DE 82 heads to the west of DE 52 near Greenville as Campbell Road. The road has two lanes cars can travel on without a median, which is a physical divider between the travel lanes in each direction. East of DE 52, the road continues to DE 100 as Kirk Road. The road passes areas of homes with trees and fields. Then it crosses over the Hoopes Reservoir. Not far after the reservoir, DE 82 makes a left turn onto New London Road to go south. The route passes through large areas of trees, turning to the west as it makes many turns. The road goes near more fields and homes in a rural area before coming to an intersection with Mt. Cuba Road. Here, DE 82 goes northwest on Creek Road and passes next to the Red Clay Creek and the Wilmington and Western Railroad on a road with many trees. It makes more turns and goes over the creek two times before crossing the railroad two times. In this area, the route passes the Ashland Nature Center. The route comes to the community of Yorklyn, where the route turns southwest for a short time and passes a few buildings in rural areas. After making a turn to the northwest to go on Creek Road, DE 82 heads north next to the Red Clay Creek. The Wilmington and Western Railroad turns to the southwest away from the road. A short distance past Yorklyn, the route comes to the Pennsylvania border, where it becomes PA 82 and goes toward Kennett Square, Pennsylvania. All of DE 82 is a part of the Red Clay Valley Scenic Byway, a scenic byway (road) name given to many roads in the Red Clay Creek valley.