Prognostic importance of quantita- tive exercise Doppler echocardiography in asymptomatic valvular aortic stenosis. Circulation. 2005;112:I377 82. 4. Mar chaux S, Hachicha Z, Bellouin A, et al. Usefulness of exercise-stress echocardiography for risk stratification of true asymptomatic patients with aortic valve stenosis. Eur Heart J. 2010;31:1390 7. 5. Otto CM, Pearlman AS, Kraft CD, et al. Physiologic changes with maxi- mal exercise in asymptomatic valvular aortic stenosis assessed by Doppler echocardiography. J Am Coll Cardiol. 1992;20:1160 7. 6. Pierard LA, Lancellotti P. Stress testing in valve disease. Heart. 2007;93:766 72. 7. Magne J, Mahjoub H, Dulgheru R, et al. Left ventricular contrac- tile reserve in asymptomatic primary mitral regurgitation. Eur Heart J. 2014;35:1608 16. 8. Donal E, Mascle S, Brunet A, et al. Prediction of left ventricular ejection fraction 6 months after surgical correction of organic mitral regurgita- tion: the value of exercise echocardiography and deformation imaging. Eur Heart J Cardiovasc Imaging. 2012;13:922 30. 9. Wahi S, Haluska B, Pasquet A, et al. Exercise echocardiography predicts development of left ventricular dysfunction in medically and surgically treated patients with asymptomatic severe aortic regurgitation. Heart. 2000;84:606 14. 10. Gentry JL 3rd, Parikh PK, Alashi A, et al. Characteristics and outcomes in a contemporary group of patients with suspected significant mitral stenosis undergoing treadmill stress echocardiography. Circ Cardiovasc Imaging. 2019;12:e009062. 11. Lancellotti P, Dulgheru R, Go YY, et al. Stress echocardiography in patients with native valvular heart disease. Heart. 2018;104:807 13. 2.4. Basic Principles of Medical Therapy 1. Yancy CW, Jessup M, Bozkurt B, et al. 2017 ACC/AHA/HFSA focused update of the 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America. Circulation. 2017;136:e137 61. 2. 