this study was conducted to evaluate the prophylactic effect of ginger extract on ethanol - induced reproductive toxicity in male rats by measuring the total homocysteine ( thcy ) , trace elements , antioxidant enzymes activity including glutathione peroxidase , superoxide dismutase ( sod ) and catalase , and malondialdehyde ( mda ) .
twenty - eight adult male sprague  dawley rats were randomly divided into four experimental groups and treated daily for 28 days as follows : control , control+ginger ( 1 g / kg of body weight ( b.w)/day by gavage ) , test group ( ethanol 4 g / kg of b.w / day by gavage ) , and treated group ( ethanol+ginger ) . at the end of the experiment , all the rats were sacrificed and their testes were removed and used for the measurement of the above factors .
the results in the test group indicated that ethanol decreased antioxidant enzymes activity and increased mda and thcy compared with the control groups ( p<0.05 ) . in the treated group , ginger extract
improved antioxidant enzymes activity and reduced thcy and mda level compared with the test group ( p<0.05 ) .
it can be concluded that ethanol causes oxidative stress in testis and ginger extract improves the trace elements , antioxidant enzymes activity , and decreases thcy and mda .
 background : ginger is a natural dietary component with antioxidant and anti - carcinogenic properties . 
 this study was conducted to evaluate the prophylactic effect of ginger extract on ethanol - induced reproductive toxicity in male rats by measuring the total homocysteine ( thcy ) , trace elements , antioxidant enzymes activity including glutathione peroxidase , superoxide dismutase ( sod ) and catalase , and malondialdehyde ( mda).methods : twenty - eight adult male sprague  dawley rats were randomly divided into four experimental groups and treated daily for 28 days as follows : control , control+ginger ( 1 g / kg of body weight ( b.w)/day by gavage ) , test group ( ethanol 4 g / kg of b.w / day by gavage ) , and treated group ( ethanol+ginger ) . at the end of the experiment , all the rats were sacrificed and their testes were removed and used for the measurement of the above factors.results:the results in the test group indicated that ethanol decreased antioxidant enzymes activity and increased mda and thcy compared with the control groups ( p<0.05 ) . in the treated group , ginger extract improved antioxidant enzymes activity and reduced thcy and mda level compared with the test group ( p<0.05).conclusion : it can be concluded that ethanol causes oxidative stress in testis and ginger extract improves the trace elements , antioxidant enzymes activity , and decreases thcy and mda . 
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