On February 5, 2012, Manningham made a catch in the fourth quarter of Superbowl XLVI to set up the win against the Patriots. Trailing by 2 points with 3 minutes 46 seconds remaining, the Giants started the winning drive. Eli Manning lofted a long pass down the left sideline to Mario Manningham, who kept his feet inbounds by inches with two defenders around him. The Giants went on to beat the New England Patriots 21-17. Manningham ended the game with 5 catches for 73 yards. Most people think that he will not return to the Giants.