Based on statin half-lives, an interruption of 2 4 weeks is reasonable. Statin treatment then can be reinitiated with the same statin (if symptoms were deemed non-statin related), or with a different statin at recommended intensity (if symptoms resolved after discontinuation). If intolerance persists, providers could consider decreases in dosage. Also, intermittent dosing is an acceptable option in patients with continued tolerance issues. Only in the rare case of a serious adverse event (e.g., rhabdomyolysis) should statins be discontinued. The Work Group systematically reviewed evidence on the role of vitamin D deficiency in statin-induced myopathy. The confidence in the quality of the two available cohort studies was very low based on a small number of patients and different protocols for vitamin D supplementation.[119,120] Thus, the Work Group was unable to make a recommendation on vitamin D supplementation. As this is a Reviewed, New-added recommendation, the Work Group systematically reviewed evidence related to this recommendation [114,116,119,120] and considered the evidence put forth in the 2014 CPG.[56] The Work Group s confidence in the quality of the evidence was very low. The evidence was limited by the observational nature of data and outcomes assessment. For almost all patients, there are no significant harms associated with the trial of a different statin or implementation of intermittent dosing, and there is a potential benefit of continuing treatment. Because most agents in the class are available in generic formulations, it is unlikely that switching statins will add a substantial financial burden. With proper education, it is expected that most patients will be amenable to a change in statin or an intermittent dosing schedule. 