 we report a genome - wide association study to iron status . 
 we identify an association of snps in tpmrss6 to serum iron ( rs855791 , combined p = 1.51020 ) , transferrin saturation ( combined p = 2.21023 ) , and erythrocyte mean cell volume ( mcv , combined p = 1.11010 ) . 
 we also find suggestive evidence of association with blood haemoglobin levels ( combined p = 5.3107 ) . 
 these findings demonstrate the involvement of tmprss6 in control of iron homeostasis and in normal erythropoiesis . 
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