Key Question Specific Criteria For all KQs, SRs of clinical study types appropriate for the respective key question (as outlined below) were the first line of evidence KQ 1: RCTs and diagnostic cohort studies that reported on the diagnostic characteristics of the screening test (e.g., sensitivity, specificity, repeatability) KQ 2: RCTs or non-randomized, prospective comparative studies KQ 3, 4: RCTs, overall sample size 30 KQ 9: RCTs or non-randomized, prospective comparative trials, total sample size 100; retrospective comparative trials total sample size 400 (minimum 200/arm) KQ 10, 11: RCTs KQ 12: RCTs, non-randomized comparative trials, and diagnostic cohort studies c. Literature Search Strategy Information regarding the bibliographic databases, date limits, and platform/provider can be found in the table below. Additional information on the search strategies, including topic-specific search terms and search strategies can be found in Appendix J. Table A-3. Bibliographic Database Information Name Date Limits Platform/Provider Cochrane Database of Systematic Reviews (Cochrane Reviews) Cochrane Central Register of Controlled Trials December 15, 2013 to March 25, 2019 Wiley Database of Abstracts of Reviews of Effects December 15, 2013 to March 25, 2019 Wiley EMBASE (Excerpta Medica) December 15, 2013 to March 25, 2019 Elsevier Health Technology Assessment Database (HTA) December 15, 2013 to March 25, 2019 Wiley PubMed (In-process and Publisher records) December 15, 2013 to March 25, 2019 National Library of Medicine C. Convening the Face-to-face Meeting In consultation with the COR, the Champions, and the Work Group, the Lewin Team convened a three and one half day face-to-face meeting of the CPG Champions and Work Group members on June 3 6, 2019. These experts were gathered to develop and draft the clinical recommendations for an update to the 2014 VA/DoD HTN CPG. 