The "arrondissement" of Mâcon is bordered to the north by the "arrondissement" of Chalon-sur-Saône, to the northeast by the "arrondissement" of Louhans and to the west by the "arrondissement" of Charolles. It is also bordered by two departments of the Auvergne-Rhône-Alpes region: the Rhône department to the south and the Ain department to the east.