He had four children with his first wife, actress Silvana Mangano, who died in 1989. He later married movie producer Martha Schumacher with whom he had two daughters. One of the children from his first marriage, Raffaella De Laurentiis, is also a producer; another, Federico De Laurentiis (28 February 1955 – 15 July 1981), died at 26 in an airplane crash. His granddaughter is Giada De Laurentiis, host of "Everyday Italian", "Behind the Bash", "Giada at Home" and "Giada's Weekend Getaways" on Food Network. His nephew is Aurelio De Laurentiis, a film producer and the chairman of SSC Napoli football club.