In 2011, Santana was appointed as the Chief of Staff and Strategic Technical Advisor at Tribunal Constitucional de la República Dominicana, where she co-led to establish the first constitutional court in the Dominican Republic. She has worked as a legal consultant at The Organisation for Economic Co-operation & Development (OECD) and The World Bank. Santana co-founded Matternet, a drone delivery platform which received an FAA regulatory waiver to operate in the United States.