Dershowitz is known for his role in several important legal cases and as a commentator on the Arab–Israeli conflict. As a criminal lawyer, he has won 13 of the 15 murder and attempted murder cases he has handled, and has represented many celebrity clients, such as Mike Tyson, Patty Hearst, Jeffrey Epstein and Jim Bakker. His most famous cases include his role in 1984 in overturning the conviction of Claus von Bülow for the attempted murder of his wife, Sunny, and as the appellate adviser for the defense in the trial of O.J. Simpson in 1995. In 2020, he was hired by President Donald Trump to defend him during his impeachment trial.