduction of the map and hr through cardiodepressive action .
earlier studies also indicated the positive effect of propofol as an anaesthetic in reducing map through its effect on precapillary arterioles .
moreover , when compared with the combination of sevoflurane and rfn , no significant differences in intraoperative bleeding were observed .
additionally , this combination enables continuous monitoring of the volatile anaesthetic concentration as well as easy adjustment of map during the procedure .
some studies have also shown that the return of cognitive functions to the initial level within the first hour seems to be faster in patients on sevoflurane than in those on propofol . although the positive effects of controlled hypotension ( including reduced blood loss , time of intervention , and increased comfort of the surgeon )
are well known , the method is still limited by concerns regarding the impact of severe hypotension .
permanent brain damage , emboli in cerebral circulation , difficult awakening of the patient , and even death  all these complications might occur when hypotension is too deep .
the cerebral blood flow ( cbf ) is controlled by different metabolic , chemical ( po2 , pco2 ) , and neural mechanisms and autoregulation . under physiological conditions , cbf remains constant despite map changes from 50 to 150 mmhg .
brain ischemia , injuries , arterial hypertension , and other pathological and pharmacological factors may disturb the mechanisms of autoregulation .
volatile anaesthetics used in anaesthesia may limit or even abolish autoregulation of cbf , thus increasing the vulnerability of brain tissues to map alterations during surgery .
although brain tissues are susceptible to hypoxemic damage , research has shown that lowering the map to 2/3 of the initial value does not cause any damage . on the other hand , there is no evidence that these conditions influence the epidemiology of functional disorders , especially those affecting cognitive functions .
earlier studies confirmed the impact of the patient s initial general condition , age , accompanying diseases , drugs , and addiction to psychoactive substances on cognitive functions .
the influence of iatrogenic factors , including the duration of hospitalization , time of surgical procedure , and drugs administered , has also been noted .
one of the main factors influencing patients condition is the quality of anaesthetic management , including hemodynamic stability .
maintaining homeostasis of body functions is the golden rule of proper anaesthetic management and it is crucial to minimize complications .
the objective of this study was to evaluate the effects of controlled induced hypotension on the cognitive functions of patients undergoing functional endoscopic sinus surgery ( fess ) .
the study was approved by the bioethics committee of the pozna university of medical sciences ( decision number 298/13 ) and was conducted in accordance with the declaration of helsinki .
the study was conducted on patients undergoing functional endoscopic sinus surgery in heliodor wicicki university hospital in pozna between 16 april and 18 june 2013 and between 15 october and 20 december 2014 .
the inclusion criteria were as follows : age 1875 , good mental status confirmed with the mini - mental state examination ( mmse ) minimum score of 27 points , no drugs taken that influence cognitive functions , no vision impairment or vision corrected with glasses , and no severe hearing disorders influencing the quality of communication .
patients with poorly controlled hypertension , ischemic disease , and autonomic system impairment were excluded from the study .
all the subjects in the study were able to communicate in polish and had no manual dysfunctions . during the trial period ,
84 patients were qualified , 76 of whom agreed to take part : 3 of them were disqualified due to pre - existent disorders of cognitive functions , with the mmse score under 27 points , 1 person due to daltonism ( which makes it impossible to complete the stroop test ) , and 3 people due to psychiatric drugs taken .
moreover , 21 patients withdrew on the day of the surgery , as they did not feel well enough to complete the psychometric tests . in 1 case ,
the surgery ( mfess ) was too short to achieve the target map and this patient was excluded from the study .
eventually , 47 patients ( american society of anesthesiologists  asa score 13 ) were qualified for the study : 30 men ( 64% ) and 17 women ( 36% ) , with a mean age of 46 years ( sd 16 ) . during the surgery
, the anesthesiologists set the target map according to the patient s general condition as well as their own experience and preferences .
the patients were allocated to 3 groups postoperatively , according to the mean map during the surgery as a fraction of the preoperative map ( mapm%map0 ) : group i  mild hypotension ( mapm%map0>75% ) , group ii 
intermediate hypotension ( 65% < mapm%map0 75% ) , and group 3  severe hypotension ( mapm% map0 65% with the minimum value of 53% ) .
the groups were homogenous in terms of age , gender , bmi , initial results of basic blood tests , and the mmse result .
one day before the surgery , all the patients qualified for the study completed psychometric tests , which evaluated cognitive functions : the stroop test , trail making test ( tmt ) , and verbal fluency test ( vft ) in the stroop test variant a , the patient s task is to say aloud the names of colors printed on a sheet of paper .
variant b evaluates the speed of naming colors in which the names are printed , but none of the names are printed in the proper color .
the stroop test evaluates the interference of ambiguous stimuli describing colors , which prolongs the reaction time when the patient has to react to a new criterion .
the larger the difference between variants b and a is and the number of mistakes made , the more impaired the cognitive functions are .
the prefrontal cortex , cingulate cortex , cerebellum , and basal nuclei are all activated while the patient is performing this test [ 1619 ] .
the stroop test was also used in the largest multicentre trials ispocd 1 and 2 , evaluating patients undergoing non - cardiosurgical interventions . in the tmt
, the patient has to connect dots : in variant a they represent numbers ( 1 , 2 , 3 ,  25 ) , in variant b
 numbers and letters , alternately ( 1 , a , 2 , b , 3 , c ,  12 , k ) .
it allows assessment of scanning , processing speed , and mental elasticity [ 17,18,2027 ] .
the vft evaluates both semantic ( categorical ) and phonemic ( such as  words that begin with the letter ...  ) verbal fluency . for each of 6 categories ( semantic : animals , vegetables , fruits ; phonemic : s ,
l , n ) the number of unique words given by the patient within 1 minute was registered .
the vft needs access to long - term memory ( ltm ) , processing functions , executive functions , and memory processes [ 20,3033 ] . on the day of the surgery , 1 hour before induction , all the patients were administered midazolam ( 7.511.25 mg ) . an invasive blood pressure ( ibp ) cannula
after 3-minute oxygenation with 100% o2 anaesthesia was induced with propofol ( 1.53 mg / kg ) , rfn ( 0.4 g / kg / h ) , rocuronium ( 5 mg ) and suxamethonium ( 0.51 mg / kg ) .
anaesthesia was maintained with rfn ( 0.050.5 g / kg / h ) and sevoflurane ( 0.60.9 mac ) , according to the patient s individual needs . during the procedure , ecg , spo2 , hr ,
map , etco2 , fio2 , and peak airway pressure ( pap ) were controlled continuously and the values were noted every 5 minutes .
the flow of sevoflurane and rfn was stopped when the surgery terminated . in 18 cases ( 38% ) , the anesthesiologist decided to administer ephedrine ( 5 mg ) to raise the map after lowering it below the target value .
there were 37 patients who underwent the tests 3 times  on the day before the surgery ( day 1 ) , on the day of the surgery ( day 2 ) , and on the day following the surgery ( day 3 ) .
ten patients were discharged in the morning on the day following the surgery due to good general condition , which made it impossible to complete the tests for the third time .
the tests were conducted every day between 6 pm and 9 pm . on the day of the surgery ,
the basic demographic data and the results of the screening tests were presented as the mean and standard deviation .
the distribution of the demographic data , stroop test results , tmt results , vft results were analyzed with the kolmogorov - smirnov test .
the differences in the test results between the groups were analyzed with anova for dependent variables .
friedman s anova was used to investigate the number of mistakes made , due to their non - gaussian distribution .
the time of completion of each test , the number of mistakes , and difference between variant b and a ( b - a  best represented cognitive functions in this test ) were analyzed , separately for the whole group ( with 2 attempts ) and for those who completed 3 attempts .
no statistically significant differences between the groups were observed . in each group , on day 2 the results of variant a were worse than on day 1 .
the results are shown in tables 2 , 3 , and figure 1a , 1b ( showing the b - a result ) .
the time of completion of each test , the number of mistakes , and difference between variant b and a ( b - a 
best represented cognitive functions in this test ) were analyzed , separately for the whole group ( with 2 attempts ) and for those who completed 3 attempts .
a , the time of completion on day 2 was shorter in group a and longer in group b and c. however , the difference was not statistically significant .
the comparison with the 3-day results and the comparison of the b - a results did not confirm this observation .
the results are shown in tables 4 , 5 , and figure 1c , 1d ( showing the b - a result ) . the number of words given and mistakes made were registered for each attempt and then analyzed .
no statistically significant differences were shown . in a number of categories ( fruits , vegetables , and animals , when 3 attempts were considered )
an increase in the number of words given was noted in groups 1 and 2 , while in group 3 the result remained constant or decreased .
the time of completion of each test , the number of mistakes , and difference between variant b and a ( b - a  best represented cognitive functions in this test ) were analyzed , separately for the whole group ( with 2 attempts ) and for those who completed 3 attempts .
no statistically significant differences between the groups were observed . in each group , on day 2 the results of variant a were worse than on day 1 .
the results are shown in tables 2 , 3 , and figure 1a , 1b ( showing the b - a result ) .
the time of completion of each test , the number of mistakes , and difference between variant b and a ( b - a  best represented cognitive functions in this test ) were analyzed , separately for the whole group ( with 2 attempts ) and for those who completed 3 attempts .
a , the time of completion on day 2 was shorter in group a and longer in group b and c. however , the difference was not statistically significant .
the comparison with the 3-day results and the comparison of the b - a results did not confirm this observation .
the results are shown in tables 4 , 5 , and figure 1c , 1d ( showing the b - a result ) .
the number of words given and mistakes made were registered for each attempt and then analyzed .
no statistically significant differences were shown . in a number of categories ( fruits , vegetables , and animals , when 3 attempts were considered )
an increase in the number of words given was noted in groups 1 and 2 , while in group 3 the result remained constant or decreased .
anaesthesia has both short - term ( reversible ) and long - term impacts on the central nervous system .
these changes result from the direct and indirect effects of anaesthetic drugs , but they are also related with the patient s initial condition , other drugs administered , and environmental factors ( e.g. , stress and elevated sympathetic activity ) , which are still under investigation .
there are 3 types of cognitive deterioration after surgery : delirium , short - term cognitive disturbance , and true pocd , which is a subtle deterioration in the cognitive function lasting weeks , months , or longer .
recent studies show that applying peep does not influence the quality of the surgery field as long as the peak inspiratory pressure ( pip ) is maintained below 15 cmh2o . in our study
all the patients were maintained with peep 5 cmh2o and pip below 15 cmh2o whenever possible .
the results of the stroop test confirm that hypotension lasting about an hour does not influence the processing of interfering stimuli , even as soon as 34 hours postoperatively .
the prolongation of the completion time of variant a on day 2 and 3 was similar in each group and it was probably caused by the patients discomfort due to the nasal pack inserted at the last phase of the surgery .
however , variant b was performed better every day , additionally reducing the b - a index .
this shows that the learning effect , characteristic of the stroop test at all ages , was also observed in all the groups after the surgery in controlled hypotension .
this observation corresponds with the results of a study by davidson , who showed a correlation between practice and stroop test results .
the results of the tmt are difficult to interpret due to significant differences between the patients results within each group , represented by high values of sd . although the results suggested that the patients from groups 2 and 3 needed more time to complete the test on day 2 and day 3 , the statistical value of this observation was limited .
another study proved the influence of age and education on the tmt results in a population of 911 individuals .
the groups in this study were too small to achieve statistical significance when they were divided into subgroups .
conducting the tmt in a larger population managed in controlled hypotension might provide new data regarding scanning , processing speed , and mental elasticity .
no complications in the functions of kidneys , lungs , nervous system , and cardiovascular system were observed .
the time of anaesthesia and post - operative pain in the numeral rating scale , which could have affected cognitive functions , did not differ significantly between the groups .
the study was limited by lack of feedback from the surgeons regarding visibility in the surgical field .
simultaneous evaluation of the vision quality ( ideally assessed by the same surgeon ) and cognitive function would be an interesting subject for further research .
the results of psychometric tests conducted on the patients undergoing fess in controlled hypotension did not differ significantly between the groups .
controlled hypotension seems to be equally safe for the patient as anaesthetic management in normotension , simultaneously decreasing the complication rate .
 backgroundcontrolled induced hypotension guarantees less blood loss and better visibility of the surgical site . 
 the impact of hypotension on post - operative cognitive functions is still being discussed . 
 the objective of this study was to evaluate the effects of controlled induced hypotension on the cognitive functions of patients undergoing functional endoscopic sinus surgery ( fess).material / methodswe allocated 47 patients with a good grade of preoperative cognitive functions evaluated with the mini - mental state examination to 3 groups ( 1  mild hypotension , 2  intermediate hypotension , 3  severe hypotension ) according to the degree of mean intraoperative arterial pressure compared with preoperative blood pressure . 
 cognitive functions were evaluated preoperatively , 6 h , and 30 h postoperatively with standardized tests : the stroop test , trail making test ( tmt ) , and verbal fluency test ( vft ) . 
 a decrease in the test results and increase in the number of mistakes made were considered an impairment of cognitive functions.resultsa total of 47 patients ( group 1  mild hypotension  15 , group 2  intermediate hypotension  
 19 , group 3  severe hypotension  13 ) were included in the study . 
 a significant decrease was observed in all the 3 groups after stroop a test 6h postoperatively but it improved 30h postoperatively , without differences between the groups . neither a significant decrease in the test results nor an increase in the number of mistakes was noted for stroop b tests , tmt a&b tests and vft.conclusionsthe degree of controlled intraoperative hypotension during fess did not influence the results of psychometric tests . 
Background
Material and Methods
Results
Stroop test
TMT
VFT
Discussion
Conclusions