the prevalence of human immunodeficiency virus ( hiv ) infection in india is 0.34%.(1 ) even though the survival of people living with hiv ( plwh ) has improved with the advent of anti - retroviral therapy ( art ) , their life is affected by social factors like stigma / discrimination . hence , quality of life ( qol ) which gives a holistic picture of their health status has gained importance.(2 ) further , knowing the factors affecting the qol of plwh would be helpful in making important policy decisions and health care interventions .
literature on the factors influencing qol was not consistent as qol depends on the socio - cultural milieu in which the individual lives.(3 ) one such variation observed in hiv was with relation to gender .
in chennai , it was found that females experienced poor qol in the sociological domain , and men in the psychological domain,(4 ) whereas , the multicentric preliminary study of whoqol with two centers in india found that women experienced less qol across all domains.(5 ) on the contrary , in africa , it was found that gender does not influence qol.(6 ) since india accounts for nearly half of the asia 's hiv prevalence,(7 ) there is a definite need to study qol and the factors influencing it in the indian setting .
measuring qol would help to identify the most affected domain , and knowledge on factors influencing it will aid in taking appropriate intervention .
it would also provide regional and objective data for planning interventions for the betterment of plwh . 
 to assess the quality of life of plwh.to study the socio - cultural and demographic determinants of quality of life in plwh . 
  to assess the quality of life of plwh . to study the socio - cultural and demographic determinants of quality of life in plwh .

 to assess the quality of life of plwh.to study the socio - cultural and demographic determinants of quality of life in plwh . 
  to assess the quality of life of plwh . to study the socio - cultural and demographic determinants of quality of life in plwh .
this descriptive study was conducted in puducherry , a union territory of india with a population of 9,74,345.(8 ) two tertiary care government hospitals , jawaharlal institute of postgraduate medical education and research ( jipmer ) and general hospital ( gh ) of puducherry , and three non governmental organizations ( ngo ) namely pondicherry network of positives ( pnp+ ) , community care centre ( ccc ) and shanthi bhavan were providing care for plwh in puducherry .
the pilot study found that plwh utilizing the services of puducherry gh were also utilizing the services of the ngo .
hence , the study was conducted at jipmer and the three ngo 's during 2005 - 07 .
sample size of 200 was calculated using the mean domain score of 11.4 and standard deviation ( sd ) of 3.7 from the preliminary study of whoqol - hiv.(5 ) recruitment was continued till 200 subjects of > 18 years of age were interviewed . as plwh were utilizing the services of more than one centre , register was maintained to avoid duplication .
based on feasibility , at each visit to these study centers , first three subjects were recruited from their registers .
quality of life was assessed using hiv specific world health organization quality of life scale ( whoqol - hiv )  bref which was field - tested in six centers across the world , including two centers in india .
it contains six domains namely physical , psychological , level of independence , social relationships , environment and spirituality / religiousness / personal belief ( srpb).(5 ) social support and hiv related stigma and was assessed using multidimensional scale of perceived social support and hiv stigma scale , respectively .
all these scales had an excellent internal consistency.(5911 ) interview schedules also included information on socio - demographic , clinical and social characteristics .
it was translated into the local language tamil , back translated and reviewed by a panel of two clinicians and five medical social workers .
non - judgmental attitude and non - responsive body language was followed to minimize bias .
the study was approved by the institute research council and institute ethics committee at jipmer . during the first one year of the study period , facility for checking cluster differentiation 4 ( cd4 ) count was not accessible to most subjects .
hence , the performance scale in who classification system was used for staging the disease clinically which was as follows : stage i 
bedridden > 50% of the day during the last month.(12 ) data was analyzed using statistical package for the social sciences ( spss ) version 13 using the guidelines of the various scales .
higher score in the multidimensional scale of perceived social support and hiv stigma scale indicated good social support and greater hiv related stigma , respectively .
factors influencing qol were identified using backward stepwise multiple linear regression with the six domain scores as the dependent variables .
age , gender , residence ( urban / rural ) , marital status , years of education , per - capita income , change of income after the diagnosis of hiv infection , duration since diagnosis , disease stage and intake of anti - retroviral therapy ( art ) , disclosure of hiv status , peer counseling , social support and hiv related stigma were the independent variables .
mean age of the subjects was 35 years ( standard deviation - sd 8.6 ) .
duration since diagnosis varied widely from 1 week to 12 years . most plwh contracted hiv through heterosexual route ( 153 , 76.5% ) and 71 ( 35.5% ) subjects were under art . among the subjects in stage
hundred ( 50% ) subjects reported decrease in income after the diagnosis of their hiv status because of manifestations of the infection , decrease in work capacity and decrease in number of working days .
but nine subjects earned more after the diagnosis of hiv as they felt the need to earn more money to meet their health care .
psychological and srpb were the most affected domains [ mean = 12.7 , table 2 ] .
level of independence was the least affected domain [ mean = 14.7 , table 2 ] .
some common expressions of subjects regarding their present quality of life were  i am not able to ask for my property , as my relatives are scaring me that they will disclose my hiv status .   now i am alright , but if i start having diarrhea i can not even do my day - to- day activities .
.when i see very thin persons attending the clinic , i am afraid that one day i may also become like them . 
these comments showed the helpless situation , fear / concern for uncertainties in future , and the fluctuating health status of these plwh .
however , a few plwh commented positively ;  after the diagnosis of hiv , i have tried to find a new meaning in my life .
 demographic characteristic of study subjects mean scores in the domains and the human immunodeficiency virus .
specific facets of world health organization quality of life scale ( whoqol - hiv )  bref table 3 shows the influence of the various factors on the qol domains .
the regression models explained between 20% and 57% of the variance in the different domains .
the determination coefficients ( adjusted r ) were highest for the social relationship domain ( 57% ) followed by the psychological domain ( 51% ) .
early stage of disease and better social support has significant positive influence on all domain of qol .
disease stage was the most influential determinant of all domains except social relationship and environment .
plwh experiencing greater hiv related stigma obtained lower scores in the psychological , environment and srpb domain .
it is noteworthy to mention that decrease in income after the diagnosis of hiv negatively influenced psychological , social relationship and environment domain .
females obtained lower scores in the psychological and the srpb domain . with time , the qol of plwh improved .
other important significant determinants of qol identified by multivariate analysis were peer counseling , disclosure of hiv status , age and residence [ table 3 ] . in our study ,
multiple linear regression of factors influencing quality of life of people living with human immunodeficiency virus infection in the study
the study revealed that psychological domain and srpb which includes facets such as self - esteem , negative feelings , purpose in life , fear of death etc .
similar results were also found in preliminary study of whoqol.(5 ) schonnesson reported that though symptoms due to hiv decreased with art ; stigma / discrimination and uncertainties had not decreased thereby affecting them psychologically.(13 ) the score of the present study in level of independence , social relationship and srpb domains were significantly better than that reported from bangalore ( india ) .
however the physical and psychological domains scores of the present study were lower than that from delhi ( india).(5 ) this indicates a wide variation in qol even within the country .
decrease in income after the diagnosis of hiv was not well studied in the indian scenario . in our study ,
about half of the subjects earned less after the diagnosis of hiv due to manifestations of hiv .
less income decreased their access to resources , affecting their living environment and social life.(14 ) they also faced challenges for meeting their increased health care cost .
hence , vocational counseling and support for self employment provided through the ngo would improve the qol of plwh .
our study and the preliminary study of whoqol hiv , showed that disease stage significantly influenced all the six domains.(15 ) hence , art which delays the progression of disease should be made accessible to all .
similarly rivero - mendez et al . also found that art had a positive effect on physical well - being.(16 ) factors such as younger age,(15 ) female gender,(415 ) rural background and shorter duration of hiv status(17 ) were the high risk for poor quality of life , as identified in our study and also in literature .
our study and study by molassiotis et al . showed the positive influence of peer counseling on qol.(18 ) hence counseling and support from peer counselors for these high risk groups would improve their qol .
the influence of social support and hiv related stigma was consistent with other studies conducted across various cultural background.(1923 ) noteworthy , that in our study , social support had a major influence on all domains of qol , especially social relationships and environment domain .
lower hiv related stigma had a positive impact on the environment , srpb and the psychological domain .
however , the study being descriptive , temporal ambiguity of the associations exists , for example whether good social support led to good qol , or good qol made the plwh perceive the available support as good .
peer counseling and individual counseling at every contact with the health care professional should be encouraged for the high risk group .
the qol of plwh will also benefit the stake holders such as family , community and organizations working for plwh .
 context : with anti - retroviral therapy ( art ) for human immunodeficiency virus infection ( hiv ) coming into picture , quality of life ( qol ) has gained importance . 
 knowledge on the factors affecting qol would be helpful in making important policy decisions and health care interventions.aims:the aim of this study is to assess the quality of life of people living with hiv ( plwh ) and to identify the factors influencing their qol.materials and methods : the study was done among 200 plwh attending a tertiary care hospital , and three non governmental organizations at puducherry , india , from november 2005 to may 2007 . 
 qol was assessed using hiv specific world health organization quality of life scale ( whoqol - hiv )  bref questionnaire which has six domains ( physical , psychological , level of independence , social relationships , environment and spirituality / religiousness / personal belief ) . 
 social support and stigma were measured using  multidimensional scale of perceived social support  and  
 hiv stigma scale ,  respectively , using likert scale . 
 factors influencing qol were identified using backward stepwise multiple linear regression with the six domain scores as the dependent variables.results:male : female ratio was 1:1 and 58% were in early stage of the disease ( stage i / ii ) . 
 psychological and srpb ( spirituality religiousness and personal beliefs ) domains were the most affected domains . 
 all the regression models were statistically significant ( p<0.05 ) . 
 the determination coefficient was highest for the social relationship domain ( 57% ) followed by the psychological domain ( 51% ) . 
 disease stage and perceived social support significantly influenced all the domains of whoqol . 
 younger age , female gender , rural background , shorter duration of hiv , non - intake of art and greater hiv related stigma were the high risk factors of poor qol.conclusion:interventions such as art , family , vocational and peer counseling would address these modifiable factors influencing qol , thereby improving the qol of plwh . 
Introduction
Objectives
Materials and Methods
Results
Discussion
Conclusion