The group rose to fame in 2003, releasing their first album titled "Cartel de Santa: Vol. I". The album included songs that became hits, such as: "Asesinos de Asesinos", "Cannabis Sativa", "La Pelotona", and "Todas mueren por mí". This album was produced by Jason Roberts, who has also produced for artists such as: Cypress Hill, Ice Cube, House of Pain, Control Machete and Plastilina Mosh That same year, Cartel de Santa, launched a musical video of the song "Perros", which was broadcast to Latin America by MTV. However, the most important album of his career was released a year later, in 2004, titled Cartel de Santa Vol. II, which included songs such as "Blah Blah Blah ", La Llamada", "Crónica Babilonia", "El Arte del Engaño" and "El Dolor del Micro" (featuring Julieta Venegas).