46% of patients in trial had CKD (3% Subgroup status: Ejection fraction: All reduced NYHA class: Mixed Chronic Heart Failure Treating Heart Failure NICE 2018. All rights reserved. Subject to Notice of rights. ISBN: 978-1-4731-3093-7 (a) GFR approximated using creatinine level (umol/l) and average participant demographics using the abbreviated MDRD equation: 186 x (Creat / 88.4)-1.154 x (mean age)-0.203 x (0.742 x (proportion female%)) (b) Ten or more years elapsed between the publication of the main trial results and the publication of the reported sub- group analysis Treating Heart Failure Chronic Heart Failure NICE 2018. All rights reserved. Subject to Notice of rights. 