several countries , such as chile ( 46.1  100,000 inhabitants ) , costa rica ( 41.2  100,000 inhabitants ) , ecuador ( 37.8  100,000 inhabitants ) , and peru ( 37.5  100,000 inhabitants ) have a high rate , while other countries , such as paraguay ( 19.5  100,000 inhabitants ) , argentina ( 14.6  100,000 inhabitants ) , and mexico ( 13.1  100,000 inhabitants ) , have much lower rates.2,3 in mexico , according to the official histopathological registry of neoplasms , gastric cancer is the fifth - most prevalent form of cancer in the general population ( 3.4% ) , with a calculated incidence rate of 10.9 per 100,000 inhabitants .
types of cancer that are more common in mexico are cancer of the uterine cervix , skin cancer ( nonmelanoma ) , breast cancer , and prostate cancer ( which is the most common form of cancer in the country ) .
gastric cancer is the second - leading cause of death from cancer in mexico , and the most common cause of death from gastrointestinal cancer . in general , mexico is considered a low - risk area , with a mortality rate of 5.0 per 100,000 inhabitants,3 with great geographic variability within the country .
the state of chiapas has the highest mortality rate ( 6.4 per 100,000 ) ; the federal district comprising mexico city and surroundings has a rate of 4.5 per 100,000 inhabitants , and the state of mexico , has a rate of 2.5 per 100,000 .
men are affected more frequently than women at a ratio of 1.5:12:1.4 in mexico , gastric cancer has been most frequently observed in persons aged between 50 and 70 years ; however , < 10% of cases are detected prior to the age of 45 years.5 the proportion of young patients with gastric adenocarcinoma has varied from 6%8% in studies in which patients were defined as young when aged < 41 years and from 2%6% in studies in which young patients were defined as being < 36 years of age . in these younger population subsets , epidemiological differences exist in localization , with an increase of lesions at the proximal level as well as in those in the antral region .
lesions at the proximal level have been most often experienced by those whose race can be characterized as white ( 71% vs 29% ) , while antral lesions were predominant in those who were characterized as black ( 64% vs 36%).6 with respect to clinical and pathological characteristics among people aged < 30 years compared with those 3039 years of age , both groups exhibited similar symptoms , undifferentiated neoplasms , and poor prognosis . a delay in diagnosis existed in both groups and exerted influence on patient management and prognosis.711 in patients with a familial history of gastric cancer , with symptoms of ulcer that do not improve with adequate medical management , or who have received a diagnosis of an ulcer
, panendoscopy should be performed , with a biopsy for early diagnosis.12 the majority of young patients come in for an appointment with a long disease history and with advanced disease.13
the instituto nacional de cancerologa de mxico ( incan ) is a cancer center that cares for 3,985 patients with cancer per year .
gastric cancer represents 3.7% of neoplasms seen at the institute , with 150 cases of gastric cancer reported annually .
our study attempts to retrospectively evaluate the general characteristics and behavior of gastric cancer in patients < 30 years of age seen at this institution .
at the incan s surgery department , we carried out a review of cases of patients aged < 30 years who had received a diagnosis of gastric cancer between january 1985 and january 2006 . from this search
, we identified a total of 2153 cases , among which only 30 were corroborated in patients aged < 30 years .
this group was eligible for this retrospective analysis . for each case , we included age , gender , familial oncological history , signs and symptoms referred , types of preparatory studies performed , and methods utilized for diagnosis ; in addition , we considered follow - up time and time lapse to death or date of last medical appointment . overall survival ( os ) time was considered , as were the date of specific treatment initiation , whether the patient died ( due to any cause ) , and date of last medical appointment .
we only employed descriptive statistical methods in statistical analysis with central tendency and dispersion measurements .
survival curves were estimated using the kaplan  meier method , and the log - rank test was utilized to compare survival data . in all cases ,
we employed the spps ( v 19.0 ibm corporation , armonk , ny , usa ) for windows software package for statistical analysis .
we reported on 30 patients aged < 30 years , with an age range of 1830 years .
the patient cohort included 16 males and 14 females ; 33% of the population had oncological histories , including four cases of cervical uterine cancer , three cases of leukemia , and one case each of breast cancer , gall bladder cancer , and colon cancer . among the other important patient characteristics ,
44% had a report of signet ring cell adenocarcinoma ; 70% indicated that pain was the primary manifestation of a disorder ; 83% were diagnosed by endoscopy ; 56.6% had been submitted to computerized axial tomography ( cat ) as the auxiliary diagnostic method ; and 40% of patients had been managed outside of our institution using a variety of therapeutic regimens ( see table 1 ) ; thus , only 56.6% of patients were candidates for management at our institution .
of this group , only 40% ( 12 patients ) were scheduled to undergo surgery ( see table 2 ) . of these
, 42% ( five patients ) qualified for tumor resection , an additional five ( 42% ) were submitted to gastrojejunal anastomosis - type derivations , and two ( 16% ) were submitted to exploratory procedures ( one laparoscopy and one laparotomy ) .
the predominant histology found was signet ring cell adenocarcinoma , in 13 patients ( 44% ) .
twenty - five patients ( 83% ) were diagnosed with clinical stage iv disease , and five ( 17% ) with clinical stage iii disease ( see table 4 ) . with respect to symptoms , 70% ( 21 patients ) presented with pain , and 3 patients each ( 10% ) presented with a clinical profile of gastric obstruction or early gastric fullness ( see table 5 ) ; duration from symptom initiation to disease diagnosis was 612 months in 80% of cases , and 12 years in 10% of cases ( see table 6 ) .
average follow - up was 5 months ( range , 1 day to 26 months ) .
it is noteworthy that only four ( 13% ) patients had a 1-year follow - up ; 15 ( 50% ) patients had a < 1 month follow - up period and 11 ( 37% ) patients had a follow - up period of between 2 months and < 1 year .
the clinical and pathological characteristics of gastric cancer diagnosed in young patients have been described in various recently published reports . in a population that included patients who were over and under the age of 30 years
, bedikian et al reported that both groups presented with similar symptoms , predominantly undifferentiated neoplasms , and poor prognosis.8 in 51 patients aged < 45 years , these authors observed that this cancer was more frequent in females ( 57% vs 36.3% ) , with the most common cancer type being diffuse ( according to the lauren classification ) .
lymphatic invasion presented with greatest frequency ( 59% vs 38.9% ) and with greatest frequency in stage iv at diagnosis ( 49% vs 35.7% ) ; notwithstanding this , no difference was observed in 5- to 10-year survival rates between young patients and those aged > 45 years.8 in a retrospective analysis of 72 cases of patients aged < 40 years compared with 51 cases of patients above 70 years of age , park et al showed that at the time of diagnosis young patients had a greater frequency of muscular layer invasion ( 65.3% vs 39.2% ) without differences in survival.15 on the other hand alterations have been studied in cell signaling pathways that can induce the genesis of gastric cancer , hereditary or not , and among these we find mutations in cdh1 .
it is thought that fewer than 10% of patients who develop gastric cancer with signet ring cells do so prior to the age of 45 years ( in our series , this was 44% ) , and that , if they do so , their genetic information is different from that which leads to sporadic carcinomas at an older age . additionally , the role of environmental carcinogenic factors in carcinogenesis is presumably less prominent in young people than is the genetic one ; thus , hereditary gastric cancer and early - onset gastric cancer can aid in the study of carcinogenesis at this age . in our series , 33% had familial oncological histories without formation of hereditary or familial cancer , suggesting a genetic transmission component because the most frequently found types of cancer were cervical uterine cancer and leukemia.11,12 gastrointestinal adenocarcinomas of the esophagus , stomach , and colon exhibit distinct patterns of genomic instability and oncogenesis .
focal amplifications were substantially more prevalent in gastric / esophageal adenocarcinomas than in colorectal tumors .
these genomic amplifications act as biomarkers to guide therapy.1416 it is thought that gastric cancer results from a combination of environmental factors and an accumulation of specific genetic alterations , due to the fact that the growing genetic instability mainly affects older patients , as different p53 alterations in different events of gastric carcinogenesis have demonstrated.17 rugge et al related gastric epithelial dysplasia ( ged ) with the development of cancer , concluding that in ged 1 with atrophic gastritis in older patients and in ged 2 strict follow - up must be conducted .
surgical management is justified for ged 3.18 there is a tendency of late diagnosis of the disease in young patients .
physicians should have a high suspicion of the disease in patients with a familial history of gastric cancer , with ulcer symptoms that do not improve with adequate medical management , or when an ulcer is diagnosed .
in addition , panendoscopy should be inevitably carried out with a biopsy for early diagnosis , which can increase the survival of young patients ; the latter can increase with knowledge of the patient s familial history , such as the existence of carriers of pernicious anemia , and of their first - degree relatives , in whom progression of atrophic gastritis is 20 times more rapid than in general population.19,20 tumor staging directly affects treatment options and survival ; in many cases , we encountered unstaged disease , although not in all patients .
also , there are differential staging levels for age , gender , race , marital status , disease incidence , and lethality.20 two general rules are clear now that helicobacter pylori is accepted as the cause of atrophic gastritis and as a determining factor in the severity of the disease ; that the severity of atrophic gastritis is related to cancer risk ; and that atrophic gastritis is associated with other diseases such as duodenal ulcer , gastric ulcer , gastric carcinoma , and mucosa - associated lymphatic tissues ( [ malt]-type gastric lymphoma ) .
first , the pattern of gastritis is the greatest determinant of the disease ; second , countries with a high prevalence of gastric cancer , such as japan and peru , have a low prevalence of duodenal ulcer.18,21,22 isik et al concluded that young patients ( < 40 years of age ) with gastric cancer present with poorly differentiated adenocarcinoma and with more advanced and metastatic disease ; the patient s health status , tumor localization , metastatic sites , and smoking status did not confer significant difference in disease state , which coincides with our series that reported a histology of poorly differentiated signet ring cell adenocarcinoma in 44% of our patient population.23 smith and stabile , in a report on 350 patients , and with 30 patients ( 9% ) aged < 35 years compared with those aged > 35 years , found a greater incidence of invasion of adjacent organs ( 74% vs 29% ) and distant metastasis ( 81% vs 50% ) in patients younger than 35 years , as well as a reduced possibility of curative surgery ( 58% vs 17% ) and greater postsurgical mortality ( 22% vs 2%).24 age as an adverse prognostic factor appears to be related to a greater degree with delay in diagnosis .
lai et al , in a series of 6954 patients divided into three groups by age ( with 12.7% of patients aged < 40 years , 66.7% aged 4165 years , and 20.6% > 65 years of age ) , concluded that patients < 40 years of age exhibited significantly better survival than those in group two ; multivariate analysis indicated that age was an independent prognostic factor.25 to date , the reason for the occurrence of gastric cancer in young people remains inexplicable . in our series , we did not find that women predominantly have gastric cancer in this age group , as has been reported in other series in the literature.26 conversely , in our study , 54% of the patients with gastric cancer were men .
additionally , we found that despite aggressive surgical resection or neoadjuvancy , the outcomes from having gastric cancer continue to be invariably devastating .
however , an attempt should be made to identify the subgroup of patients who can benefit from screening , and in whom early detection can be recommended .
attempting to identify the environmental factors that favor the progression or development of gastric cancer would also be ideal .
we also recommend searching for a tumor marker to detect this disease in its earliest stages , given that therapies used for standard management of gastric cancer to date have not substantially improved the disease s prognosis .
prevention of the disease is optimal , as gastric cancer is truly difficult to control once it has been established .
to date , there has been a trend toward late diagnosis of gastric cancer in younger patients who present with symptoms .
physicians should account for the possibility of gastric cancer in patients with a familial history , or with symptoms of ulcer that do not improve under adequate medical management . with the diagnosis of an ulcer ,
panendoscopy should without exception be conducted to obtain a biopsy for early diagnosis , which can increase survival in young patients .
the clinical and pathological characteristics of gastric cancer in a series of patients included the following : similar proportion in both genders .
delay in diagnosis of young patients leads to presentation at advanced disease stages and to young patients being candidates for palliative care . despite the lack of demonstrating a statistically significant p
the patients studied were found to have progressed to advanced disease stages , when treatment was oriented toward palliative care of the disease .
 backgroundgastric cancer is an aggressive disease with nonspecific early symptoms . 
 its incidence and prognosis in young patients has shown considerable variability.purpose of the studyour objective was to retrospectively study patients from our institution aged < 30 years with gastric carcinoma . 
 the study was undertaken to describe the experience of gastric cancer in this population , and to demonstrate its specific clinical and pathological characteristics.materials and methodswe reviewed the cases of histologically confirmed gastric cancer between 1985 and 2006 at the instituto nacional de cancerologa of mexico ( incan ) ; emphasis in our review was placed on clinical presentation , diagnostic and therapeutic intervention , pathology , and the results.resultsthirty cases of gastric carcinoma were reviewed . 
 the patients median age was 27 years ( range , 1830 years ) and the male : female ratio was 1:1.conclusiongastric cancer exhibits different behavior in patients aged , 30 years , but delay in diagnosis and the tumor s behavior appear to be the most important factors in prognosis of the disease . 
Introduction
Patients and methods
Results
Discussion
Conclusion