Archduchess Maria Clementina was born at the Villa del Poggio Imperiale, Poggio Imperiale then located in the Grand Duchy of Tuscany which was then ruled by her father Leopold I (later Holy Roman Emperor) since 1765. She was named after Prince Clemens Wenceslaus of Saxony, her mothers uncle and brother of Maria Amalia of Saxony, Maria Clementina's maternal grandmother. 