HRs for ischemic stroke among men and women with the highest ( 443 mg/dL) com- pared with the lowest (<89 mg/dL) nonfasting triglyceride respectively. The 10-year risks of ischemic stroke were 16.7% and 12.2%, respectively, in men and women 55 years of age with triglyceride levels of 443 mg/dL.150 Similarly, the WHS found that in models adjusted for total and HDL cholesterol and measures of insulin resistance, nonfasting triglycerides, but not fasting triglycerides, were associated with cardiovas- cular events, including ischemic stroke.151 A meta-analysis of 64 randomized clinical trials that tested lipid-modifying drugs found an adjusted RR of stroke of 1.05 (95% CI, 1.03 1.07) for each 10-mg/dL increase in baseline triglycerides, although fasting status is not specified.152 In the Emerging Risk Factors Collaboration meta-analysis, triglyceride levels were not asso- ciated with either ischemic or hemorrhagic stroke risk, and determination of fasting status did not appear to change the lack of association.146 Treatment of Dyslipidemia Treatment with statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) reduces the risk of stroke in patients with or at high risk for atherosclerosis.153,154 One meta-analysis of 26 trials that included >90000 patients found that statins reduced the risk of all strokes by 21% (95% CI, 15 27).153 Baseline mean LDL cholesterol in the studies ranged from 124 to 188 mg/dL and averaged 149 mg/dL. The risk of all strokes was estimated to decrease by 15.6% (95% CI, 6.7 23.6) for each 10% reduction in LDL cholesterol. Another meta-anal- ysis of randomized trials of statins in combination with other preventive strategies that included 165792 individuals showed that each 1-mmol/L (39-mg/dL) decrease in LDL cholesterol reduction in stroke.155 Several meta-analyses also found that beneficial effects are greater with greater lipid lowering. 