Between 1992 and 1998, she appeared in the long-running ITV soap opera, "Coronation Street", as hairdresser Fiona Middleton. She made a guest appearance in 2019. Subsequently, she joined the original cast of the BBC medical drama series, "Holby City", as staff nurse Jasmine Hopkins, but left at the end of the third series in 2001, as the next series would be longer. Griffin has also appeared in the BBC dramas, "Cutting It", and "Down to Earth".