"Alpha and Omega" received mixed reviews from critics. The Rotten Tomatoes website said "With bland visuals and a dull, predictable plot, Alpha and Omega is a runt in 2010's animated litter." In Metacritic, the movie had a score of 37 out of 100, based on 15 critics. Some critics liked the voice performances by Justin Long and Hayden Panettiere. Other critics said it had a weak storyline, poor animation, and a predictable plot. In Amazon, "Alpha and Omega" received mostly positive reviews, for its animation, voice acting, characters and sense of humor.