During the Great Plague of London (1665-1666), the disease called the bubonic plague killed about 200,000 people in London, England. In seven months, almost one quarter of London's population (one out of every four Londoners) died from the plague. At its worst, in September of 1665, the plague killed 7,165 people in one week. After this, the number of people dying from the plague began to slow down. 