Her parents were Jacques Louis de Rouvroy, Duke of Ruffec (1698-1746) and his wife Catherine Charlotte Thérèse de Gramont (1707-1755). She was known as "Mademoiselle de Ruffec" before marriage. she was formally married to Prince Charles Maurice Grimaldi of Monaco, "Count of Valentinois" on 10 December 1749. The wedding took place in the private chapel of the Hôtel Saint-Simon in Paris with the express permission of Louis XV. The couple eventually separated in 1766, having had no children.