Sakaguchi was born in Sakai on October 15, 1987. In 2003, at the age of 15, she debuted in the Nadeshiko League at Speranza FC Takatsuki. After graduating from high school, she joined Tasaki Perule FC in 2006. She was selected Best Eleven in 2007. However, the club was disbanded in 2008 due to financial strain. She went to the United States and joined USL W-League club FC Indiana in 2009. In 2010, she returned to Japan and joined Albirex Niigata. She was selected Best Eleven in 2011. In 2012, she moved to Nippon TV Beleza (later "Nippon TV Tokyo Verdy Beleza"). She was selected MVP awards for 3 years in a row (2015-2017). However she hurt her knee in April 2018 and she lost her regular position. In 2021, she moved to Omiya Ardija Ventus with teammate Saori Ariyoshi.