Irene Hirano Inouye ("née" Yasutake; October 7, 1948 – April 7, 2020) was an American business executive. She was a "sansei", or a third-generation Japanese-American. She was the founding president of the U.S.-Japan Council from 2009 until her death in 2020. She also served as president and founding chief executive officer of the Japanese American National Museum in Los Angeles, California from 1988 to 2008.