 common fragile sites ( cfss ) tend to break upon replication stress and have been suggested to be  hot spots  for genomic instability . 
 recent evidence , however , implies that in the wake of dna damage , ww domain - containing oxidoreductase ( wwox , the gene product of the fra16d fragile site ) , associates with ataxia telangiectasia - mutated ( atm ) and regulates its activation to maintain genomic integrity . 
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