The song reached number one on the US Hot 100 chart. It stood at number one for two weeks. The song became the group's second number one song. They became the second group to do this. The first was OutKast with "Hey Ya!" (2003) and "The Way You Move" (2004). "Sexy and I Know It" reached number one in Australia, Canada and New Zealand. The song was featured in the fifth season of "Gossip Girl". The song was covered in "Glee".