preparation of solid dispersion of domperidone : domperidone inclusion complexes were prepared with -cd in different ratio ( 1:1 , 1:2 and 1:3 ) by kneading method
. preparation of fast dissolving films : solid dispersion of domperidone and -cyclodextrin ( 1:3 ) was selected and dispersed in half quantity of water and to it methanol is added along with tween-80 and heated at 60c . in other half quantity of water , hpmc e15
it is dried in oven at 60c for 5 hrs to obtain the film . 

morphological properties : properties such as homogeneity , color , transparency and surface of the oral films were evaluated by visual inspection.film mass : the mass of three films were determined by an analytical balance and means.d was calculated.film thickness : film thicknesses were measured at five positions ( central and the four corners ) using the digital vernier caliper and the mean thickness was calculated.folding endurance study : it was measured manually by repeatedly folding a film at the same place till it broke.in vitro disintegration studies : the film as per the dimensions ( 3  2 cm ) required for dose delivery was placed on a stainless steel wire mesh placed in a petridish containing 10 ml phosphate buffer ph 6.8 .
time required for the film to break was noted as in vitro disintegration time.dissolution and drug release : dissolution test of films was performed using ( 900 ml ; phosphate buffer ph 6.8 with usp dissolution apparatus ii at 50 rpm and 370.5c temperature .
the drug release was analyzed spectrophotometrically at max 286.5 nm using ultraviolet ( uv ) spectrophotometer ( shimadzu model no : 1800 ) . 
 
morphological properties : properties such as homogeneity , color , transparency and surface of the oral films were evaluated by visual inspection .
film mass : the mass of three films were determined by an analytical balance and means.d was calculated .
film thickness : film thicknesses were measured at five positions ( central and the four corners ) using the digital vernier caliper and the mean thickness was calculated .
folding endurance study : it was measured manually by repeatedly folding a film at the same place till it broke . in vitro disintegration studies : the film as per the dimensions ( 3  2 cm ) required for dose delivery was placed on a stainless steel wire mesh placed in a petridish containing 10 ml phosphate buffer ph 6.8 .
dissolution and drug release : dissolution test of films was performed using ( 900 ml ; phosphate buffer ph 6.8 with usp dissolution apparatus ii at 50 rpm and 370.5c temperature .
the drug release was analyzed spectrophotometrically at max 286.5 nm using ultraviolet ( uv ) spectrophotometer ( shimadzu model no : 1800 ) .

 morphological properties : properties such as homogeneity , color , transparency and surface of the oral films were evaluated by visual inspection.film mass : the mass of three films were determined by an analytical balance and means.d was calculated.film thickness : film thicknesses were measured at five positions ( central and the four corners ) using the digital vernier caliper and the mean thickness was calculated.folding endurance study : it was measured manually by repeatedly folding a film at the same place till it broke.in vitro disintegration studies : the film as per the dimensions ( 3  2 cm ) required for dose delivery was placed on a stainless steel wire mesh placed in a petridish containing 10 ml phosphate buffer ph 6.8 .
time required for the film to break was noted as in vitro disintegration time.dissolution and drug release : dissolution test of films was performed using ( 900 ml ; phosphate buffer ph 6.8 with usp dissolution apparatus ii at 50 rpm and 370.5c temperature .
the drug release was analyzed spectrophotometrically at max 286.5 nm using ultraviolet ( uv ) spectrophotometer ( shimadzu model no : 1800 ) . 
 
morphological properties : properties such as homogeneity , color , transparency and surface of the oral films were evaluated by visual inspection .
film mass : the mass of three films were determined by an analytical balance and means.d was calculated .
film thickness : film thicknesses were measured at five positions ( central and the four corners ) using the digital vernier caliper and the mean thickness was calculated .
folding endurance study : it was measured manually by repeatedly folding a film at the same place till it broke . in vitro disintegration studies : the film as per the dimensions ( 3  2 cm ) required for dose delivery was placed on a stainless steel wire mesh placed in a petridish containing 10 ml phosphate buffer ph 6.8 .
dissolution and drug release : dissolution test of films was performed using ( 900 ml ; phosphate buffer ph 6.8 with usp dissolution apparatus ii at 50 rpm and 370.5c temperature .
the drug release was analyzed spectrophotometrically at max 286.5 nm using ultraviolet ( uv ) spectrophotometer ( shimadzu model no : 1800 ) .
all the formulation contained varied amount of polymer and hence thickness of each film was varied between the ranges of 0.14 mm-0.36 mm . when the concentration of hpmc e15 is increased from 5%-10% , thickness of the strip increased .
folding endurance was measured manually and it was found to decrease with increase in the concentration of film forming polymer hpmc e15 .
the surface ph of all the formulation was found to be in the range of 6.8 - 7.2 and hence will not cause any irritation to oral mucosa .
f1 formulation found to give minimum disintegration time ( 45 sec ) as compared to other formulations .
the drug release rate decreases as the concentration of the film forming agent hpmc e15 increases in the formulation .
after 15 min interval more than 75% of drug was released from batches as defined in the guidances such as usp30 .
films were prepared of domperidone--cyclodextrin solid dispersion by the use of hpmc e15 as a film forming agent and peg-400 as a plasticizer .
domperidone mouth dissolving films were prepared successfully by the use of solid dispersion of domperidone with -cyclodextrin and it can be used to treat emesis caused by various conditions in geriatric , bedridden and non - cooperative patients due to its ease of production .
 the present investigation was undertaken with the objective of formulating mouth dissolving film(s ) of the antiemetic drug domperidone to enhance the convenience and compliance by the elderly and pediatric patients . 
 domperidone is a drug of choice in case of nausea and vomiting produced by chemotherapy , migraine headaches , food poisoning and viral infections . 
 it causes dopamine ( d2 and d3 ) receptor blockage both at the chemoreceptor trigger zone and at the gastric level . 
 it shows high first pass metabolism which results in poor bioavailability ( 10 - 15% ) . in view of high first pass metabolism and short plasma half - life 
 it is an ideal candidate for rapid release drug delivery system . 
 the solid dispersions of domperidone were prepared with the use -cyclodextrin in various ratios ( 1:1 , 1:2 , 1:3 ) and solubility study was performed to determine the ratio in which solubility of domperidone was highest ( 1:3 ) . 
 the selected solid dispersions were then utilized for the preparation of film by solvent casting method utilizing hpmc e15 as a film forming agent and peg-400 as plasticizer . 
 five formulae were prepared and were evaluated for their in vitro dissolution characteristics , in vitro disintegration time , and their physico - mechanical properties . 
 the promising film ( f1 ) showed the greatest drug dissolution ( more than 75% within 15 min ) , satisfactory in vitro disintegration time ( 45 sec ) and physico - mechanical properties that are suitable for mouth dissolving films . 
Materials and Methods
Evaluation of films
Results and Discussions
Conclusion