nelson syndrome is a rare condition defined by enlargement of a pituitary adenoma following bilateral adrenalectomy for treatment of cushing disease.1 the incidence of nelson syndrome in adults varies between 8 and 29%,2 but it may be seen more frequently in patients who undergo adrenalectomy at a younger age.3 the pathophysiology of the disease is complex and controversial,124 and it is unknown what factors drive corticotroph cells in these patients .
blood tests showing rising adrenocorticotropic hormone ( acth ) levels and imaging showing an enlarging pituitary mass confirm the diagnosis.4 treatment depends on surgery and/or radiotherapy.145 we present the case of a patient with recurrent nelson syndrome whose effective treatment requires novel imaging due to prior sellar reconstruction with a metal plate ; this case suggests that metabolic radionuclide imaging may be a new option for managing patients with nelson syndrome .
in 1968 , the then 8-year - old patient underwent bilateral adrenalectomy for treatment of cushing disease .
four years later , she developed bitemporal hemianopsia , was found to have increased acth , and was diagnosed with nelson syndrome . after external beam radiation and transsphenoidal decompression of her tumor , a right frontal craniotomy for tumor resection and hypophysectomy provided symptomatic relief until 1983 , when her acth again began to rise .
transsphenoidal exploration failed to find tumor ; the surgeon reconstructed the sellar floor with metallic mesh encased in methyl methacrylate .
her acth normalized until 1998 , when another successful endonasal tumor resection was performed . in 2002 , the patient underwent a craniotomy for resection of a radiation - induced left frontal meningioma .
in 2005 , at the age of 45 , she presented with a clinical spectrum characteristic of past acth overabundance : skin pigmentation , retro - orbital headache , and mouth ulcers .
her acth was measured at greater than 3,000 pg / ml ( normal range 0 to 46 pg / ml ) .
pituitary - protocol magnetic resonance imaging ( mri ) demonstrated two potential sites of recurrent tumor : one adjacent to the sella and a second lower on the clivus .
metallic artifact from the previously placed mesh made interpretation of the study difficult ( fig .
1 ) .   t1-weighted postgadolinium magnetic resonance imaging ( mri ) . ( a ) midline sagittal .
concern for residual tumor along sellar floor seen in ( a ) and ( c ) , as well as within the sphenoidal body ( b ) .
to better elucidate which region may have been responsible for her elevated acth , the patient was sent for octreotide scintigraphy . despite poor spatial resolution ,
however , in light of her radiation - induced meningioma , the patient refused radiosurgical treatment and insisted on pursing surgical options .
the patient then underwent a fludeoxyglucose positron emission tomography ( fdg pet ) scan with fine - cut computed tomography ( ct ) coregistration to better delineate her tumor and adjacent bony landmarks .
2 , the anatomic relationship between the area of increased glucose uptake and the sellar floor was well defined .
the ct was imported to the brainlab neuronavigation system ( brainlab ag , feldkirchen , germany ) . during surgery ,
the mesh plate was found encased with scar and carefully removed . with the aid of intraoperative navigation ( fig .
3 ) , the left floor of the sella was explored ; a bony crevice was found , and pathologic tissue within it was removed . using gentle suction and various ring curettes , all tissue within the osseous cave
her postoperative course was uneventful , and she was discharged home on postoperative day 4 . at her first postoperative visit 1 week after discharge , her headaches had resolved , her skin tone began lightening , and she had resumed her preoperative activities .
serial acth levels dropped precipitously , eventually reaching a nadir of 90 pg / ml .
she remained asymptomatic for the remainder of her life before succumbing to complications from acute myeloleukemia in 2010 .  
( a ) fine - cut axial computed tomography ( ct ) . ( b ) 18-fludeoxyglucose positron emission tomography ( fdg pet ) .
( c ) coregistration overlay demonstrating area of increased glucose uptake along the floor of the sella to the left of midline .  
intraoperative screen shot from brainlab neuronavigation system ( brainlab ag , feldkirchen , germany ) displaying a registered probe placed at the spot suggested by coregistration in ( a ) axial , ( b ) coronal , and ( c ) sagittal projections .
rates of recurrence differ according to tumor pathology,6 but it has been suggested that patients with prior target gland destruction , as in patients with nelson syndrome , face higher recurrence rates due to loss of inhibitory feedback.7 in one large series , rates of recurrence for acth tumors was 12% , whereas 25% of those with nelson syndrome faced recurrence within 10 years.6 in the work - up of both de novo and recurrent disease , mri is the imaging modality of choice . unfortunately , reliable direct visualization of microadenomas is limited to tumors greater than 4 mm .
advanced imaging techniques , such as dynamic scanning and delayed postcontrast images , can depict smaller adenomas , but there is a huge potential for misinterpretation.8 thus , acth - secreting adenomas , which are frequently very small , are correctly identified by mri in only about half of cases.9 additionally , for a subset of patients , mri may be contraindicated .
furthermore , imaging of the sella and its contents may be compromised by parasellar metallic artifact from either concomitant previously treated aneurysms11 or as a result of previous sellar surgery . in the latter case ,
metallic artifact may stem from metallic mesh used during buttress repair of the sellar floor1213 or metallic debris from prior drilling.14 if mri is contraindicated or provides insufficient image quality for any of the aforementioned reasons , alternate imaging modalities must be considered .
ct scans , which are routinely ordered to provide surgeons valuable osseous anatomic detail for purposes of operative planning , may be used to visualize sellar - regions tumors , particularly when contrast is administered.15 even on older generation machines , the spatial resolution of ct scanners has allowed for the detection microadenomas as small as 3 to 4 mm,16 but the poor sensitivity of ct for microadenoma detection does not allow this to be done reliably.17 ct scans , like mri , are susceptible to metallic artifact that may degrade image quality18 in patients who have had prior attempts at resection .
scintigraphy , particularly with in - octreotide , may also aid in the diagnosis of pituitary adenomas .
scintigraphy is a nuclear medicine imaging test in which cameras capture emitted radiation from previously administered radioisotopes to form two - dimensional images .
octreotide is a somatostatin analog that binds to several somatostatin receptor subtypes.19 the normal anterior pituitary gland contains these octreotide - binding somatostatin receptor subtypes , but techniques have been developed to detect additional uptake from pituitary adenomas.20 importantly , somatostatin receptor expression , and consequentially scintigraphy visualization , differs by adenoma type .
a high proportion of growth hormone - and thyroid - stimulating hormone - secreting tumors are visualized after in - octreotide administration , whereas prolactin and nonfunctioning adenomas display variable somatostatin receptor expression.2122 acth - secreting tumors present a slightly more complicated picture . in patients with newly diagnosed cushing disease , tumors
do not demonstrate increased uptake,23 but a majority of recurrent acth - secreting tumors are visualized.22 it has been speculated that this difference may be due to decreased somatostatin receptor expression in the setting of long - term cortisol exposure.23 pet scans are another nuclear medicine study in which gamma rays are detected from previously administered radiotracers linked to biologically active molecules . in some cases pet nucleotides
have been used to measure expression of specific receptors , such as dopamine,24 or enzymes , such as monoamine oxidase b.25 much more frequently used , however , are nucleotides targeted at the more general measures of glucose uptake , via the glucose analog fdg , or anabolism , via the amino acid analog c - methionine .
both have found value in the detection of pituitary adenomas,262728293031323334 but c - methionine may have greater utility in detecting microadenomas.29 additional diagnostic utility imaging has been gained by coregistering axial pet images with either ct35 or mri.36 however , although pet coregistration with either mri373839 or ct40 has been used in intraparenchymal tumor surgery , this is the first report of pet coregistration in the setting of pituitary tumor .
 recurrent pituitary disease presents unique challenges , including in some cases difficulty localizing a tumor radiographically . here , we present the case of a patient with recurrent nelson syndrome whose radiographic work - up was complicated by a significant parasellar metallic artifact . 
 positron emission tomography ultimately localized the lesion , and coregistration with computed tomography allowed for accurate intraoperative navigation . 
 additionally , we review a range of imaging techniques available in the evaluation of pituitary disease . 
Introduction
Case Presentation
Discussion