Barber was drafted by the Dallas Cowboys in the 4th round (109 overall) of the 2005 NFL Draft. Despite his talent, Barber's career has been harmed by injuries. he never rushed for 1,000 yards or over. He was voted to the Pro Bowl in 2007 after 204 rushing yards, 975 yards, and 10 touchdowns. He added 44 catches, 282 yards, and two receiving touchdowns in 2007.