Reed was drafted by the Baltimore Ravens in 2002. He had seven interceptions in his first season. Reed also developed a talent for blocking punts. In 2004, Reed had what may have been his best career season. He intercepted nine passes, made one sack, had 358 total return yards, and scored twice. This earned Reed the NFL Defensive Player of the Year Award in 2004. One of his touchdowns was a record 106 yards after he intercepted a pass. That was an NFL record until Reed broke his own record in 2008 with a 107 yard interception return for a touchdown. In 2010, Reed intercepted nine passes even though he missed six games because of an injury. 