After completing high school in Galați, and graduating from the Popular School for the Arts in Brașov, where he studied harmony and counterpoint with Victor Bickerich, Lupu continued his piano studies at the Bucharest Conservatory (1959–1961) with Florica Musicescu (who also taught Dinu Lipatti), and Cella Delavrancea, studying also composition with Dragos Alexandrescu. At the age of 16, in 1961, he was awarded a scholarship to the Moscow P.I. Tchaikovsky State Conservatory, where he studied for seven years. In Moscow, he first studied with Galina Eguiazarova (a pupil of Alexander Goldenweiser) for two years, and then with Heinrich Neuhaus (who also taught Sviatoslav Richter and Emil Gilels) and later with his son, Stanislav Neuhaus. He graduated in 1969. However, in a 1981 interview, when asked about what types of influences his teachers had on him, Lupu answered that he thought of himself as more audodidactic: "My first teacher took me to every orchestral concert, and I am also grateful for what I learned in Moscow, but I think of myself, basically (in music anyway), as somebody who is more autodidactic. I took some from Furtwängler, Toscanini, everywhere...more and more so since I left Moscow."