Hooker was born on August 22, 1917 in Coahoma County near Clarksdale, Mississippi. He was born to William Hooker and Minnie Ramsey and was the youngest of eleven children. He and his siblings were home-schooled and they were only allowed to listen to religious songs. His parents separated in 1921 and his mother married William Moore, a blues singer the next year. Moore introduced Hooker to the guitar. John would later credit Moore for his distinctive playing style.