In May 1995, Reeve was paralyzed in an accident when riding a horse. He had to use a wheelchair for the rest of his life. He then made many campaigns in support of people with spinal cord injuries. He founded the Christopher Reeve Foundation and co-founded the Reeve-Irvine Research Center. Reeve died at age 52 on October 10, 2004 from heart problems caused by an infection. Director Richard Donner dedicated his new version of "Superman II" (2006) to Reeve. The TV series episode ""Devoted"" from season four of "Smallville", which ran in 2004, is also dedicated to his memory. Also, "Everyone's Hero", which he directed, and 2006's "Superman Returns" are dedicated to him and his wife, Dana.