Manfredini, who became the world's oldest living person after Besse Cooper's death on 4 December 2012, died of natural infection at 9:30am on 17 December 2012, just 13 days later and a week before her successor as the oldest living woman Japanesewoman Koto Okubo's 115th birthday, at age 115 years, 257 days, and was succeeded as the oldest living person by Japaneseman Jiroemon Kimura, who was just 15 days younger, and as the oldest living person in the United States by Gertrude Weaver, who was 15 months younger.