However, a number of 'wretched miscarriages' again made their relations cold. On 14 March 1622, while playing with her ladies, Anne fell on the stairs. She suffered her second miscarriage. Louis angrily blamed her. He was also upset with Mme de Luynes for not being careful enough. After this, the King grew to dislike the influence the duchesse de Luynes had over Anne. He disliked the duchesse even more when Luynes died (December 1621). Anne remained without a child for 16 more years.