fundus examination revealed a round - shaped hypopigmented macular lesion including a few yellow spots in the fovea [ fig .
fa showed a macular transmission hyperfluorescent ring in which patchy hyperfluorescent and normofluorescent areas existed [ fig .
fundus autofluorescence imaging showed scattered patchy hyperautofluorescent areas matching the hypopigmented fundus lesion [ fig .
spectral - domain optical coherence tomography ( sd - oct , spectralis oct , heidelberg engineering , heidelberg , germany ) demonstrated hyper reflective accumulations ( humps ) involving rpe inner band and photoreceptor outer segments ( oss ) .
outer nuclear layer and inner segment / os ( is / os ) line was distorted because of the accumulations .
multifocal electroretinogram ( mferg , roland - consult retiscan system , wiesbaden , germany ) showed decreased amplitude in the central 2.3. the p1 amplitude in the central response was 50.3 nv / deg [ fig .
arden ratios in electrooculogram ( eog ) were 2134 in the right eye and 1650 in the left eye .
total error score in farnsworth - munsell-100 ( fm-100 ) hue test was 35 in the right eye and 157 in the left eye .
the patient reported a viral ( possibly ) upper respiratory tract infection 710 days prior to the visual loss .
a probable diagnosis of arpe was suggested , and the patient was followed in next weeks .
( a ) fundus photograph demonstrating round - shaped hypopigmented macular lesion including a few yellow spots in the fovea .
( c ) fluorescein angiography showing a macular transmission hyperfluorescent ring in which pathcy hyperfluorecent and normofluorescent areas existed .
( e ) spectral - domain optical coherence tomography image showing hyperreflective accumulations ( humps ) involving rpe inner band and photoreceptor outer segments .
( f ) multifocal electroretinogram showing depressed central ring amplitude best - corrected visual acuity improved gradually up to 20/20 in the next 5 weeks with no treatment .
there was almost no change in fa and fof imaging compared to the initial imaging [ fig . 2c and d ] .
sd - oct showed almost entirely restored is / os line almost no distortion in the outer nuclear layer .
irregularities and humps decreased , but there were still some persisting hyper reflective spots in the rpe inner band and photoreceptor oss [ fig .
the p1 amplitude of the central response increased to 114 nv / deg in mferg [ fig .
arden ratios were 2080 in the right eye and 2071 in the left eye [ fig . 3 ] .
the patient reported significantly improved central vision in amsler grid testing when compared with the initial testing .
total error scores in the fm-100 hue test was 42 in the right eye and 83 in the left eye .
( e ) spectral - domain optical coherence tomography image showing the decreased hyperreflective accumulations ( f ) .
multifocal electroretinogram showing normalized central ring amplitude electrooculogram recordings in the right ( a ) and left eye ( b ) during the initial examination and at the 5th week examination ( c and d , respectively )
the diagnosis of arpe depends on the presence of a characteristic fine pigment stippling in the macular area , at the level of the rpe , surrounded by yellow - white haloes of hypopigmentation .
spectral - domain optical coherence tomography findings suggest that the initial lesion in arpe is possibly located at the level of the photoreceptor os and rpe .
the disruption of photoreceptor is / os line with a wider disruption of the rpe inner band is almost typical in the reported cases .
the rpe inner band is considered to be related with the verhoeff 's membrane that is constituted by tight junctions of rpe cells or with basal infoldings and apical processes of rpe cells . in our case , however , photoreceptor is / os line is discernible throughout the lesion .
the main finding in our case was humps in the inner band of the rpe and photoreceptor oss .
our findings support the speculation that arpe is a postinflammatory response of the os of photoreceptors and the rpe .
eog explores the response of rpe to light and is a function of all rpe cells in the retina .
that is probably related with the increased metabolic need of rpe cells in the macula with respect to rpe cells in the peripheral retina .
the localized accumulation in sd - oct images likely reflects undigested oss of the photoreceptors .
the diminished central amplitudes with progressively increasing amplitudes toward periphery in mferg confirm the functional deterioration of cone photoreceptors in the central retina .
the electrophysiologic findings may mean that rpe cells in the peripheral retina can overcome the increased metabolic load although the rpe cells in the macula can not due to the high concentration of photoreceptors .
our case showed that mferg recording was more correlated to visual acuity than structural imaging modalities ( fa , fof , sd - oct ) .
spectral - domain optical coherence tomography and mferg findings in our case support the hypothesis that rpe is possibly the initial site of involvement in arpe . mferg depression confirmed the functional involvement of cone photoreceptors in the disease process .
 a 20-year - old man applied with vision loss in the left eye . 
 right eye examination was unremarkable . 
 best - corrected visual acuity ( bcva ) in the left eye was 20/200 . 
 fundus examination revealed a few yellow spots within a round - shaped macular lesion . 
 autofluorescence imaging showed hyperautofluorescence in the lesion . 
 central amplitudes in multifocal electroretinogram ( mferg ) were depressed . 
 the patient reported a rhinopharyngitis 710 days before the visual loss . 
 the patient was diagnosed as acute retinal pigment epithelitis . 
 bcva improved gradually up to 20/20 in 4 weeks . 
 mferg amplitudes returned to normal . 
 a slight pigmentary distortion was the only residual fundus finding . 
Case Report
Discussion
Conclusion