The river flows east past Esanatoglia and curves north by Matelica before crossing the border into the province of Ancona near Cerreto d'Esi. The river continues flowing north before curving northeast near Genga. It then flows near Serra San Quirico, Maiolati Spontini, Castelplanio, Castelbellino, Jesi, Chiaravalle and Montemarciano.