Jennings declared for the NFL Draft in 2006. He was chosen by the Packers with the 52nd pick in the 2006 NFL Draft. In his fourth game, Jennings caught Brett Favre's 400th touchdown pass. He was voted Rookie of the Week that week. Jennings finished the season with 45 catches for 632 yards and 3 touchdowns. His next season was better, with twelve touchdowns and 932 yards. After his first thousand yard season in 2009, Jennings got a 26.35 million dollar contract. In 2010 and 2011, Jennings made the Pro Bowl. He also played in the Super Bowl in 2010, where he had two touchdowns in a Packers victory. He had to miss most of the 2011 and 2012 seasons with injuries.