Daptomycin 6 mg/kg IV every 24 h; For all staphylococci plus rifampin, plus gentamicin (for first 2 wk) if prosthetic material present Gram-negative enteric bacilli Ceftazidime, cefepime, cefotaxime, or ceftriaxone plus gentamicin (or tobramycin or amikacin, depending on susceptibility) A broad-spectrum penicillin plus gentamicin (or tobramycin or amikacin) divided every 8 h up to 18 g daily Gentamicin or tobramycin 3 6 mg kg 1 IV IV divided every IV divided every 8 h up to 2 4 g daily IV divided every 6 h up to 12 g daily IV divided every 12 h IV every 24 h up to 4 g daily Gentamicin or tobramycin 3 6 mg kg 1 IV IV divided every 8 12 h up HACEK group Ceftriaxone or cefotaxime or Ampicillin-sulbactam Ampicillin (for susceptible organisms) plus aminoglycoside IV divided every 4 6 h up to 12 g daily IV divided every 6 h up to 12 g daily Gentamicin or tobramycin 3 6 mg kg 1 IV IV divided every 12 h or IV every 24 h up to 4 g daily IV divided every 4 6 h up to 12 g daily IV divided every 8 12 h up to 15 mg kg 1 Fungi Candida spp, Aspergillus spp Surgical resection plus amphotericin B with or without flucytosine IV administered over Amphotericin B followed by imidazole (eg, fluconazole, itraconazole, voriconazole) suppression if surgery cannot be performed orally divided every 6 h Amphotericin liposomal/lipid-associated (3 in a single dose daily IV administered over 3 4 h Amphotericin liposomal/lipid-associated 3 5 in a single dose daily BID indicates twice per day; HACEK, Haemophilus species, Aggregatibacter species, Cardiobacterium hominis, Eikenella corrodens, and Kingella species; IV, intravenously; MBC, minimum bactericidal concentration; and MRSA, methicillin-resistant Staphylococcus aureus (includes resistance to oxacillin, nafcillin, and cephalosporins). 