Negga has appeared in the movies "Capital Letters" (2004), "Isolation" (2005), "Breakfast on Pluto" (2005) and "Warcraft" (2016). She has also played roles in television, such as in the BBC miniseries "Criminal Justice", RTÉ's "Love/Hate", E4's "Misfits", ABC's "Agents of S.H.I.E.L.D." and AMC's "Preacher".