On 26 December 2017, Falkholt was involved in a car crash which killed both her parents instantly. As the vehicle burst into flames, both Jessica and her sister Annabelle, aged 21, were pulled out of the vehicle alive, but Annabelle later died in Liverpool Hospital. She was hospitalized and placed under critical condition and life-support. She had surgery to remove her kidney and part of her skull. On 12 January 2018, a spokesperson for St George Hospital confirmed that her life support had been turned off but that she remained in a critical condition. She died five days later on 17 January at the age of 29.