Psilocybin mushrooms have probably been used since prehistoric times. They may be seen in rock art. Many cultures have used these mushrooms in religious rites. Psychedelic mushrooms have been used by native peoples of Mesoamerica for religious communion and healing. Catholic missionaries were against the use of magic mushrooms. In Modern society, they are sometimes used recreationally. Their medical use in psilocybin-assisted psychotherapy is studied, for example, in the treatment for anxiety and depression in patients with life-threatening cancer, the treatment of depression and to help quit smoking.