[100] In this systematic review, omega-3 supplementation ranged from 0.5 grams/day to greater than 5 grams/day.[100] Some studies used omega-3 enriched foods, or dietary advice to increase omega-3 consumption, compared to placebo or usual diet. Most studies assessed LCn3 supplementation with capsules, but some used LCn3- or alpha-linolenic acid-rich or enriched foods or dietary advice compared to placebo or usual diet.[100] Omega-3 enriched foods included margarine, juice, bread, walnuts, or other foods. Control groups received olive, corn, sunflower oils, or other types of fats. The duration of studies As this is a Reviewed, New-added recommendation, the Work Group systematically reviewed evidence related to this recommendation.[100] The Work Group s confidence in the quality of the evidence was moderate. The evidence showed no effect of omega-3 supplements on CV mortality, composite CV events, MI, stroke, or all-cause mortality. There were inconclusive results for the risk of adverse effects, including bleeding and thrombosis, and risk of bias in the RCTs evaluated. Thus, the Work Group decided upon a Weak against recommendation. Future studies should measure the potential effects of omega-3 supplements on CVD risk factors. Recommendation 21. There is insufficient evidence to recommend for or against the use of fiber, garlic, ginger, green tea, and red yeast rice supplements to reduce cardiovascular risks. (Neither for nor against | Reviewed, New-added) Discussion No studies evaluated the long-term effects of fiber, garlic, ginger, green tea, and red yeast rice supplements on CVD morbidity or mortality. Instead, these studies evaluated the safety of these interventions. Most of these studies evaluated these substances in their supplemental form not as they naturally occur in foods. In foods, these substances may have different effects. Fiber The systematic review by Hartley et al. 