After Alexander the Great's campaigns in 330s BC and the subsequent collapse of the Achaemenid Empire, Tsopk remained part of the newly independent kingdom of Greater Armenia. In the early 200s BC, at the instigation of the Seleucid Empire, which was trying to weaken the Armenian kingdom, Tsopk, along with Commagene, split from Greater Armenia, forming the Hellenistic kingdom of Tsopk-Commagene. The kingdom was ruled by a branch of the Armenian royal dynasty of Orontids. Tsopk later split from the Tsopk-Commagene kingdom as well, forming an independent kingdom.