APPENDIX 2: CONCURRENCE WITH INSTITUTE OF MEDICINE STANDARDS FOR SYSTEMATIC REVIEWS AND FOR GUIDELINES IOM Standards for Systematic Reviews Part of KDIGO Process? 2.1 Establish a team with appropriate expertise and experience to conduct the systematic review Yes 2.1.1 Include expertise in the pertinent clinical content areas Yes 2.1.2 Include expertise in systematic review methods Yes 2.1.3 Include expertise in searching for relevant evidence Yes 2.1.4 Include expertise in quantitative methods Yes 2.1.5 Include other expertise as appropriate Yes 2.2 Manage bias and conflict of interest (COI) of the team conducting the systematic review Yes 2.2.1 Require each team member to disclose potential COI and professional or intellectual bias Yes (not intellectual bias) 2.2.2 Exclude individuals with a clear financial conflict Yes 2.2.3 Exclude individuals whose professional or intellectual bias would diminish the credibility of the review in the eyes of the intended users Not explicitly 2.3 Ensure user and stakeholder input as the review is designed and conducted Yes 2.3.1 Protect the independence of the review team to make the final decisions about the design, analysis, and reporting of the review Yes 2.4 Manage bias and COI for individuals providing input into the systematic review Yes 2.4.1 Require individuals to disclose potential COI and professional or intellectual bias Yes (not intellectual bias) 2.4.2 Exclude input from individuals whose COI or bias would diminish the credibility of the review in the eyes of the intended users No 2.5 Formulate the topic for the systematic review Yes 2.5.1 Confirm the need for a new review Yes 2.5.2 Develop an analytic framework that clearly lays out the chain of logic that links the health intervention to the outcomes of interest and defines the key clinical questions to be addressed by the systematic review No 2.5.3 Use a standard format to articulate each clinical question of interest No 2.5.4 State the rationale for each clinical question No 2.5.5 Refine each question based on user and stakeholder input Yes 2.6 Develop a systematic review protocol Yes 2.6.1 Describe the context and rationale for the review from both a decision-making and research perspective No 2.6.2 Describe the study screening and selection criteria (inclusion/exclusion criteria) Yes 2.6.3 Describe precisely which outcome measures, time points, interventions, and comparison groups will be addressed Yes 2.6.4 Describe the search strategy for identifying relevant evidence Yes 2.6.5 Describe the procedures for study selection Yes 2.6.6 Describe the data extraction strategy Yes 2.6.7 Describe the process for identifying and resolving disagreement between researchers in study selection and data extraction decisions No 2.6.8 Describe the approach to critically appraising individual studies Yes 2.6.9 Describe the method for evaluating the body of evidence, including the quantitative and qualitative synthesis strategies Yes IOM Standards for Systematic Reviews Part of KDIGO Process? 