The game follows the Simpson family and the people who live in Springfield, who see many strange things that happen in their town. When the Simpsons themselves decide to find out what is going on, they find out that aliens Kang and Kodos are filming a reality television series about the city. To make the show more interesting, the aliens release Buzz Cola, a soda that makes people go crazy, into Springfield's water supply. With help from Professor Frink, Homer is able to destroy the aliens' spaceship, and Springfield and its people are returned to normal.