 the measurement of a deuterium equilibrium 
 isotope effect ( eie ) 
 for the aryl chcl interaction 
 of anion receptor 1h/1d is reported . 
 computations corroborate 
 the results of solution measurements for a small , normal eie in the 
 full complex ( kah / kad = 1.019  0.010 ) . 
 interestingly , 
 isotope effects involving fragments of the anion receptor ( urea , aryl 
 ring , etc . ) 
 are predicted to produce an inverse effect . 
 this points 
 to an unusual and subtle structural organization effect of the anion 
 receptor complex that changes the nature of the combined interactions 
 to a normal isotope effect . 
 the reversal of eie values suggests that 
 overall architecture of the anion receptor can dramatically impact 
 the nature of bonding in these complexes . 
Supplementary Material