Eleanora Luisa Gonzaga (13 November 1686 – 16 March 1741) was the Duchess of Rovere and Montefeltro as the wife of Francesco Maria de' Medici. She was the only child of Vincenzo Gonzaga, Duke of Guastalla and Sabbioneta and his second wife, Maria Vittoria Gonzaga. She did not bear any children and died mad. 