Her husband was heartbroken at the death of his wife. At the time, there were rumours that she had been poisoned but it seems likely that the real cause of Marie Louise's death was appendicitis. Shortly after the Queen's death, the Spanish ministers began to look for a second wife for the King. The main candidates were the Tuscan princess Anna Maria Luisa de' Medici and the Maria Anna of Neuburg and the latter was chosen. Charles II died childless in 1700 ending the Spanish branch of the House of Habsburg.