Mbembe was born near Otélé in Cameroon in 1957. He obtained his Ph.D. in history at the University of Sorbonne in Paris, France, in 1989. He has held appointments at Columbia University in New York, Brookings Institution in Washington, D.C., University of Pennsylvania, University of California, Berkeley, Yale University, Duke University and Council for the Development of Social Science Research in Africa (CODESRIA) in Dakar, Senegal. He was assistant professor of history at Columbia University, New York, from 1988–1991, a senior research fellow at the Brookings Institution in Washington, D.C., from 1991 to 1992, associate professor of history at the University of Pennsylvania from 1992 to 1996, executive director of the Council for the Development of Social Science Research in Africa (Codesria) in Dakar, Senegal, from 1996 to 2000. Achille was also a visiting professor at the University of California, Berkeley, in 2001, and a visiting professor at Yale University in 2003. He was a research professor in history and politics at Harvard University's W. E. B. Du Bois Research Institute.