Sarro's opera "Berenice" was chosen to open the Teatro Argentina in Rome in 1732. When the royal music master Francesco Mancini died in 1737, Sarro took over his job. Later that year, his opera ' ("Achilles in Skyros") was chosen to open the new Teatro di San Carlo in Naples. Sarro's wife Caterina died in April 1739. Three months later, he married Rachele de Siena. He was 59 years old. She was 27. Sarro's last new opera, ', was performed in 1741 at the Teatro di San Carlo. It tells the story of Flavius Aetius, a Roman general in the 5th century. ("Ezio" is the Italian name for "Aetius".) Domenico Sarro died in 1744. He was 64 years old. When he died, the composer Leonardo Leo took over his job as the royal music master.