Nicolae Paulescu, a Romanian professor of physiology at the University of Medicine and Pharmacy in Bucharest, was the first to isolate insulin. He did that in 1916. He called it pancrein. He isolated it by developing an aqueous pancreatic extract which, when injected into a diabetic dog, proved to have a normalizing effect on blood sugar levels. He had to interrupt his experiments because of World War I. In early 1921 he wrote four papers about his work carried out in Bucharest and his tests on a diabetic dog. Later that year, he detailed his work by publishing an extensive whitepaper on the effect of the pancreatic extract injected into a diabetic animal, which he called: "Research on the Role of the Pancreas in Food Assimilation", with the paper received the 22 June 1921 by the "Archives Internationales de Physiologie", with the photocopy of the article available in the Gerstein Science Information Centre.https://insulin.library.utoronto.ca/islandora/object/insulin%3AT10137