Vanadium isotopes can be significantly fractionated during the delivery, cycling, and burial to the ocean. Temporal variations of V in seawater could be controlled by the aforementioned isotope fractionation and fluxes of various V sources and sinks to the ocean that is likely related to the global redox state of the oceans. A possible mechanism for the V isotopic offset between seawater and hydrogenous Fe-Mn crusts and nodules is the fractionation during the adsorption of V on the surface of the Fe-Mn oxyhydroxide.