Page et al 2015 ACC/AHA/HRS SVT Guideline e537 6.2. Management of Asymptomatic Pre-Excitation 6.2.1. PICOTS Critical Questions See the ERC systematic review report, Risk Stratification for Arrhythmic Events in Patients With Asymptomatic Pre- Excitation for the complete evidence review on the manage- ment of asymptomatic pre-excitation,9 and see Online Data Supplements 13, 14, and 15 for additional data on asymptomatic pre-excitation, which were reproduced directly from the ERC s systematic review. These recommendations have been designated with the notation SR to emphasize the rigor of support from the ERC s systematic review. PICOTS Question 1 did not provide adequate data for a recommendation; the other 3 PICOTS ques- tions are addressed in the recommendations in Section 6.2.2. As noted in Section 1.1, the recommendations in Section 6.3 are based on a separately commissioned systematic review of the available evidence, the results of which were used to frame our decision making. Full details are provided in the ERC s systematic review report.9 The following 4 questions were considered by the ERC: 1. What is the comparative predictive accuracy of inva- sive EP study (without catheter ablation of the acces- sory pathway) versus noninvasive testing for predicting arrhythmic events (including SCD) in patients with asymptomatic pre-excitation? 2. What is the usefulness of invasive EP study (without catheter ablation of the accessory pathway) versus no testing for predicting arrhythmic events (including SCD) in patients with asymptomatic pre-excitation? 3. What is the usefulness of invasive EP study (without catheter ablation of the accessory pathway) or noninva- sive EP study for predicting arrhythmic events (includ- ing SCD) in patients with asymptomatic pre-excitation? 4. 