I-83 enters Pennsylvania southeast of New Freedom, passing to the east of Shrewsbury and goes due north towards York. The route goes around the boroughs of Loganville and Jacobus before entering the city of York. North of Pennsylvania Route 295, I-83 is known as the Susquehanna Expressway. I-83 has this name as it passes to the south and west of Valley Green. I-83 then goes north towards Harrisburg. South of Harrisburg, I-83 interchanges with Interstate 76, the Pennsylvania Turnpike. North of I-76, I-83 continues due north, passing through New Cumberland, before merging with Pennsylvania Route 581 in Lemoyne.