 akap79/150 is a protein scaffold thought to position specific kinases ( pka , pkc ) and phosphastases ( calcineurin ) in appropriate synaptic domains so that their activities can regulate excitatory synaptic strength . using a viral - mediated molecular replacement strategy in rat hippocampal slices 
 , we found that akap is required for nmda receptor - dependent ltd solely due to its interaction with calcineurin . 
Supplementary Material