In 1999, three of his songs appeared in the video game of PC Kingpin: Life of Crime. B-Real also contributed with any of the voices of the people of the game. This same year launched an album of big successes in Spanish, "The big successes in Spanish." Cypress Hill Merged genders in the 2000 with his double-album Skull & Bones. The first disk, "Skull", was composed by songs of rap whereas "Bones" was more centred in the rock. The album was a Top 5 in Billboard 200 and #3 in Canada. The first single was "Rock Superstar" for the radio of rock and "Rap Superstar" for the urban radio, a subject that definitely put to the band again in the musical firmament, and that came him like ring to the finger, since in this time songs with this style, more than the Nu metal that also used in the song "Can´t get the best of me", were hitting as never. The group also launched "Live at the Fillmore", a disk of the concert of Fillmore, San Francisco in 2000.