, study arms did not need to have the same blood pressure goal or the comparator was a placebo) Usual care Placebo No treatment No goal Key Question 7 Initial therapy (where comparator is from a different class than the Intervention): thiazide- type diuretics, ACEIs, CCBs, beta blockers Add-on therapy: a drug/class from list above other than initial therapy, or other drugs/ classes (e.g., MRA) could be used as add-on therapy Key Question 8 Initial therapy: thiazide-type diuretics, ACEIs, CCBs, beta blockers With second drug added in at a later time from list above Key Question 9 Placebo A different fourth drug (any) Key Question 10 Usual care No intervention Wait list Active intervention unrelated to blood pressure Another telemonitoring method from intervention list with a different intensity Key Question 11 Usual care No intervention Wait list Active intervention unrelated to blood pressure Another intervention from intervention list with a different intensity Key Question 12 No screening d. Outcomes Key Question 1 Critical outcomes: specificity, sensitivity, positive predictive values (PPV), negative predictive values (NPV), area under curve (AUC), etc. 