The title of the song refers to Santería, a religion practiced in the Caribbean. The song tells a story about a jealous ex-boyfriend that plans to take revenge out on the man that stole his girlfriend. He mentions using violent force when he talks about "popping a cap in Sancho" and "putting that barrel straight down Sancho's throat". Lead singer Bradley Nowell refers to the man as "sancho" and his ex-girlfriend as "heina". In Mexico, "sancho" is often used to describe a man who steals another man's girlfriend. "heina" is used to describe a man's woman or girlfriend.