This route was taken by three groups, in total 2,800 Cherokees. The first group left on June 6 and reached the territory after 13 days. All groups started at Ross's Landing at the Tennessee River. They used boats to travel to the Ohio River. They then took this river southward, which took them to the Mississippi River. From there they moved through the Arkansas River westwards. They arrived near Fort Coffee, Oklahoma. The second and third group had a lot of problems with diseases, so their trip took longer.