In March 2010, Jenneke won 1st place in the 100 m hurdles and broke the Australian record in the women's sprint medley relay at the 2010 Australian Junior Championships. She ran in the 2011 Pirtek Athletic Allstars event. In July 2010, Jenneke was in Australia's team at the 2010 Singapore Youth Olympic Games, running the 100 meter hurdles and the women's medley relay. In the hurdles, she came in second place with a time of 13.56 seconds, which the fastest she had ever run, and the medley relay team finished in fourth place. Her medal was the first Australia won at the Games in her sport.