On 15 March, 1722 at Vercelli, she married Charles Emmanuel of Savoy, Prince of Piedmont and later King of Sardinia as Charles Emmanuel III. He was the second son of Victor Amadeus II and Anne Marie d'Orléans and the heir apparent to the Savoyard throne. The following year, she gave birth to a son who was created the Duke of Aosta. She died a few days later on 12 March 1723 at the age of nineteen in Turin. Her only child died in 1725 in his second year, thus she has no descendants. She was buried at Turin Cathedral and was moved to the Basilica of Superga in Turin in 1786. 