Ponce de León returned in 1521 with 200 settlers. They brought cattle, horses, and what they needed to farm the land. As they were building the settlement they were attacked by local Indians. In the fighting Ponce de León received a mortal wound, possibly by a poisoned arrow. The party returned to Cuba where Ponce de León died. He was buried in what is now San Juan before the alter of the Dominican church. His remains were later moved to San Juan cathedral.