In October 1629, the plague reached Milan, Lombardy's commercial center. In the city Milan, it killed about 64,000 people, which was 25% of Milan's people. It killed between 12% and 60% of all the people in Italy. The papal city of Bologna lost an estimated 15,000 citizens to the plague, with neighboring smaller cities of Modena and Parma also being heavily affected. This outbreak of plague also spread north into Tyrol, an alpine region of western Austria and northern Italy. 