In 2000, Dushku starred in "Soul Survivors" with her "Race The Sun" co-star Casey Affleck. She followed that up with the cheerleader comedy "Bring It On" with Kirsten Dunst. She was very busy in 2001: shooting "The New Guy" in Texas and having to travel up to New York where she was working again with actor Robert De Niro and director Michael Caton-Jones in "City by the Sea". She played James Franco's junkie girlfriend and mother of his child. The same year Kevin Smith asked Dushku to be a part of "Jay and Silent Bob Strike Back". Dushku co-starred with Shannon Elizabeth, Ali Larter, Ben Affleck, and others.