He made his first movie "The Dybbuk" in 1952. It was a television movie. He acted in several movies, such as "You Only Live Twice", where he played James Bond villain Ernst Stavro Blofeld, and "The Great Escape". Pleasence is known for his role as Dr. Samuel Loomis in John Carpenter's "Halloween". Since then, he appeared in five out of the six movies of the "Halloween movie series". Pleasence did not appear in "" because it was a different story from the last two movies.