"Dictyostelium" shares many molecular features with macrophages. Macrophages are the human host of "Legionella". The cytoskeletal composition of "D. discoideum" is similar to that of mammalian cells. So are the processes driven by these components, such as phagocytosis, membrane trafficking, endocytic transit and vesicle sorting. Like leukocytes, "D. discoideum" have chemotaxis. Hence, "D. discoideum" is a suitable model system to see the influence of host cell factors during "Legionella" infections.