In 2010, he played in his second World Cup, where he reached the semifinals. He played against Zhang Jike, where he only just lost 3:4 after a 3:1 lead. In the 3rd place match, he lost to Timo Boll. He finished the Cup in 4th place. At the WTTC, Mizutani won 3rd place with his team again. At the Pro Tour Grand Finals, he won his first gold medal. At the Japan, China, and Korea Open, he won a gold each time. At the Asian Games, he won 3rd place.