as with nearly every technological advance , the development of genomics holds out the promise of fruitful military applications .
mehlman and li persuasively  and , i believe , correctly  argue that the appropriate bioethical framework for the use of genomic science by the military should be derived primarily from two overriding principles .
first comes the traditional ( though often disputed ) bioethical principle of paternalism . while paternalism in the usual medical context may well be a problematic notion , it is clear in the military context that commanders bear a responsibility for the health and safety of those under their command .
proportionality normally applies only to engagements in which civilian casualties can be expected , and states that a military action is permissible only if the harm to civilians and civilian objects is proportional to the military advantage which directly results from that action . expanding the principle to our own troops
, we say that a soldier can be compelled to undergo a risky procedure only if the harm which can be expected to befall her is proportional to the military advantage which can be expected to result .
proportionality , in mehlman and li 's extended sense , thus requires that , for every proposed genomic intervention , we estimate both the harms to friendly forces and the military advantage gained against our enemies . without the ability to gauge these two quantities
, it will be impossible to evaluate whether or not an action is indeed proportional .
the difficulty of estimating proportionality has , for example , been raised by schmitt and thurnher , leading them to doubt ( due to the context sensitivity and subjectivity of 
military advantage ) whether proportionality calculations could ever be accurately executed by an autonomous robotic weapons system . in this commentary ,
in fact , i think it is quite likely that  situated as it is in the intersection between military ethics and traditional medical ethics , and illuminated by many studies of prior successes and failures of medical research by the military  these two criteria are exactly those which ought to be used to guide discussion of the ethical use of genomics by the military .
rather , i wish to explore in detail one facet of their framework : the estimation of harms and benefits in the context of genomics . unlike several of the case studies that they discuss
, i argue that there are significant in - principle ( not just research - based or in - practice ) problems with the connection between genotypes and phenotypes .
these issues will , at the very least , make incredibly difficult any proper assessment of the proportionality of genomic intervention by the military .
at worst  and i will argue that there are good reasons to think that we are indeed at worst 
i want to stress that i do not intend this to be an argument against mehlman and li 's framework . on the contrary , as i have said above , i believe that mehlman and li have set the bar in precisely the correct place .
that bar , however , is significantly higher than it may seem on a first reading .
justifying any complex military use of genomics will be  and should be , for precisely the reasons that i will outline here  a difficult , if not impossible , enterprise .
the fundamentals of my critique are drawn from recent work in both biology and the philosophy of biology . but first , a brief introduction .
an organism is born with a particular genome  the contents of its dna or  genetic code.
the genotype , however , is only one of the resources that produce the traits of the organism that we actually see  its phenotype .
of course , it is phenotypic traits with which we are actually concerned , as these are the environmentally expressed characteristics , behaviors , morphologies , and so forth that actually matter to the organism during its life .
the determination of this relationship is one of the most difficult open problems in contemporary biology .
an organism 's development , the environment into which it is born and in which it later lives , and interactions between vast networks of genes make it difficult to precisely trace the connection between the simple possession or absence of a particular gene and the possession or absence of some corresponding phenotype in a one - to - one way . as many commentators have put it , the traditional metaphor of genes as a 
this has led to the reconceptualization of this connection as the genotype  phenotype map ( or gp map)the relation from genotypes to phenotypes , which includes all the complex , non - linear interactions of development , genes , and environment . for some traits in some systems ,
this complexity can be worked around . in mendel 's original study of pea plants ( which we all learn in our high school biology classes )
, mendel 's data give the distinct impression that the very simple traits of peas with which he was concerned ( green v. yellow peas or smooth v. wrinkled skin ) can be predicted accurately by merely determining whether or not the plant at issue possesses a particular gene .
however , to understate the issue , a soldier is not a green , wrinkly pea .
a dod report referenced by mehlman and li cites as traits of interest phenomenally complex phenotypes such as susceptibility to  post - traumatic stress disorder , the ability to tolerate conditions of sleep deprivation , dehydration , or prolonged exposure to heat , cold , or high altitude , or the susceptibility to traumatic bone fracture , prolonged bleeding , or slow wound healing. later , mehlman and li describe  genetic variants associated with coolness under fire ( p. 28 ) as a target for possible military genomic screening .
assuming that coolness under fire is a concept sufficiently well defined to count as a phenotype in the first place , it will clearly be a massively complicated one .
for the sake of argument , let 's say that we are able to ignore entirely the influences of development and environment on  coolness under fire. this is obviously implausible , but we will be able to make trouble even without considering these factors . to get an idea of the complexity of the genetic regulatory networks that produce traits ,
they describe a single network which controls the differentiation of two body layers in the embryo of the sea urchin . the resulting diagram contains more than 40 genes , in a highly interconnected , robust , and self - regulating network . and
this is a network for a single step in the development of a highly simplified and well - understood model organism .
inference of gene networks in mammals is even more difficult , confounded by more complex regulatory architecture , higher post - transcriptional modification , and the need to refer not only to gene expression data , but also perturbation ( knock - down or over - expression ) experiments . thus far
, we 've seen a variety of in - practice concerns with the estimation of the gp map  but as of yet , nothing of an in - principle sort , nothing that would lead us to believe that it is impossible for sufficient research into human systems to solve the problem .
after all , if davidson can describe the genomic regulatory networks for sea urchin embryo development , is it not merely a difference in degree between these networks and those present in humans ?
why is trouble in the gp map a difficulty for us here in the first place ?
for this , we must return to the concept of proportionality . if we are to accurately estimate either the harm that might befall our own troops or the military advantage that would result from a particular genomic intervention , we clearly must know what phenotypic effects intervening on a particular gene will have in a particular population . and
this problem , then , just is the problem of understanding the gp map . without the ability to translate from genetic to phenotypic effects , estimations of both halves of the proportionality calculus will be hard to come by .
they argue that  the military must be mindful of relying too heavily on the results of genomic tests that have not been adequately validated ( p. 31 ) , mentioning particularly the popular media 's tendency to overstate the significance and potential power of genomic results .
they explore , then , in some detail , the question of how the military ought to move forward in cases where there is a compelling reason to deploy a genomic technology which hasn't been fully tested , drawing an extensive analogy to off - label use of vaccines against chemical and biological weapons , as deployed fairly extensively in the gulf war and since ( pp . 
this analogy , however , fails to capture the way in which these problems with the gp map are disconcerting for ethical evaluations of military genomic technologies . in the vaccine case
, we have a straightforward instance of an absence sufficient testing data  an intervention which could readily be shepherded through the traditional clinical trial procedure but has not been , as a result of a lack of time , funding , interest from pharmaceutical companies , or what have you .
i think the kinds of concerns already mentioned make it clear that mehlman and li understate the problems in testing and validation for genomic interventions of any real complexity .
but for the remainder of the paper , i wish to briefly pursue a more troublesome argument .
given the kinds of in - principle difficulties present in the notion of the gp map , i find it likely that it is in fact impossible to obtain enough knowledge concerning the connections between genotype and interesting phenotypes to successfully evaluate proportionality .
a plethora of current theoretical and experimental work has indeed improved our knowledge of the gp map . as chronicled by pigliucci , studies from computer science
have increased our understanding of modularity and network structure , gene networks are far better understood experimentally than they once were , and rna folding has served as a fruitful model for more complex gp relationships .
but while this work indicates that progress has been made in simple systems , there is room for skepticism beyond such cases .
pigliucci argues that  a truly satisfactory empirical understanding of gp relations in complex organisms may [ be ] forever beyond our grasp because of practical epistemic limitations. what are these practical epistemic limitations ?
in short , while a minor gap in our empirical understanding of the gp map may only constitute an in - practice experimental difficulty , a large enough number of these  minor gaps rises to the level of inability in principle to make accurate predictions .
two such twins , who have ( almost ) identical genotypes , serve as a natural experiment that can isolate and thus estimate the contribution to a disease ( or other phenotype ) arising solely from that disease 's genetic basis . after statistical analysis in which the study authors estimated the contribution of the genome to some 20 different diseases , they discovered that  most sequenced patients would not gain any useful information , since their risk of disease , even with full knowledge of their genome ,  would be similar to that of the general population . in the best - case scenario ,
the majority of patients might be alerted to one or a few disease risks. further , this study was in search of disease phenotypes  and on the basis of our genetic studies of cancer , for example , we have reason to think that many disease phenotypes are much less complex than those singled out by mehlman and li as of potential military interest . and
it is not difficult to see why it is that ,  for the foreseeable future , [ empirical charting of the gp map ] seems feasible only for simple instances of gp. estimation of the gp map requires input from studies of gene networks and evolution , from development , from physiology and morphology , from ecology , from environmental studies , from behavior , and even , in humans , from sociology and studies of culture . as boudry and pigliucci put it ,
 once we start talking about complex organisms , particularly those characterized by flexible developmental trajectories , all bets are off. it is thus likely that , despite the many advances in our understanding of the gp map in recent years , the shape of this map for organisms of any significant complexity  not to mention humans  is so intricate as to be , at best , far , far beyond our current capacities for estimation , and at worst ( which is the more likely outcome ) forever beyond our knowledge .
mehlman and li have done a great service in laying out and carefully arguing for a comprehensive approach to understanding the ethics of the use of genomic science by the military . indeed , in at least some cases  where the phenotypes at issue are relatively simple 
the collection of genomic data by the military and screening of our armed forces has the potential to improve health outcomes for our troops , a goal which we all should support .
the obstacles to this simpler kind of program are of an in - practice sort ; it would require expensive data collection and analysis , a problem that the military is particularly well poised to solve .
but when it comes to phenotypes that are much more complex than this  phenotypes like  coolness under firedifficulties of an in - principle sort arise .
the complexity of the relationship between genotypes and phenotypes makes it unlikely that it is possible for us to obtain enough data to accurately estimate the potential harm to our troops and the potential military advantage that would accrue from a genomic intervention .
it will , therefore , be impossible to estimate the proportionality of interventions like these . on mehlman and li 's framework , then , we can not determine , for many traits ( many of the traits in which the military seems to be most interested , at least according to the documents which mehlman and li cite ) , whether or not such an intervention is ethical .
far from a problem with their analysis , however , i believe that mehlman and li have offered a framework that encourages an appropriate level of caution regarding these types of experiments . for complex , human phenotypes , it should be difficult to ethically justify such an intervention , and it is a virtue of their ethical framework that it lets us see precisely why .
 mehlman and li offer a framework for approaching the bioethical issues raised by the military use of genomics that is compellingly grounded in both the contemporary civilian and military ethics of medical research , arguing that military commanders must be bound by the two principles of paternalism and proportionality . 
 i agree fully . 
 but i argue here that this is a much higher bar than we may fully realize . just as the principle of proportionality relies upon a thorough assessment of harms caused and military advantage gained 
 , the use of genomic research , on mehlman and li 's view , will require an accurate understanding of the connection between genotypes and phenotypes  accurate enough to ameliorate the risk undertaken by our armed forces in being subject to such research . 
 recent conceptual work in evolutionary theory and the philosophy of biology , however , renders it doubtful that such knowledge is forthcoming . 
 the complexity of the relationship between genotypic factors and realized traits ( the so - called  
 gp map ) makes the estimation of potential military advantage , as well as potential harm to our troops , incredibly challenging . 
 such fundamental conceptual challenges call into question our ability to ever satisfactorily satisfy the demands of a sufficiently rigorous ethical standard . 
INTRODUCTION
THE LONG AND WINDING ROAD FROM GENOTYPES TO PHENOTYPES
IN-PRINCIPLE WORRIES IN THE GP MAP
CONCLUSIONS