Of the 54 recommendations that are included in the 30 statements in this update, 20 (38%) are strong recommendations (Grade 1) and none is based on high- quality (Grade A) evidence. The absence of high-quality evidence highlights the need for further research to guide VTE treatment decisions. As new evidence becomes available, these guidelines will need to be updated. Goals of our group and CHEST include transition to continually updated living guidelines. The modular format of this update is designed to facilitate this development, with individual topics and questions being addressed as new evidence becomes available. We will also facilitate implementation of our recommendations into practice by developing new and convenient ways to disseminate our recommendations. This will enable achievement of another of our goals reduction in the burden of VTE in individual patients and in the general population. Acknowledgments Author contributions: C. K. was the chair of the panel. C. K., E. A., A. B., J. O., D. J., and L .M. were executive committee members of the panel. C. K. and N. S. were the topic editors for Treatment of Acute Pulmonary Embolism Out of Hospital . C. K. and D. J. were the topic editors for Pulmonary Thromboendarterectomy in the Treatment of Chronic Thromboembolic Pulmonary Hypertension . E. K. and A. B. were the topic editors for Compression Stocking to Prevent Post- Thrombotic Syndrome . E. K. and A. B. were the topic editors for Thrombolytic Therapy in Patients with Upper Extremity Deep Vein Thrombosis . D. J. and C. S. K. were the topic editors for Management of Recurrent Venous Thromboembolism on Anticoagulant Therapy . H. B. and N. S. were the topic editors for Whether and How to Anticoagulate Patients with Isolated Distal Deep Vein Thrombosis . 