Thereafter, for a brief while, Sir Sikandar also worked as Deputy-Governor of the Reserve Bank of India but in July 1936, on the demise of Sir Fazli Husain, he returned to take on leadership of the Unionist party for the general elections held in Winter of the same year, winning by a simple majority and forming a coalition government along with the Indian National Congress and the Sikh Akali Dal. Sikandar was now chosen as Leader of the House and the Premier or Chief Minister of the Punjab. He remained in this position from 1937 to December 1942, when he died of a sudden heart failure.