(Weak for |Reviewed, New-replaced) Discussion Out-of-office blood pressure monitoring methods comprise: (a) 24-hour and daytime/awake ambulatory blood pressure monitoring (ABPM) and (b) home blood pressure monitoring (HBPM). The 2014 VA/DoD HTN CPG included recommendations on ABPM and HBPM to assist in the diagnosis of HTN prior to initiation of drug therapy. The current recommendation is based on very low quality evidence from the 2014 VA/DoD HTN CPG literature review,[44-48] which found that ABPM and HBPM are better predictors of cardiovascular events compared with routine (not AOBP) office blood pressure measurements. However, ABPM and HBPM were not used as entry criteria or as treatment goals in cardiovascular outcome clinical trials. Moreover, with accumulating evidence that AOBP may be equivalent to ABPM and HBPM (see Recommendation 2 and the evidence in the next paragraph), the role of ABPM and HBPM may no longer be as important in confirming the diagnosis of HTN using out-of-office blood pressure measurements as was thought to be the case in 2014. Furthermore, because no studies comparing ABPM versus HBPM on clinical outcomes were identified in the present systematic evidence review, two separate recommendations on ABPM and HBPM from the 2014 VA/DoD HTN CPG were combined into a single Weak for recommendation. Evidence from two SRs demonstrated that fully automated office blood pressure measurements were similar to SBP and DBP obtained with day-time/awake ABPM and HBPM. Pappaccogli et al. (2019) showed no significant difference for both SBP (-1.85 mm Hg) and DBP (0.12 mm Hg) in the pooled analysis of 16 studies comparing AOBP with daytime ABPM.[37] The same SR compared AOBP and HPBM using pooled data from seven studies and also found no statistically significant difference in SBP and DBP between the two methods. 