Minamino was born in Izumisano. He started his club career at J1 League club Cerezo Osaka in 2012 and in his first season he was named "J.League Rookie of the Year". In 2014, he moved to Austrian club Red Bull Salzburg. He spent four successful season at Salzburg before moving to Liverpool on 1 January 2020. On February 1, 2021 Minamino joined Southampton on loan for the rest of the 2020-21 Premier League season.