infections caused by opportunistic pathogens , such as yeasts , are becoming important reasons of morbidity and mortality because of alterations in the immune system and invasive hospital procedures 1 .
aids , organ transplantation , chemotherapy , invasive procedures and radiotherapy increased the prevalence of immunocompromised individuals and also diabetes mellitus , and the over use of extended spectrum antibiotics made an increment in these infections 2 - 4 .
infections due to yeast like fungi increase at intensive care units 5 . in the last two decades
yeast like fungi are the fourth agent in the blood stream infections . c. albicans , c.tropicalis and c. parapsilosis are the most common yeast like fungi causing blood stream infection 6 .
the aim of our study was to evaluate the distribution of yeast like fungi isolated from clinical specimens at tepecik education and research hospital infectious diseases and clinical microbiology department mycology laboratory which was recently opened .
yeast like fungi were isolated from the various clinical specimens ( wound , urine , blood , respiratory specimen ) between 13.01.2010 and 19.08.2011 at tepecik education and research hospital infectious diseases and clinical microbiology department mycology laboratory .
all the isolates were identified to species level by the germ tube test , chrom agar candida ( salubris , istanbul , turkey ) , cornmeal tween 80 medium ( salubris , istanbul , turkey ) and carbohydrate assimilation profile using the id32c yeast identification system ( biomerieux , france ) .
these samples were received from intensive care units ( icus ) , pediatrics , internal medicine , infectious diseases and clinical microbiology , urology and ear nose throat departments .
the specimens consisted of 144 urine ( 42.7% ) , 155 blood culture ( 45.9% ) , 13(3.8% ) respiratory specimen and 25 ( 7.4%)'wound .
the isolated yeast strains were 130 ( 38.6% ) c.albicans , 47 ( 13.9% ) c.tropicalis , 96 ( 28.4%)c .
parapsilosis , 25 ( 7.4% ) c.glabrata , 13 ( 3.8% ) c.krusei , 10 ( 2.9% ) c.kefyr , four ( 1.2% ) c. guillermondii , five ( 1.5% ) c. pelliculosa , four ( 1.2% ) c.dubluniensis , two ( 0.6% ) c. famata , and one ( % 0.3 ) c. lusitaniae .
the distribution of yeast like fungi acoording to specimen type and various departments were shown in table 1 and table 2 .
candida are prevalent all around the world and cause infectios within a spectrum of noninvasive infections to invasive opportunistic infections .
exogeneous infections are due to hands of hospital staff , contaminated biomaterials and catheters 7 , 8 .
hematologic disorders , immunosuppresive therapy , bone marrow transfer , organ transplantation , use of extended spectrum antibiotics , radiotherapy , burns , and longer duration in intensive care units are the main risk factors 9 .
investigated the yeast like fungi isolated from clinical specimens between august 2003 - 2005 at mersin university hospital microbiology laboratory .
872 yeast like fungal strains from 471 patients and 811 clinical specimens were taken into the study . c. albicans was the most common yeast like fungi isolated in all clinical specimens and c. parapsilosis ( 51.8% ) was the one in blood culture strains .
there was a decrease in c. tropicalis . c. albicans was the most common isolated strain overall
; but there is a increase in non c. albicans especially in intensive care units 10 .
investigated 390 fungi like yeast isolated from intensive care units over a four year period .
blood culture , tracheal aspirate and urine were the most common specimens and c.albicans was 53.3% , c. tropicalis 14.5% , c. glabrata 12.2% and c. parapsilosis 6.5%.detected .
according to the authors c. albicans was the most common isolated strain and an increase in non albicans isolates such as c. glabrata and c. tropicalis was detected 11 .
evaluated the blood culture of twenty patients in one year period and the most common isolated strain was c. albicans 
 12 . in our study
the most frequently isolated strain from blood cultures was c.parapsilosis and c.albicans was in second place .
these consisted of c.albicans ( 49% ) , c. parapsilosis ( 23% ) , c. tropicalis ( 14% ) , c. glabrata ( 12% ) , one c.guillermondii and one c. krusei .
according to the authors the most common isolated strain was c. albicans and the most prevalent non c. albicans isolates were c. parapsilosis and c. tropicalis .
they also think that when considering candidemias , studies evaluating predisposing factors should be held in order to decrease morbidity and mortality and also to take the preventive measures 13 .
kocoglu et al . investigated the distribution and the antifungal susceptibility of yeast like fungi at gaziantep university hospital mycology laboratory from various clincal specimen in an one year period .
the most common one was c.albicans ( 56.8% ) , secondly c.tropicalis ( 7.7% ) and thirdly c. sake ( 6.8% ) .
evaluated the newborn candidosis cases at the newborn intensive care unit between august 2005-january 2006 in italy .
twenty two cases were investigated and the clonal spread of c. albicans isolates were shown 15 .
motta et al . investigated the distribution and the antifungal susceptibility of yeast like fungi isolated from blood cultures at a tertiary education hospital in brazil in 2006 . the isolated yeast like fungi were c.albicans ( 52.2% ) , c. parapsilosis ( 22.1% ) , c. tropicalis ( 14.8% ) and c. glabrata ( 6.6% ) , respectively .
according to the authors candidemia incidence is high and the distribution of candida species and their antifungal susceptibility should be known 16 .
dimopoulos et al . evaluated the candidemia cases that took place after hospitalization at icu .
64.3% of the cases were c. albicans and 35.7% were non c. albicans 
 17 .
investigated the mucosal candida colonisation in 273 hiv seropositive patients in a two year period in iran .
273 oral and 86 vaginal specimens were examined . among these 50% c. albicans was isolated and this was followed by c. glabrata ( 21.4% ) , c. dubliniensis ( 13.3% ) , c. krusei ( 9.8% ) , c. kefyr ( 3.1% ) , c. parapsilosis ( 1.6% ) and c. tropicalis ( 0.8% ) 18 .
investigated the ditribution and antifungal susceptibility of yeast like fungi isolated from blood culures during a ten year period in mycology reference laboratory in kuwait .
c. albicans ( 39.5% ) was the predominant strain and followed by c. parapsilosis , c. albicans and c. krusei .
c. albicans , c. albicans , c.tropicalis and c. glabrata were all susceptible to amphotericin b. c. parapsilosis isolates were 2% resistant to amphotericin b. nine c. albicans strains were resistant to fluconazole .
the authors think that the data in this study is similar to various other studies .
although there is over use of fluconazole ve amphotericin b in clinical practice , there is not an increase in resistance rate 19 .
recently there is an increase in invasive infections caused by candida due to immunsuppresive individuals , patients with organ transplantation and hospitalization at icus . in this study ,
isolated yeast strains were 130 ( 38.6% ) c.albicans , 47 ( 13.9% ) c.tropicalis , 96 ( 28.4% ) c.parapsilosis , 25 ( 7.4% ) c.glabrata , 13 ( 3.8% ) c.krusei , 10 ( 2.9% ) c.kefyr , four ( 1.2% ) c. guillermondii , five ( 1.5% ) c. pelliculosa , two ( 0.6% ) c. famata , one ( % 0.3 ) c. lusitaniae and four ( 1.2% ) c.dubluniensis . in our study
the most common isolated strain was c. albicans and this is similar to most of the studies stated above .
c. parapsilosis was the most isolated strain in blood cultures and this may be due to invasive procedures and the use of catheters .
five c.pelliculosa isolates were identified from blood culture at the same department and this may indicate nosocomial infection due to application of invasive procedures in that unit .
the prevalence of non albicans isolates c. glabrata and c. krusei were low . because of this situation azolles could be a choice in antifungal treatment
. since our mycology laboratory has been recently developed , the greater number of received samples and identified candida species will help us to monitor and choose appropriate antifungal treatment at our hospital in the future .
 objective : 
 candida infections have increased due to transplant patients , prolonged icu stay and invasive procedures . the most common isolated strain is c. albicans . 
 the aim of this study was to evaluate the distribution of candida isolates at tepecik education and research hospital.materials and methods : yeast like fungi were isolated between 13.01.2010 and 19.08.2011 at mycology laboratory . 
 the identification was done by conventional methods and carbohydrate assimilation profile using the id32c identification system ( biomerieux , france).results : yeast like fungi were isolated from 337 clinical specimens . 
 they consisted of urine , blood culture , respiratory specimen and wound . 
 the most isolated yeast strains were c.albicans ( 38.6% ) , c.tropicalis ( 13.9% ) , c. parapsilosis ( 28.4% ) , c.glabrata ( 7.4% ) , c.krusei ( 3.8%).conclusion : recently there is an increment in candida infections . in this 
 study the most common strain was c.albicans and the rate c. glabrata and c. krusei isolates were lower than expected . c. parapsilosis was the most isolated strain in blood cultures and this may be due to invasive procedures and the use of indwelling catheters . 
Introduction
Materials and Methods
Results
Discussion