Two local companies, Great American Bank and Custom Foods, Inc., and one national company, Goodcents Deli Fresh Subs, are headquartered in De Soto. Huhtamaki Americas, Inc. and Engineered Air, two international companies, chose De Soto for their North American headquarters. Merck Animal Health, one of the world's biggest manufacturers of animal health supplies, chose De Soto for one of its U.S. manufacturing facilities.