Three U.S. Routes go through Edwards County. They all meet in Kinsley. An east-west route, U.S. Route 50 goes around Belpre and Lewis before connecting with westbound U.S. Route 56 in Kinsley. The single road then goes through Offerle and west into Ford County. U.S. Route 183 goes from Kiowa County in the south to Kinsley, where it connects east U.S. 56 as a single highway to Pawnee County. K-19 starts at U.S. Route 50 near Belpre, and goes north into Pawnee County.