Cotton started working with the Muddy Waters Band in 1955. He performed songs like "I Got My Mojo Working" and "She's Nineteen Years Old". After leaving Muddy's band in 1966, Cotton toured with Janis Joplin. Alone, Cotton wrote classic songs like "Cotton Crop Blues", "Rocket 88" and "Hold Me In Your Arms". He formed the James Cotton Blues Band in 1967. They performed all of Cotton's classics and more.