 we report the first total synthesis 
 of the complex akuammiline 
 alkaloid picrinine , which was first isolated nearly five decades ago . 
 
 our synthetic approach features a concise assembly of the [ 3.3.1]-azabicyclic 
 core , a key fischer indolization reaction to forge the natural product s 
 carbon framework , and a series of delicate late - stage transformations 
 to complete the synthesis . 
 our synthesis of picrinine also constitutes 
 a formal synthesis of the related polycyclic alkaloid strictamine . 
Supplementary Material