Angelica was born in 1756. She grew up in Albany, New York. Her parents were Philip Schuyler and Catharine Van Rensselaer Schuyler. Philip Schuyler had fought in the French and Indian War. He went to the New York State Assembly and Continental Congress. During the Revolutionary War, Philip Schuyler was a Major General in the Continental Army. Her parents had fifteen children, and eight lived to be adults. Angelica's sister Elizabeth would later marry Alexander Hamilton. The Schuyler family had almost twenty slaves.