Conducting the Systematic Review Based on the decisions made by the Champions and Work Group members regarding the scope, the KQs, and the PICOTS statements, the Lewin Team produced an SR protocol prior to conducting the review. The protocol was reviewed and approved by the Champions and Work Group members. It described in detail the final set of KQs, the methodology to be used during the SR process, and the inclusion/exclusion criteria to be applied to each potential study, including, but not limited to, study type, sample size, and PICOTS criteria. Extensive literature searches identified 16,492 citations potentially addressing the KQs of interest to this evidence review. Of those, 11,050 were excluded upon title review for clearly not meeting inclusion criteria (e.g., not pertinent to the topic, not published in English, published prior to study inclusion publication date). Overall, 5,442 abstracts were reviewed with 4,723 of those being excluded for the following reasons: not an SR or an accepted study design (see the General Criteria for Inclusion in Systematic Review and Key Question Specific Criteria), did not address a KQ of interest to this review, did not report on an outcome of interest, or published outside cut-off publication dates. A total of 719 full- length articles were reviewed. Of those, 405 were excluded at a first pass review for the following: not addressing a KQ of interest, not enrolling the population of interest, not meeting inclusion criteria for clinical study or SR, not meeting inclusion criteria for any KQ, or being a duplicate publication. A total of 314 full-length articles were thought to address one or more KQs and were further reviewed. Of these, 217 were ultimately excluded and reasons for their exclusion are presented in Figure A-1. 