In 2005, Mirza reached the third round of the Australian Open, losing to the champion Serena Williams. On February 12, 2005, she became the first Indian woman to win a WTA singles title, beating Alyona Bondarenko of Ukraine in the Hyderabad Open Finals. At the 2006 Doha Asian Games, Mirza won the silver in the women's singles category and the gold in the mixed doubles partnering Leander Paes. She was also part of the Indian women's team that won the silver in the team event.