He was diagnosed with Alzheimer's disease in February 2011, causing him unable to speak and unable to recognising anybody else, including his family. Following several years of bad health, Shamsuddin died at 5:45 pm at a clinic in Taman Melawati, after choking on cekodok on Wednesday, 1 March 2017 at the age of 81. Shamsuddin's second son Putera Hang Nadim confirmed on his father's death.