Thurmond was born on December 5, 1902 in Edgefield, South Carolina. His family used to own slaves, including ancestors of Al Sharpton. He studied at Clemson Agricultural College of South Carolina. Thurmond graduated in 1923. He was married to Jean Crouch from 1947 until they divorced in 1960. Then he was married to Nancy Moore from 1968 until his death in 2003. He had five children.