The first episode begins in the year 3000, a time where there are many technological advancements, as well as a place where 21st century problems are treated as everyday situations. In a jab at segregation, for example, the series depicts the human prejudice against mutants as being so great that the latter have been forced to live underground in the sewers. The characters' home on Earth is the city of New New York, built over the ruins of present-day New York City, referred to as "Old New York".