Tucci was born on November 11, 1960 in Peekskill, New York. He was raised in Katonah, New York. He studied at John Jay High School and at SUNY Purchase. Tucci was married to Kathryn Spath from 1995 until her death in 2009. Then he was married to Felicity Blunt since 2012. He has three children with Spath. He currently lives in London.