On 11 July 1643 at the Louvre, "Mademoiselle de Vendôme" married Charles Amadeus of Savoy, Duke of Nemours. The young prince was a member of a cadet branch of the house of Savoy which had settled in France. The young prince was a direct descendant of Philip II, Duke of Savoy as was Élisabeth. They had two daughters who would marry the heirs to the thrones of Savoy and Portugal, and three sons who died shortly after birth.