In 2016, Guy Scott decided would not seek re-election to his Lusaka Central seat in Parliament in the August general election. Charlotte Scott applied to run for her husband's seat and was endorsed by the United Party for National Development (UPND) as the party's official nominee. Scott and her main opponent, the PF's Margaret Mwanakatwe, were considered the front-runners for Lusaka Central during the election out of the five candidates for the seat. However, she was unsuccessful as Margaret Mwanakatwe won the vacant seat.