Table 143: Summary of studies included in the review Study Intervention and comparison Population Outcomes Comments Intervention 1: Long term oxygen therapy (LTOT) prescribed for 15 hours per day including overnight hours. Nocturnal oxygen therapy (NOT) (assumed to be 8 hours per night) Comparator: Best medical therapy (BMT) which consisted of Participants with severe heart failure with NYHA class III or IV left ventricular systolic dysfunction receiving optimal medical therapy who were stable but severely symptomatic Age (mean (SD)): Quality of life (MLWHF) at 3 months Quality of life months Hospitalisation at NRS for breathlessness at 6 minute walk test at 6 months Outcomes were downgraded for indirectness due to the long follow up period Chronic Heart Failure Domiciliary oxygen therapy in people with advanced heart failure NICE 2018. All rights reserved. Subject to Notice of rights. ISBN: 978-1-4731-3093-7 Study Intervention and comparison Population Outcomes Comments maximally tolerated medical management and target doses of a renin-angiotensin system inhibitor, a beta-adrenoceptor antagonist and an aldosterone antagonist Gender (M/F): Ethnicity not reported UK Domiciliary oxygen therapy in people with advanced heart failure Chronic Heart Failure NICE 2018. All rights reserved. Subject to Notice of rights. 