Lineage B.1.429, also known as CAL.20C, has by five distinct mutations (I4205V and D1183Y in the ORF1ab-gene, and S13I, W152C, L452R in the spike proteins S-gene). B.1.429 might be more transmissible. The CDC has listed B.1.429 and the related B.1.427 as "variants of concern," and says that they have a ~20% increase in transmissibility.