A 4-week regimen of intravenous aqueous crystalline pen- icillin G (or ampicillin if penicillin G is unavailable) achieves a high cure rate.112 This approach avoids aminoglycoside-con- taining regimens for children with impairment of renal func- tion, concurrently administered nephrotoxic drugs, or eighth cranial nerve impairment. In adult patients, 4 weeks of ther- apy with ceftriaxone given once daily also is a recommended In adults, a 4-week course of ceftriaxone therapy has a bacteriologic cure rate of 98%,113 but only limited and retrospective data on the use of ceftriaxone in the treatment of IE in children have been published. The advantage of using ceftriaxone is that children initially treated for IE in the hos- pital can be transitioned to home intravenous therapy with an antibiotic that only requires a single infusion daily. Although home treatment for part of the antibiotic course appears to be becoming a more frequently used option, this decision is rea- sonable but requires careful selection of the appropriate can- didate based on family accommodations and access to home A 2-week course of therapy with penicillin, ampicillin, or ceftriaxone combined with an aminoglycoside has become increasingly popular and results in bacteriologic cure rates of up to 98% in adults.114 This regimen is commonly used for uncomplicated cases of native valve IE but is not recom- mended for patients who have had clinical symptoms of endo- carditis for >3 months or those who have an extracardiac focus of infection, an intracardiac abscess, or a mycotic aneurysm. It is not recommended by this committee for children because of lack of data, and it should be used with caution in people at increased risk for adverse events caused by aminoglycoside therapy, such as those with renal impairment or those taking other nephrotoxic drugs. 