Plasma brain natriuretic peptide- guided therapy to improve outcome in heart failure: the STARS-BNP Mul- ticenter Study. J Am Coll Cardiol. 2007;49:1733 9. 54. Karlstrom P, Alehagen U, Boman K, et al. Brain natriuretic peptide-guided treatment does not improve morbidity and mortality in extensively treated patients with chronic heart failure: responders to treatment have a signifi- cantly better outcome. Eur J Heart Fail. 2011;13:1096 103. 55. Lainchbury JG, Troughton RW, Strangman KM, et al. N-terminal pro-B- type natriuretic peptide-guided treatment for chronic heart failure: results from the BATTLESCARRED (NT-proBNP-Assisted Treatment To Lessen Serial Cardiac Readmissions and Death) trial. J Am Coll Cardiol. 2009;55:53 60. 56. Persson H, Erntell H, Eriksson B, et al. Improved pharmacological therapy of chronic heart failure in primary care: a randomized Study of NT-proBNP Guided Management of Heart Failure SIGNAL-HF (Swedish Intervention study Guidelines and NT-proBNP AnaLysis in Heart Failure). Eur J Heart Fail. 2010;12:1300 8. 57. Pfisterer M, Buser P, Rickli H, et al. BNP-guided vs symptom-guided heart failure therapy: the Trial of Intensified vs Standard Medical Therapy in El- derly Patients With Congestive Heart Failure (TIME-CHF) randomized trial. JAMA. 2009;301:383 92. 58. Shah MR, Califf RM, Nohria A, et al. The STARBRITE trial: a randomized, pilot study of B-type natriuretic peptide-guided therapy in patients with advanced heart failure. J Card Fail. 2011;17:613 21. 59. Troughton RW, Frampton CM, Yandle TG, et al. Treatment of heart failure guided by plasma aminoterminal brain natriuretic peptide (N-BNP) con- centrations. Lancet. 2000;355:1126 30. 60. Singer AJ, Birkhahn RH, Guss D, et al. Rapid Emergency Department Heart Failure Outpatients Trial (REDHOT II): a randomized controlled trial of the effect of serial B-type natriuretic peptide testing on patient management. Circ Heart Fail. 2009;2:287 93. 61. Stienen S, Salah K, Moons AH, et al. 