One of the most important applications of DCS is related to the thermal unfolding of the proteins, a process called denaturation.The DCS’s role in this process is used to determine the temperature range over which proteins exhibit structural changes. In addition to that, when the protein solution is treated under constant heat rate and constant pressure, DSC can determine apparent heat capacities of the proteins. In fact, the denatured proteins turn out to have higher heat capacities and proper detection of changes on them over time can help to find out the extent of unfolding.