Near the city is the junction of two major highways: US 385 and I-80. This junction is about halfway between Cheyenne, Wyoming, and North Platte, Nebraska. This location has encouraged the growth of Sidney as a major transportation service area on the Interstate highway. Because the I-80/US 385 interchange is many miles southeast of the town center, a new commercial area has developed. This are includes truck stops, convenience stores, shopping centers, motels, restaurants, and other commercial enterprises.