Mirza picked up her first Grand Slam title at the 2009 Australian Open. Partnered with Mahesh Bhupathi, she won the mixed doubles title beating Nathalie Dechy (France) and Andy Ram (Israel) 6-3, 6-1 in the final in Melbourne. She then entered the Pattaya Women's Open Tournament in Bangkok where she reached the finals after a string of good performances. She lost the finals to Vera Zvonareva 7-5, 6-1. She made the semis in doubles in the same tournament.