Mizuno was born in Shizuoka on September 6, 1985. After graduating from Shimizu Commercial High School, he joined J1 League club JEF United Ichihara (later "JEF United Chiba") in 2004. He played many matches as right side midfielder from 2005. The club won the champions in the 2005 and 2006 J.League Cup. In January 2008, he moved to Scottish Premier League club Celtic. In June 2010, he returned to Japan and joined J2 League club Kashiwa Reysol. The club won the champions in 2010 J2 and was promoted to J1 from 2011. The club won the champions in 2011 J1 League and 2012 Emperor's Cup. In 2013, he moved to Ventforet Kofu. In 2015, he moved to his first club JEF United Chiba. From 2016, he played for Vegalta Sendai, Sagan Tosu, Roasso Kumamoto and SC Sagamihara.