Matarazzo is a lesbian. On July 31, 2008, Matarazzo's publicist announced that Matarazzo was engaged to musician Caroline Murphy. In 2012, popular media news outlets announced that Matarazzo and Murphy had split amicably. On January 11, 2018, Matarazzo proposed to her girlfriend, comedian and writer Heather Turman, and the two were married on November 11, 2018.