Bryce was born on May 6, 1880. Her father was General Lloyd Stephens Bryce, the United States Ambassador to the Netherlands. Her mother was Edith Cooper Bryce, a Millionairess who died in 1916 leaving $ 3,000,000 to her family in her will. She married John Sergeant Cram. She founded Peace House, dedicated to the advancement of peace. She died on February 28, 1960. She was buried in Green-Wood Cemetery.