She gave her husband four children, two of which would survive infancy the future Cosimo III and Francesco Maria de' Medici, Duke of Rovere and Montefeltro. She was the Duchess of Rovere and Montefeltro in her own right and these went to her youngest son when she died. She was later the guardian of her three grandchildren. Her marriage bought a lot of art treasures to the House of Medici which are today at the Palazzo Pitti Uffizi Gallery in Florence. She did not get on with her daughter in law Marguerite Louise d'Orléans. 