Santana has also worked with NASA to work on the UAS Traffic Management Software System for low-altitude airspace operations under Matternet’s partnership program. Since then she has co-led several advisory committees for drone including the Federal Drone Advisory Committee, Unmanned Aircraft Systems Advisory Group and F38 Subcommittee on Markings for Small UAS. Santana also co-drafted the public-private partnership for Hyperloop Transportation Technologies, to enable a multi-state Hyperloop system in the United States. In 2017, she founded a software company, Social Glass that builds an artificial intelligence based software to help the government with automation of processes and help in the decision making.