Management of RWI involves selecting a balanced GWC and requires that both the chair and a majority of GWC members have no rel- evant RWI (see Appendix 1 for the definition of relevance). GWC members are restricted with regard to writing or voting on sections to which their RWI apply. In addition, for trans- parency, GWC members comprehensive disclosure informa- tion is available as an online supplement. Comprehensive disclosure information for the Task Force is available as an additional supplement. The Task Force strives to avoid bias by selecting experts from a broad array of backgrounds repre- senting different geographic regions, sexes, ethnicities, races, intellectual perspectives/biases, and scopes of clinical prac- tice. Selected organizations and professional societies with related interests and expertise are invited to participate as partners or collaborators. Individualizing Care in Patients With Associated Conditions and Comorbidities The ACC and AHA recog- nize the complexity of managing patients with multiple condi- tions, compared with managing patients with a single disease, and the challenge is compounded when CPGs for evaluation or treatment of several coexisting illnesses are discordant or CPGs attempt to define practices that meet the needs of patients in most, but not all, circumstances and do not replace clinical judgment. Clinical Implementation Management in accordance with CPG recommendations is effective only when followed; there- fore, to enhance their commitment to treatment and compliance with lifestyle adjustment, clinicians should engage the patient to participate in selecting interventions on the basis of the patient s individual values and preferences, taking associated conditions and comorbidities into consideration (eg, shared decision making). Consequently, there are circumstances in which deviations from these guidelines are appropriate. 