we thank leigh conroy for her help with the matlab algorithms and dr iris kulbatski for her help with editing the manuscript . this work was supported by funding provided to r. dacosta by the canadian institutes for health research .
 the dorsal skinfold window chamber ( dswc ) model is a unique tool that enables analysis of various aspects of tumor biology and therapeutic response . 
 although the protocol for the murine dswc model is standardized , certain tumors fail to grow or require a particular environment to promote growth . 
 given such limitations , we optimized the dswc model for a slow - growing tumor that regresses spontaneously in the standard protocol . 
 we further characterized the vascular network in the tumor model compared with that of non - tumor - bearing mice and observed significant differences in multiple parameters related to vascular structure and function . 
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Acknowledgments