the previous issue of critical care includes a report of a multicenter study in which cardiac index and gastric mucosal ph targets were compared during resuscitation of patients with septic shock .
similar to all other hemodynamic variables with the exception of central venous oxygen saturation , the value of a cardiac index target in the resuscitation of patients in septic shock has not been established .
in contrast , achievement of other goals in the treatment of septic patients ( for instance , early and adequate antibiotic treatment ) has been associated with improved outcomes . because ' normal ' systemic hemodynamics do not necessarily guarantee adequate tissue oxygen supply , monitoring organ perfusion or function
it has been shown that persistent microcirculatory alterations are associated with organ failure and mortality in patients with septic shock .
gastric mucosal ph ( phi ) is an interesting parameter that has been shown to predict outcome in many patient groups .
phi is a composite variable that reflects not just adequacy of local perfusion but also systemic metabolic acid - base homeostasis and ventilation .
the interaction of the components of phi and their response to treatment may confound the interpretation and prognostic relevance of gastric mucosal acidosis . in the study conducted by palizas and coworkers , resuscitation to a phi goal
conceptually , there are four interpretations of these findings : the tested variables ( cardiac index and phi ) are not relevant to survival ; the defined targets were not adequate ; the targets were relevant but only in combination with the achievement of other goals ; and finally , the efforts to achieve the goals were not adequate , and the goal therefore was not achieved .
cardiac output determines tissue oxygen delivery and is certainly an important variable with respect to the resolution of septic shock . however , other variables contribute to tissue oxygen transport , and the demands may also vary . in that sense ,
as the authors state themselves , a goal representing a presumed adequate relationship between oxygen delivery and consumption ( for example , mixed venous oxygen saturation ) would have been preferable .
its strong association with mortality makes phi an ideal target variable for improving outcomes . in the study reported by palizas and coworkers ,
the target cardiac index was achieved at baseline in nearly 90% of patients . because the mortality was 30% ,
it is clear that the target should have been higher , if increasing cardiac index is believed to be beneficial .
it is a relatively common practice to increase minute ventilation in order to normalize arterial ph when bicarbonate is low .
whether a ( normal ) phi of 7.32 can be achieved at all during the early phase of septic shock is questionable
. the use of vasoconstrictors can decrease mesenteric perfusion , and metabolic effects of adrenaline ( epinephrine ) may increase pco2 further .
there is no information on how other aspects of septic shock treatment were addressed ( antibiotics , source control , ventilator settings , and so on )
the authors indicate that crystalloids and colloids were given , but in their protocol only saline is listed .
although colloids can be harmful in sepsis , normal saline ( or colloids in saline ) can cause hyperchloremic metabolic acidosis and thereby decrease mucosal phi .
adrenaline ( epinephrine ) , noradrena - line ( norepinephrine ) , dopamine , and dobutamine were used to improve blood pressure and flow .
although adrenaline can impair splanchnic perfusion in septic shock , dobutamine appears to be able to reverse these changes , at least in part .
phi was measured every 6 hours , and no data are given on the frequency of cardiac index assessments .
four daily assessments of the treatment 's influence on the target variable may be too few , especially in view of the fact that splanchnic blood flow is highly variable in septic patients .
it would have been interesting to see how the individual therapeutic interventions influenced the target variables . without this information ,
nevertheless , the work by palizas and coworkers   reminds us that mucosal acidosis persists in the majority of patients who ultimately will die after resuscitation from septic shock . monitoring and treating
cardiac output determines tissue oxygen delivery and is certainly an important variable with respect to the resolution of septic shock . however , other variables contribute to tissue oxygen transport , and the demands may also vary . in that sense ,
as the authors state themselves , a goal representing a presumed adequate relationship between oxygen delivery and consumption ( for example , mixed venous oxygen saturation ) would have been preferable .
in the study reported by palizas and coworkers , the target cardiac index was achieved at baseline in nearly 90% of patients . because the mortality was 30% ,
it is clear that the target should have been higher , if increasing cardiac index is believed to be beneficial .
in contrast , the incidence of low phi was high . however , the variable is influenced by arterial carbon dioxide tension ( pco2 ) .
it is a relatively common practice to increase minute ventilation in order to normalize arterial ph when bicarbonate is low .
thus , the mucosalarterial pco2 gradient would have been a better choice . whether a ( normal ) phi of 7.32 can be achieved at all during
the use of vasoconstrictors can decrease mesenteric perfusion , and metabolic effects of adrenaline ( epinephrine ) may increase pco2 further .
there is no information on how other aspects of septic shock treatment were addressed ( antibiotics , source control , ventilator settings , and so on )
the authors indicate that crystalloids and colloids were given , but in their protocol only saline is listed .
although colloids can be harmful in sepsis , normal saline ( or colloids in saline ) can cause hyperchloremic metabolic acidosis and thereby decrease mucosal phi .
adrenaline ( epinephrine ) , noradrena - line ( norepinephrine ) , dopamine , and dobutamine were used to improve blood pressure and flow .
although adrenaline can impair splanchnic perfusion in septic shock , dobutamine appears to be able to reverse these changes , at least in part .
phi was measured every 6 hours , and no data are given on the frequency of cardiac index assessments .
four daily assessments of the treatment 's influence on the target variable may be too few , especially in view of the fact that splanchnic blood flow is highly variable in septic patients .
it would have been interesting to see how the individual therapeutic interventions influenced the target variables . without this information ,
nevertheless , the work by palizas and coworkers   reminds us that mucosal acidosis persists in the majority of patients who ultimately will die after resuscitation from septic shock . monitoring and treating
the department of intensive care medicine at inselspital has or has had research contracts and/or collaboration contracts with edwards lifescience , ge healthcare , pulsion , orion pharma , berna biotech and b. braun medical .
 the need to achieve adequate tissue oxygen delivery early in patients with septic shock is well established . 
 however , it is less well recognized that tissue hypoperfusion can exist despite normalization of systemic hemodynamics . 
 efforts to resuscitate septic patients until adequate tissue perfusion has been achieved can potentially improve outcome . in a multicenter study , 
 130 patients with septic shock were resuscitated within 12 hours of diagnosis using a protocol including goals for mean arterial and pulmonary artery occluded pressures , urinary output , arterial ph , and hemoglobin goals . 
 they were then randomly assigned to further resuscitation with either a cardiac index (  3 l / minute per m2 ) or a gastric mucosal ph (  7.32 ) target . the intensive care unit length of stay and 28-day mortality did not differ between groups , but more patients in the cardiac index group were in the target range , both at baseline and after resuscitation , as compared with the gastric mucosal ph group . 
 in contrast to cardiac index , gastric mucosal ph at baseline and at 24 and 48 hours predicted mortality . whether other targets for the chosen variables , or different and  in particular  earlier resuscitation efforts would have favored one group 
 can not be concluded from the data provided . 
None
Were the tested parameters relevant for survival?
Were the defined targets adequate?
Were other important targets achieved?
Were the measures to achieve the goals adequate and the goals achieved?
Abbreviations
Competing interests