Domenico Sarro was born in Trani, a city in the Apulia region of Italy. His parents were Filippo and Isabella Sarro. When he was ten years old, his parents sent him to a conservatory (music school) in Naples. Some music historians say that his first music school was the . Others say he also studied at the . (" is the Italian word for "conservatory".) He may also have been a teacher at the . His first important piece of music was an opera called "Opera d'amore" ("The Work of Love"). It was performed in Naples in 1702. The Prince of Villafranca helped Sarro when he was a young man. The Prince helped him to get the job of assistant music master () to the King of Naples in 1704. The Prince also paid Sarro to write pieces of music for him.