a computed tomography ( ct ) incidentaloma is an incidentally detected and previously unsuspected finding or abnormality that is not related to the indication for obtaining the ct examination .
chest ct incidentalomas are pandemic in modern health care due to many factors , including the explosion in the use of chest ct scanning , particularly in the emergency department , in oncology centers , and in screening for coronary artery disease ( cad ) and lung cancer .
multidetector ct results in huge numbers of thin ct sections with excellent spatial resolution , leading to the detection of many incidental findings .
incidentalomas on chest ct scans may represent normal findings , normal variants , or abnormal findings .
abnormal findings may be of little or no clinical significance ( e.g. a calcified lung granuloma ) , requiring no further evaluation , or they may be highly significant , requiring immediate treatment ( e.g. a large , central pulmonary embolus ) . commonly , however , incidentalomas are of questionable clinical significance ( e.g. a thyroid nodule ) , necessitating further evaluation via clinical correlation , follow - up and/or additional testing .
a systematic review of 11 chest ct studies performed for cad and lung cancer screening revealed that the proportion of patients with at least one incidental imaging abnormality requiring follow - up varied from 3% to 41.5% ; the wide variation was largely due to considerable differences in follow - up recommendations for incidental findings across studies .
overall , 7.7% and 14.2% of participants in cad or lung cancer screening studies , respectively , had further investigations of incidental findings .
other individual cad screening studies found major extracardiac incidentalomas in 516% of patients . a lung cancer screening study involving 5200 participants discovered incidental findings in 3% , leading to 12 invasive procedures ; however , only 8 of these were clinically relevant .
the nelson lung cancer screening trial found that 129/1929 ( 7% ) ct examinations revealed clinically relevant incidental findings , resulting in 118 additional imaging tests ; furthermore , 8 of these showed new incidental findings .
eleven patients underwent more than one additional imaging study , and ultimately , only 15 patients needed clinical treatment or further follow - up of their incidental findings .
only one incidental cancer was detected ( pancreatic cancer ) , which was incurable due to the presence of metastatic disease .
based on these results , the authors advised against systematically searching for and reporting of incidental findings on lung cancer screening studies , as this practice may lead to additional costs , patient anxiety , and risk of iatrogenic injury . despite the conclusions of the authors of the nelson study , most radiologists feel obligated to report incidental findings and give suggestions regarding the clinical significance and appropriate work - up of such findings .
for some findings , there are well established clinical guidelines , whereas , for others , no specific guidelines exist .
the following sections give suggested guidelines for reporting incidental findings , based on the best evidence that is currently available in the medical literature .
thyroid abnormalities , such as nodules ( solitary or multiple ) , cystic lesions , calcifications and diffuse glandular enlargement , are often detected on chest ct examinations ( fig .
thyroid nodules are found in approximately 16% of chest ct scans , more commonly in women .
most incidentally found thyroid lesions are benign , with an approximately 911% prevalence of malignant lesions .
the differential diagnosis for an incidental thyroid abnormality in euthyroid individuals includes nontoxic multinodular goiter , follicular adenoma , thyroiditis , simple cyst , and carcinoma ( primary or secondary ) .
clinical features that correlate with malignancy include : age ( younger than 35 years or older than 70 years ) ; size ( > 2.5  cm ) ; presence of dysphagia or hoarseness ; history of external neck radiation in childhood or adolescence ; firm , irregular and/or fixed nodule at physical examination ; presence of cervical lymph node enlargement ; multiple endocrine neoplastic syndromes ; personal or family history of thyroid malignancy ; and possibly male gender . 
 figure 1incidental nodule in the left lobe of the thyroid gland ( arrow ) .
furthermore , it has been reported that ct is unreliable in distinguishing simple cysts , complex cysts , and solid nodules .
ct underestimates the number of nodules relative to sonography , suggesting that sonography is a useful adjunctive test after the incidental detection of a thyroid abnormality on ct ; furthermore , current management guidelines for thyroid nodules are based on morphologic sonographic characteristics .
although sonography is sensitive in detecting thyroid nodules , it is not accurate in diagnosing malignancy ; its major usefulness is in guiding thyroid biopsies .
once an incidental thyroid nodule is found , referral to a thyroid specialist may be the most cost - effective option for further evaluation , although ultrasonography may also be suggested . according to the guidelines of the american thyroid association , generally , only nodules > 1 
cm need further evaluation , because they have a greater potential to represent clinically significant cancers compared with lesions < 1  cm , and because of cost / benefit considerations regarding the work - up of all small nodules . however , it is probably prudent to correlate even small nodules with physical examination and assessment of individual risk factors .
mildly enlarged mediastinal lymph nodes are commonly seen in patients with congestive heart failure ( chf ) ( fig . 2 ) , and they should be recognized as a manifestation of this disease process , rather than as a marker of potential malignancy . in one study of 31 patients with subacute chf , 42% ( 13/31 )
showed enlarged mediastinal lymph nodes ; in 8/13 patients the lymph node enlargement regressed within 1 week after treatment of the heart failure .
the lymph nodes were mildly to moderately enlarged , measuring 2  cm in short axis diameter , and were generally located in the right and left paratracheal , subcarinal , anterior mediastinal and precarinal regions . the severity of left heart decompensation correlated with the frequency of lymph node enlargement .
other correlative findings included inhomogeneity of the mediastinal fat , consistent with edema , and ill - defined lymph node margins .
lymph node enlargement has also been reported for acute chf ; ct findings of acute failure such as ground glass opacities , smooth septal thickening , fissural and peribronchovascular thickening , air space consolidation , perihilar parenchymal disease , pleural and pericardial effusions , and cardiomegaly may help to establish the diagnosis of chf , and concomitant , enlarged mediastinal lymph nodes are to be expected .
enlarged lymph nodes are also seen in association with chronic chf ; in these patients the myriad manifestations of acute failure may not be present , and therefore the cause of the nodal enlargement may not be immediately obvious without clinical information regarding cardiac function . a proposed mechanism for nodal
enlargement postulates that elevated left ventricular filling pressure leads to decreased pulmonary drainage and the accumulation of excessive interstitial fluid , with dilatation of lymphatics draining the lungs and heart , resulting in lymph node enlargement . 

ct shows ground glass pulmonary opacities , parenchymal consolidation and smooth septal thickening ( a ) , as well as bilateral pleural effusions , consistent with chf .
there are transvenous pacemaker leads in the superior vena cava and enlarged mediastinal lymph nodes ( b , arrows ) .
ct shows ground glass pulmonary opacities , parenchymal consolidation and smooth septal thickening ( a ) , as well as bilateral pleural effusions , consistent with chf .
there are transvenous pacemaker leads in the superior vena cava and enlarged mediastinal lymph nodes ( b , arrows ) . if incidental , mild mediastinal lymph node enlargement is seen in the setting of chf , no further work - up is necessary , unless there are other clinical or imaging features to suggest an underlying malignancy .
mediastinal lymph node enlargement is common in various types of interstitial lung disease ( ild ) , including usual interstitial pneumonitis ( uip ) , nonspecific interstitial pneumonitis ( nsip ) , collagen vascular disease ( cvd ) , sarcoidosis , extrinsic allergic alveolitis ( eaa ) , respiratory bronchiolitis , and desquamative interstitial pneumonitis ( dip ) ( fig .
the prevalence of enlarged nodes was 84% ( 46/55 ) in sarcoidosis , 67% ( 41/61 ) in idiopathic pulmonary fibrosis ( ipf ) , 70% ( 14/20 ) in cvd , 53% ( 9/17 ) in eaa , and 36% ( 8/22 ) in cryptogenic organizing pneumonia ( cop ) , previously known as idiopathic bronchiolitis obliterans organizing pneumonia ( boop ) .
involved nodes typically occur in the right lower paratracheal and subcarinal regions , and enlargement is typically mild ( the mean size of the largest lymph node was 1.4  cm in one study ) .
similar to the situation for incidental , mild mediastinal lymph node enlargement in chf , no further work - up is indicated in the absence of other clinical or imaging features that are suggestive of a coexistent malignancy . 

figure 3incidental mediastinal lymph node enlargement ( b , arrow ) in a patient with pulmonary interstital fibrosis ( a ) .
incidental mediastinal lymph node enlargement ( b , arrow ) in a patient with pulmonary interstital fibrosis ( a ) .
the cisterna chyli ( cc ) is a bulbous convergence of lymphatic channels formed by the right and left lumbar trunks and the intestinal trunk ; it is often mistaken for an enlarged lymph node on cross - sectional imaging , either as an incidental finding , or in the setting of cancer staging ( fig .
4 ) . the key to correct identification includes knowledge of the anatomy and morphology of the structure .
the cc is located in the retrocrural region at the level of t11l2 , usually on the right , between the aorta and azygos vein .
it is continuous with the thoracic duct , which ascends in the right side of the mediastinum medial to the azygos vein , eventually crossing to the left and emptying into the confluence of the left subclavian and jugular veins .
it is generally approximately 7  mm in axial cross - sectional diameter and 1530  mm long ; it has been suggested that diameter larger than 10  mm correlates with the presence of an underlying malignancy .
although the cc usually shows the attenuation of water ( average 5 hu ) , the attenuation may be elevated due to increased protein content or after the injection of intravenous contrast ( particularly in patients with renal failure ) .
fatty attenuation may occasionally be seen , most likely due to dietary fat intake ; a fat - fluid level may rarely be detected .
the cc may vary in size depending on the phase of respiration , degree of hydration , and the peristalsis of the muscular lower one - third of the thoracic duct .
the structure is visible on approximately 16% of ct scans and can usually be differentiated from an abnormal lymph node by its characteristic appearance and location . 

figure 4the cc ( a , arrow ) may simulate an abnormal retrocrural lymph node .
the cc is continuous with the thoracic duct ( b and c , arrows ) .
the cc is continuous with the thoracic duct ( b and c , arrows ) .
results of cad and lung cancer screening studies have shown a high prevalence ( 2553% ) of lung nodules on chest ct examinations .
nodules representing granulomas are particularly common in endemic areas for histoplasmosis , such as the central united states .
approximately half of smokers older than age 50 years have small nodules on thin - section ct , and most of these nodules are benign . when assessing an indeterminate nodule for possible malignant potential , the first rule of thumb is to look for comparison examinations . a solid nodule that is stable for at least 2 years
the likelihood of malignancy is directly correlated with nodule size ; < 1% of nodules < 4  mm in diameter in smokers turn into lethal cancers , compared with approximately 1020% of nodules that are about 8 mm .
benign morphologic features include certain types of calcification ( laminated , concentric , dense central nidus , popcorn ) and the presence of fat ( consistent with a hamartoma ) .
smooth nodule margins , polygonal shape , and subpleural location are also suggestive of benignancy .
incidental perifissural nodules are extremely common ; these are generally well circumscribed , smooth , triangular or oval , contacting or closely related to a pleural fissure , occurring below the level of the carina and often showing a septal attachment to the pleural surface ( figs . 5 and 6 ) .
these nodules probably represent lymph nodes , and it has been reported that they have low or no chance of malignancy in the setting of lung cancer screening . 

figure 5small , incidental perifissural nodules ( arrow ) associated with the left major fissure . 

figure 6small , incidental perifissural nodule associated with the minor fissure and showing a septal attachment ( arrow ) to the anterior pleural surface .
small , incidental perifissural nodule associated with the minor fissure and showing a septal attachment ( arrow ) to the anterior pleural surface . when an incidental , indeterminate lung nodule is encountered ( without established long - term stability or clearly benign morphologic features )
, the fleischner society guidelines should be utilized in recommending further work - up or imaging follow - up .
these guidelines stratify patients according to clinical risk for developing lung cancer and nodule size .
although most radiologists are familiar with the guidelines , the latter are often applied inappropriately or incorrectly .
for example , the guidelines only apply to incidental nodules , meaning that the nodules are unrelated to any known underlying disease .
it is inappropriate to use the guidelines for patients with a known primary neoplasm that may metastasize to the lungs or for patients with an unexplained fever , in whom a nodule may represent infection .
in addition , the guidelines only apply to patients 35 years of age or older , because primary lung cancer is rare in young patients , and this population is at greater risk from radiation exposure compared with older patients . according to the guidelines ,
no follow - up is recommended for a small nodule ( 4  mm ) in a low - risk patient , because the risk of malignancy is less than 1% ; yet many radiologists incorrectly recommend follow - up for such a nodule , perhaps due to disagreement with the guidelines , medicolegal concerns , or , more likely , lack of familiarity with the details of the guidelines .
furthermore , it should be remembered that conservative management of incidentally found lung nodules is often appropriate for very elderly patients and patients with major co - morbid disease and shorter life expectancy .
pure ground glass nodules should be approached differently than solid nodules . most small ( < 5  mm ) ground glass nodules probably represent foci of atypical adenomatous hyperplasia ( aah ) , although the differential diagnosis includes infection , inflammation , fibrosis , organizing pneumonia , and hemorrhage ( fig . 7 ) .
although aah lesions are felt to be pre - malignant , they tend to grow extremely slowly , and therefore follow - up is not recommended for such small lesions ( < 5  mm ) . on the other hand , a 3- to 6-month follow - up ct may be recommended for a pure ground glass nodule that measures 510  mm ; a persistent nodule likely represents aah or adenocarcinoma in situ ( previously called bronchioloalveolar cell carcinoma ) .
these nodules should be followed with serial ct examinations for at least 3 years in order to document long - term stability . for ground glass nodules
> 10  mm , a 3-month follow - up examination may be optimal ; persistence suggests the presence of adenocarcinoma in situ or invasive adenocarcinoma .
these nodules can be followed to assess for long - term stability , although a more aggressive approach , including biopsy or resection , may be chosen .
features that correlate with malignancy include increase in nodule size , increase in overall attenuation , and development of a solid component ( figs . 8 and 9 ) . 

figure 7small , incidental ground glass nodule ( arrow ) that likely represents a focus of aah . 

figure 9incidental ground glass nodule ( a , arrow ) grew into a mixed solid and ground glass nodule 4 years later ( b , arrow ) .
small , incidental ground glass nodule ( arrow ) that likely represents a focus of aah
incidental ground glass nodule ( a , arrow ) grew into a mixed solid and ground glass nodule 4 years later ( b , arrow ) .
incidental findings are frequently found on chest ct examinations . although most of these findings are not clinically significant , some may represent incidentally discovered malignancies .
detection of incidentalomas may lead to a large number of expensive follow - up examinations , extra radiation in healthy people , unnecessary invasive procedures and patient anxiety .
when reporting an incidental finding , the radiologist should indicate the probability of the importance of the finding , and should offer evidence - based guidelines for further work - up or follow - up when necessary .
 abstracta computed tomography ( ct ) incidentaloma is an incidentally detected and previously unsuspected finding or abnormality that is not related to the indication for obtaining the ct examination . 
 the aim of this article is to review the frequency of incidentalomas on chest ct scans , discuss the potential clinical significance of the findings , and suggest guidelines for reporting , further evaluation , and follow - up , with particular focus on thyroid lesions , enlarged mediastinal lymph nodes and lung nodules . 
Introduction
How common are chest CT incidentalomas?
Incidental thyroid lesions
Incidental mediastinal lymph node enlargement in congestive heart failure
Incidental mediastinal lymph node enlargement in interstitial lung disease
The cysterna chyli simulating mediastinal lymph node enlargement
Incidental lung nodules
Conclusions