Usually, "C. diff "infection can be prevented. Hand-washing is one of the best ways to prevent "C. diff" infection. If a person has "C. diff" bacteria on their hands, they can kill the bacteria by washing their hands with soap and water. "C. diff" bacteria on surfaces (like doorknobs and medical equipment) can be killed with bleach. Many hospitals and other health care facilities have special bleach wipes which kill "C. diff". Washing sheets and clothes with bleach and detergent also kills "C. diff".