Santana got her Bachelor's degree in Law from the Pontificia Universidad Católica Madre y Maestra in 2009. She enrolled at Ecole nationale d'administration for a Master of Public Administration and thereafter completed a program in the Foundations of American Law and Legal Education from the Georgetown University. In 2012, she completed an LLM from The George Washington University and also enrolled for a program in Policy, Law and Ethics of Exponential Technologies from Singularity University.