 to identify risk variants for childhood acute lymphoblastic leukemia ( all ) we conducted a genome - wide association study of 2 case - control series , analyzing the genotypes of 291,423 tagging snp genotypes in a total of 907 all cases and 2,398 controls . 
 we identified risk loci for all at 7p12.2 ( ikzf1 , rs4132601 ; or = 1.69 , p = 1.20 x 10 - 19 ) , 10q21.2 ( aridb5 , rs7089424 ; or = 1.65 , p = 6.69 x 10 - 19 ) and 14q11.2 ( cebpe , rs2239633 ; or = 1.34 , p = 2.88 x 10 - 7 ) . 
 the 10q21.2 ( aridb5 ) risk association appears to be selective for the subset of b - cell precursor all with hyperdiploidy . 
 these data show that common low - penetrance susceptibility alleles contribute to the risk of developing childhood all and provide novel insight into disease causation of this hematological cancer ; notably all 3 risk variants map to genes involved in transcriptional regulation and differentiation of b - cell progenitors . 
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