. Mr. Justice Rehnquist
delivered the opinion of the Court.
. Respondent was tried before a jury in Massachusetts Superior Court and convicted of first-degree murder. The jury recommended that the death penalty not be imposed, and respondent was sentenced to life imprisonment. He appealed to the Supreme Judicial Court of Massachusetts contending, inter alia, that certain of the prosecutor’s remarks during closing argument deprived him of his constitutional right to a fair trial. The Supreme Judicial Court' affirmed. That court acknowledged that the prosecutor had made improper remarks, but determined that they were not so prejudicial as to require reversal.
Respondent then sought habeas corpus relief in the United States District Court for the District of Massachusetts. The District Court denied relief, stating: “[T]he prosecutor’s arguments were'not so prejudicial as to deprive [DeChristoforo] of his constitutional right to a fair trial.” The Court of Appeals for the First Circuit reversed by a divided vote. The majority held that the prosecutor’s remarks deliberately conveyed the false impression that respondent had unsuccessfully sought to plead to a lesser charge and that this conduct was a denial of due process. We granted certiorari, 414 U. S. 974 (1973), to consider whether such remarks, in the context of the entire trial, were sufficiently prejudicial to violate respondent’s due process rights. We hold they were not and so reverse.
I
Respondent and two companions were indicted for the first-degree murder of Joseph Lanzi, a passenger in the car in which the defendants were riding. Police had stopped the car at approximately 4 a. m. on April 18, 1967, and had discovered Lanzi’s dead body along with two firearms, one of which had been fired. A second gun, also recently fired, was found a short distance away. Respondent and one companion avoided. apprehension at that time, but the third defendant was taken into custody. He later pleaded guilty to second-degree murder.
Respondent and the other defendant, Gagliardi, were finally captured and tried jointly, The prosecutor made little claim that respondent fired any shots but argued that he willingly assisted in the killing. Respondent,' on the other hand, maintained that he was an innocent passenger.’ At the close of the evidence but before final argument, Gagliardi elected to plead guilty , to a charge of second-degree murder. The court advised the jury that Gagliardi had pleaded guilty and that respondent’s trial would continue. Respondent did not seek an instruction that the jury was to draw no inference from the plea, and no such instruction was given.
Respondent’s claims of constitutional error focus on two remarks made by the prosecutor during the course of his rather lengthy closing argument to the jury. The first involved the expression of a personal opinion as to guilt, perhaps offered to rebut a somewhat personalized argument by respondent’s counsel. The majority of the Court of Appeals agreed with the Supreme Judicial Court of Massachusetts that this remark was improper, but declined to rest its holding of a violation of due process on that remark. It turned to a second remark that it deemed “more serious.”
The prosecutor’s second challenged comment was directed at respondent’s motives in standing trial: “They [the respondent and his counsel] said they hope that you find him not guilty. I quite frankly think that they hope that you find him guilty of something a little less than first-degree- murder.” Respondent’s counsel objected immediately to the statement and later sought an instruction that the remark was improper and should be disregarded. The court then gave the following instruction:
“Closing arguments are not evidence for your consideration. ...
. “Now-in his. closing, the District Attorney, I noted, made a statement: T don’t know what they want you to do by way of a verdict. They said they hope that you find him not guilty. I quite frankly think that they hope that you find him guilty of something a little less than first-degree' murder.’ There is no evidence of that whatsoever, of course, you are instructed to disregard that statement made by the District Attorney.
“Consider the case as though no such statement was made.” '
The majority of the Supreme Judicial Court of Massachusetts, though again not disputing that the remark was improper, held that it was not so prejudicial as to require a mistrial and further stated that the trial judge’s instruction “was sufficient to safeguard the defendant’s rights.” Despite this decision and the District Court’s denial of a writ of habeas corpus, the Court of Appeals found that the commént was potentially so misleading and prejudicial that it deprived respondent of a constitutionally fair trial.
Ths Court of Appeals reasoned that the jury would be naturally curious about respondent’s failure to plead guilty and that this curiosity would be heightened by Gagliardi’s decision to plead guilty at the close of the evidence. In this context, the court thought, the prosecutor’s comment that respondent hoped for conviction on a lesser offense would suggest to the jury that respondent had sought to plead guilty but had been refused. Since the prosecutor was in a position to know such facts, the jury may well have surmised that respondent had already admitted guilt in an attempt to secure reduced charges. This, said the Court of Appeals, is the inverse of, but a parallel to, intentional suppression of favorable evidence. The prosecutor had deliberately misled the jury, and even if the statement was made thoughtlessly, “in a first degree murder case there must be some duty on a prosecutor to be houghtful.” Therefore, the District Court had erred in denying respondent’s petition.
II
The Court of Appeals in this case noted, as petitioner urged, that its review was “the narrow one of due process, and not the broad exercise of supervisory power that [it] would possess in regard to [its] own trial court.” We regard this observation as important for not every trial error or infirmity which might call for application of supervisory powers correspondingly constitutes a “failure to observe that fundamental fairness essential to the very concept of justice.” Lisenba v. California, 314 U. S. 219, 236 (1941). We stated only this Term in Cupp v. Naughten, 414 U. S. 141 (1973), when reviewing an instruction given in a state court:
“Before a federal court may overturn a conviction resulting from a state trial in which this instruction was used, it must be established not merely that the instruction is undesirable, erroneous, or even 'universally condemned,’. but that it violated some right which was guaranteed to the defendant by the Fourteenth Amendment:”
This is not a case, in which the State has denied a defendant the benefit of a specific provision of the Bill of Rights, such as the right to counsel, Argersinger v. Hamlin, 407 U. S. 25 (1972), or in which the prosecutor’s remarks so prejudiced a specific right, such as the privilege against compulsory self-incrimination, as to amount to a denial of that right. Griffin v. California, 380 U. S. 609 (1965). When specific guarantees of the Bill of Rights are involved, this Court has taken special care to assure that prosecutorial conduct in no way impermissibly infringes them. But here the claim is only that a prosecutor’s remark about respondent’s expectations at trial by itself so infected the trial with unfairness as to make the resulting conviction a denial of due process. We do not believe that examination of the entire proceedings in this case supports that contention.
Conflicting inferences have been drawn from the prosecutor’s statement by the courts below. Although thé Court of Appeals stated flatly' that “the prosecuting attorney turned Gagliardi’s plea into a telling stroke against [DeChristoforo]” by implying respondent had offered to plead guilty as well, the dissent found the inference to be “far less obvious.” The Supreme Judicial Court of Massachusetts stated that it considered the. same argument illogical:
“It is not logical to conclude that the jury would accept any implied argument of the prosecutor that, because one of the men whom the defendant blamed for the murder had pleaded guilty, the defendant was any less firm in his assertion that he himself was not guilty of any crime whatsoever.”
Thus it is by no means clear that the jury did engage in the hypothetical analysis suggested by the majority of the Court of Appeals, or even probable that it would seize such a comment out of context and attach this particular meaning to it. Five Justices of the Supreme Judicial Court of Massachusetts and at least one federal judge have all confessed difficulty in making this speculative connection.
In addition, the trial court took special pain's to correct any impression that the jury could consider the prosecutor’s statements as evidence in the case. . The prosecutor, as is customary, had previously told the jury that his argument was not evidence, and the trial judge specifically re-emphasized that point. Then the judge directed the jury’s attention to the remark particularly challenged here, declared it to be unsupported, and admonished the jury to ignore it. Although some occurrences at trial may be too clearly prejudicial for such a curative instruction to mitigate their effect, the comment in this case is hardly of such character.
In Cupp v. Naughten, supra, the respondent had challenged his conviction on the ground that a “presumption of truthfulness” instruction, given by the state trial court, had deprived him of the presumption of innocence and had shifted the State’s burden of proof to himself. Holding that the instruction, although perhaps not advisable, did not violate due process, we stated:
“In determining the effect of this instruction on the validity of respondent’s conviction, we accept at the outset the well-established proposition that a single instruction to a jury may not be judged in artificial isolation, but must be viewed in the context of the overall charge. Boyd v. United States, 271 U. S. 104, 107 (1926). While this does not mean that an instruction by itself may never rise to the level of constitutional error, see Cool v. United States, 409 U. S. 100 (1972), it does recognize that a judgment of conviction is commonly the culmination of a trial which includes testimony of witnesses, argument of counsel, receipt of .exhibits in evidence, and instruction of the jury by the judge. Thus not only is the challenged instruction but one of many such instructions, but the process of instruction itself is but one of several components of the trial which may result in the judgment of conviction.”
Similarly, the prosecutor’s remark here, admittedly an ambiguous one, was but one moment in an extended trial and was followed by specific disapproving instructions. Although the process of constitutional line drawing in this regard is necessarily imprecise, we simply do not believe that this incident made respondent’s trial so fundamentally unfair as to deny him due process.
m
We do not find the cases cited by the Court of Appeals to require a different result. In Miller v. Pate, 386 U. S. 1 (1967), the principal case relied upon, this Court held that a state prisoner was entitled to federal habeas relief upon a showing that a pair of stained undershorts, allegedly belonging to the prisoner and repeatedly described by the. State during trial as stained with blood, was in fact stained with paint. In the course of its opinion, this Court said:
“It .was further established that counsel for the prosecution had known at the time of the trial that the shorts were stained with paint. . . .
“. . . The record of the petitioner’s trial reflects the prosecution’s consistent and repeated misrepresentation that People’s Exhibit 3 was, indeed, ‘a .garment heavily stained with blood.’ ” Id., at 6.
A long series of decisions in this Court, of course, had established the proposition that the “Fourteenth Amendment cannot tolerate a state criminal conviction obtained by the knowing use of false evidence.” Id., at 7. The Court in Miller found those cases controlling,
We countenance no retreat from that proposition in observing that it falls far short of embracing the prosecutor’s remark in this case. The “consistent and repeated misrepresentation” of a dramatic exhibit in evidence may profoundly impress a jury and may have a significant impact on the jury’s deliberations. Isolated passages of a prosecutor’s argument, billed in advance to the jury as a matter of opinion not of evidence, do not reach the same proportions. Such arguments, like all closing arguments of counsel, are seldom carefully constructed in toto before the event; improvisation frequently results in syntax left imperfect and meaning less than crystal clear. While these general observations in no way justify prosecutorial misconduct, they do suggest that- a court should not lightly infer that a prosecutor intends an ambiguous remark to have its most damaging meaning or that a jury, sitting through lengthy exhortation, will draw that meaning from the plethora of less damaging interpretations.
The Court of Appeals’ reliance on Brady v. Maryland, 373 U. S. 83 (1963), is likewise misplaced. In Brady, the prosecutor had withheld evidence, a statement by the petitioner’s codefendant, which was directly relevant to the extent of the petitioner’s involvement in the crime. Since the petitioner had testified that his codefendant had done the actual shooting and since the petitioner’s counsel was not contesting guilt but merely seeking to avoid the death penalty, evidence of the degree of the petitioner’s participation was highly significant to the primary jury issue. As in Miller, manipulation of the evidence by the prosecution was likely to have an important effect on the jury’s determination. But here there was neither the introduction of specific misleading evidence important to the prosecution’s case in chief nor the nondisclosure of specific evidence valuable to the accused’s defense. There were instead a few brief sentences in the prosecutor’s long and expectably hortatory closing argument which might or might not suggest to a jury that the respondent had unsuccessfully sought to bargain for a lesser charge. We find nothing-in Brady to suggest that due process is so easily denied.
The result reached by the Court of Appeals in this case leaves virtually meaningless the distinction between ordinary trial error of a prosecutor and that sort of egregious misconduct held in Miller and Brady, supra, to amount to a denial of constitutional due process. Since we believe that distinction should continue to be observed, we reverse the, judgment of the Court of Appeals. .
It is so ordered.
Respondent and his codefendants were also indicted for illegal possession of firearms, and respondent received a four- to five-year sentence on that charge. The conviction is in no way related to the issues before the Court in this case.
Commonwealth v. DeChristoforo, Mass. —, 277 N. E. 2d 100 (1971).
App. 231.
473 F 2d 1236 (1973).
The trial court stated:
“Mr. Foreman, madam and gentlemen of the jury. You will notice that the defendant Gagliardi is not in the dock. He has pleaded ‘guilty,’ and his case has been disposed of.
“We will, therefore, go forward with the trial of the case of Commonwealth vs DeChristoforo.” App. 99.
The challenged remark was: “I honestly and .sincerely believe that there is no doubt in this case, none whatsoever.” Id., at 130.
The Court of Appeals noted: “[A]t least' the jury knows that the prosecutor is an advocate and it may be expected, to some degree, to discount such remarks as seller’s talk.” 473 F. 2d, at 1238.
App. 129.
No instruction was sought at .the time although the court apparently was willing to give one. The. trial judge later told counsel: “[H]ad there been a motion made by. you at that time to have me instruct the jury along the lines of eliminating that from their minds, or something of that nature, I certainly would have complied, because I did consider at the time the argument was beyond the grounds of complete propriety, but certainly far from being grounds for a mistrial.” Id,., at 133.
Id., at 143-144.
— Mass., at —, 277 N. E. 2d, at 105.
473 F. 2d, at 1240.
Id., at 1238.
414 U. S., at 146.
Respondent does suggest that the prosecutor’s statements may have deprived him of the right to confrontation. See Pointer v. Texas, 380 U. S. 400 (1965). But this argument is without merit, for the prosecutor here simply stated his own opinions and intro- • duced no statements made by persons unavailable for questioning at trial.
473 F. 2d, at 1239.
Id., at 1241 (Campbell, J., dissenting).
App. 157.
Id., at 119.
See n. 10, supra.
414 U. S., at 146-147.
See, e. g., Mooney v. Holohan, 294 U. S. 103 (1935); Napue v. Illinois, 360 U. S. 264 (1959).
We do.not, by this decision, in any way condone.prosecutorial misconduct, and we believe' that trial courts, by admonition and instruction, api appellate courts, by proper exercise of their supervisory power, will continue to discourage it. We only say that, in the circumstances of the case, no prejudice amounting to a denial of constitutional due process was shown.