The House of Orsini is an Italian noble family. It was one of the most influential princely families in Italy during the Middle Ages and the Renaissance. Three popes belonged to the Orsini family: Celestine III (1191–1198, born Gicinto Bobone), Nicholas III (1277–1280, born Giovanni Gaetani Orsini), and Benedict XIII (1724–1730, born Pietro Francesco Orsini). The Orsini family also produced 34 Cardinals of the Roman Church and many other important political and religious people.