Spina has worked for RUR Architects and Keller Easterling in New York and Gerardo Caballero Architects. He opened his own office Banchini + Spina Arquitectos in Rosario, Argentina (1998-2002). At SCI-Arc, he was the coordinator of the Applied Studies Program from 2005 to 2009 and the Architectural Technologies Postgraduate Program from 2011 to 2019. He has been a member of the Board of Trustees since 2016.