Merle Frohms played together with boys for Fortuna Celle until 2011 and was signed by VfL Wolfsburg in late 2010. In her first season, she was part of the second team but wasn't used. On 9 December 2012, she debut in a 3–0 victory against FSV Gütersloh 2009 in what was her only game for the 2012–13 season. The following season she was moved to the second team as she played in sixteen matches for the team in the 2. Frauen-Bundesliga as the team finished in third place.