 ovarian cancer is the leading cause 
 of death among women with gynecological 
 malignancies . 
 acquired resistance to chemotherapy is a major limitation 
 for ovarian cancer treatment . 
 we report here the first use of nanoscale 
 metal  organic frameworks ( nmofs ) for the co - delivery of cisplatin 
 and pooled small interfering rnas ( sirnas ) to enhance therapeutic 
 efficacy by silencing multiple drug resistance ( mdr ) genes and resensitizing 
 resistant ovarian cancer cells to cisplatin treatment . 
 uio nmofs with 
 hexagonal - plate morphologies were loaded with a cisplatin prodrug 
 and mdr gene - silencing sirnas ( bcl-2 , p - glycoprotein [ p - gp ] , and survivin ) 
 via encapsulation and surface coordination , respectively . 
 nmofs protect 
 sirnas from nuclease degradation , enhance sirna cellular uptake , and 
 promote sirna escape from endosomes to silence mdr genes in cisplatin - resistant 
 ovarian cancer cells . 
 co - delivery of cisplatin and sirnas with nmofs 
 led to an order of magnitude enhancement in chemotherapeutic efficacy in vitro , as indicated by cell viability assay , dna laddering , 
 and annexin v staining . 
 this work shows that nmofs hold great promise 
 in the co - delivery of multiple therapeutics for effective treatment 
 of drug - resistant cancers . 
Supplementary Material