When Edward VI died of tuberculosis in 1553 Mary I took the throne when crowds cheered for her in London, which people at the time said was the largest show of affection for a Tudor monarch. Mary, a loyal Catholic who had been influenced greatly by the Catholic King of Spain and Holy Roman Emperor, Charles V, tried to get the country back to Catholicism. This led to 274 burnings of Protestants, and much hatred from her people. Mary lost Calais, the last English possession on the Continent, and became even more unpopular (except among Catholics) at the end of her reign.