However, ozone is toxic to animals and plants above concentrations of about 0.1 ppm. In humans, it can cause nasal and throat irritation, and nausea. Extended exposure can cause lung oedema. 0.100 ppm is the maximum allowable limit for industrial, public, or occupied spaces in England, Japan, France, the Netherlands and Germany. The Ozone layer is in the 10 to 50 kilometer range of the Earth's atmosphere.