The EpiPen is meant to be injected into the thigh muscle, on the outside of the leg, as soon as anaphylaxis is suspected. There is no reason why it should not be used if a person is having an anaphylactic reaction. The injection may be repeated every 5 to 15 minutes if the person is still having breathing problems or other major symptoms. A second dose is needed in 16 to 35% of cases. More than two doses are rarely needed.