Van Hout played for K.F.C. Verbroedering Geel as a youth. He joined Willem II in 2004. On 6 August 2009, Standard Liege signed the goalkeeper from K.V. Kortrijk on a three-year contract. On 11 June 2011, he returned to Kortrijk on a one-year contract. Kristof is the joint tallest footballer in the professional game along with Elgin City FC Paul Millar. Both are 6' 10" tall.