NSAIDs are the most common treatment for gout. No specific type of NSAID is significantly more or less effective than any other. Improvement may be seen within 4 hours. Treatment is recommended for 1–2 weeks. NSAIDs are not recommended for people with certain other health problems such as bleeding from the stomach, esophagus or intestines, renal failure, or heart failure. While indomethacin has historically been the most commonly used NSAID, ibuprofen may be preferred due to its lack of side effects. A proton pump inhibitor may be given to people at risk of experiencing gastric side effects.