a 60-year - old woman , 135 cm in height and 39 kg in weight , was scheduled for right thyroid lobectomy due to thyroid cancer .
she had severe kyphoscoliosis , and surgery was planned under a sternotomy because the thyroid was located below the sternum .
she tolerated light ordinary life activity , but she felt short of breath during exercise and sleeping . at those times , she had been taking inhaled oxygen intermittently .
on preoperative examination , she did not complain of respiratory difficulty , and both lungs had clear sounds .
however , her neck was very short , and movement limitations were noted ( fig .
chest computed tomography showed severe kyphoscoliosis with destructive vertebral body fusion in the cervical and upper thoracic spine .
the trachea was deviated at an angle of 90 degrees with stenosis just below the deviated area , with the smallest diameter being 6.5  13 mm ( fig .
2 ) . a pulmonary function test revealed the presence of severely restricted pulmonary disease .
the measurements demonstrated fev1 of 0.55 l ( 35% of predicted ) , fvc of 0.7 l ( 35% of predicted ) and fev1/ fvc 78% .
the arterial blood gas analysis in room air was pao2 62.6 mmhg , paco2 44.8 mmhg and ph 7.406 .
other preoperative laboratory tests including echocardiography and thyroid function test were unremarkable . when the patient entered the operating room , the routine monitoring systems , including electrocardiogram , pulse oximetry , and non - invasive blood pressure were started .
proper bag - and - mask ventilation was assured and rocuronium 30 mg was administered to facilitate endotracheal intubation . under direct laryngoscopy , no laryngeal structures could be identified due to the limited neck movement .
subsequently , we used the glidescope videolaryngoscope ( saturn biomedical systems inc . , burnaby , british columbia , canada ) and were able to obtain a proper laryngeal view
however , the tube could not be advanced more than 3 cm beyond the vocal cords due to resistance despite the good laryngeal view .
we attempted intubation again with 5.5 and 5.0 mm tubes , but the same problem was encountered .
other attempts with various methods , such as full rotation of the tube tip , applying a lubricant , and using fiberoptic bronchoscopy , also failed due to same problem .
intubation was tried with a 7.0 mm tube , but the location of the cuff between the vocal cords resulted in gas leakage around the tube despite ballooning .
ultimately , intubation was accomplished with an 8.0 mm tube without cuff ballooning and saline - soaked gauzes were packed around the tracheal inlet to minimize gas leakage and to fasten the tube in the trachea .
then , positive pressure ventilation could be performed successfully , and dexamethasone 5 mg was administered to minimize airway edema .
anesthesia was maintained with sevoflurane in 50% oxygen / air , and a ventilator was set to deliver peak airway pressure of 22 cmh2o at a respiratory rate of 12 to 14 breaths / min .
the tidal volume was maintained around 300 ml , and oxygen saturation by pulse oximetry remained above 95% throughout the anesthesia .
the thyroid gland was very difficult because it was unusually located on the back of the trachea and adhered to neighboring soft tissues .
after the surgery was complete , muscle relaxation was reversed with sugammadex 200 mg , and extubation was uneventful .
the operation time was 3 h 30 min , and the anesthesia time was 5 h 5 min .
after the operation , the patient was transferred to the intensive care unit and was kept for 5 days because of newly developed atelectasis and pleural effusion in the right lung .
chest physiotherapy such as coughing , deep - breathing exercise , and ambulation was also performed .
her pulmonary condition gradually improved , and she was discharged on postoperative day 20 without sequelae .
the abnormal thoracic cage geometry limits the vital capacity and chest wall compliance , generally resulting in restrictive respiratory disease .
this induces alveolar ventilation / perfusion mismatch , worsening of gas exchange , and desaturation .
pulmonary hypertension is the result of increased pulmonary vascular resistance caused by compressed lung vasculature and the response to arterial hypoxia .
the patient complained of dyspnea intermittently , the arterial blood gas analysis showed mild hypoxemia , and pulmonary function tests revealed the presence of severely restrictive pulmonary disease .
however , the patient had been taking medications for dyspnea , and the disease was well - controlled without pulmonary hypertension . rather , an important issue in this patient was the anatomic deformity of the airway , which was anticipated to make endotracheal intubation difficult .
first , her neck was very short , and her neck movement was limited due to kyphoscoliosis with destructive vertebral body fusion
this problem was overcome by using a relatively new airway device : the glidescope videolaryngoscope . compared with direct laryngoscopy
, the glidescope videolaryngoscope has been shown to provide a superior laryngoscopic view for endotracheal intubation .
we were able to obtain a proper laryngeal view using this device and could insert a tracheal tube between the vocal cords easily .
her trachea was severely deviated to an angle of 90 degrees and stenosed below the deviated area .
the tracheal deviation could be caused by various factors including a thyroid goiter , a tumor in the neck and thorax , trauma , congenital cardiac disease , lung collapse   and , like this patient , spinal deformities such as kyphoscoliosis .
whatever the cause may be , in most previous reports , authors tried to advance a tracheal tube below the deviated area and the results were successful . but davies   had reported a case of intubation failure in a patient with combination of marked tracheal deviation and a tracheal diverticulum . in that case , the airway was secured using a laryngeal mask airway during the operation . in the present case , we also tried insert a tracheal tube through the deviated area with various methods . but the tube could not be advanced more than 3 cm beyond the vocal cords despite the proper laryngeal view .
the use of supraglottic airway devices was not considered in this patient because they could have been relatively unsafe during the sternotomy and dissection of the thyroid gland which was unusually located on the back of the trachea .
in addition , if the supraglottic airway device needed to be adjusted , it might have been difficult because the patient 's neck was very short .
therefore , we ultimately decided to place the tube tip above the resistive tracheal area and to additionally pack saline - soaked gauzes around the tracheal inlet to minimize gas leakage and to fasten the tube in the trachea .
then , mechanical ventilation was performed successfully , and the operation proceeded uneventfully . in conclusion , severe kyphoscoliosis could be associated with difficult airway management due to a distorted airway anatomy .
if a tracheal tube could not advance easily in a patient with this disease , one should not force the passage of a tube against resistance . depending on the surgical procedure , using supraglottic airway devices or positioning a tracheal tube above the area of resistance may be useful alternatives .
 we report on a case of difficult endotracheal intubation in a patient with marked tracheal deviation at an angle of 90 degrees combined with stenosis due to kyphoscoliosis with vertebral body fusion . 
 after induction of general anesthesia , a proper laryngeal view was easily obtained using a videolaryngoscope . but a tracheal tube could not be advanced more than 3 cm beyond the vocal cords due to resistance , despite various attempts , including the use of small size tubes , full rotation of the tube tip , and fiberoptic bronchoscopy . ultimately , the airway was successfully secured by placing a tube tip above the area of resistance and by additionally packing saline - soaked gauzes around the tracheal inlet to minimize gas leakage and to fasten the tube in the trachea . 
Case Report
Discussion