qt was received as gifted by torrent pharmaceuticals pvt . ltd . , polyox n 10 , polyox n 80 , polyox n 750 and polyox n 205 were gifted by dow chemicals pvt
preliminary trials were carried out for selection of appropriate grades of polyox from different grades mentioned above .
concentration of polymer and plasticizers were optimized by central composite design . in this design 2 factors
the amount of polyox n750 ( x1 ) and peg 400 ( x2 ) were selected as independent variables .
the tensile strength , folding endurance , % drug released at 10 min ( y10 ) and disintegration time were selected as dependent variables .
preliminary trials were carried out for selection of appropriate grades of polyox from different grades mentioned above .
concentration of polymer and plasticizers were optimized by central composite design . in this design 2 factors
the amount of polyox n750 ( x1 ) and peg 400 ( x2 ) were selected as independent variables .
the tensile strength , folding endurance , % drug released at 10 min ( y10 ) and disintegration time were selected as dependent variables .
different grades of polyox were used for film formation like n10 , n80 , n750 and n205 .
initially , preliminary trials were carried out to select ideal grade of polymer used for film formation and then used for optimization of other parameters of film .
different mentioned grades were tried between 1 - 4% concentrations . from the result , it was observed that by increasing the concentration of polymer up to 2% , thickness and strength of film was improved . but by increasing concentration more than 2% , folding endurance of film was improved but increase in disintegration time more than limit .
thus , 2% concentration of polymer was used for further optimization of plasticiser and sweeteners .
plasticizer tried were glycerin , peg 400 , and propylene glycol in 15% concentration each .
glycerin and propylene glycol showed more sticky film which was unable to detach from surface .
polyox n750 was selected for further optimization of film property due to its excellent film forming nature with optimum viscosity for rapid dissolving film .
comparison of % elongation of design batches comparison of film thickness of design batches optimization of concentration of polyox n750 and % of peg as plasticisers was optimized systematically using with central composite design ( ccd ) .
it was observed that disintegration time of all the batches ranges between 6 - 30 sec , tensile strength between 0.106  0.760
kg / cm , folding endurance between 10 - 89 and drug release profile with in 10 min 80%-99% .
all the batches showed more than 80% drug release profile in initial 10 min . from all evaluation parameter , r10 batch with 2%
polyox 750 and 15% of peg 400 was considered as promising batch with all satisfactory parameters . for
validation of optimum formulation , check point r14 was prepared and evaluated for all the response .
observed value was found close to the predicted value , which indicated good correlation of results .
optimized film was analyzed by dsc spectra and compared with dsc spectra of pure drug .
spectra showed presence of drug peak at same energy of enthalpy as that of pure qt .
formulation was stored at 65% relative humidity and 37c temperature in the humidity oven . after 3 months film
some predictable changes were observed in film property like decrease in disintegration time and more softness of film due to higher amount of moisture .
film texture was evaluated after 3 months of storage which indicates increase in stickiness of film at higher relative humidity .
the results of central composite design revealed that the entire factor significantly influences the dependent variable .
thus , it can be concluded that by adopting a systematic formulation approaches , an optimum point can be reached in the shortest time with minimum effort .
thus , developed film can be useful for curing the emergency condition like schizophrenia which gives rapid relief within short time .
stability study data shows need of proper storage condition for film to protect from effect of moisture .
 quick dissolving film prepared by various grades of polyox like polyox n10 , n80 , n750 and n205 . 
 polyox having excellent film forming capacity with rapid hydration power which leads to rapid disintegration of film upon contact with saliva . 
 film is optimized for concentration of polymer and plasticizer using ccd design . 
 the tensile strength , folding endurance , % drug released at 10 min ( y10 ) and disintegration time were selected as dependent variables . 
 the data revealed that 2% of polyox n 750 and 15% of peg 400 showed excellent film forming property with rapid drug release profile . 
Materials and Methods
Formulation
Results and Discussion
Conclusion