In addition, this guideline introduces a chapter dedicated to proper blood pressure measurement. The goal of the guideline is to serve as a useful resource for clinicians and patients by providing actionable recommendations with useful infographics based on a rigorous formal systematic review. Another aim is to propose research recommendations for areas in which there are gaps in knowledge. The guideline targets clinicians treating high blood pressure and CKD, while taking into account policy and resource implications. Development of this guideline update followed an explicit process of evidence review. Treatment approaches and guideline recom- mendations are based on systematic reviews of relevant studies, and appraisal of the quality of the evidence and the strength of recommendations followed the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Limitations of the evidence are discussed, and areas of future research are presented. Keywords: albuminuria; ambulatory blood pressure monitoring; angiotensin-converting enzyme inhibitor; angiotensin II receptor blocker; antihypertensive agents; automated of ce blood pressure; blood pressure measurement; blood pressure targets; children; chronic kidney disease; creatinine; diabetes; dietary sodium; evidence-based; guideline; home blood pressure monitoring; hyperkalemia; KDIGO; kidney transplant recipient; lifestyle; mineralocorticoid receptor antag- onist; of ce blood pressure; physical activity; potassium; proteinuria; renin-angiotensin system; standarized of ce blood pressure; systematic review; weight loss CITATION In citing this document, the following format should be used: Kidney Disease: Improving Global Outcomes (KDIGO) Blood Pressure Work Group. KDIGO 2021 Clinical Practice Guideline for the Management of Blood Pressure in Chronic Kidney Disease. Kidney Int. 2021;99(3S):S1 S87. This guideline, including all statements and evidence, will be published simultaneously on MAGICapp (https://kdigo.org/guidelines/blood-pressure-in-ckd/). This online format will facil- itate rapid updates as new evidence emerges. 