the verbal informed patient consent was acquired for the case report publication during the acute rehabilitation .
institutional review board approval was not sought for this case report . whether a patient visits a clinic or
is admitted to the hospital , the importance of a detailed physical examination must be emphasized as a resource leading to an appropriate diagnosis and treatment .
every medical student starts his or her medical career with learning how to take a good history from the patient and perform a thorough physical examination .
this report details such a case where a thorough initial physical examination resulted in the diagnosis of subacute hemorrhagic stroke in a patient with esophageal adenocarcinoma .
a 65-year - old male , an experienced civil engineer , with a history of gastroesophageal reflux disease and hiatal hernia with a new complaint of progressive difficulty swallowing associated with a recent 20-pound weight loss was referred to an oncologist .
the patient was evaluated by the oncology specialist 2 weeks later , and esophagogastroduodenoscopy was performed that revealed a distal esophageal mass , which was identified through a biopsy as moderately differentiated adenocarcinoma .
subsequent positron emission tomography and computed tomography ( ct ) scan studies performed 2 weeks later revealed distal esophageal wall thickening with an increased uptake extending into the proximal stomach but no brain lesions .
the patient received neoadjuvant chemotherapy and en bloc esophagectomy with cervical esophagostomy , pyloroplasty , and jejunostomy feeding tube placement during the subsequent admission to a tertiary medical center .
the patient was medically stabilized and evaluated for admission to a rehabilitation unit . during the rehabilitation admission examination ,
the patient was found to have left homonymous hemianopsia as a new physical examination finding .
the patient also had some confusion with decreased initiation , not being able to perform at his educational level .
considering these new findings along with his recent history of invasive and possibly metastatic esophageal adenocarcinoma , the admission team decided to proceed with a magnetic resonance imaging ( mri ) study of the brain .
the differential diagnosis of brain metastasis versus a new stroke was proposed by the primary treating team .
according to the radiology department report , it was likely a primary brain neoplasm , such as a neural or glial tumor , or lymphoma , but less likely a focus of metastatic disease , given its appearance .
however , according to the oncology department evaluation , the lesion was more consistent with a metastatic tumor than a primary brain lesion .
he was treated with oral antiepileptics . at the same time , the patient complained of having shortness of breath and was diagnosed as having pleural effusions .
a pathological examination of thorasentesis concluded that no malignant cells were present in the pleural effusion fluid .
a series of two head ct scans within 2448 hours were performed to rule out any acute hemorrhage ( figure 2a ) .
the tumor was found to be accessible for resection per neurosurgery evaluation with a plan for tumor resection when the patient was medically stable .
a subsequent craniotomy and lesion biopsy followed by pathology investigation surprisingly identified the lesion as a subacute cortical ischemic stroke negative for neoplasm .
he was provided with appropriate treatment and secondary stroke prophylaxis and was able to complete the rehabilitation on the acute rehabilitation floor .
in the case presented , the diagnosis of subacute ischemic stroke was made on the basis of focal findings during a detailed admission physical examination in the university - based acute rehabilitation unit .
the patient was found to have mild chronic delirium with an inability to concentrate , decreased initiation , affected short - term memory , and homonymous hemianopsia .
all new focal deficit findings , such as homonymous hemianopsia , require additional attention and further investigation .
there are several case reports in the literature strongly suggesting that physicians have to conduct a complete medical history and arrange a specialist consultation for all patients focal findings such as visual field cuts.1 the top differential diagnostic considerations for a presentation of homonymous hemianopsia for this patient were metastatic lesion from a known esophageal carcinoma , stroke , and a primary brain tumor .
according to the mri report , the lesion was  likely primary brain neoplasm , such as a neural or glial tumor , or lymphoma  and  less likely a focus of metastatic disease given the appearance  on the scan images ( figure 1a and b ) .
it is very important to use the knowledge of the morphological presentation , and probability for each type of malignancy , to perform the second step in the evaluation of the patient when the clinical presentation led to the discovery of pathology .
this case presents a complicated identification of the pathology , due to a very unusual presentation of the lesion leading radiology , oncology and neurosurgery departments to believing that the lesion was a tumor with unspecified etiology .
it was only surgical resection that allowed identifying the correct pathology of the brain lesion as a subacute stroke .
the incidences of metastatic lesions from esophageal adenocarcinoma were previously reported in the literature , estimating 2% of patients with esophageal carcinoma having brain metastasis.2 however , a more recent cohort study found 16% of patients with esophageal carcinoma having metastasis to the brain.3 visual field defects after stroke are also well reported in the literature .
the incidence of homonymous field defects was estimated at 8% in all patients with stroke with the majority ( 54% ) located in occipital lobes.4 the estimated lesions located in the lateral geniculate body ( 1% ) are published in the literature.4,5 patients impairments after stroke are significantly exacerbated by visual field defect.6 the most common clinical sign of infarctions in the posterior cerebral arteries distribution are visual field defect followed by neuropsychological deficits and higher order dysfunction including memory impairment as has been presented in this case.7 acute confusional state and delirium are also common especially in the elderly population.7 recent data suggested that confusion and delirium from a stroke in the right posterior cerebral artery distribution is significantly lower in comparison to the left or bilateral posterior artery distribution.8 delirium was reported to remain for an appreciable poststroke period and was a marker of a poor prognosis.9 in this case , the patient is a well - educated and experienced engineer and the owner of an engineering company .
the slow initiation and inferior performance , in light of his level of education , on the admission physical examination , and reported delirium state during the treatment before the admission to the rehabilitation floor , could be explained by the delirium and memory impairment after the posterior artery stroke .
the poststroke visual field defect can result in significant disability and reduction in quality of life .
patients with visual field cut can have a severely reduced quality of life and require additional neuropsychological and visual rehabilitation.4,6 only a thorough physical examination during admission helped to challenge prior negative positron emission tomography scan data and led to the diagnosis of subacute stroke , and following appropriate treatment , secondary stroke prophylaxis and rehabilitation , instead of brain radiation and chemotherapy .
 this case report describes the detection of homonymous hemianopsia and delirium during the admission physical examination of a patient with esophageal adenocarcinoma , resulting in the new diagnosis of subacute hemorrhagic stroke . 
 the poststroke visual field defect can result in significant disability and reduction in quality of life . 
 patients with visual field cut show a severely reduced quality of life and require additional neuropsychological and visual rehabilitation . 
 only thorough physical examination is able to challenge prior negative positron emission tomography scan , leading to the diagnosis of subacute stroke and , following appropriate treatment , secondary stroke prophylaxis and rehabilitation , instead of brain radiation and chemotherapy . 
Case presentation
Discussion
Conclusion