On August 31, 2017, he was announced to be Daniel Biss's running mate in the 2018 gubernatorial election. Ramirez-Rosa was dropped from the ticket on September 6, 2017. After Luis Gutiérrez announced his retirement from Congress, Ramirez-Rosa announced his candidacy for Gutiérrez’s seat, Illinois' 4th congressional district; he withdrew on January 9, 2018.