Margaret of Anjou (; 23 March 1430 – 25 August 1482) was the Queen of England by marriage to King Henry VI from 1445 to 1461 and again from 1470 to 1471. She was born in the Duchy of Lorraine into the House of Valois-Anjou. Margaret was the second eldest daughter of René, King of Naples and Isabella, Duchess of Lorraine.