Differential scanning calorimetry (DSC), is an analysis tool widely used in materials sciences, thermochemistry, drug purity and food quality testing. Its speed and ease of operation give instant information about the thermodynamic characteristics that play an important role in understanding complex processes during the formation of substances; for instance, polymer cross-linking, heat exchange due to folding and unfolding of proteins or formation mechanism of single or double stranded DNA. The DSC was firstly invented in 1962 by E.S. Watson and M.J. O’Neil and made available to the market in 1963 at the "Analytical Chemistry and Applied Spectroscopy" conference held in Pittsburgh.