For most of its history, Cherokee County had more of a Democratic lean in presidential elections than the rest of the state, particularly before 1968. Since then, its only voted for Democratic candidates twice in 1976 & 1992, when it was their second & fourth best county in the state, respectively. From 1996 on, the county has swung powerfully Republican similar to the rest of Southeast Kansas, with Hillary Clinton posted the worst percentage for a Democratic candidate ever at only 23.3%.