or (statin* or lovastatin or meglutol or pravastatin or atorvastatin or simvastatin).ti. #5 Non-statins Gemfibrozil/ or fenofibrate/ or niacin/ or exp Fatty Acids, Omega-3/ or exp Ezetimibe/ or exp Proprotein Convertase 9/tu or exp "Bile Acids and Salts"/tu OR (fibrate* or gemfibrozil or fenofibrate or bezafibrate or (nicotinic ADJ acid*) or niacin or (bile ADJ acid ADJ sequestrant*) or (bile ADJ acid ADJ resin*) or ezetimibe or (omega* ADJ3 fatty adj acid*) or "fish oil" or pcsk9 or pcsk-9 or "pcsk 9" or ((eicosapentaenoic or docosahexaenoic) ADJ acid*)).ti,ab. #6 Outcomes of interest Exp secondary prevention/ OR exp primary prevention/ OR exp mortality/ OR exp morbidity/ OR exp death/ OR exp myocardial infarction/ OR cerebrovascular accident/ OR stroke/ OR exp Angina, Unstable/ OR (stroke* OR (cerebrovascular ADJ accident*) OR morbidity OR mortality OR death OR (heart ADJ attack*) OR (myocardial ADJ infarct*) OR ((vascular OR cardiac OR coronary OR cerebrovascular) ADJ2 event*) OR (heart ADJ infarct*)).ti,ab. OR (morbidity OR mortality OR prevent* OR outcome*).ti,ab. OR (secondary ADJ prevention).ti,ab. OR (primary ADJ prevention).ti,ab. OR angina.ti,ab. OR ae.fs.OR to.fs. OR safety/ or exp patient harm/ OR ((side ADJ effect*) OR (adverse ADJ event*) OR safe OR safety).ti,ab. analyses Randomized controlled trials/systematic review/meta-analysis hedge [see Search Limits at the end of this table] #10 Apply limits See Search Limits at the end of the table Question Set # Concept Strategy Question Strategies to improve patient tolerance to statins #1 Dyslipidemia exp dyslipidemias/ OR exp cholesterol/ OR exp lipids/ OR (dyslipidemia* OR dyslipidaemia* OR dyslipidproteinemia* OR dyslipidproteinaemia* OR hyperlipidemia* OR hyperlipidaemia* OR hypercholesterolemia* OR hypercholesterolaemia* OR hyperlipoproteinemia* OR hyperlipoproteinaemia* OR hypertriglyceridemia* OR hypertriglyceridaemia* OR hyperlipemia OR hyperlipaemia OR cholesteryl* OR cholesterol* OR lipid* OR lipoprotein* OR tryglycer* OR triaclyglycer* OR "HDL-C" OR "LDL-C" OR "HDL C" OR "LDL C").ti,ab. 