Sir Alexander Fleming, a Scottish scientist, is commonly said to be the person who learned about the antibacterial attacks of a fungus known as "Penicillium notatum" in 1928. But in March 2000, Costa Rican doctors showed some notebooks with research belonging to Picado. In these notebooks, he explained his experiments between 1915 and 1927. These experiments had been developed to explain that Penicillium decreased bacterial activity.