(2016) included 78 studies comparing HTN treatment to placebo and 14 studies comparing intensive HTN therapy to standard treatment. Across a broad range of initial baseline SBPs greater than 130 mm Hg, a 10 mm Hg lowering in SBP was associated with improvements in the composite cardiovascular outcome.[54] Thus, there is likely benefit to further reductions of SBP for those patients with a baseline SBP between 130 and 150 mm Hg. The SR by Ettehad et al. (2016) demonstrated benefit from a 10 mm Hg reduction in SBP but did not evaluate a specific target or threshold.[54] Different SRs have come to different conclusions in recommending a specific target for SBP less than 150 mm Hg with conclusions that are highly sensitive to inclusion criteria of studies in the SRs. The SR by Saiz et al. (2018) considered six RCTs in hypertensive patients with a history of CVD (MI, angina, stroke, and/or peripheral vascular occlusive disease), targeting a blood pressure less than or equal to 135/85 mm Hg when compared to standard therapy and found no benefit for the more intensive approach.[55] This mirrors the findings from the SR by Weiss et al. (2017) that looked at studies targeting a lower threshold.[56] In contrast, the SR by Reboussin et al. (2018) found significant reductions in the risk of major cardiovascular events associated with an SBP target of less than 130 mm Hg.[57] The largest individual study to date examining SBP targets, the Systolic Blood Pressure Intervention Trial (SPRINT), included HTN patients age 50 and over and demonstrated a 25% reduction in cardiovascular events in the intensive treatment group targeting an SBP of 120 mm Hg.