"Hit & Run" has seven levels, each with missions and a unique plot. The player can only move, or control one certain character in each level. The game's playable characters are Homer Simpson, Bart Simpson, Lisa Simpson, Marge Simpson, and Apu Nahasapeemapetilon. When walking, the playing character can walk, run, and perform many attacks: a normal kick, a jumping kick, and a smashing move. To drive, the player can either drive one of the many vehicles that are on the road, a feature taken from "Grand Theft Auto 3", or use a phone booth to choose a car. The game's driving missions are also similar to those of "Grand Theft Auto 3". In both games, the player races against other characters, gets items before a timer runs out, and wrecks other cars.