In 2004, Worthington was given an AACTA Award for his role in the independent movie "Somersault". He is known for his roles in the movies "Avatar" (2009), "Terminator Salvation" (2009), "Clash of the Titans" (2010) and its sequel "Wrath of the Titans" (2012), "Man on a Ledge" (2012), "Everest" (2015), "Hacksaw Ridge" (2016), "The Shack" (2017) and "Fractured" (2019). He will appear in the "Avatar" sequels "Avatar 2" (2021) and "Avatar 3" (2022). He also played Captain Alex Mason in the video game "" (2010). He appeared again as Mason in "" (2012) and "" (2018). He also played real-life FBI profiler Jim Fitzgerald in the drama miniseries "" (2017).