Diller's career would begin in 1952 and would later appear in almost 100 of movies and television programs, her movie include; "The Fat Spy", "The Boneyard", "Happily Ever After", "Silence of the Hams", and in "A Bug's Life". Her television programs appearances also include; "Alice Through the Looking Glass", "The Pruitts of Southampton" aka "The Phyllis Diller Show", "The Muppet Show", "Hey Arnold!", "The Powerpuff Girls" and as Peter Griffin's mother in "Family Guy".