It is possible to spread diseases through kissing, but it is also possible to exaggerate the danger. Exotic diseases like herpes and mononucleosis can be spread, but that is rare, and spreading HIV this way is almost unknown. Colds and the flu are much more likely to be spread. Mononucleosis is well known for being spread through kissing. Many diseases that can be spread by sharing drinks can also be spread by kissing.