In 2000, her second studio album, "Tu Veneno" (Your Poison) was released and was presentation in "Gala de la Hispanidad", "Gala de Murcia" (both in Spain) and "Festival de la Calle 8" in Miami. She was nominated for Latin Grammy Awards, but lost to Christina Aguilera's "Mi Reflejo". Oreiro was first Uruguayan nominated for a Grammy. She was crowned Queen of that event at Viña del Mar Festival 2000 in Chile. 3rd music video of album "Cómo Te Olvido" (2001) was directed by Tudor Giurgiu in Dracula's Castle, Romania.