Don married the girl he was in love with in high school, Melvamay Kolokea Wong, on November 21, 1951. She was the mother to the first six of his children. Ho was married for 48 years until she died on June 8, 1999. While in the military, Ho lived in many states with his family until he was called home to help his mother Honey Ho, with the family bar business called Honey's.