She has published over 700 journal articles, books, and book chapters on topics in clinical cardiology, vascular biology and hypertension. Dr Oparil has received a number of honorary memberships, lectureships, and distinguished awards for her contributions to hypertension research, including the Irving Page-Alva Bradley Lifetime Achievement Award, given by the AHA Council for High Blood Pressure Research (2002); the 2008 Harriet Dustan Award, sponsored by the AHA Council for High Blood Pressure Research; the Virginia Frantz 22 Award for Distinguished Women in Medicine (2010) presented by Columbia University College of Physicians and Surgeons; and the ICS Distinguished Lecture Award (2011), sponsored by the Institute of Cardiovascular Sciences. Dr Oparil is a cardiologist with a special interest in the fundamental mechanisms of CVD and in applying this information to the development of novel treatments. Her research ranges from molecular and cellular studies to whole animal studies to clinical trials. She has made a number of innovative discoveries with major clinical impact: 1) observing that angiotensin-converting enzyme (ACE) is involved in vascular disease, leading to the development of ACE-Is; 2) identifying endothelin as the major mediator of pulmonary hypertension and pulmonary vascular disease, leading to the development of a class of drugs for patients with pulmonary hypertension; and 3) defining novel pathways by which blood vessels are protected from injury by estrogens, providing crucial information on potential targets for future gene therapy. She has made many significant contributions to vascular biology and hypertension research. 