true metastases from solid tumors in lung , skin ( melanoma ) , gastrointestinal tract , kidney , testes , and endocrine glands are reported only in 0.2% of all surgical prostatic specimens and 2.9% of all male postmortems .
lung is the most common primary site of metastases to the prostate . in all series direct spread of bladder carcinoma
clinical context , morphological features , and immunohistochemical localization of prostate specific antigen ( psa ) are supposed to clarify the differential diagnosis between a secondary and a primary tumor .
we report an unusual and rare case of secondary signet ring cell carcinoma ( srcc ) of prostate in which the clinical data pointed toward the diagnosis of a primary srcc .
signet ring cell morphology was also not helpful as incidence of primary srcc was more than that of secondary srcc in prostate .
immunohistochemistry ( ihc ) for psa not only proved the case to be a secondary srcc but also initiated the process for diagnosis of the occult primary malignancy in the patients stomach .
a 74-year - old male patient presented with frequency of micturition , dysuria , and features of urinary outlet obstruction developing progressively over a period of last 3 months .
he was a smoker , occasional drinker , and complained of no other features of clinical interest except infrequent dyspepsia .
transrectal ultrasonography showed grade iii prostatomegaly measuring 5.54.24.8 cm ( 58 g ) , with suspicious hypoechoic areas in the peripheral zone and residual urine of 80 ml .
serum total psa level was 9.71 ng / ml and free - to - total psa ratio was 10.8 . on digital rectal examination
the prostate was elastic , slightly hard , painless , and with prominent retroprostatic sulci .
cystoscopic examination found no primary abnormality of the bladder and extensive transurethral resection of prostate ( turp ) was performed under anesthesia with resultant specimen measuring 45 g. histopathology revealed nests and singly infiltrating poorly differentiated , hyperchromatic , pleomorphic adenocarcinoma cells majority of which were of signet ring morphology [ figures 13 ] .
individual cells and cell nests were seen lying haphazardly among bundles of smooth muscle fibers and also within lymphovascular spaces but no perineural invasion , mucinous fibroplasia or glomerulations were noted . initial diagnosis of signet ring variant of invasive prostatic adenocarcinoma with gleason score 4 + 5=9 was thought of but ihc for psa [ figure 3 ( inset ) ] and carcinoembryonic antigen ( cea ) were simultaneously performed as primary prostatic signet ring cell adenocarcinoma is rare and it is mandatory to exclude other mucinous tumors of non - prostatic origin based on morphology and immunohistochemistry and if necessary using clinical information .
the globoid optically clear cytoplasm of the signet ring cells were stained positively with alcian blue at ph 2.5 confirming the contents as acid mucin [ figure 1 ( inset ) ] .
gastric endoscopic biopsy was subsequently performed 2 weeks after turp and histopathology showed infiltrating signet ring cell carcinoma of stomach .
( inset : same signet ring cells with positive alcian blue stain at ph 2.5 . ) signet ring cells lying haphazardly among bundles of smooth muscle fibers .
some primary adenocarcinomas of the prostate will have a signet - ring - cell appearance , yet the vacuoles do not contain intracytoplasmic mucin . these vacuolated cells may be present as singly invasive cells , in single glands , and in sheets . only a few cases of prostate cancer have been reported with mucin positive signet ring cells .
one should exclude other mucinous tumors of nonprostatic origin based on morphology and immunohistochemistry and if necessary using clinical information .
immunohistochemical stain for psa is diagnostically helpful in distinguishing prostatic adenocarcinomas from other neoplasms secondarily involving the prostate and establishing prostatic origin in metastatic carcinomas of unknown primary .
a minority of higher grade prostatic adenocarcinomas are psa negative , although some of these tumors have been shown to express psa mrna .
some prostatic adenocarcinomas lose psa immunoreactivity following androgen deprivation or radiation therapy . in gastric signet ring cell carcinoma ( who classification )
more than 50% of the tumor consists of isolated or small groups of malignant cells containing intracytoplasmic acid mucin that stain with alcian blue at ph 2.5 .
the present case once again underlines the fact that metastatic src carcinoma although rare should be considered as a differential before diagnosing a primary src carcinoma of prostate .
a detailed clinical examination and special attention to any prior history of mild symptoms like dyspepsia might lead to the performance of an upper gastrointestinal endoscopy which can help in much earlier detection of a primary gastric tumor .
the most important feature for differentiation in this case with an occult primary was psa immunostain supplemented by an alcian blue stain at ph 2.5 .
dr . tapas moitra , associate professor , department of urology , north bengal medical college , sushrutanagar , darjeeling .
 true metastases to prostate from solid tumors are reported only in 0.2% of all surgical prostatic specimens and 2.9% of all male postmortems . 
 clinical context , morphological features , and immunohistochemical localization of prostate specific antigen ( psa ) are supposed to clarify the differential diagnosis between a secondary and a primary tumor . 
 we report an unusual and rare case of secondary signet ring cell carcinoma ( srcc ) of prostate in which the clinical data and signet ring cell morphology pointed toward the diagnosis of a primary srcc . 
 immunohistochemistry ( ihc ) for psa not only proved the case to be a secondary srcc but also initiated the process for diagnosis of the occult primary malignancy in the patients stomach . 
I
C
D
A