The first European to come to the region may have been the Spaniard Alonso de Ojeda in 1499. The northeastern tip of South America, cape São Roque, was first seen by European navigators in 1501. This was during a 1501-1502 Portuguese expedition led by Amerigo Vespucci. He named the spot after the saint of the day. The Vespucci expedition also named the Potengi river, "Rio Grande". The name is Portuguese for "Great River". The area and state were named after the river. For decades, no permanent European settlement was made in the area.