Cheadle extended his global recognition with his role as the superhero War Machine in the Marvel Cinematic Universe, replacing Terrence Howard. He currently appeared in "Iron Man 2" (2010), "Iron Man 3" (2013), "" (2015), "" (2016), "" (2018), "Captain Marvel" (2019) and "Avengers: Endgame" (2019) and will appear in the upcoming Disney+ series Iron Heart.