Such people should be kept under regular review if they are given prophylactic anticoagulation. There was insufficient evidence to support any recommendation on the safety and efficacy of anticoagulants versus antiplatelets for the treatment of people with acute ischaemic stroke associated with antiphospholipid syndrome. 2022 The consensus of the committee is that it would be safe to start statins after 48 hours. 2022 Recommendations for research As part of the 2022 update, the guideline committee made an additional 2 research recommendations. As part of the 2019 update, the guideline committee retained the research recommendations on avoidance of aspiration pneumonia, aspirin and anticoagulant treatment for acute ischaemic stroke, aspirin treatment in acute ischaemic stroke, early mobilisation and optimum positioning of people with acute stroke, blood pressure control, and safety and efficacy of carotid stenting. The committee made an additional research recommendation on MRI brain scanning. Key recommendations for research 1 Impact of intensive blood pressure lowering on people who are frail What is the efficacy and safety of intensive interventions to lower blood pressure compared with less intensive interventions for people with acute intracerebral haemorrhage who are frail at presentation? [2022] For a short explanation of why the committee made this recommendation for research, see the rationale section on blood pressure control for people with acute intracerebral haemorrhage. Full details of the evidence and the committee's discussion are in evidence review E: intensive interventions to lower blood pressure in people with acute intracerebral haemorrhage. 2 Impact of intensive interventions to lower blood pressure on cognitive function, functional ability and quality of life What are the long-term effects of intensive interventions to lower blood pressure on cognitive function, functional ability and quality of life compared with standard 2022 interventions in people with acute intracerebral haemorrhage? 