Bruce Alan Beutler M.D. (born December 29, 1957 in Chicago, Illinois) is an American immunologist and geneticist of Jewish descent. Together with Jules Hoffmann, he received one-half of the 2011 Nobel Prize in Physiology or Medicine, for "discoveries concerning the activation of innate immunity" (the other half went to Ralph Steinman for "his discovery of the dendritic cell and its role in adaptive immunity").