The estimate of the effect for each level of intervention intensity among patients with a cardiovascular diagnosis was very similar (RR, 1.42 [95% CI, 1.29 1.56]). There was insufficient direct evidence to conclude that adding bupropion or varenicline to intensive counseling increases cessation rates over what is achieved by counseling alone.391 A subsequent 2016 multicenter, double-blind, randomized, placebo-controlled trial in which 302 smokers hospitalized with an acute coronary syndrome were randomized to varenicline or placebo for 12 weeks showed that at 24 weeks abstinence rates were 47.3% in the varenicline group versus 32.5% in the placebo group. Continuous abstinence rates were 35.8% in the varenicline group versus 25.8% in the placebo group.393 Patients in both groups received low- intensity counseling. See Tables XCIII and XCIV in online Data Supplement 1. Powers et al 2019 Guidelines for Management of AIS e399 6.11. Stroke Education 6.11. Stroke Education COR LOE New, Revised, or Unchanged Patient education about stroke is recommended. Patients should be provided with information, advice, and the opportunity to talk about the impact of the illness on their lives. I C-EO Recommendation and COR unchanged from 2016 Rehab Guidelines. LOE revised. Additional reference support for this guideline is provided in online Data Supplement 1.394 544 Writing Group Disclosures Writing Group Member Employment Research Grant Other Research Support Speakers Bureau/ Honoraria Expert Witness Ownership Interest Consultant/ Advisory Board Other William J. 