In 2006, Cartel de Santa recorded his third album, called Cartel de Santa, Vol. Prohibido that included the singles "Cheka Wey" (which also featured a music video); "Hey Si me Ven"; "Súbele A La Greibol"; "Mexico, Lindo Y Bandido" and "La Ranfla Del Cartel". A few months later, Babo was arrested for accidentally killing one of his friends, the state deemed him a qualified homicide. Because of this, the group released a compilation album Greatest Hits and some extra themes to raise funds and release the rapper from prison. Babo was released nine months later in January 2008.