The first five issues had two stories in each issue. One story was by Snyder and the other by Stephen King. Both stories were drawn by Rafael Albuquerque. As of the sixth issue, Scott Snyder became the only writer. In its second year of publication, a spin-off mini-series was created. It was titled "American Vampire: Survival of the Fittest". This mini-series was drawn by Sean Murphy. It is about a vampire-hunting organization from the main series.