Botulism is caused by a species of "Clostridium", C. botulinum. It is transmitted through food containing endospores or through a wound. The most potent neurotoxin known is produced when the bacteria is exposed to low oxygen and body temperature. Foods which have been improperly canned are responsible for 90% of the cases of botulism. Natural, unpasteurized honey has been known to transmit infection and intoxication with the pathogen and the neurotoxin. Botulism is a neuroparalytic disease causing a flaccid paralysis; the neurotoxin blocks neurotransmitters. This results in an inability to contract muscles. The neurotoxin has been used medically in the management of severe pain by anaesthetists and also cosmetically to reduce wrinkles.