we describe one patient who was affected by an and presented high level increase of serum liver enzymes , along with sever thrombocytopenia .
a 14-year - old boy with an was admitted in the pediatric psychiatric emergency department of alzahra hospital with impaired electrolyte levels , bradycardia , hypotension , liver dysfunction , and thrombocytopenia .
a ten - time increase in liver enzymes and thrombocytopenia were observed on admission . after two months of treatment ,
improvement of initial clinical symptoms and recovery of liver enzymes and thrombocytopenia after the treatment suggested that liver dysfunction and thrombocytopenia may be observed in an patients and should be taken care of by physicians .
a 14-year - old boy with an 8-month history of an referred to our outpatient clinic ( department of pediatrics , alzahra hospital ) . because of his physical condition ( weight loss , bradycardia , imbalanced electrolytes , hypothermia , hypotension , and lung and liver dysfunction ) we decided to hospitalize him ( figure 1 ) . a male patient with anorexia nervosa . on admission to the psychiatric unit ,
his body weight and body mass index ( bmi ) were 31 kg and 13.2 , respectively .
in addition , his liver enzymes were high , and his platelet decreased as shown in table 1 .
other causes of acute liver dysfunction such as hepatotoxic drugs , alcohol , cocaine and viral hepatotoxic diseases were evaluated and then ruled out .
we started to treat the patient with conservative management including stabilizing electrolytes by serum therapy and nourishment using a high calorie diet . a marked decrease in serum transaminase and an increase in platelet count
were observed with a gradual normalization of all the biochemical parameters within one months of hospitalization .
he started eating and his electrolytes got balanced and his family became happy about his recovery .
therefore , he was discharged after one months of hospitalization and successfully continued his rehabilitation program on an outpatient basis .
this was one of the uncommon cases of an with a high level increase ( 10 times more ) of liver enzymes and sever thrombocytopenia .
minor degrees of liver injury have been reported in up to 40% of patients with an.13 although the mechanism of liver injury in an has thought to be due to protein - calorie malnutrition of the kwashiorkor type accompanied with fatty changes , this has not been rigorously demonstrated and the mechanism is still unknown.1314 in an , malnutrition has been reported to cause thrombocytopenia along with liver dysfunction.2 one report has described temporal changes in liver enzyme levels , platelet count , and thyroid peroxidase ( tpo ) levels in a patient with an.3 acute liver failure with a massive increase of serum liver enzyme may be a sever , though relatively uncommon , complication caused by severe malnutrition such as that secondary to an.46 as reported in the literature , serum transaminases do not reach such high values during the refeeding syndrome.7 to avoid complications of refeeding syndromes,7 nutritional rehabilitation is started with a low - energy oral and parental nutrition ( 25 kcal / kg body weight ) . therefore , follow up of serum liver enzymes should be part of our evaluation to prevent the uncommon but serious risk of acute liver failure .
our case report showed an an patient with increased level of liver enzymes about 10 times more than normal range , as well as severe thrombocytopenia , which is uncommon .
therefore , it is concluded that physicians should be aware of high level increase of liver enzymes and severe thrombocytopenia which may occur in an .
 background : anorexia nervosa ( an ) is a difficult - to - treat psychosomatic disease . 
 very few cases of acute liver failure associated with an have been described . 
 we describe one patient who was affected by an and presented high level increase of serum liver enzymes , along with sever thrombocytopenia . 
 then , we discuss the possible etiopathogenic factors.methods:a 14-year - old boy with an was admitted in the pediatric psychiatric emergency department of alzahra hospital with impaired electrolyte levels , bradycardia , hypotension , liver dysfunction , and thrombocytopenia.results:a ten - time increase in liver enzymes and thrombocytopenia were observed on admission . after two months of treatment , 
 the levels were within the normal range.conclusions:improvement of initial clinical symptoms and recovery of liver enzymes and thrombocytopenia after the treatment suggested that liver dysfunction and thrombocytopenia may be observed in an patients and should be taken care of by physicians . 
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Case presentation
Discussion
Conclusion
Authors Contributions