Khan's early films included 'Zherilay', 'Ishq', 'Naag Devta', 'Pyar hi pyar', 'Sailab', 'Dil', 'Aag', 'Shama' and 'Sahiba'. These were followed by films such as 'Hina', 'Anjuman', 'Chakuri', 'Chandni', 'Neelam' and 'Insaniat'. Later she appeared in 'Hathi Meray Sathi' directed by Shameem Ara and in 'Rani Beti Raj Karegi' directed by Altaf Hussain. In 2002, Asif Ali Pota's 'Fire' and Samina Peerzada's 'Shararat' were released starring Reema in the lead role. She later also started making some films as a producer and part-time director. 