In patients undergoing isolated CABG, transfusions are associated with reduced long-term survival and worse quality About 10% to 20% of the cardiac patients who are transfused receive roughly 80% of the transfusions that are administered.1075,1078 These high-risk patients often can be identified preoperatively to facilitate measures directed at blood conservation. Several reports have identified risk fac- tors for blood transfusions,1079 1082 including advanced age, preoperative anemia, small body size, reoperative CABG, priority of operation, duration of CPB, presence of preoper- ative coagulopathy, and preoperative antithrombotic ther- apy.1080,1083 1088 A multimodal approach that includes trans- fusion algorithms, point-of-care testing, and a focused blood conservation strategy can limit the percentage of patients requiring transfusion and the amount of blood transfusions About 60% to 70% of CABG patients are taking aspirin at the time of the procedure.536,1089,1090 Although aspirin in- creases perioperative blood loss and blood transfusion re- quirements,1091 1098 the amount of blood loss can be mini- mized by avoiding CPB1099 and by using blood conservation techniques. In a meta-analysis of data from 805 patients,1100 doses of preoperative aspirin 325 mg were associated with increased bleeding (mean difference, 230 mL), whereas those who received 325 mg preoperatively did not have a significant increase in blood loss (mean difference: 65.3 mL; 95% CI: 20.2 to 150.8; P 0.134). Some subjects undergoing CABG are receiving DAPT. 