Very little is known for sure about Lucrezia. Whether she was involved in the political activities of her father and brothers is unclear. They certainly arranged several marriages for her to important and powerful men. Presumably, this helped their own political ambitions. Lucrezia was married to Giovanni Sforza (Lord of Pesaro), Alfonso of Aragon (Duke of Bisceglie), and Alfonso I d'Este (Duke of Ferrara). Tradition has it that Alfonso of Aragon was an illegitimate son of the King of Naples and that her brother Cesare may have had him murdered when his political value faded.