The building's construction began around 1550, sixteen years after Quito was founded by Spanish conquistadors, and was finished in approximately 1680. The building was officially inaugurated in 1605. It is not known who designed the original plans for the complex, though the most-accepted theory is that they were sent from Spain, based on the topographical study of Ricke and Gosseal. It is also possible that architects came from Spain for the construction of the monastery, or that Ricke and Gosseal managed the entire construction.