Yazigi was born in 1959 in Lattakya, Syria. He studied for a civil engineering degree at the University of Tishreen in Latakia, Syria. He studied theology at the University of Thessaloniki in Greece and received a master's degree in 1989 and a PhD in 1992. The title of his thesis was "Eschatology & Ethics: The Eschatological Foundations of the Life in Christ According to St. John Chrysostom." He also studied Byzantine music and iconography in Greece and Mount Athos.