In 331 BCE Alexander the Great took over the Persian Empire. Upon his death in 323 BCE his empire crumbled, and the province of Yehud became part of the kingdom of Egypt, ruled by the Ptolemaic dynasty. Ptolemaic rule was mild: Alexandria became the largest Jewish city in the world, and Ptolemy II Philadelphus of Egypt (281-246 BCE) promoted Jewish culture, sponsoring the Septuagint translation of the Torah. This period also saw the beginning of the Pharisees and other Jewish Second Temple parties such as the Sadducees and Essenes. But in the early 2nd century BCE Yehud fell to the Seleucid Syrian ruler Antiochus IV Epiphanes (174-163 BCE), who, in contrast to the tolerance shown by the Ptolemids, attempted complete Hellenization of the Jews. His desecration of the Temple sparked a national rebellion, which ended in the expulsion of the Syrians and the re-consecration of the Temple under the Maccabees