primary non - hodgkin lymphomas of the gastrointestinal tract are rare , accounting for only 14% of malignancies arising in the stomach , small intestine or colon .
mucosa - associated lymphoid tissue ( malt ) lymphoma comprises 78% of all b - cell lymphomas and at least 50% of primary gastric lymphomas .
it reaches its peak incidence between the ages of 50 and 60 years and there is a slight male predominance .
patients with gastric malt lymphoma typically present with nonspecific symptoms such as nausea , vomit , non - ulcer dyspepsia , epigastric discomfort , anorexia , weight loss , or occult gastrointestinal bleeding .
physical examination is often normal , but may reveal a palpable mass or peripheral lymphadenopathy when the disease is advanced .
laboratory studies also tend to be normal at presentation and anemia may be present in selected cases . the diagnosis should be confirmed by biopsy .
findings on upper endoscopy are diverse , including mucosal erythema , benign - appearing gastric ulcer or nodular lesion .
multiple biopsies should be obtained from both suspicious - appearing lesions and normal - appearing mucosa in the stomach since gastric malt lymphoma can occasionally present as multifocal disease with involvement of tissue that appears to be unaffected on initial visualization .
conventional pinch biopsies may miss the diagnosis , since gastric malt lymphoma can infiltrate the submucosa without affecting the mucosa .
in epithelial tissues , malt lymphomas are composed of morphologically heterogeneous small b - cells including marginal zone ( centrocyte - like ) cells , monocytoid cells , and small lymphocytes .
the risk of misdiagnosing such lesions as poorly differentiated gastric cancer in endoscopic biopsies , particularly in low - grade malt lymphomas in which lel may be particularly abundant , is well described .
a 76-year - old woman was referred for the management of poorly differentiated gastric adenocarcinoma diagnosed at the time of a routine screening upper endoscopy .
her past medical history was unremarkable and family history showed that her father had gastric cancer .
a diagnostic upper endoscopy in our unit revealed a 2 cm raised , submucosal lesion with central erosion in the upper body of the stomach ( fig .
1 ) . repeat biopsies of the lesion were interpreted as inflamed gastric mucosa with positive helicobacter pylori .
we also performed systematic gastric biopsies to rule out any foci of malt lymphoma changes within the stomach , however the results were not significant . computed tomography of the chest and abdomen was negative for any lymphadenopathy or distant metastases .
based on the localized endoscopic findings and repeat negative biopsy results , we performed an endoscopic submucosal dissection ( esd ) for diagnostic therapy .
histological study revealed a well - circumscribed lymph follicle containing large germinal centers in the submucosa invading the muscularis mucosa and mucosa ( fig .
centrocyte - like cells and epitheliotropic proliferation ( lel ) invading into the mucosa with obliteration of the gastric glands ( fig .
3 ) were also seen . while the lel was initially interpreted as poorly differentiated adenocarcinoma , the pathological evidence obtained from esd established the diagnosis of a malt lymphoma of the stomach ( c - stage ie ) .
after eradication of h. pylori with antibiotics , the patient has had no local or distant recurrences during the subsequent 2 years of surveillance follow - up .
the world health organization ( who)/revised european american lymphoma ( real ) classification scheme groups all lymphomas involving extranodal sites ( gastrointestinal tract , thyroid , lung , breast , orbit and skin ) into the category of malt lymphomas .
although patients with gastric malt lymphoma often present with stage i or ii extranodal disease , those patients may have vastly different presentations depending on its size and location : asymptomatic , gastric outlet obstruction , or weight loss .
gastric malt lymphoma often presents as multifocal disease within the stomach and systematic gastric biopsy is crucial for diagnosis . in this localized malt lymphoma case ,
theoretically , since gastric malt lymphomas develop from mucosa - associated lymphoid tissue , esd should be adequate to obtain lymphoma tissue for the definite diagnosis .
a previous study showed an association between previous h. pylori infection and the development of gastric malt lymphoma and that eradication of h. pylori with antibiotics results in regression of gastric malt lymphomas [ 6 , 7 ] .
is classified as an indolent non - hodgkin lymphoma , stable asymptomatic patients with persistently positive biopsies have been successfully followed until disease progression . in conclusion ,
esd is a reasonable option for the diagnosis of localized gastric malt lymphomas in selected cases in whom adequate tissue samples are difficult to obtain .
 the risk of misdiagnosing neoplastic cells typically infiltrating an epithelium forming a lymphoepithelial lesion as poorly differentiated gastric cancer in endoscopic biopsies , particularly in low - grade mucosa - associated lymphoid tissue ( malt ) lymphomas , is described . 
 a 76-year - old woman was referred for management of a poorly differentiated gastric adenocarcinoma . 
 diagnostic endoscopy in our unit showed a 2 cm raised , submucosal lesion with central erosion in the upper body of the stomach , but repeat biopsies of the lesion were interpreted as inflamed gastric mucosa and negative for malignancy . 
 systematic gastric biopsies to rule out any foci of malt lymphoma changes were also negative . therefore , endoscopic submucosal dissection was performed to obtain an accurate specimen . 
 histology revealed centrocyte - like cells and a lymphoepithelial lesion invading into the mucosa with obliteration of the gastric glands , which was initially interpreted as poorly differentiated adenocarcinoma . 
Introduction
Case Report
Discussion