Izatullo Khayoyev (; 22 June 1936 – 26 April 2015) was a Tajik politician. He was the Vice-President of Tajikistan between December 1990 and 25 June 1991 and Prime Minister of Tajikistan between 25 June 1991 and 9 January 1992. He served as Chairman of the Council of Ministers of the Tajik Soviet Socialist Republic from 4 January 1986 until 6 December 1990.