A total of 32 teams will play in the first qualifying round: 31 teams which enter in this round, and 1 winner of the preliminary round. Seeding of teams will be based on their 2021 UEFA club coefficients. For the winner of the preliminary round, whose identity will not be known at the time of draw, the club coefficient of the highest-ranked remaining team will be used. The first team drawn in each tie will be the home team of the first leg.