The Catholic Church is led by the Pope, the Bishop of Rome, who lives in Vatican City. According to Catholics, the Church is guided by the Holy Spirit who also guides the Pope. The Church teaches that when the Pope speaks officially on the subject of Catholic faith and morals, he cannot be wrong. The Popes have only used this infallibility very rarely, but have done so throughout history; some examples include the Tome of St. Leo, the declaration of the Immaculate Conception, and various anathemas (religious condemnations issued by the Popes against certain heresies).