the german pathologist rudolph virchow was probably the first to describe the histologic features of myxofibroma in 1863 , although the lesions of jaws were not particularly mentioned . in 1947 ,
odontogenic myxoma is an uncommon benign mesenchymal odontogenic tumor arising from the dental papilla , follicle , or the periodontal ligament .
the evidence for its odontogenic origin arises from its almost exclusive location in the tooth 
bearing areas of the jaws , its occasional association with missing or unerupted teeth and the presence of odontogenic epithelium . clinically , odontogenic myxoma is a benign painless , invasive , slowly enlarging mass causing marked asymmetry of the face .
it usually occurs in second and third decades of life and causes expansion of bony cortices , displacement and loosening of teeth .
radiographically , its appearance ranges from unilocular pericoronal radiolucency with variable trabecular pattern giving rise to soap bubble , tennis racquet , or honey comb appearance .
histopathologically , the odontogenic myxoma is characterized by loose , abundant mucoid stroma that contains rounded , spindle shaped or angular cells .
various surgical procedures were mentioned which includes curettage , excision ( 0.5 mm from apparent normal bony margin ) , resection ( 1 cm from apparent bony margin ) , resection with disarticulation , excision of tumor with dento - alveolarsegment and preservation of the mandibular lower boarder and maxillectomy .
while generally considered a slow - growing neoplasm , odontogenic myxomas may be infiltrative and aggressive with high recurrence rates .
due to poor follow - up and lack of reports , a precise analysis of recurrence rates is still missing . in view of its rarity ,
a 25-year - old male patient presented at st joseph dental college , eluru with painless gradually progressive swelling in the left side of the jaw for 2 years .
the intraoral examination of the maxillary and mandibular arch revealed permanent dentition except for the absence of three - dimensional ( 3d ) molars in the maxillary jaw and amalgam filling of tooth 15 , 16 , 26 and 46 .
the extra oral and general examinations revealed no other abnormalities . on palpation , there was diffuse , non tender swelling of 2  2 cm involving tooth 36 with the expansion of cortical plates .
based on the clinical and radiographic finding , a provisional diagnosis of odontogenic cyst was made .
fine needle aspiration was attempted to confirm the provisional diagnosis , but it was inconspicuous and this attempted aspiration precipitated pain and inflammation to the subject .
keeping the view of provisional diagnosis and small size of the lesion , surgical excision with curettage was done under local anesthesia and the excised tissue was sent for the histopathological examination . grossly , the excised mass was brownish - white in color , without encapsulation and soft in consistency [ figure 1 ] .
microscopic examination revealed haphazardly arranged stellate , spindle - shaped cells in an abundant , loose myxoid stroma that contains only few collagen fibrils , thus confirming it to be odontogenic myxoma .
photograph showing the biopsy specimen of case 1 a 26-year female reported to the department of oral and maxillofacial surgery with a chief complaint of swelling on the left side of the face since 1 month .
on intraoral examination , the swelling presented as an exophytic growth , soft to firm in consistency and tender .
on palpation , the swelling was diffuse , firm , non - fluctuant , hard and tender .
displacement of the teeth along with expansion of buccal and lingual cortical plates was evident .
preoperative intraoral photograph case 2 the panoramic tomogram was taken which showed well - demarcated multilocular radiolucent lesion with honey comb or tennis racquet appearance [ figure 3 ] .
hence , the provisional diagnosis of odontogenic keratocyst , ameloblastoma , central giant cell granuloma and odontogenic myxoma was made .
incisional biopsy was performed under local anesthesia and the specimen was sent for the histopathological examination . on examination ,
the specimen showed a dense and diffuse collection of the fibers and fibroblasts and small inconspicuous strands of odontogenic epithelium .
radiograph showing honeycomb or tennis racquet appearance based on the incisional biopsy report , progressive nature of the lesion and cortical expansion , radical resection with hemimandibulectomy was advised .
a submandibular approach was followed under general anesthesia to expose this ill - defined mandibular mass [ figure 4 ] .
after the incision through skin , dissection was carried out through subcutaneous tissues , platysma , deep fascia and finally , the pterygomassetric sling with periosteum is divided to approach the inferior border of the mandible .
subperiosteal reflection of the masseter muscle is done along the lateral surface of the mandible to expose the coronoid process , sigmoid notch and condylar neck .
the anterior portion of the resection is determined and dissected using the saw blade for complete osteotomy .
the specimen is completely removed and the surgical area is irrigated [ figure 5 ] .
reconstruction is done by placing the iliac graft , which can be appreciated in the postoperative radiograph [ figure 6 ] .
the resected specimen is sent for the histopathological examination , which discovered it to be odontogenic myxoma [ figure 7 ] .
intraoperative procedure opg showing reconstruction with iliac graft h and e stained section showing stellate , spindle - shaped cells in an abundant , loose myxoid stroma
a 25-year - old male patient presented at st joseph dental college , eluru with painless gradually progressive swelling in the left side of the jaw for 2 years .
the intraoral examination of the maxillary and mandibular arch revealed permanent dentition except for the absence of three - dimensional ( 3d ) molars in the maxillary jaw and amalgam filling of tooth 15 , 16 , 26 and 46 .
the extra oral and general examinations revealed no other abnormalities . on palpation , there was diffuse , non tender swelling of 2  2 cm involving tooth 36 with the expansion of cortical plates .
based on the clinical and radiographic finding , a provisional diagnosis of odontogenic cyst was made .
fine needle aspiration was attempted to confirm the provisional diagnosis , but it was inconspicuous and this attempted aspiration precipitated pain and inflammation to the subject .
keeping the view of provisional diagnosis and small size of the lesion , surgical excision with curettage was done under local anesthesia and the excised tissue was sent for the histopathological examination . grossly , the excised mass was brownish - white in color , without encapsulation and soft in consistency [ figure 1 ] .
microscopic examination revealed haphazardly arranged stellate , spindle - shaped cells in an abundant , loose myxoid stroma that contains only few collagen fibrils , thus confirming it to be odontogenic myxoma .
a 26-year female reported to the department of oral and maxillofacial surgery with a chief complaint of swelling on the left side of the face since 1 month .
on intraoral examination , the swelling presented as an exophytic growth , soft to firm in consistency and tender . the mucosa overlying the swelling was pale pink in color [ figure 2 ] .
on palpation , the swelling was diffuse , firm , non - fluctuant , hard and tender .
displacement of the teeth along with expansion of buccal and lingual cortical plates was evident .
preoperative intraoral photograph case 2 the panoramic tomogram was taken which showed well - demarcated multilocular radiolucent lesion with honey comb or tennis racquet appearance [ figure 3 ] .
hence , the provisional diagnosis of odontogenic keratocyst , ameloblastoma , central giant cell granuloma and odontogenic myxoma was made .
incisional biopsy was performed under local anesthesia and the specimen was sent for the histopathological examination . on examination ,
the specimen showed a dense and diffuse collection of the fibers and fibroblasts and small inconspicuous strands of odontogenic epithelium .
radiograph showing honeycomb or tennis racquet appearance based on the incisional biopsy report , progressive nature of the lesion and cortical expansion , radical resection with hemimandibulectomy was advised .
a submandibular approach was followed under general anesthesia to expose this ill - defined mandibular mass [ figure 4 ] .
after the incision through skin , dissection was carried out through subcutaneous tissues , platysma , deep fascia and finally , the pterygomassetric sling with periosteum is divided to approach the inferior border of the mandible .
subperiosteal reflection of the masseter muscle is done along the lateral surface of the mandible to expose the coronoid process , sigmoid notch and condylar neck .
the anterior portion of the resection is determined and dissected using the saw blade for complete osteotomy .
the specimen is completely removed and the surgical area is irrigated [ figure 5 ] .
reconstruction is done by placing the iliac graft , which can be appreciated in the postoperative radiograph [ figure 6 ] .
the resected specimen is sent for the histopathological examination , which discovered it to be odontogenic myxoma [ figure 7 ] .
intraoperative procedure opg showing reconstruction with iliac graft h and e stained section showing stellate , spindle - shaped cells in an abundant , loose myxoid stroma
odonogenic myxoma is a nonencapsulated benign tumor of the jaw bones , comprising around 36% of all odontogenic tumors .
previous studies by white et al . , refer the tip of the incidence with an age range of 1170 years , but the majority of the cases are between 10 and 40 years of age .
our two cases surpass the second decade of life , but can be addressed within the range referred in the literature . although its most frequent location is the posterior mandible , other locations such as the incisive sector , upper maxilla and mandibular condyle must be considered .
present cases showed lesion in the mandible with extension in the posterior region of the mandible .
pain , displacement of teeth and parasthesia are uncommon , thus the lesion can reach considerable size before the patients becomes aware of its presence and seeks treatment .
our cases showed a large mass as the main aspect in physical examination , but in case one patient developed pain after aspiration .
radiologically , the appearance may vary from a unilocular radiolucency to a multicystic lesion with a well defined or diffused margin .
a unilocular appearance may be seen more commonly in children and in the anterior parts of the jaws . in tooth - bearing areas , the tumor is often scalloped between the roots ;
differential diagnosis must be established with other clinically similar entities , such as simple cyst , ameloblastoma , intraosseous hemangioma , giant cell granuloma , osseous aneurismatic cyst and metastasis .
histologically , odontogenic myxoma shows a spectrum of fibrous connective tissue stroma is present , from myxoid to dense hyalinized and from relatively acellular to cellular .
calcification may or may not be present.[1014 ] the variation in the histopathological diagnosis between the initial biopsy as odontogenic fibroma and the final diagnosis as odontogenic myxoma in our case 2 could be attributed either to the biological spectrum of this lesion or non  inclusion of myxomatous areas in the incisional biopsy .
the tumor is not radiosensitive and treatment is by surgery . despite surgery it has been established as the treatment of choice of these tumors , no unanimous consensus exists concerning the extension of surgery .
although it is our opinion that enucleation should be avoided , curettage with scarification of the cavity with acrylic bur may be used for small mandibular lesions particularly in the anterior region and especially where the patient is educated and available for periodic reviews .
in the present cases , the surgical management involved an intra and extra oral approaches .
prognosis after excision is excellent in this 2-year follow up period in both the cases .
odontogenic myxoma is a slow growing benign , locally malignant tumor , notorious for recurrence .
due to the unspecific nature of these lesions along with diagnostic and operative dilemmas related to myxomatous tumors , a sound knowledge with proper histopathological diagnosis is required for maxillofacial surgeons to improve skills in their management .
 odontogenic tumors represents a broad spectrum of lesions ranging from benign to malignant to dental hamartomas all arising from odontogenic residues , that is , the odontogenic epithelium , ectomesenchyme with variable amounts of dental hard tissues formed in the same sequence as in normal tooth development . 
 we report two cases of myxoma , which were misdiagnosed initially and latter , reported as odontogenic myxoma ; and were treated by conservative surgical excision in one case and radical resection with hemimandibulectomy in the other case . 
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Case 1
Case 2
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