Interstate 81 begins in Tennessee at Interstate 40 in Dandridge. The route follows the Appalachian Mountains for much of its route through Tennessee and Virginia, serving such cities as the twin cities of Bristol, Tennessee and Bristol, Virginia, Roanoke, Blacksburg, Lexington, Staunton, Harrisonburg, and Winchester. In Harrisonburg, I-81 cuts through the James Madison University campus. It follows its older counterpart, U.S. Route 11, for its entire length in Virginia.