"The Political Cesspool" has over the years featured many guest appearances, including political activists, Holocaust deniers, economists, and musicians. Former Tennessee gubernatorial candidate Carl "Twofeathers" Whitaker, who claims partial Native American ancestry and is known for his strong support of the Minuteman movement, has appeared on the show, as has conservative Native American activist David Yeagley. Filmmakers Merlin Miller ("A Place to Grow", "Jericho") and Craig Bodeker ("A Conversation about Race") have featured.