San Francisco de Macorís is at to the northwest of Santo Domingo, in the "Cibao Oriental" (in English, "Eastern Cibao"), the eastern part of the Cibao Valley. Most of the municipality is in the valley but the northern part of it is on the "Cordillera Septentrional" (in English, "Northern mountain range"); the mountains here are not very high. The altitude of the city of San Francisco de Macorís is above sea level.