People have been aware of gout since ancient times. Historically, it has been referred to as "the king of diseases and the disease of kings" or "the disease of rich men". The first documentation of the disease is from Egypt in 2,600 b.c. in a description of arthritis of the largest toe. The Greek physician Hippocrates around 400 b.c. commented on it in his "Aphorisms" and noted its absence in eunuchs (men who have had there testicles removed at a young age) and women before menopause. Aulus Cornelius Celsus (30 a.d.) described the linkage with alcohol, later onset in women, and associated kidney problems: