Studies done with animals have shown that artificial sweeteners cause weight gain. A sweet taste causes insulin to be produced. This will store some of the sugar in the blood in tissues, including fat. With artificial sweeteners, the amount of sugar in the blood does not increase. This means that there will be too little sugar in the blood. This is known as hypoglycemia. On the next meal, more food will be eaten to get the blood sugar level back to normal values. 