On August 22, 2017, Cancelo joined Inter Milan on a one-year loan until June 30, 2018, with an option to make the transfer permanent. The deal also saw Geoffrey Kondogbia join Valencia on loan. He made his Serie A debut on August 26, 2017 in a 3-1 win against AS Roma. He would suffer a knee ligament injury in late August 2017, while on international duty. His first game back from injury was a 3-2 win on October 15, 2018 against AC Milan.He was a member of the 2017-18 Serie A Team of the Year After the season, Inter Milan decided to not make the loan permanent.