a 56-year - old female was referred to oculoplastics at the king khaled eye hospital ( kkesh ) due to complaints of continuous pain and discharge in the right socket that had begun 4 months prior to presentation .
the patient had a history of perforating trauma followed by phthisis bulbi in the right eye when she was 3 years old , and she underwent enucleation without placement of an orbital implant a few years later . when she was 35 years old , she underwent surgery for the placement of an rtv silicone subperiosteal implant in the right orbit to improve the socket volume .
ptosis repair was carried out at the age of 37 years , dermis fat graft at the age of 47 years , and a mucous membrane graft and deepening sutures to improve the cul - de - sac at the age of 52 years . on examination , she had a bulging dystopic external prosthesis and the eyelids did not close properly .
the socket was inflamed , grade 3 , with mild redness and copious discharge ( fig . 1 ; upper row ) .
the patient was treated with neomycin , bacitracin and dexamethasone drops ( maxitrol ; allergan inc . ,
a ct scan of the orbit showed dense material along the extraconal space of the right orbital cavity adjacent to the right orbital roof and lateral wall with rarefaction along the inner layer and minimal hyperostosis ( fig . 1 ; lower row ) .
the patient underwent surgical excisional biopsy of the foreign body through a crease approach . during the surgery
, we found that the material was surrounded by a hard pseudocapsule with the consistency of bone and inflammatory tissue .
a 48-year - old male was referred to the kkesh due to complaints of pain , copious discharge , redness , contracted cavity and poorly fitting prosthesis in the left eye .
the patient had been involved in a road traffic accident when he was 28 years old .
he underwent enucleation of the left eye without placement of a spherical implant in the left socket .
subsequently , multiple surgeries were performed for socket reconstruction followed by mucous membrane graft , deepening sutures , implantation of a secondary polymethyl methacrylate implant and , later , removal thereof due to dehiscence and exposure , as well as pyogenic granuloma excision . on examination ,
examination of the left eye and ocular adnexa indicated an anophthalmic cavity with a grade 4 contracted socket , inflammation , with significant discharge and redness .
the patient was treated with corticosteroids resulting in temporary improvement with recurrence after tapering the steroid .
ct scan and magnetic resonance imaging ( mri ) indicated an irregular foreign body located in the left orbital roof , associated with adjacent inflammatory changes involving the extraocular muscles ( fig .
a rubber - like foreign body was identified and removed after removal of the surrounding bony layer ( fig .
a 56-year - old female was referred to oculoplastics at the king khaled eye hospital ( kkesh ) due to complaints of continuous pain and discharge in the right socket that had begun 4 months prior to presentation .
the patient had a history of perforating trauma followed by phthisis bulbi in the right eye when she was 3 years old , and she underwent enucleation without placement of an orbital implant a few years later . when she was 35 years old , she underwent surgery for the placement of an rtv silicone subperiosteal implant in the right orbit to improve the socket volume .
ptosis repair was carried out at the age of 37 years , dermis fat graft at the age of 47 years , and a mucous membrane graft and deepening sutures to improve the cul - de - sac at the age of 52 years . on examination , she had a bulging dystopic external prosthesis and the eyelids did not close properly .
the socket was inflamed , grade 3 , with mild redness and copious discharge ( fig . 1 ; upper row ) .
the patient was treated with neomycin , bacitracin and dexamethasone drops ( maxitrol ; allergan inc . ,
a ct scan of the orbit showed dense material along the extraconal space of the right orbital cavity adjacent to the right orbital roof and lateral wall with rarefaction along the inner layer and minimal hyperostosis ( fig . 1 ; lower row ) .
the patient underwent surgical excisional biopsy of the foreign body through a crease approach . during the surgery
, we found that the material was surrounded by a hard pseudocapsule with the consistency of bone and inflammatory tissue .
a 48-year - old male was referred to the kkesh due to complaints of pain , copious discharge , redness , contracted cavity and poorly fitting prosthesis in the left eye .
the patient had been involved in a road traffic accident when he was 28 years old .
he underwent enucleation of the left eye without placement of a spherical implant in the left socket .
subsequently , multiple surgeries were performed for socket reconstruction followed by mucous membrane graft , deepening sutures , implantation of a secondary polymethyl methacrylate implant and , later , removal thereof due to dehiscence and exposure , as well as pyogenic granuloma excision . on examination ,
examination of the left eye and ocular adnexa indicated an anophthalmic cavity with a grade 4 contracted socket , inflammation , with significant discharge and redness .
the patient was treated with corticosteroids resulting in temporary improvement with recurrence after tapering the steroid .
ct scan and magnetic resonance imaging ( mri ) indicated an irregular foreign body located in the left orbital roof , associated with adjacent inflammatory changes involving the extraocular muscles ( fig .
a rubber - like foreign body was identified and removed after removal of the surrounding bony layer ( fig .
the clinical symptoms of both our cases at presentation were pain , copious discharge , intense inflammation , redness and a contracted socket . also , both patients had a history of multiple surgeries to correct the chronic problems in the anophthalmic socket .
the chronic discharge in both patients was related to an intense chronic inflammation in the orbital tissues .
this is a very common symptom in patient with an anophthalmic cavity likely due to various causes including dry socket ( common in sockets because of the absent corneal reflex ) , incomplete blink , meibomian gland inflammation , giant papillary conjunctivitis ( mechanical damage from the external prosthesis to the conjunctiva and hypersensitivity to proteins deposited over the prosthesis ) , implant exposition or pyogenic granuloma ( secondary to suture or implant exposure ) .
both patients complained about pain , which may be due to chronic inflammation in the socket .
alternatively , pain may be due to  phantom eye syndrome that can occur in one third of anophthalmic cavity carriers as a result of the interruption of the sensory nerves impulse , due to the reorganization of the neurosensory cortex , or due to the regenerative sprouting of the axons resulting in a neuroma . in the current study ,
both patients presented with contracted cavities with chronic inflammation of the socket related to progressive contraction of the anophthalmic cavity , often associated with the presence of myofibroblast , a modified fibroblast linked to the contracted sockets [ 5 , 6 ] .
one of the primary goals of anophthalmic socket treatment is the restoration of an adequate orbital volume through the use of appropriately sized spherical alloplastic implants .
complications of all types of implants can result in discharge , implant exposure , conjunctival thinning , pyogenic granuloma formation , implant infection , with persistent pain or discomfort .
notably , the two cases reported here did not receive a spherical implant in the anophthalmic socket , but a silastice rtv silicone rubber base for volume replacement in the anophthalmic socket .
this is a biomaterial which can be used in the orbital floor , lateral wall and roof .
the rtv silicone rubber base is a brand injectable silicone rubber elastomer , considered to be a biologically inert , nontoxic , nonreactive thermally stable elastomer , which is resistant to oxidation and vulcanizes at room temperature .
rtv silicone with a catalyst was placed in a dissected pocket subperiosteally along orbital walls to correct the volume deficit in both cases , vulcanizing the implant in situ into soft silicone rubber and conforming the implant to the orbital wall [ 9 , 10 ] . in the current cases , ct studies imaged the implant as a foreign body , which was confirmed by mri in 1 patient .
the rtv implant was placed in both patients a few years after the enucleation , and they developed inflamed and contracted sockets with poor cosmetic results .
however , good outcomes without complications have been reported with this implant [ 11 , 12 , 13 ] .
the most important difference between our cases and the literature is the duration of follow - up .
our cases had the implant inserted 21 years ( case 1 ) and 20 years ( case 2 ) ago , which represents the longest follow - up for rtv implants .
hence , long - term follow - up is fundamental to understand the biocompatibility of the implants , as complications such as rejection and subsequent infection , cellulitis , or migration of the material could occur with any type of implants over the lifetime of the patient .
we do not know why the previous surgeons opted to use subperiosteal instead of spherical implants to replace socket volume in both patients .
both patients had fat atrophy , deep socket , superior sulcus atrophy and poor cosmesis with the prosthesis due to the sunken cavity .
other common complications related to silicone implants include hemorrhage , infection , periorbital cellulitis , migration , extrusion , skin fistulae , and sino - orbital fistulae
. the index of suspicion should be high when there is persistent conjunctival inflammation despite topical antimicrobial drops , discomfort on palpation of the implant , and pyogenic granuloma .
some have reported that locally all the silicone implants ( injectable , sheets or blocks ) induce a limited foreign body reaction , which may result in a fibrous pseudocapsule around the implant with the possibility of contraction , leading to migration of the implant [ 3 , 12 ] , with the possibility of chronic inflammation secondary to the presence of the silicone orbital implant . in the current cases , the chronic inflammation resolved in both patients after the removal of the implants .
if , at some point , an implant was placed , chronic inflammation indicates that implant removal is warranted and lifetime follow - up is required [ 14 , 15 ] . in conclusion , our cases presented with chronic inflammation in an anophthalmic socket due to a foreign body reaction against the injectable silicone rtv implant .
anophthalmic cavity carriers presenting with recurrent inflammation have to be investigated according to their previous orbital surgeries and the type of implants .
orbital imaging is helpful in localizing the cause and determining treatment , such as implant removal .
the authors received no financial support for this study and have no financial or proprietary interest in the materials presented in this study .
 two case reports are used to illustrate the signs and symptoms , complications and treatments of chronic socket inflammation due to intraorbital implants . the ophthalmic examination , 
 surgeries and treatments are documented . 
 two anophthalmic cases that underwent enucleation and multiple orbital surgeries to enhance the anophthalmic socket volume developed pain , intense discharge and contracted cavities with chronic inflammation in the socket which was nonresponsive to medical therapy . computed tomography indicated a hypodense foreign body in both cases causing an intense inflammatory reaction . 
 the implants were removed by excisional surgery and a room temperature vulcanized silicone implant was retrieved in both cases . 
 socket inflammation resolved in both cases after implant removal . 
 an intraorbital inflammatory reaction against an intraorbital implant can cause chronic socket inflammation in patients with a history of multiple surgeries . 
 diagnosis requires imaging and the definitive treatment is implant removal . 
Case Reports
Case 1
Case 2
Discussion
Statement of Ethics
Disclosure Statement