Seyoum Mesfin Gebredingel (25 January 1949 – 13 January 2021) was an Ethiopian politician. He was Ethiopia's Minister of Foreign Affairs from 1991 until September 2010. He was Ethiopia's Ambassador to the People's Republic of China from 2010 until 2017. Mesfin was born in Adigrat, Ethiopia. He was a member of the People's Revolutionary Democratic Front.