All-cause and cardiovas- cular mortality in treated patients with severe hypertriglyceri- daemia: a long-term prospective registry study. Atherosclerosis. 2010;211:618 23. S4.5.2-13. Christian JB, Arondekar B, Buysman EK, et al. Determining triglycer- ide reductions needed for clinical impact in severe hypertriglyceride- mia. Am J Med. 2014;127:36 44 e1. S4.5.2-14. Chait A, Brunzell JD. Severe hypertriglyceridemia: role of familial and acquired disorders. Metabolism. 1983;32:209 14. S4.5.2-15. Bays HE, Ballantyne CM, Kastelein JJ, et al. Eicosapentaenoic acid ethyl ester (AMR101) therapy in patients with very high triglycer- ide levels (from the Multi-center, plAcebo-controlled, Randomized, double-blINd, 12-week study with an open-label Extension [MARINE] trial) Am J Cardiol. 2011;108:682 90. S4.5.2-16. Wiggins BS, Saseen JJ, Page RL 2nd, et al. Recommendations for management of clinically significant drug-drug interactions with statins and select agents used in patients with cardiovascular dis- ease: a scientific statement from the American Heart Association. Circulation. 2016;134:e468 95. S4.5.2-17. Basar R, Uzum AK, Canbaz B, et al. Therapeutic apheresis for severe hypertriglyceridemia in pregnancy. Arch Gynecol Obstet. 2013;287:839 43. 4.5.3. Issues Specific to Women S4.5.3-1. Ouyang P, Wenger NK, Taylor D, et al. Strategies and methods to study female-specific cardiovascular health and disease: a guide for clinical scientists. Biol Sex Differ. 2016;7:19. S4.5.3-2. Grandi SM, Vallee-Pouliot K, Reynier P, et al. Hypertensive disorders in pregnancy and the risk of subsequent cardiovascular disease. Paediatr Perinat Epidemiol. 2017;31:412 21. S4.5.3-3. Shostrom DCV, Sun Y, Oleson JJ, et al. History of gestational diabe- tes mellitus in relation to cardiovascular disease and cardiovascular risk factors in US women. Front Endocrinol (Lausanne). 2017;8:144. S4.5.3-4. Catov JM, Newman AB, Roberts JM, et al. Preterm delivery and later maternal cardiovascular disease risk. Epidemiology. 2007;18:733 9. S4.5.3-5. Muka T, Oliver-Williams C, Kunutsor S, et al. 