Closure of PFO is not indicated for preventing stroke in patients with migraine (Class III; Level of Evidence B). Metabolic Syndrome TheNationalCholesterolEducationProgram(AdultTreatment Panel III) originally defined metabolic syndrome as the pres- ence of 3 of the following: (1) abdominal obesity as deter- mined by waist circumference >102 cm (>40 in) for men and >88 cm (>35 in) for women; (2) triglycerides 150 mg/dL; (3) HDL cholesterol <40 mg/dL for men and <50 mg/dL for women; (4) BP 130/ 85 mmHg; and (5) fasting glucose A modified criterion for fasting glucose was published in 2004.617 The International Diabetes Foundation (IDF) then modified the definition by requiring inclusion of a waist circumference >88 cm for men and >80 cm in women plus 2 of the other National Cholesterol Education Program Adult Treatment Panel III criteria.618 In 2009, a harmonized definition was proposed wherein an identical set of thresholds was used for all components except waist circumference, an area in which further evidence for the relationship to CVD events was felt to be required.619 In the interim, the Harmonized Definition Work Group suggested that national or regional cut points for waist circumference should be used. 