He was drafted with the 18th overall pick by the Pittsburgh Penguins in the 2000 NHL Entry Draft. His made his NHL debut with the Penguins during the 2002–03 NHL season, playing in 6 games and recording no points. On July 2, 2008, the Penguins signed Orpik to a six-year, $22.5 million contract. On June 12, 2009, Orpik was able to win the Stanley Cup with the Penguins when they defeated the Detroit Red Wings in Game 7.