The show takes place in San Francisco, California. The show stars China Anne McClain, Sierra McCormick and Jake Short. They are middle school students in a gifted education program called the "Advanced Natural Talent" (or "A.N.T.") program. On November 30, 2011, "A.N.T. Farm" was accepted for a second season. It started on June 1, 2012. The last show aired on March 21, 2014.