Christianity has a long history in Anatolia which, nowadays part of the Republic of Turkey's territory, was the birthplace of numerous Christian Apostles and Saints, such as Apostle Paul of Tarsus, Timothy, St. Nicholas of Myra, St. Polycarp of Smyrna and many others. Two out of the five centers (Patriarchates) of the ancient Pentarchy were located in present-day Turkey: Constantinople (Istanbul) and Antioch (Antakya). All of the first seven Ecumenical Councils which are recognized by both the Western and Eastern churches were held in present-day Turkey. Of these, the Nicene Creed, declared with the First Council of Nicaea (İznik) in 325, is of utmost importance and has provided the essential definitions of present-day Christianity.