However, in 1959, when Dr. Pall's first wife, Josephine, died of aplastic anemia, he began to work on the Pall filter. Mrs. Pall had undergone multiple blood transfusions in the course of an illness, which were ultimately unsuccessful. The Pall filter makes blood transfusions significantly safer by filtering out white blood cells, thereby reducing the incidence of transfusion reactions and viral infections. Today, Pall Corporation has sales in excess of $2.0 Billion.