OR (('high density lipoprotein cholesterol'/exp OR 'low density lipoprotein cholesterol'/exp) AND 'goal attainment'/exp) OR ((cholesteryl* OR cholesterol* OR lipid* OR lipoprotein* OR tryglycer* OR triaclyglycer* OR "HDL-C" OR "LDL-C" OR "HDL C" OR "LDL C" OR "non HDL C" OR "non-HDL C" OR "non-HDL-C") NEAR/5 (goal OR goals OR target* OR level OR levels)):ti,ab #4 Statins 'hydroxymethylglutaryl coenzyme A reductase inhibitor'/exp OR 'hypocholesterolemic agent'/exp OR ((hydroxymethylglutaryl OR hydroxy-methylglutaryl) NEAR/5 reductase):ti OR (HMG NEXT/1 CoA):ti OR (statin* OR lovastatin OR meglutol OR pravastatin OR atorvastatin OR simvastatin):ti #5 Non-statins 'fibric acid derivative'/exp OR 'gemfibrozil'/exp OR 'hypocholesterolemic agent'/exp OR 'nicotinic acid'/exp OR 'bile acid sequestrant'/exp OR 'ezetimibe'/exp OR 'omega 3 fatty acid'/exp OR (fibrate* OR gemfibrozil OR fenofibrate OR bezafibrate OR (nicotinic NEXT/1 acid*) OR niacin OR ( bile acid NEXT/1 (sequestrant* OR resin*)) OR ezetimibe OR ((omega* OR marine) NEXT/3 fatty) OR pcsk9 OR pcsk-9 OR pcsk 9 OR ((eicosapentaenoic OR docosahexaenoic) NEXT/1 acid*) OR icosapent ethyl OR fish oil ):ti,ab #6 Outcomes of interest 'secondary prevention'/exp OR 'primary prevention'/exp OR 'prevention and control'/exp OR 'treatment outcome'/exp OR 'morbidity'/exp OR 'mortality'/exp OR 'all cause mortality'/exp OR 'cerebrovascular accident'/exp OR 'heart infarction'/exp OR 'unstable angina pectoris'/exp OR (stroke* OR (cerebrovascular NEXT/1 accident*) OR morbidity OR mortality OR death OR (heart NEXT/1 attack*) OR (myocardial NEXT/1 infarct*) OR ((vascular OR cardiac OR coronary OR cerebrovascular) NEXT/2 event*) OR (heart NEXT/1 infarct*)):ti,ab OR (morbidity OR mortality OR prevent* OR outcome*):ti,ab OR (secondary NEXT/1 prevention):ti,ab OR (primary NEXT/1 prevention):ti,ab OR angina:ti,ab OR ('adverse event'/exp OR 'side effect'/exp OR 'safety'/de OR ((side NEXT/1 effect*) OR (adverse NEXT/1 event*) OR safe OR safety)):ti,ab Question Set # Concept Strategy Question Pharmacologic treatment to reach specific LDL-C or non-HDL-C goals (cont.) 