the cardia study is a multicenter , longitudinal investigation of the evolution of ischemic heart disease risk starting in young adulthood ( 17 ) .
the study began in 19851986 with 5,115 black and white adults 1830 years of age from four metropolitan areas ( birmingham , al ; chicago , il ; minneapolis , mn ; and oakland , ca ) .
study participants were sampled to obtain roughly equal numbers of blacks ( 51.5% ) and whites ( 48.5% ) , men ( 45.5% ) and women ( 54.5% ) , 1824 years of age ( 44.9% ) and 2530 years of age ( 55.1% ) , and with a high school education or less ( 39.7% ) and with more than a high school education ( 60.3% ) .
participants were contacted by telephone every year and examined in person at baseline and 2 , 5 , 7 , 10 , 15 , 20 , and 25 years after baseline .
a majority of the group was examined at each of the follow - up examinations ( 91 , 86 , 81 , 79 , 74 , 72 , and 72% of survivors , respectively ) . at each clinical examination , participants were asked to present fasting in the morning .
tobacco use , strenuous physical activity , and intake of caffeine , food , and alcohol were proscribed .
the examinations followed standardized protocols harmonized over time and included measurements of blood pressure ( bp ) , anthropometrics , and phlebotomy and structured questionnaires on sociodemographics , medical and family history , psychosocial characteristics , and diet , among others .
the cardia study was approved by the institutional review board of each participating institution , and signed informed consent was obtained at each examination . during each clinic exam , blood was drawn from an antecubital vein , and after serum separation , aliquots were stored at 70c until shipped on dry ice to a central laboratory .
procedures followed in the collection and storage of plasma samples , laboratory quality - control procedures , and methodology for analysis of plasma triglycerides , hdl cholesterol , ldl cholesterol , and total cholesterol are described elsewhere ( 18 ) .
serum glucose was measured at year 0 using the hexokinase ultraviolet method by american bio - science laboratories ( van nuys , ca ) and at subsequent examinations using hexokinase coupled to glucose-6-phosphate dehydrogenase by linco research ( st .
bp was measured three times at 1-min intervals . at the baseline through year 15 follow - up exams , bp was measured using the hawksley ( lancing , sussex , u.k . ) random - zero sphygmomanometer ; the first and fifth phase korotkoff sounds were recorded ( 17 ) . at the year 20 and 25 exams , bp was measured with an automated sphygmomanometer ( omron hem907xl oscillometer ; omron , schaumburg , il ) .
the protocol specified the appropriate cuff size ( small , medium , large , or extra - large ) based on the upper arm circumference , which was measured by the bp technician at the midpoint between the acromion and the olecranon .
omron values were recalibrated to corresponding random zero values based on a study of both measurement techniques in 903 participants at year 20 , as estimated random zero systolic value = 3.74 + 0.96  omron systolic value , and estimated random zero diastolic value = 1.30 + 0.97  omron diastolic value ( 19 ) .
anthropometry ( height , weight , and waist circumference ) was measured at each exam .
body weight was measured to the nearest 0.2 kg using a calibrated balance beam scale in participants wearing light clothing .
height ( without shoes ) was measured to the nearest 0.5 cm using a vertical ruler and waist circumference to the nearest 0.5 cm at the minimal abdominal girth ( 20 ) .
diet was assessed at years 0 , 7 , and 20 by using an interviewer - administered cardia diet history questionnaire ( 21 ) .
interviewers asked open - ended questions about dietary consumption in the past month within 100 food categories that referenced 1,609 separate food items .
additionally , visits per week to fast food restaurants were queried at each examination , and frequency of breakfast , lunch , dinner , and morning , afternoon , and evening snacks ( days / week ) was queried at years 7 and 20 .
an a priori dietary quality score based on overall dietary intake was included as a covariate ( 16 ) . in brief , 46 food groups considered beneficial or adverse with respect to health effects were categorized by increasing consumption level with scores of 04 ( for 20 food groups considered beneficial ) , 40 ( for 13 food groups considered adverse ) , or 0 ( for 13 food groups considered neutral ) .
the a priori dietary quality score was the sum of category scores , with a theoretical maximum of 132 .
based on prior findings , it was assumed that a higher a priori dietary pattern score indicated better diet quality ( 2224 ) .
nutrient and energy estimates had larger variability among blacks than among whites ( 21,25 ) . for other covariates ,
sex , race , date of birth , education , and cigarette smoking were ascertained by a structured interview or self - administered questionnaire at each examination .
a physical activity score was derived from the cardia physical activity history , which is a simplified version of the minnesota leisure time physical activity questionnaire ( 26 ) .
obesity was defined as bmi 30 kg / m and abdominal obesity as waist circumference > 88 cm for women or > 102 cm for men .
hypertension was defined as systolic bp 140 mmhg , diastolic bp 90 mmhg , or self - reported use of antihypertensive medication .
the metabolic syndrome was defined using the national cholesterol education program ( ncep ) adult treatment panel ( atp ) iii criteria ( 27 ) as the presence of three or more of the following five conditions : 1 ) abdominal obesity , 2 ) fasting triglycerides 150 mg / dl , 3 ) hdl cholesterol < 40 mg / dl in men and < 50 mg / dl in women , 4 ) bp 130 mmhg systolic or 85 mmhg diastolic or use of antihypertensive medications , and 5 ) fasting glucose 100 mg / dl or use of diabetes medications .
incidence of type 2 diabetes was defined as use of diabetes medication ( assessed at every visit ) , a fasting blood glucose level of 6.99 mmol / l ( 126 mg / dl ) ( measured at years 1025 ) , 2 h postchallenge glucose 11.1
mmol / l ( 200 mg / dl ) ( performed at the year 10 , 20 , and 25 exams ) , and/or an hba1c 6.5% ( 48 mmol / mol ) ( assessed at the year 20 and 25 visits ) . from the total sample of 5,115 , we excluded 1,029 who did not participate in the year 7 clinical exam , a further 171 who did not participate in any clinical exam in years 1025 , 60 with diabetes at year 7 , 215 without dietary data or with reported energy intakes not in the range of 8008,000 kcal / day for men and 6006,000 kcal / day for women , and 42 missing other data ( alcohol , smoking , or physical activity ) for an analytic sample of 3,598 . for analyses on outcomes other than type 2 diabetes ,
participants prevalent with the condition at year 7 were also excluded and total n is provided in tables .
breakfast intake frequency categories were created that allowed for logical cut points with a sufficient number of subjects .
baseline ( year 7 ) characteristics were calculated across breakfast intake frequency categories reported at this exam .
multivariable least squares  adjusted means from general linear models ( sas proc glm ) were used to estimate weight gain in kilograms and increase in waist circumference in centimeters by breakfast intake frequency categories .
the models adjust for age , study center , race , sex , education ( years ) , cigarette smoking ( current , former , or never ) , physical activity ( units / week ) , alcohol consumption ( ml / day ) , fast food restaurant use ( visits / week ) , overall dietary quality score , frequency of lunch / dinner and morning / afternoon / evening snacks ( days / week ) , total energy intake ( kcal ) , and weight or waist circumference and height at year 7 , respectively .
all participants were free of diabetes at each time point in the analysis of weight and waist circumference changes .
proportional hazards ( cox ) regression ( sas proc phreg ) was used to examine the association between breakfast intake frequency categories and incidence of metabolic conditions .
time to event was calculated from the date of the baseline examination ( year 7 ) to the date of the first follow - up examination meeting the criteria for the incident outcome ( cases ) or to the date of the last cardia examination for each participant without the incident outcome ( censored ) .
the main model included age ( years ) , study center , race , sex , education ( years ) , cigarette smoking ( current , former , or never ) , physical activity ( units / week ) , alcohol consumption ( ml / day ) , fast food restaurant use ( visits / week ) , dietary quality score , frequency of lunch / dinner and morning / afternoon / evening snacks ( days / week ) , and total energy intake ( kcal ) . depending on the outcome , either waist circumference ( cm ) or bmi ( kg / m ) from year 7 was included in a second model , and , for hypertension , a third model further adjusted for systolic bp at year 7 in analyses examining potential mediators .
there was no evidence that proportional hazards assumptions were violated for any of the outcomes as indicated by the lack of significant interaction between the breakfast intake frequency variable and time in the models .
tests for trend were performed by assigning the median value of intake frequency to the category and entering this as a continuous ordinal variable into the models .
effect modification of the associations was considered by level of the dietary quality index , bmi , race , and sex .
all analyses were conducted with sas statistical software version 9.2 ( sas institute , cary , nc ) .
the cardia study is a multicenter , longitudinal investigation of the evolution of ischemic heart disease risk starting in young adulthood ( 17 ) .
the study began in 19851986 with 5,115 black and white adults 1830 years of age from four metropolitan areas ( birmingham , al ; chicago , il ; minneapolis , mn ; and oakland , ca ) .
study participants were sampled to obtain roughly equal numbers of blacks ( 51.5% ) and whites ( 48.5% ) , men ( 45.5% ) and women ( 54.5% ) , 1824 years of age ( 44.9% ) and 2530 years of age ( 55.1% ) , and with a high school education or less ( 39.7% ) and with more than a high school education ( 60.3% ) .
participants were contacted by telephone every year and examined in person at baseline and 2 , 5 , 7 , 10 , 15 , 20 , and 25 years after baseline .
a majority of the group was examined at each of the follow - up examinations ( 91 , 86 , 81 , 79 , 74 , 72 , and 72% of survivors , respectively ) . at each clinical examination , participants were asked to present fasting in the morning .
tobacco use , strenuous physical activity , and intake of caffeine , food , and alcohol were proscribed .
the examinations followed standardized protocols harmonized over time and included measurements of blood pressure ( bp ) , anthropometrics , and phlebotomy and structured questionnaires on sociodemographics , medical and family history , psychosocial characteristics , and diet , among others .
the cardia study was approved by the institutional review board of each participating institution , and signed informed consent was obtained at each examination . during each clinic exam , blood was drawn from an antecubital vein , and after serum separation , aliquots were stored at 70c until shipped on dry ice to a central laboratory .
procedures followed in the collection and storage of plasma samples , laboratory quality - control procedures , and methodology for analysis of plasma triglycerides , hdl cholesterol , ldl cholesterol , and total cholesterol are described elsewhere ( 18 ) .
serum glucose was measured at year 0 using the hexokinase ultraviolet method by american bio - science laboratories ( van nuys , ca ) and at subsequent examinations using hexokinase coupled to glucose-6-phosphate dehydrogenase by linco research ( st .
bp was measured three times at 1-min intervals . at the baseline through year 15 follow - up exams , bp was measured using the hawksley ( lancing , sussex , u.k . ) random - zero sphygmomanometer ; the first and fifth phase korotkoff sounds were recorded ( 17 ) . at the year 20 and 25 exams , bp was measured with an automated sphygmomanometer ( omron hem907xl oscillometer ; omron , schaumburg , il ) .
the protocol specified the appropriate cuff size ( small , medium , large , or extra - large ) based on the upper arm circumference , which was measured by the bp technician at the midpoint between the acromion and the olecranon .
omron values were recalibrated to corresponding random zero values based on a study of both measurement techniques in 903 participants at year 20 , as estimated random zero systolic value = 3.74 + 0.96  omron systolic value , and estimated random zero diastolic value = 1.30 + 0.97  omron diastolic value ( 19 ) .
anthropometry ( height , weight , and waist circumference ) was measured at each exam .
body weight was measured to the nearest 0.2 kg using a calibrated balance beam scale in participants wearing light clothing .
height ( without shoes ) was measured to the nearest 0.5 cm using a vertical ruler and waist circumference to the nearest 0.5 cm at the minimal abdominal girth ( 20 ) .
diet was assessed at years 0 , 7 , and 20 by using an interviewer - administered cardia diet history questionnaire ( 21 ) .
interviewers asked open - ended questions about dietary consumption in the past month within 100 food categories that referenced 1,609 separate food items .
additionally , visits per week to fast food restaurants were queried at each examination , and frequency of breakfast , lunch , dinner , and morning , afternoon , and evening snacks ( days / week ) was queried at years 7 and 20 .
an a priori dietary quality score based on overall dietary intake was included as a covariate ( 16 ) . in brief , 46 food groups considered beneficial or adverse with respect to health effects were categorized by increasing consumption level with scores of 04 ( for 20 food groups considered beneficial ) , 40 ( for 13 food groups considered adverse ) , or 0 ( for 13 food groups considered neutral ) .
the a priori dietary quality score was the sum of category scores , with a theoretical maximum of 132 .
based on prior findings , it was assumed that a higher a priori dietary pattern score indicated better diet quality ( 2224 ) .
nutrient and energy estimates had larger variability among blacks than among whites ( 21,25 ) . for other covariates ,
sex , race , date of birth , education , and cigarette smoking were ascertained by a structured interview or self - administered questionnaire at each examination .
a physical activity score was derived from the cardia physical activity history , which is a simplified version of the minnesota leisure time physical activity questionnaire ( 26 ) .
obesity was defined as bmi 30 kg / m and abdominal obesity as waist circumference > 88 cm for women or > 102 cm for men .
hypertension was defined as systolic bp 140 mmhg , diastolic bp 90 mmhg , or self - reported use of antihypertensive medication .
the metabolic syndrome was defined using the national cholesterol education program ( ncep ) adult treatment panel ( atp ) iii criteria ( 27 ) as the presence of three or more of the following five conditions : 1 ) abdominal obesity , 2 ) fasting triglycerides 150 mg / dl , 3 ) hdl cholesterol < 40 mg / dl in men and < 50 mg / dl in women , 4 ) bp 130 mmhg systolic or 85 mmhg diastolic or use of antihypertensive medications , and 5 ) fasting glucose 100 mg / dl or use of diabetes medications .
incidence of type 2 diabetes was defined as use of diabetes medication ( assessed at every visit ) , a fasting blood glucose level of 6.99 mmol / l ( 126 mg / dl ) ( measured at years 1025 ) , 2 h postchallenge glucose 11.1
mmol / l ( 200 mg / dl ) ( performed at the year 10 , 20 , and 25 exams ) , and/or an hba1c 6.5% ( 48 mmol / mol ) ( assessed at the year 20 and 25 visits ) .
from the total sample of 5,115 , we excluded 1,029 who did not participate in the year 7 clinical exam , a further 171 who did not participate in any clinical exam in years 1025 , 60 with diabetes at year 7 , 215 without dietary data or with reported energy intakes not in the range of 8008,000 kcal / day for men and 6006,000 kcal / day for women , and 42 missing other data ( alcohol , smoking , or physical activity ) for an analytic sample of 3,598 . for analyses on outcomes other than type 2 diabetes ,
participants prevalent with the condition at year 7 were also excluded and total n is provided in tables .
breakfast intake frequency categories were created that allowed for logical cut points with a sufficient number of subjects .
baseline ( year 7 ) characteristics were calculated across breakfast intake frequency categories reported at this exam .
multivariable least squares  adjusted means from general linear models ( sas proc glm ) were used to estimate weight gain in kilograms and increase in waist circumference in centimeters by breakfast intake frequency categories .
the models adjust for age , study center , race , sex , education ( years ) , cigarette smoking ( current , former , or never ) , physical activity ( units / week ) , alcohol consumption ( ml / day ) , fast food restaurant use ( visits / week ) , overall dietary quality score , frequency of lunch / dinner and morning / afternoon / evening snacks ( days / week ) , total energy intake ( kcal ) , and weight or waist circumference and height at year 7 , respectively .
all participants were free of diabetes at each time point in the analysis of weight and waist circumference changes . proportional hazards ( cox ) regression ( sas proc phreg ) was used to examine the association between breakfast intake frequency categories and incidence of metabolic conditions .
time to event was calculated from the date of the baseline examination ( year 7 ) to the date of the first follow - up examination meeting the criteria for the incident outcome ( cases ) or to the date of the last cardia examination for each participant without the incident outcome ( censored ) .
the main model included age ( years ) , study center , race , sex , education ( years ) , cigarette smoking ( current , former , or never ) , physical activity ( units / week ) , alcohol consumption ( ml / day ) , fast food restaurant use ( visits / week ) , dietary quality score , frequency of lunch / dinner and morning / afternoon / evening snacks ( days / week ) , and total energy intake ( kcal ) .
depending on the outcome , either waist circumference ( cm ) or bmi ( kg / m ) from year 7 was included in a second model , and , for hypertension , a third model further adjusted for systolic bp at year 7 in analyses examining potential mediators .
there was no evidence that proportional hazards assumptions were violated for any of the outcomes as indicated by the lack of significant interaction between the breakfast intake frequency variable and time in the models .
tests for trend were performed by assigning the median value of intake frequency to the category and entering this as a continuous ordinal variable into the models .
effect modification of the associations was considered by level of the dietary quality index , bmi , race , and sex .
all analyses were conducted with sas statistical software version 9.2 ( sas institute , cary , nc ) .
based upon the year 7 data , 43.2% of participants reported infrequent breakfast intake ( 03 days / week ) , 21.7% reported eating breakfast frequently ( 46 days / week ) , and 35.1% of participants reported eating breakfast daily ( 7 days / week ) ( table 1 ) . with higher levels of breakfast intake ,
a greater proportion of participants were white and female and were on average more educated , consumed less alcohol , did not currently smoke , were more physically active , had a lower bmi , visited fast food restaurants less frequently , and had a higher dietary quality score .
participant characteristics according to breakfast frequency ( days per week ) : cardia year 7 , 19921993 over 18 years of follow - up , there was a significant mean weight gain in all participants free of diabetes throughout the study ; yet , frequent ( 46 days / week ) and daily breakfast consumers gained less weight relative to non- or infrequent breakfast consumers ( supplementary fig .
specifically , participants reporting daily breakfast intake gained 1.91 kg less than those reporting infrequent intake ( 03 days / week ) ( p = 0.001 ) over 18 years after full adjustment for demographic , lifestyle , dietary habits , and baseline weight .
, there was a stepwise decrease in crude incidence rate , and the incidence rate was nearly halved in daily breakfast consumers relative to those who were infrequent breakfast consumers ( 03 days / week ) ( table 2 ) .
these graded associations were evident in the main cox regression model adjusting for demographics , lifestyle covariates , and dietary habits .
relative to infrequent intake of breakfast , frequent breakfast intake ( 46 days / week ) and daily breakfast intake were each significantly associated with a decreased risk of abdominal obesity , obesity , metabolic syndrome , hypertension , and type 2 diabetes in a ranked manner . after adjustment for baseline measures of adiposity ( waist circumference [ cm ] or bmi [ kg / m ] ) , the associations were attenuated but a significant inverse association persisted between daily breakfast intake and abdominal obesity , obesity , metabolic syndrome , and hypertension .
hr and 95% ci of metabolic outcomes according to breakfast frequency : cardia years 725 ( 19921993 to 20102011 ) the estimates for incident type 2 diabetes were mediated upon adjustment for bmi in the whole - population hr and 95% ci for frequent breakfast intake ( hr 0.82 [ 95% ci 0.631.07 ] ) and daily intake ( 0.81 [ 0.631.05 ] ) . however , there was evidence that the results for type 2 diabetes differed in black women from those for the rest of the study sample ( table 3 ) . in black women , breakfast intake frequency
was not associated with incident type 2 diabetes , whereas the results were consistent and strongly inversely associated in black men and white men and women even after adjustment for bmi .
black women had the highest rate of incident diabetes in the cohort and greatest mean level of bmi in year 7 ( 29.0
kg / m ) relative to the rest of the study population ( black men , 27.0 kg / m ; white men , 26.0 kg / m ; white women , 24.9 kg / m ) .
adjustment for hypertensive status and medication did not materially alter the results for incident type 2 diabetes .
hr and 95% ci of type 2 diabetes according to breakfast frequency , stratified results : cardia years 725 ( 19921993 to 20102011 ) there was no evidence that the results varied for any of the other outcomes by race , sex , or bmi at baseline .
there was no evidence that adjustment for family history of type 2 diabetes or hypertension materially altered any of the results .
the frequency of lunch , dinner , or snacks was not associated with any of the outcomes . of note
, we also examined the association between breakfast intake frequency and future dyslipidemia ( low hdl cholesterol and elevated triglycerides per atp iii criteria ) .
there was an inverse , but nonsignificant , association with greater breakfast intake ( data not presented ) .
we hypothesized that the association between breakfast intake frequency and metabolic risk may vary by the quality of the overall dietary pattern , i.e. , any association may be limited to those with higher relative diet quality . however , we found no evidence in formal tests for interaction or stratified analyses that the relationship between breakfast intake frequency and metabolic risk was differential by overall dietary quality .
we present results from the analysis with metabolic syndrome ( table 4 ) as they are typical of findings for the outcomes examined .
we ranked the dietary quality score into quartiles , with the lowest representing the poorest overall quality and the highest representing a theorized best overall dietary pattern . across quartiles of dietary quality
, there was a stepwise decrease in incidence rate of metabolic syndrome with greater breakfast intake frequency .
the highest incident rates of metabolic syndrome were observed in infrequent breakfast consumers ( 03 days / week ) in the bottom half of overall dietary quality , whereas the lowest incident rates of metabolic syndrome were observed in the daily breakfast eaters in the top half of overall dietary quality . in the main stratified cox regression model ( model 1 ) , there was a graded inverse association with incident metabolic syndrome with more frequent breakfast intake across overall dietary quality ; however , the results were only suggestively significant in the lowest quartile of diet quality .
hr and 95% ci of metabolic syndrome according to breakfast frequency by overall dietary quality : cardia years 725 ( 19921993 to 20102011 ) we also performed a sensitivity analysis with metabolic syndrome as the outcome exploring the statistical effect of adjustment for common breakfast foods in the study ( timing of consumption was not asked ) .
the whole grain breakfast cereal food group was the only breakfast - oriented food to materially alter the point estimates in model 2 with metabolic syndrome as the outcome ( hr 0.86 [ 95% ci 0.721.02 ] ) for daily breakfast relative to infrequent breakfast .
the refined grain cereals , eggs , sausage / processed meats , fried potatoes , and donuts / pastries / cakes food groups did not materially alter the point estimates . of note , breakfast frequency at year 7 displayed an r = 0.46 ( p < 0.0001 ) correlation with breakfast frequency at year 20 . accounting for the year 20 breakfast data significantly depleted the analytic sample ( 4260% of sample depending on outcome ) since any prospective examination between year 20 and 25 exams required data from year 7 and 20 , no history of the respective metabolic condition at year 20 , and attendance at the year 25 exam . in the sensitivity
analyses accounting for the average breakfast intake over time in this subgroup ( years 7 and 20 ) , the results did not materially differ from the results presented using the year 7 data .
in black and white young adult men and women , frequent ( 46 days / week ) and daily ( 7 days / week ) breakfast consumption was associated with a decreased risk of developing abdominal obesity , obesity , metabolic syndrome , hypertension , and type 2 diabetes over 18 years of follow - up relative to their peers with infrequent breakfast consumption ( 03 days / week ) .
these findings remained significant for daily breakfast intake for all outcomes except type 2 diabetes after accounting for baseline measures of adiposity .
however , the inverse relationship between greater breakfast frequency and type 2 diabetes risk remained independent of bmi in black men and white men and women , whereas in black women , there was no association between breakfast intake and type 2 diabetes incidence . of note ,
counter to our hypothesis , the results were not explained by the overall quality of the dietary pattern .
prospective research examining a range of breakfast intake frequencies with metabolic outcomes is limited . in the only other study to examine a range of breakfast intakes ,
there was a gradient of bmi change in adolescents across categories of breakfast frequency , with never eaters experiencing the greatest increase and daily eaters experiencing the smallest increase ( 8) . in the health professionals study , breakfast consumers ( yes vs. no ) had a lower risk of a 5-kg weight gain over 10 years ( 9 ) . in a tangentially related study , greater intake frequency of both refined and whole grain ready - to - eat cereals was associated in a dose - dependent manner with lower mean weight gain and lower risk of becoming overweight ( bmi 25 kg / m ) ( 10 ) . in a similar examination of physicians health study data
, there was an inverse association between greater intake of cereal and risk of developing hypertension , although with greater limits in the interpretation due to the dietary assessment ( 12 ) . in a study of australian children who were followed up as young adults , those who reported yes at both childhood and young adulthood at a dichotomous assessment of breakfast consumption ( yes vs. no ) had lower levels of clinical cardiometabolic risk factors relative to those who skipped at different life - course points ( 14 ) .
two different studies have examined aspects related to breakfast in relation to type 2 diabetes . in the health professionals study , men who did not eat breakfast ( yes vs. no ) were at an increased risk of developing type 2 diabetes , and those who had a high western dietary pattern score and did not eat breakfast experienced an even greater risk of incident type 2 diabetes ( 13 ) .
the physicians health study also found that more frequent intake of ready - to - eat cereal , especially whole grain cereal , was inversely associated with risk of incident type 2 diabetes ( 11 ) .
two other studies have linked aspects of breakfast intake with reduced risk of mortality during their follow - up periods ( 28,29 ) . in summary ,
our study and these other studies all suggest that breakfast intake , or frequent consumption of foods associated with breakfast intake , is important for metabolic health .
cardia provides a unique and thorough look at the topic with data on the spectrum of possible breakfast intake frequencies as a dietary behavior .
this ability to examine the range of breakfast intake uniquely distinguishes it from previous research on the topic and better aligns the data with real - world behavior ( 8,15,16 ) .
furthermore , the quality of the overall dietary pattern is important for health ( 16 ) , but this did not explain our results , suggesting that the act of  breaking the fast  may have important metabolic health implications beyond the quality of the overall dietary pattern .
there are a number of plausible mechanisms whereby eating breakfast may improve acute and long - term factors salient for metabolic risk .
as summarized by timlin and pereira ( 6 ) , a spectrum of research provides evidence that the act of eating breakfast , as well as the content , plays important roles in factors related to appetite and hormone , glucose , insulin , and lipid metabolism . indeed , the time of day and frequency of eating , as well as content , have important independent effects on energy intake , dietary content , and hormonal response that are central to energy balance and thus adiposity ( 30,31 ) .
greater breakfast intake frequency was strongly and inversely associated with long - term risk of obesity in this study .
this appears to be a mechanism by which breakfast intake may reduce risk for metabolic syndrome , type 2 diabetes , and hypertension .
since these estimates were not completely mediated by adiposity in our statistical models , this suggests that breakfast intake impacts other avenues , likely hormonal glucose , insulin , and lipid metabolism factors central to these conditions ( 32 ) .
a few studies with experimental designs examined the effects of eating breakfast or a larger portion of daily energy intake in the morning on weight loss with some suggestion of benefit , but with mixed results possibly due to study design and sample size ( 33,34 ) .
other small experimental studies have found that omitting breakfast and the composition of breakfast have effects on appetite and metabolic parameters that could impact long - term metabolic risk ( 3537 ) .
further trials have demonstrated that the content of breakfast is likely important for lower metabolic risk as breakfast meals emphasizing low - glycemic whole grains had beneficial effects on appetite and metabolic parameters throughout the day ( 36,3840 ) .
the sensitivity analysis we performed examining different breakfast - type foods aligns with this point .
overall , the small base of prospective and experimental research on breakfast intake suggests that it may have an independent beneficial role in metabolic health .
prospective population studies examining breakfast habits and larger and longer experimental studies examining specific mechanisms addressing both the act of eating breakfast and the content would provide a more definitive level of evidence on breakfast intake and metabolic health
. they would also inform the level of emphasis that should be given to this dietary habit in relevant dietary interventions and overall dietary recommendations .
our study has a number of strengths : long - term , prospective study design , with high rates of follow - up ; standardized , valid , and reliable measurements of dietary practices ; extensive clinical measures and data on covariates with which to explore confounders and mediators of the associations under investigation ; and the demographics of the cohort , young adult black and white men and women from four u.s .
metropolitan areas who have been examined during a period of life when substantial weight gain occurs and metabolic complications develop .
limitations include some level of measurement error with the dietary assessment , although this would most likely result in nondifferential misclassification with respect to any of the outcomes and likely underestimation of risk .
although a working scientific definition of breakfast has been proposed in the time since cardia began ( 6 ) , there was no explicit definition of what constituted a breakfast meal in the cardia study .
the self - report of other lifestyle - related data may also result in some misclassification and residual confounding in our models . because of this , it is possible that the association between daily breakfast intake and significantly reduced metabolic risk is a proxy for an overall better diet and lifestyle . in conclusion ,
young adults who reported eating breakfast everyday had a significantly lower risk of an array of metabolic outcomes relative to their peers who infrequently or never ate breakfast , independent of adiposity and the overall quality of the dietary pattern .
our study and other burgeoning evidence ( 814 ) suggest that the science is catching up to the early nutritional beliefs related to the topic and eating a daily breakfast meal is a dietary habit that may be highly relevant for metabolic health .
 objectivethe relation of breakfast intake frequency to metabolic health is not well studied . 
 the aim of this study was to examine breakfast intake frequency with incidence of metabolic conditions.research design and methodswe performed an analysis of 3,598 participants from the community - based coronary artery risk development in young adults ( cardia ) study who were free of diabetes in the year 7 examination when breakfast and dietary habits were assessed ( 19921993 ) and participated in at least one of the five subsequent follow - up examinations over 18 years.resultsrelative to those with infrequent breakfast consumption ( 03 days / week ) , participants who reported eating breakfast daily gained 1.9 kg less weight over 18 years ( p = 0.001 ) . in a cox regression analysis , there was a stepwise decrease in risk across conditions in frequent breakfast consumers ( 46 days / week ) and daily consumers . the results for incidence of abdominal obesity , obesity , metabolic syndrome , and hypertension remained significant after adjustment for baseline measures of adiposity ( waist circumference or bmi ) in daily breakfast consumers . 
 hazard ratios ( hrs ) and 95% cis for daily breakfast consumption were as follows : abdominal obesity hr 0.78 ( 95% ci 0.660.91 ) , obesity 0.80 ( 0.670.96 ) , metabolic syndrome 0.82 ( 0.690.98 ) , and hypertension 0.84 ( 0.720.99 ) . 
 for type 2 diabetes , the corresponding estimate was 0.81 ( 0.631.05 ) , with a significant stepwise inverse association in black men and white men and women but no association in black women . 
 there was no evidence of differential results for high versus low overall dietary quality.conclusionsdaily breakfast intake is strongly associated with reduced risk of a spectrum of metabolic conditions . 
RESEARCH DESIGN AND METHODS
Study and data collection
Assessment of outcomes
Statistical analysis
RESULTS
CONCLUSIONS