In the series, the vampire population is made up of many different species. Most people do not know vampires exist. The series shows how vampires evolve and deal with conflict between the species throughout history. The series is mostly about a new American species of vampires. This group was born American West in the late 1800s. The first of this new species is an outlaw named Skinner Sweet. After becoming a vampire, Sweet leans that he is a new kind of vampire. He is stronger and faster than other species. Sunlight does not hurt him. He has new strengths. He also has different weaknesses. The series shows his movements through several decades of American history. It also follows the only vampire he is known to have created, Pearl Jones. Jones is a young woman who was trying to work as an actress in the 1920s silent film industry. She was attacked by a group of European vampires who were hiding in Hollywood. Sweet saved her by giving her his blood. This turned her into an American vampire like him. After this, tried to get revenge on the vampires who attacked her. The relationship between Jones and Sweet is an important part of the series.