Giorgio Orsini descends from ancient and noble House of Orsini. Hard times had been fallen upon the House branch Giorgio belonged to. Mateo, Giorgio's father, as much as Giorgio himself, has forced to support himself and his family by manual labor. As the architect and sculptor, he was educated in the art workshop of sculptors Giovanni and Bartolomeo Buon in Venice. While in Venice, Giorgio married Elizabetta da Monte, who brought him a fair dowry, money and homes in Venice. He invested Elizabetta's money in a grocery store and in a merchant ship which brought them good returns. Elizabetta's husband entrusted her of a power of attorney by which she was able to attend to his affairs while he was absent. In July 1455 Giorgio bought home from a local nobleman Simeonich, where he engraved his family's heraldic symbol - a bear. When signing contracts, Giorgio often used his art name Georgius Dalmaticus, Sixty five years after his death, his grandson, Giacomo, an advocate by vocation, was recognized as a descendant of the noble House of Orsini. Giorgio's and Elizabetta's daughter Flavia married another Dalmatian painter, Giorgio Culinovich (Schiavone) in the year of 1463. Other source claims that the Orsinis' daughter's name was Elena (who married Schiavone).