Guglielmo Epifani (24 March 1950 – 7 June 2021) was an Italian trade unionist and politician. From 2002 to 2010 he was the General Secretary of the Italian General Confederation of Labour (CGIL). On 11 May 2013 Epifani was appointed Secretary of the Democratic Party (PD). From 2013 until his death, he was a member of the Chamber of Deputies.