Tattoo removal is most commonly performed using lasers that break down the ink particles in the tattoo into smaller particles. Dermal macrophages are part of the immune system, tasked with collecting and digesting cellular debris. In the case of tattoo pigments, macrophages collect ink pigments, but have difficulty breaking them down. Instead, they store the ink pigments. If a macrophage is damaged, it releases its captive ink, which is taken up by other macrophages. This can make it particularly difficult to remove tattoos. When treatments break down ink particles into smaller pieces, macrophages can more easily remove them.