Tsangarides was best known for his work with many heavy metal bands, including Judas Priest, Anvil, Gary Moore, Thin Lizzy, Helloween, Angra, Anthem, Yngwie Malmsteen and Tygers of Pan Tang. Tsangarides worked with many pop and alternative artists as well, including Depeche Mode, Tom Jones, Concrete Blonde, and The Tragically Hip.