Clay and his wife had eleven children (six daughters and five sons): Henrietta (1800–1801), Theodore (1802–1870), Thomas (1803–1871), Susan (1805–1825), Anne (1807–1835), Lucretia (1809–1823), Henry, Jr. (1811–1847), Eliza (1813–1825), Laura (1815–1817), James Brown, (1817–1864), and John (1821–1887).