pseudomonas aeruginosa is a gram - negative , aerobic bacterium found in water and soil .
it is a normal flora of the skin and gastrointestinal tract of human beings ( 1 , 2 ) .
this bacterium as an opportunistic pathogen is one of the most important microorganisms in nosocomial infections in immune - compromised patients including patients with malignancies , cystic fibrosis and burns with multiple pathogenic factors and high rate of resistance to most of the antibiotics .
the presence of glycocalyx in cellular membrane is responsible for easy binding of the bacterium to the host cell , biofilm formation and protection of bacteria against penetration of antimicrobial agents and phagocytic system ( 3 ) . in a previous study
, p. aeruginosa has been isolated from nosocomial pneumonia ( 16% ) , nosocomial urinary tract infections ( 12% ) , post - operative wound infections ( 85% ) and hospital blood infections ( 10% ) which included 23% of total isolated bacteria from admitted patients ( 4 ) .
selection of the appropriate treatment approach against p. aeruginosa is limited due to its resistance to common recommended antibiotics ( 5 , 6 ) .
bacterial resistance to antibiotics is increasing which makes humans to apply effective antimicrobial agents with fewer side effects such as medicinal plants instead of medicines with less efficacy and greater side effects ( 7 ) .
plants have different chemical compounds like secondary metabolites ( 8 , 9 ) with many biochemical and bioactivity properties showing applications in various industries such as pharmaceutical , chemical , cosmetic and food industry ( 1013 ) .
the aim of this study was to introduce the most important native medicinal plants of iran being effective on p. aeruginosa .
all required information was obtained by literature review using keywords including p. aeruginosa , medicinal plant extracts or essential oils of published articles in authentic scientific databases such as science direct , wiley - blackwell , springer , google scholar , scientific information database ( sid ) and magiran .
according to literature review , our results showed 12 different native medicinal plants were effective against p. aeruginosa in iran including eucalyptus camadulensis , marticaria chamomilla , ferula gummosa boiss , lawsonia inermis , ocimumgra tissimum , allium sativum , satureja hortensis l , satureja bachtiarica bunge , satureja khuzestanica ( jamzad ) , thymus daenensis celak , thymus carmanicus jalals and camellia sinensis .
medicinal plants are good alternatives for synthetic preservatives in food and drug industry due to their antimicrobial compounds .
e. camadulensis ( eucalyptus ) leaves are rich in polyphenols and terpenoids and eucalyptol or cineole ( 26 ) .
phytochemicals results showed that alfa and beta - pinenes are the main ingredients of ferula gummosa boiss ( galbanum ) ( 27 ) and lawsoniainermis ( henna ) containsmanitol , tanic acid , mucilage and galic acid but its most important ingredient is 2-hydroxy-1,4-naphoquinone ( lawson ) recognized as bioactive agent .
ocimumgra tissimum ( basil ) contains essential oils , tannins , glycosides , saponin , anthocyanin , eugenol , linalool , methyl cinnamate , camphor and thymol .
different species of satureja ( savory ) contain monoterpenes , phenolic compounds especially carvacrol , thymol and eugenol as well as some of the sesquiterpenes .
the main phytochemical essential oils of aromatic plants are hydrocarbons , aldehydes , ketones , alcohols , phenols , ethers and esters with phenolic and terpenic sources .
the presence of linalool , alpha - pinene , beta - pinene , borneol , carvone , limonene , carvacrol , p - cymene and terpinenein essential oils of understudy plants showed antimicrobial properties particularly ( 28 ) .
these compounds with high hydrophobic properties can separate lipids from bacterial cell wall and thereby increase the permeability of the membrane which leads to ion expelling and electron imbalance and eventually cell death .
the researchers demonstrated that plant species used in popular medicine are promising resources for antimicrobial treatments ( 13 , 14 , 29 , 30 ) .
phytochemical analysis has shown that bioactive compounds of medicinal plants with their antioxidant and antimicrobial properties are good substitutions for synthetic drugs in food and drug industry .
 background and objectives : pseudomonas aeruginosa is a gram - negative , aerobic bacterium found in water and soil . 
 it is a normal flora in skin and gastrointestinal tract of human beings . 
 p. aeruginosa as an opportunistic pathogen involved in nosocomial infections having multiple pathogenic factors and shows high rate of resistance to different antibiotics . 
 the aim of this study was to identify the most important native medicinal plants of iran effective on p. aeruginosa.materials and methods : all required information was obtained by searching keywords such as p. aeruginosa , medicinal plant extracts or essential oils in published articles in authentic scientific databases such as science direct , wiley - blackwell , springer , google scholar , scientific information database ( sid ) and magiran.results:according to the literature review , our results showed 12 different native medicinal plants were effective against p. aeruginosa in iran including eucalyptus camadulensis , marticaria chamomilla , ferula gummosa boiss , lawsonia inermis , ocimumgra tissimum , allium sativum , satureja hortensis l , satureja bachtiarica bunge , satureja khuzestanica ( jamzad ) , thymus daenensis celak , thymus carmanicus jalals and camellia sinensis.conclusion:phytochemical analysis has shown that bioactive compounds of medicinal plants with their antioxidant and antimicrobial properties can be good alternatives for the synthetic medicines in food and drug industry . 
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
CONCLUSION