Expedition 64 was the 64th long-duration mission to the International Space Station (ISS), that began on 21 October 2020 with the undocking and departure of Soyuz MS-16. The Expedition started with the three crew members launched onboard Soyuz MS-17 and reached its full complement with the arrival of SpaceX Crew-1, the first operational flight of NASA's Commercial Crew Program (CCP). The expedition ended on 16 April 2021 with the departure of Soyuz MS-17.