 summarydeficits in prefrontal cholinergic function are implicated in cognitive impairment in many neuropsychiatric diseases , but acetylcholine s specific role remains elusive . 
 rhesus monkeys with selective lesions of cholinergic input to prefrontal cortex were unimpaired in tests of decision - making and episodic memory that require intact prefrontal cortex , but were severely impaired on a spatial working memory task . 
 these observations are consistent with a specific role for prefrontal acetylcholine in working memory . 
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