Since 2004, Stiles has been seen as the reappearing character Dr. Herb Melnick in several episodes of the comedy "Two and a Half Men" which stars his "Hot Shots" co-star Jon Cryer and formerly Charlie Sheen. Stiles also made short guest appearances on "Murphy Brown", "Mad About You", "Mad TV", and "Dharma & Greg". In July 2008, he was a guest star on "Reno 911!" as Sergeant Clift, an acting coach.