a 61-year - old immunocompetent woman presented with a chronic headache for 10 months that had been progressively worsening for 18 days with emesis .
the patient was a peasant with no particular exposure to avian ( especially pigeon ) feces or woodworking .
the headache got worse , with several nonbloody , nonbilious vomiting episodes , and the patient developed an ataxic gait 18 days before hospital admission .
a comprehensive physical examination of her body at admission did not show any pertinent findings .
she could not complete the hand alternating movement test , her right side of finger 
nose test was positive , and her heel - knee - tibia test was suspiciously positive , but romberg s sign was negative .
the cryptococcal antigen latex agglutination test of csf was negative the first time , but it was positive the second time ; the titer was 1:32 .
a plain magnetic resonance imaging ( mri ) scan of the head demonstrated a 262116 mm nodule as long or equal to t1 and long t2 signal in the right cerebellar hemisphere with no adjacent edema , and the nodule was significantly enhanced as nodular with a thick and annular wall after contrast administration ( figure 1c  e ) .
there was no midline shift , and the compression of adjacent structures was not apparent ( figure 1a and b ) .
the patient was considered to have a metastatic tumor or glioma in the right cerebellar hemisphere .
the cerebellar nodule was removed by neurosurgery via a suboccipital craniotomy in the left lateral position .
an 80 mm long straight incision was made 20 mm outside the right side of the occipital bone of the lower lateral hairline .
intraoperatively , the lower part of the transverse sinus and the surface layer of cerebellum were exposed .
subcortical dissection was performed until a 403020 mm firm nodule with moderate vascular supply and distinct border was identified , located at the upper portion of the right cerebellar hemisphere .
the blood vessels that supply for the nodule were cut off by electrocoagulation , and then en bloc resection of the nodule along the border was performed .
a large number of mononuclear cells and multinucleated giant cells were seen , with diffused distribution .
there was a small amount of bacteria circular structure and mesenchyme hyalinization , with a large number of lymphocytes and a few plasma cell infiltrations ; local tissue necrosis with neutrophil infiltration was also found in the frozen section tissues ( figure 1f ) .
immunohistochemical staining yielded cd68 ( + ) , cytokeratin (  ) , epithelial membrane antigen (  ) , glial fibrillary acidic protein (  ) , ki-67 (  ) , neurofilament( ) , neuron - specific enolase (  ) , soluble - protein 100 (  ) , vimentin ( + ) , cluster of differentiation 1a (  ) , and thallus periodic acid - schiff stain ( + ) . the neuropathology evidenced a right cerebellar cryptococcal granuloma .
a 61-year - old immunocompetent woman presented with a chronic headache for 10 months that had been progressively worsening for 18 days with emesis .
the patient was a peasant with no particular exposure to avian ( especially pigeon ) feces or woodworking .
the headache got worse , with several nonbloody , nonbilious vomiting episodes , and the patient developed an ataxic gait 18 days before hospital admission .
a comprehensive physical examination of her body at admission did not show any pertinent findings .
she could not complete the hand alternating movement test , her right side of finger 
nose test was positive , and her heel - knee - tibia test was suspiciously positive , but romberg s sign was negative .
the cryptococcal antigen latex agglutination test of csf was negative the first time , but it was positive the second time ; the titer was 1:32 .
a plain magnetic resonance imaging ( mri ) scan of the head demonstrated a 262116 mm nodule as long or equal to t1 and long t2 signal in the right cerebellar hemisphere with no adjacent edema , and the nodule was significantly enhanced as nodular with a thick and annular wall after contrast administration ( figure 1c  e ) .
there was no midline shift , and the compression of adjacent structures was not apparent ( figure 1a and b ) .
the patient was considered to have a metastatic tumor or glioma in the right cerebellar hemisphere .
the cerebellar nodule was removed by neurosurgery via a suboccipital craniotomy in the left lateral position .
an 80 mm long straight incision was made 20 mm outside the right side of the occipital bone of the lower lateral hairline .
intraoperatively , the lower part of the transverse sinus and the surface layer of cerebellum were exposed .
subcortical dissection was performed until a 403020 mm firm nodule with moderate vascular supply and distinct border was identified , located at the upper portion of the right cerebellar hemisphere .
the blood vessels that supply for the nodule were cut off by electrocoagulation , and then en bloc resection of the nodule along the border was performed .
a large number of mononuclear cells and multinucleated giant cells were seen , with diffused distribution .
there was a small amount of bacteria circular structure and mesenchyme hyalinization , with a large number of lymphocytes and a few plasma cell infiltrations ; local tissue necrosis with neutrophil infiltration was also found in the frozen section tissues ( figure 1f ) .
immunohistochemical staining yielded cd68 ( + ) , cytokeratin (  ) , epithelial membrane antigen (  ) , glial fibrillary acidic protein (  ) , ki-67 (  ) , neurofilament( ) , neuron - specific enolase (  ) , soluble - protein 100 (  ) , vimentin ( + ) , cluster of differentiation 1a (  ) , and thallus periodic acid - schiff stain ( + ) . the neuropathology evidenced a right cerebellar cryptococcal granuloma .
cns cryptococcosis is a kind of subacute or chronic deep mycosis caused by cryptococcus neoformans.1 cryptococcus neoformans mainly spreads via the respiratory route and infects predilection sites in cns via hematogenous spread .
it usually infects patients with immunosuppression , especially aids patients , as well as patients with obvious consumptive disease and patients who consumed extensive immunosuppressants and extensive broad - spectrum antibiotic therapy .
however , the morbidity of cryptococcosis in immunocompetent patients has increased in recent years.2 the main pathologic changes of cns cryptococcosis were meningitis , meningoencephalitis , vasculitis , and rarely , granulomas .
furthermore , intracranial cryptococcal granulomas were significantly more common in the cerebral hemisphere than in the cerebellar hemisphere .
there are two recognized varieties of cryptococcus neoformans : cryptococcus neoformans var neoformans and cryptococcus neoformans var gattii , which rarely infected immunocompromised patients while usually infecting immunocompetent patients.3,4 cerebral cryptococcoma is the most common form of expression in immunocompetent individuals.5,6 there are only a few cases of isolated cerebellar cryptococcoma that were reported in immunocompetent patients.710 the clinical feature of cns cryptococcosis is highly variable and nonspecific , which is related to immune status and the types of cryptococcus.11 because of its insidious onset , progressive intracranial hypertension may be the initial symptom , characterized by headache , nausea , and vomiting , and then followed with other symptoms , such as cranial nerve damage and focal neurological signs .
the imaging diagnosis of immunocompetent patients with cerebellar cryptococcomas is a challenge . in general , csf , including pressure measurement , routine tests , biochemistry indicators , and examination of ink stain of csf , is essential to the diagnosis .
cryptococcal antigens latex agglutination test of cerebrospinal fluid and blood examination contribute to the diagnosis , but the definitive diagnosis of cryptococcosis must be confirmed by histopathologic examination . in the current patient ,
the diagnosis of cerebellar cryptococcoma was confirmed by histopathology , whereas the csf and cryptococcal antigen latex agglutination tests were both negative .
different sites , pathological types , and stages of cns cryptococcosis may show different computed tomographic ( ct ) and mri findings.12 early stages of cryptococcosis may not show any abnormal ct findings , but a few nonspecific manifestations , including diffuse cerebral atrophy , hydrocephalus , and diffuse cerebral edema , can be found.3,13 cryptococcoma can appear as a localized tumor - like mass when the fungus has involved brain parenchyma .
cryptococcus tumors typically show long t1 and long t2 signals on mri , as well as circular enhancement.14 although certain characteristic imaging findings have been described , the differential diagnosis is still difficult because of the overlap of imaging findings with granulomatous tumors and abscesses , especially the tuberculous granuloma . early diagnosis and early initiation of treatment are associated with a good prognosis
the therapeutic goal is to control the initial infection and lifelong antifungal therapy for patients with hiv coinfection and to cure the cryptococcus infection completely for patients without hiv coinfection .
the lack of specificity of clinical manifestations and the low detection rate of cryptococcus in csf bring difficulties to its diagnosis . in this reported case ,
cns cryptococcosis manifested as an intracranial lesion , which was misdiagnosed as a tuberculoma or a cerebral tumor .
 central nervous system ( cns ) cryptococcosis is an opportunistic fungal infection that typically occurs in patients with reduced immunological function , such as patients with aids , patients receiving organ transplants , or patients receiving corticosteroid and immunosuppressive therapy . 
 cns cryptococcosis rarely occurs in immunocompetent patients . 
 cns cryptococcosis is characterized by meningitis and encephalitis and occasionally forms isolated granulomas . 
 isolated cerebellar cryptococcoma is a rare condition , especially in immunocompetent patients , and the misdiagnosis rate is high . 
 a definite diagnosis must be based on pathology . to raise awareness of this disease , 
 the clinical data of a patient with cryptococcomas in the right side of the cerebellum are reported . 
Introduction
Clinical presentation
Imaging examination
Operation
Pathological manifestations
Discussion
Conclusion