Continuous EEG monitoring should be considered in ICH patients with depressed mental status that is dispropor- tionate to the degree of brain injury. Epilepsy occurs in up to 10% of young patients (18 50 years) with ICH; the risk of poststroke epilepsy may be less in older patients.169,170 Risk factors for epilepsy include stroke severity, cortical location of the hematoma, and delayed initial seizures.169,170 There are no data to sug- gest that early use of antiseizure drugs will prevent lesion- related epilepsy. Seizures and Antiseizure Drugs: Recommendations Clinical seizures should be treated with antiseizure drugs (Class I; Level of Evidence A). (Unchanged from the previous guideline) Patients with a change in mental status who are found to have electrographic seizures on EEG should be treated with antiseizure drugs (Class I; Level of Evidence C). (Unchanged from the previous guideline) Continuous EEG monitoring is probably indicated in ICH patients with depressed mental status that is out of proportion to the degree of brain injury (Class IIa; Level of Evidence C). (Revised from the previous guideline) Prophylactic antiseizure medication is not recom- mended (Class III; Level of Evidence B). (Unchanged from the previous guideline) Management of Medical Complications The frequency of medical complications after acute stroke is high, although there is substantially more information reported for ischemic stroke than ICH. In a trial of the safety and tolerability of NXY-059 (CHANT [Cerebral Hematoma and NXY Treatment]) in patients with sponta- neous ICH, at least 1 adverse event was reported in 88% of the placebo-treated patients, 40% of which were serious (ie, resulted in prolonged hospitalization, were immediately life threatening, or were fatal). 