Carradine was born on February 5, 1906 in New York City, New York. Carradine was married to Ardanelle McCool from 1935 until they divorced in 1944. Then he was married to Sonia Sorel from 1944 until they divorced in 1956. Then he was married to Doris Rich from 1957 until her death in 1971. Then he was last married to Emily Cisneros from 1975 until his death in 1988. He has five children, Bruce (his McCool's son whom he adopted), David, Christopher, Keith and Robert.