although infrequent ( 1% to 4% in the first year ) , infective endocarditis may occur after aortic valve replacement.13 when present , prosthetic valve endocarditis is a severe problem that is associated with considerable morbidity , especially related to peripheral embolism , perivalvular abscess , and sepsis.49 acute coronary syndromes are uncommon in prosthetic valve endocarditis , with a prevalence of between 1% and 3%.10 the most likely mechanisms responsible for myocardial ischemia are the presence of preexisting coronary artery disease and coronary emboli from aortic vegetations .
other less frequent mechanisms have been described , such as obstruction of the coronary ostium due to large vegetation and severe aortic insufficiency.1014 external coronary artery compression due to infective endocarditis is also a described mechanism , but is a rare occurrence with only few cases reported in medical literature.11,1421 we report a 46-year - old patient who presented with acute myocardial infarction caused by an aortic root abscess , which resulted in the external compression of the left main coronary artery .
a 46-year - old man presented at instituto de cardiologia do distrito federal , brasilia , brazil with a history of dyspnea and fatigue exacerbated by a recent hospitalization related to pulmonary edema .
diagnosis was confirmed by echocardiography , which revealed the presence of a bicuspid aortic valve with mixed lesion , predominantly stenotic .
the operation and his postoperative recovery were uneventful , and the patient was discharged home on the sixth day after the procedure in good condition . he was prescribed the following medications to take at home : enalapril 5 mg twice daily , carvedilol 6.25 mg twice daily , furosemide 20 mg daily , and ferrous sulfate 300 mg daily ( orally ) .
approximately 1 month later , the patient returned , complaining of a high - grade fever and chills for a few days .
he was admitted to the emergency department with acute onset chest pain , dyspnea , and vomiting . on physical exam , he was lethargic , febrile , pale , and hemodynamically unstable , with cold extremities and faint pulses .
admitting electrocardiogram revealed normal sinus rhythm , signs of left ventricle hypertrophy , and st depression on posterior and lateral leads ( figure 1 ) .
the cardiologist on call interpreted the patient as having non - st elevation acute coronary syndrome , and treated him with aspirin , clopidogrel , morphine , and heparin . an emergent coronary angiogram ( figure 2a ) revealed a long , complex lesion on the left main coronary artery ( 80% lumen obstruction ) with tapering contor , suggesting extrinsic compression .
due to ongoing myocardial ischemia and hemodynamic compromise , an intra - aortic balloon pump was inserted .
before the blood cultures results were available , broad - spectrum anti biotics ( vancomycin , rifampicin , and imipenem ) and also an anti - fungal drug ( amphotericin b ) were initiated empirically .
transesophageal echocardiog - raphy showed vegetations attached to the prosthesis , aortic root abscess , and an aortic - to - right - atrium fistula .
left ventricle ejection fraction was 36% , and there were wall motion abnormalities on lateral and anterior walls .
chest computed tomography ( figure 2b ) suggested that left main compression was due to aortic root abscess or hematoma . urgent reoperative aortic valve replacement was indicated .
the operation was performed with the aid of hypothermic cardiopulmonary bypass with aortic and bicaval cannulation .
myocardial protection was achieved with cold blood cardioplegia delivered through the coronary ostium and coronary sinus .
an oblique aortic arteriotomy revealed a large anterior aortic root abscess , which had invaded the left and right coronary cuspids .
the bioprosthesis was removed , and the abscess was evacuated ; complete debridement of all infected material was also performed .
the aortic - to - right atrium fistula was closed with an autologous pericardium patch . additionally , a coronary artery bypass grafting with a reversed saphenous vein graft to left anterior descending artery was performed . prolonged cardiopulmonary bypass and mediastinal
bleeding were problems in the operating room , requiring vigorous transfusion and delayed chest closure on the next day .
postoperatively , the patient had acute renal failure requiring hemodialysis , sepsis , transient liver failure , prolonged mechanical ventilation , and complete atrioventricular block requiring permanent pacemaker .
antibiotic therapy , as previously mentioned , was initiated empirically with vancomycin , rifampicin , imipenem , and amphotericin b. rifampicin was discontinued on the second day of use due to mild liver failure .
vancomycin was replaced by teicoplanin shortly after the operation due to acute renal failure , and it was used until the 30th postoperative day .
then , it was replaced by fluconazole , which was continued for a year thereafter .
a month after the operation , the left ventricular function had improved ( ejection fraction of 58% ) with a mildly dilated ventricle and a normal aortic valve function .
the patient was discharged home 6 weeks after surgery in good condition , with no signs of active infection . at 36-month follow - up
, the patient is currently in new york heart association functional class i with no recurrent infection , and the ventricular function is normal .
the left main is widely patent and the saphenous vein graft is occluded on control chest computed tomography ( figure 3 ) .
the present case describes a rare complication of prosthetic valve endocarditis , an aortic root abscess causing external coronary artery compression and acute myocardial infarction .
this mechanism of myocardial infarction has already been described.11,1421 the most likely mechanisms responsible for myocardial infarction during infective endocarditis are preexisting coronary artery disease and coronary artery emboli from vegetations .
prosthetic valve endocarditis is associated with elevated hospital mortality ( approximately 40%)22 and morbidity dependent on the infecting pathogen , duration of illness prior to therapy , and underlying comorbidities.23 mansur et al24 presented a total of 386 complications in 223 episodes of endocarditis ( 74% complication rate ) , being 100 occurrences of cardiac complications ( severe heart failure , valve injury , pericarditis , acute myocardial infarction , conduction abnormalities , fistulous communication , perivalvular abscess , and others ) , 72 neurologic complications ( cerebral embolism , mycotic aneurysms , meningitis , stroke , intracranial hemorrhage , cerebral abscess , and others ) , 46 septic complications ( infection unresponsive to treatment , persistent fever , disseminated intravascular coagulation , and others ) , 27 renal complications ( renal failure , nephrotic syndrome ) , 16 extracranial systemic arterial complications , 26 septic pulmonary embolisms , three splenic infarctions or abscesses , and some other complications associated with infective endocarditis .
clinical presentation of acute coronary syndromes in patients with endocarditis is similar to those with coronary artery disease . as systems attempt to meet stringent door - to - balloon initiatives , it becomes imperative that a detailed history and physical exam be performed in this narrow time window in order to avoid unnecessary tests and/or therapeutic regimens .
for instance , the diagnostic work - up of a patient with a clinical history of high - grade fever and chills within a month after a straightforward aortic valve replacement with known absence of coronary artery disease includes , firstly , a transesophageal echocardiography.17 it has a sensitivity and a specificity for abscess detection of 87% and 95% , respectively.25 coronary angiogram in this particular patient was indicated based on a misdiagnosis of coronary artery disease . although the angiographic appearance is typical ( complex and long lesion that often disappears on diastole ) , coronary angiogram
should be avoided because it may cause dislodgment of septic fragments , which fortunately did not occur in this particular case .
the isolation of the causative organism of prosthetic valve endocarditis is essential , and antibiotic therapy should be delayed pending the blood culture results in cases of patients who are hemodynamically stable with an indolent clinical course .
however , patients presenting hemodynamic instability or acute disease should receive empiric broad - spectrum antibiotic therapy promptly.26 therapy should be subsequently adjusted according to the culture results .
the american heart association ( aha ) and the european society of cardiology ( esc ) guidelines recommend that prosthetic valve endocarditis should be treated for at least 6 weeks with adequate bactericidal agent .
presence of acute coronary syndrome in the setting of prosthetic valve endocarditis carries an elevated morbidity and mortality rates.27 although uncommon , external compression of coronary artery should be considered in the differential diagnosis of these patients , and adequate diagnostic work - up and treatment should be indicated.11 treatment with anti - platelet agents increased the risk of cerebral bleeding and certainly complicated the operative treatment in this patient.28 although the patient was a very high - risk surgical candidate , the urgent operation was justified due to patient s age and treatable heart problems , despite the presence of active infection , aortic root invasion , and abscess .
the root abscess perforated the membranous septum , causing aortic to right atrium fistula , and there was a huge invasion of the left coronary cuspid around the left main coronary artery , which caused its extrinsic compression and myocardial ischemia .
the treatment of prosthetic endocarditis was standard : extensive debridement , patch closure of fistula , and aortic root replacement with cryopreserved homograft.29 coronary artery bypass to left anterior descending was also performed in order to guarantee an adequate myocardial blood flow shortly after the operation . the adequate coronary button re - implant and obstruction relief established good coronary perfusion , and the saphenous vein graft has occluded due to competitive flow .
we experienced a rare complication of prosthetic valve endocarditis : external coronary artery compression due to aortic root abscess .
although uncommon , this mechanism should be considered in the differential diagnosis of patients presenting acute coronary syndrome in the setting of prosthetic valve endocarditis , and adequate diagnostic work - up and treatment should be indicated .
 a 46-year - old man with bicuspid aortic valve and severe calcific aortic stenosis was submitted to aortic valve replacement with a stented bioprosthesis . 
 he developed staphylococcus epidermidis prosthetic valve endocarditis a month later , presenting in the emergency room with acute myocardial infarction . 
 the mechanism of myocardial ischemia was a large aortic root abscess causing left main extrinsic compression . 
 he was urgently taken to the operating room , and an aortic root replacement with cryopreserved homograft was performed , associated with autologous pericardium patch closure of aortic to right atrium fistula and coronary artery bypass grafting of the left anterior descending . after a difficult postoperative period with multiple problems , he was eventually discharged home . at 36-month follow - up , 
 he is asymptomatic with no recurrent infection , and the left main coronary artery is widely patent on control chest computed tomography . 
Introduction
Case description
Discussion
Conclusion