aloe vera is one of the endemic plants in southern iran , which has been mentioned in the textbooks of persian medicine since 2500 years ago .
the aim of this study was to compare the effectiveness and cost of aloe vera gel with conventional treatments in patients with chronic ulcers .
this comparative study was conducted on 60 patients with chronic ulcers ( more than 3 weeks ) in al - zahra hospital ( isfahan , iran ) in 2015 .
the participants were divided into two groups of 30 patients per group . in one group , we used conventional treatment plus aloe vera gel and in the other group , only the conventional treatment was used . in the aloe vera group ,
the patients were followed - up a week after the treatment and then monthly for 3 months .
the male : female ratio was 1:1 in each group . the mean age of the aloe vera and control groups were 62.311.2 and 63.19.6 , respectively .
after three months follow - up , wound healing occurred in 28 ( 93.3% ) patients in the aloe vera group and 14 ( 46.7% ) patients in the control group ( p<0.05 ) .
the overall mean time of wound healing was 31.2511.2 and 63.220.4 in the aloe vera and control groups , respectively ( p<0.05 ) .
the mean hospitalization time was 35.26.4 and 67.48.9 in the aloe vera and control groups , respectively ( p<0.05 ) .
the average cost of aloe vera gel and conventional treatment per patient was $ 2 and $ 10 daily , respectively ( p<0.05 ) .
aloe vera gel is a beneficial treatment and cost effective for patients with chronic ulcers .
the use of aloe vera gel in chronic ulcer is recommended in developing countries to lessen the financial burden .
 background : aloe vera is one of the endemic plants in southern iran , which has been mentioned in the textbooks of persian medicine since 2500 years ago . the aim of this study was to compare the effectiveness and cost of aloe vera gel with conventional treatments in patients with chronic ulcers.methods:this comparative study was conducted on 60 patients with chronic ulcers ( more than 3 weeks ) in al - zahra hospital ( isfahan , iran ) in 2015 . 
 the participants were divided into two groups of 30 patients per group . in one group , we used conventional treatment plus aloe vera gel and in the other group , only the conventional treatment was used . in the aloe vera group , 
 we used aloe vera gel twice a day . 
 the patients were followed - up a week after the treatment and then monthly for 3 months.results:the male : female ratio was 1:1 in each group . 
 the mean age of the aloe vera and control groups were 62.311.2 and 63.19.6 , respectively . 
 after three months follow - up , wound healing occurred in 28 ( 93.3% ) patients in the aloe vera group and 14 ( 46.7% ) patients in the control group ( p<0.05 ) . 
 the overall mean time of wound healing was 31.2511.2 and 63.220.4 in the aloe vera and control groups , respectively ( p<0.05 ) . 
 the mean hospitalization time was 35.26.4 and 67.48.9 in the aloe vera and control groups , respectively ( p<0.05 ) . 
 the average cost of aloe vera gel and conventional treatment per patient was $ 2 and $ 10 daily , respectively ( p<0.05).conclusion : aloe vera gel is a beneficial treatment and cost effective for patients with chronic ulcers . 
 the use of aloe vera gel in chronic ulcer is recommended in developing countries to lessen the financial burden . 
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