 beauty depends on size as well as symmetry  symmetry is an important concept in biology , being related to health , mate selection strategies , and ultimately the survival of the species . while deviations from symmetry are critical perceptual units in detecting the appearance of health , the natural subtle asymmetry of the human face may be relatively unimportant for judging facial attractiveness
. a grossly perceptible asymmetry of the face , however , as seen in hemifacial hypertrophy can be highly disconcerting to the patient .
the treatment of this condition is unpredictable with an uncertain prognosis and remote chances of patient satisfaction .
we have reported a case of true hemifacial hypertrophy in a young female adult and attempted to summarize the possible treatment alternatives to the conventional surgical treatment .
a 23-year - old female patient presented to the department of oral and maxillofacial surgery with a chief complaint of asymmetry of her face .
she gave a history of an abnormally enlarged left half of her face since birth which became more prominent following menarche .
the patient had visited multiple plastic surgery units since childhood and had been diagnosed with hemihypertrophy [ figure 1 ] .
she was under a regular follow - up regimen by her gp to look for developing cancers .
there was no history of such complaints in the family and serum chemistry revealed no abnormalities .
the swelling was diffuse , soft , and extended from the frontal bone to the lower border of the mandible on the left side .
the zygomatic root was enlarged on palpation [ figures 2 and 3 ] . mouth opening and
the left half of the hard palate was enlarged with a normal complement of teeth in the maxillary arch .
the molars in the mandibular arch had been extracted at an earlier date due to caries .
three soft growths were present ; at the lower labial mucosa , the buccal mucosa , and the retromolar area .
an excisional biopsy of the growth at the left buccal mucosa was found to be lipomatous in origin .
panoramic radiograph showed that the left palate , mandibular body , ramus , condyle , and coronoid were asymmetrically enlarged .
the computed tomography showed uniform bony enlargement of the left half of the face including the frontal bone [ figure 4 ] .
based on the clinical and radiographic features , the patient was provisionally diagnosed with true hemifacial hypertrophy of the left face .
axial section computed tomography scan the patient had been informed of the possible treatment options including extensive surgery for hard and soft tissue debulking and more conservative options for only soft tissue recontouring .
she had been informed that irrespective of the treatment done , it would not be possible to achieve complete symmetry .
the patient , however , was adamant and wished for treatment only if complete symmetry could be achieved .
congenital hemihypertrophy or partial gigantism was first described by meckel in 1822 and gained widespread recognition after gesell 's classic description as  essentially a developmental deflection of the normal process of birth .
 hemihypertrophy or hemihyperplasia may be an isolated finding , or it may be associated with other syndromes such as beckwith 
idiopathic hemihyperplasia is associated with mild cognitive disability , genitourinary anomalies , and a high association with wilm 's tumor .
our case showed the presence of only an enlarged half of the face with no other part of the body exhibiting asymmetry .
the criteria for the hemifacial type as specified by rowe includes unilateral enlargement of the viscerocranium , limited superiorly to the frontal bone ( not including the eye ) , the lower border of the mandible inferiorly , the mid - line of the face medially , the ear , the pinna being included within the hypertrophic area laterally and enlargement of all tissues - teeth , bone , and soft tissues within this area [ table 1 ] .
classification of congenital hemihypertrophy by roubeir while khanna and andrade , noted that a relative disproportion is maintained due to the proportional growth of the normal and the abnormal sides , arora et al . observed that the asymmetry becomes accentuated with age . in this case , the asymmetry was detected at birth but became more apparent as the affected part enlarged at a greater rate than the rest of the body , most noticeably at the onset of menarche .
our case , similar to previous case reports revealed lipomatosis as the dominant feature at the abnormal half .
the teeth , mandible , and maxilla should be carefully scrutinized for deformities to help one reach the correct diagnosis .
true hemihypertrophy involves not only the soft tissues of the body but the hard tissues as well .
the professed causes for this condition include inherited chromosomal abnormalities endocrine dysfunctions , vascular or lymphatic malformation , atypical forms of twinning , altered intrauterine environment , and disturbances of the central nervous system pollock et al . advocated that an enlarged neural tube on one side is responsible for the unilateral increase in size .
the growth of the neural tube follows a cephalocaudal gradient of growth and it reasonable to expect that some tube segments are more involved than others .
rowe described abnormalities in the dentition of the abnormal side in three respects ; the crown size , the root size and shape , and rate of development .
he noted that not all teeth were similarly affected . in the deciduous dentition , the second molar and in the permanent dentition
the cuspids were the most commonly affected teeth followed by the first molars and premolars .
it was also interesting to note that the premolars were the most enlarged among the teeth ; however , the second molars which develop around the same period are not .
early shedding of deciduous teeth , delayed eruption of permanent teeth , prematurely developed teeth with short roots and congenitally missing teeth were often seen on the affected side .
rowe described the alveolar bone to be larger and thicker on the affected side with the largest bulk distal to the largest tooth .
there was also a propensity for an open bite as both posterior ridges developed exostoses which contacted each other during jaw closure .
pollock et al . described the buccal mucosa as one which hangs in soft pedunculus folds .
the tongue enlargement has also been described to be uniform , beginning abruptly in the midline with excrescences resembling large fungiform papillae . in the present case ,
the buccal mucosa on the affected side showed lipomatous growths , the tongue , lip , and palate were uniformly enlarged ; however , the teeth appeared to be normal in size , and the patient gave no history of abnormalities during shedding . to the unfamiliar clinician , this condition can constitute a baffling diagnostic problem .
deformities of the teeth and their related hard tissues in the jaw are key findings for correct diagnosis , particularly in hemihypertrophy limited to the face .
the treatment modalities extend from subtle soft tissue contouring to extensive surgeries to correct the underlying bony defect and reshape the overlying soft tissues .
the hard tissues can be treated by a combination of condylar recontouring , osteotomies , and ostectomies to achieve the required shape , followed by debulking of soft tissues .
extensive surgical treatment had been performed by pollock et al . and khanna and andrade who used extra- and intra - oral approaches to the deformed skeleton .
khanna and andrade performed extensive surgeries in three stages using a hard and soft tissue debulking to achieve an acceptable result , while pollock used osteotomies and recontouring to correct the bony deformities .
he advocated the treatment of the soft tissue deformity by excision , rhytidectomy , and cheiloplasty .
even though there have been sporadic reports of acceptable results following surgical treatment , dearth of literature , the possibility of aggravating the growth , the difficulties in recontouring an entire half of the face , the uncertainties of how much soft tissue reduction should be done and the possibility of suboptimal postoperative esthetics dissuaded us from approaching the condition in an aggressive surgical manner .
the ideal conditions for the use of liposuction are the existence of sufficient elasticity of the skin ; little excess skin and sufficient subcutaneous adipose tissue to be suctioned .
liposuction not only allows the flattening of contours but correction of sagging teguments , resulting in some skin retraction .
later , a small amount of fluid was introduced into the fat ( wet liposuction ) .
klein revolutionized liposuction surgery when he developed the tumescent technique that permits large - volume liposuction under local anesthesia without sedation or narcotic analgesics .
tan in his case report described tumescent liposuction in the treatment of partial hemifacial hypertrophy .
he performed the procedure using almost 50 ml of modified klein solution before the suction and reported positive results .
as described by klein < 1% of the suctioned material in this technique is whole blood .
a number of variations of this technique has been utilized for the face and neck regions .
ultrasound assisted liposuction consist of repetitive expansion and passive contraction of adipocytes , resulting in rupture of their cellular membrane and liquefaction of fat .
there are however chances of contact of the tip of the ultrasonic probe with the under surface of the skin complications such as burns , necrosis and subsequent scarring , nerve injury , and seroma formation .
another system used is the powered lipoplasty ( vibroliposuction ) by rebelo ; this involves a reciprocal  to - and - fro  motion of the cannula tip using a pneumatic - driven system .
this movement mimics action during traditional suction - assisted liposuction due to which , surgeons experience less fatigue during power liposuction with easier penetration and removal of adipose tissue . disadvantages of power liposuction include seroma formation , the creation of larger diameter tunnels ( more than the actual cannula size used ) , swelling and bruising .
recently , new laser systems have stimulated lipolysis by the means of small laser fibers introduced through a small cannula directly into the subcutaneous fat .
a confluent red diode aiming beam at the tip of the cannula provides visual guidance through transcutaneous - illumination during treatment .
large volume liposuction may require higher laser energies , increasing the risk of burns and skin necrosis .
in addition , this technique is more time consuming , as the surgeon has to move the laser cannula relatively slowly through then skin to allow for necessary time for the laser - tissue interaction and a second pass with a suction cannula is necessary for fat aspiration .
phosphatidylcholine is safe and nontoxic with no significant acute or chronic toxicity , mutagenicity or teratogenicity .
although phosphatidylcholine is the main ingredient in most injectable preparations , it must be mixed with sodium deoxycholate ( a bile salt ) to make it soluble enough for injection .
once injected into the subcutaneous tissue , the chain reaction continues over a period of 810 weeks .
peckitt demonstrated the destabilization of the adipocyte cell membrane following injection of a critical concentration of phosphatidylcholine .
this change in the physical properties of the cell membrane then appears to cause a complex enzymatic cascade involving the release of lipases and other enzymes as well as a rapid apoptotic cascade that causes adipocyte cell death .
if the critical concentration is not reached , the unstable cell membrane forms gaps or pores , allowing efflux of some of the cytoplasmic contents . despite the temporary side effects that cause a degree of discomfort
, phosphatidylcholine injections can be used successfully in the treatment of localized and small fatty areas of the face , as it requires a few injections and < 1 vial .
injection of phosphatidylcholine seems to be a better , safer , and more cost - effective treatment than liposuction in these specific cases .
the treatment modalities extend from subtle soft tissue contouring to extensive surgeries to correct the underlying bony defect and reshape the overlying soft tissues .
the hard tissues can be treated by a combination of condylar recontouring , osteotomies , and ostectomies to achieve the required shape , followed by debulking of soft tissues .
extensive surgical treatment had been performed by pollock et al . and khanna and andrade who used extra- and intra - oral approaches to the deformed skeleton .
khanna and andrade performed extensive surgeries in three stages using a hard and soft tissue debulking to achieve an acceptable result , while pollock used osteotomies and recontouring to correct the bony deformities .
he advocated the treatment of the soft tissue deformity by excision , rhytidectomy , and cheiloplasty .
even though there have been sporadic reports of acceptable results following surgical treatment , dearth of literature , the possibility of aggravating the growth , the difficulties in recontouring an entire half of the face , the uncertainties of how much soft tissue reduction should be done and the possibility of suboptimal postoperative esthetics dissuaded us from approaching the condition in an aggressive surgical manner .
the ideal conditions for the use of liposuction are the existence of sufficient elasticity of the skin ; little excess skin and sufficient subcutaneous adipose tissue to be suctioned .
liposuction not only allows the flattening of contours but correction of sagging teguments , resulting in some skin retraction .
later , a small amount of fluid was introduced into the fat ( wet liposuction ) . however , the patients frequently required blood transfusions due to blood loss .
klein revolutionized liposuction surgery when he developed the tumescent technique that permits large - volume liposuction under local anesthesia without sedation or narcotic analgesics .
tan in his case report described tumescent liposuction in the treatment of partial hemifacial hypertrophy .
he performed the procedure using almost 50 ml of modified klein solution before the suction and reported positive results .
as described by klein < 1% of the suctioned material in this technique is whole blood .
a number of variations of this technique has been utilized for the face and neck regions .
ultrasound assisted liposuction consist of repetitive expansion and passive contraction of adipocytes , resulting in rupture of their cellular membrane and liquefaction of fat .
there are however chances of contact of the tip of the ultrasonic probe with the under surface of the skin complications such as burns , necrosis and subsequent scarring , nerve injury , and seroma formation .
another system used is the powered lipoplasty ( vibroliposuction ) by rebelo ; this involves a reciprocal  to - and - fro  motion of the cannula tip using a pneumatic - driven system .
this movement mimics action during traditional suction - assisted liposuction due to which , surgeons experience less fatigue during power liposuction with easier penetration and removal of adipose tissue . disadvantages of power liposuction include seroma formation , the creation of larger diameter tunnels ( more than the actual cannula size used ) , swelling and bruising .
recently , new laser systems have stimulated lipolysis by the means of small laser fibers introduced through a small cannula directly into the subcutaneous fat .
a confluent red diode aiming beam at the tip of the cannula provides visual guidance through transcutaneous - illumination during treatment .
large volume liposuction may require higher laser energies , increasing the risk of burns and skin necrosis .
in addition , this technique is more time consuming , as the surgeon has to move the laser cannula relatively slowly through then skin to allow for necessary time for the laser - tissue interaction and a second pass with a suction cannula is necessary for fat aspiration .
phosphatidylcholine is safe and nontoxic with no significant acute or chronic toxicity , mutagenicity or teratogenicity .
although phosphatidylcholine is the main ingredient in most injectable preparations , it must be mixed with sodium deoxycholate ( a bile salt ) to make it soluble enough for injection .
once injected into the subcutaneous tissue , the chain reaction continues over a period of 810 weeks .
peckitt demonstrated the destabilization of the adipocyte cell membrane following injection of a critical concentration of phosphatidylcholine .
this change in the physical properties of the cell membrane then appears to cause a complex enzymatic cascade involving the release of lipases and other enzymes as well as a rapid apoptotic cascade that causes adipocyte cell death .
if the critical concentration is not reached , the unstable cell membrane forms gaps or pores , allowing efflux of some of the cytoplasmic contents . despite the temporary side effects that cause a degree of discomfort
, phosphatidylcholine injections can be used successfully in the treatment of localized and small fatty areas of the face , as it requires a few injections and < 1 vial .
injection of phosphatidylcholine seems to be a better , safer , and more cost - effective treatment than liposuction in these specific cases .
, rare conditions like hemifacial hypertrophy are ill understood , and the possibility of achieving perfect symmetry in these cases is a herculean task .
we feel that safer , conservative and cost effective options such as liposuction and subcutaneous injections of phosphatidylcholine must be done , especially so in cases where the surgical treatment would be deemed too extensive and not without the possibility of unsatisfactory outcomes .
the authors certify that they have obtained all appropriate patient consent forms . in the form the patient(s )
has / have given his / her / their consent for his / her / their images and other clinical information to be reported in the journal .
the patients understand that their names and initials will not be published and due efforts will be made to conceal their identity , but anonymity can not be guaranteed .
the authors certify that they have obtained all appropriate patient consent forms . in the form the patient(s )
has / have given his / her / their consent for his / her / their images and other clinical information to be reported in the journal .
the patients understand that their names and initials will not be published and due efforts will be made to conceal their identity , but anonymity can not be guaranteed .
 congenital hemihyperplasia is a rare developmental disorder characterized by unilateral overgrowth of one or more body parts resulting in marked asymmetry . 
 we are reporting here , a case of true hemifacial hypertrophy in a young female adult highlighting the clinical features and possible treatment options . 
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