Edwin Orlando Mosquera Roa (26 July 1985 – 2 December 2017) was a Colombian weightlifter. He competed in the 69 kg weight division. He won a silver medal at the 2007 Pan American Games. He also won two gold medals (2008 and 2010) and a silver medal (2016) at the Pan American Weightlifting Championships. He was at the 2008 and 2016 Summer Olympics. He was born in El Carmen de Atrato.