the following online material is available for this article : expression abundance of 69 dna repair genes during rat liver regeneration .
comparison of relative mrna levels in regenerating liver detected by real - time rt - pcr and affy - metrix rat genome 230 2.0 microarray .
 rapidly proliferating tissue may require enhanced dna repair capacity in order to avoid fixation of promutagenic dna lesions to mutations . 
 partial hepatectomy ( ph ) triggers cell proliferation during liver regeneration ( lr ) . 
 however , little is known on how dna repair genes change and how they are regulated at the transcriptional level during lr . in the present study , 
 the rat genome 230 2.0 array was used to detect the expression profiles of dna repair genes during lr , and differential expression of selected genes was confirmed by real - time rt - pcr . 
 69 dna repair genes were found to be associated with lr , more than half of which distributed in a cluster characterized by a gradual increase at 2472h and then returning to normal . 
 the expression of base excision repair- and transcription - coupled repair - related genes was enhanced in the early and intermediate phases of lr , whereas the expression of genes related to hr , nhej and dna cross - link repair , as well as dna polymerases and related accessory factors , and editing or processing nucleases , were mainly enhanced in the intermediate phase . 
 the expression changes of genes in dna damage response were complicated throughout the whole lr . 
 our data also suggest that the expression of most dna repair genes may be regulated by the cell cycle during lr . 
Supplementary Material