Patani made her debut in 2015 with Varun Tej in the Telugu movie "Loafer". She played the role of Mouni, a girl who runs away from home to escape from a forced marriage. The movie was directed by Puri Jagannath and produced by C. Kalyan. It was produced under "C.K. Entertainment". The movie was made on a budget of 200 million. It performed poorly at the box office with a total collection of 106 million. Next year, Disha appeared in a music video Befikra with Tiger Shroff. It was produced by Bhushan Kumar and Krishan Kumar. It was produced under T-Series and was composed by Meet Bros. The song was written and directed by Meet Bros. Singer Aditi Singh Sharma gave her voice in the song.