Low risk, Mid-length No studies were identified in these categories. Low risk, Long Home-based MDT No studies were identified in this category. MDT clinic One study (n=920) offering an extended follow-up in an MDT clinic for low risk stable HFREF patients was included in this category. High quality evidence showed a clinically important reduction in admissions. Low quality evidence for mortality did not demonstrate a clear effect with the confidence interval ranging from a decrease and increase in all-cause mortality. The evidence for the remaining outcomes quality of life, prescribed ACE-inhibitors, prescribed beta-blockers, and three adverse events (serum creatinine increase, hyperkalaemia and hypotension) all showed no clinical difference and were of moderate to very low quality. Nurse-led clinic This category included one study (n=160) with a long nurse-led clinic for low risk HFREF patients. Low to very low quality evidence showed a clinically important reduction in the number of admissions. Mortality did not demonstrate a clear effect with the confidence interval ranging from a decrease and increase in all-cause mortality .Low quality evidence also showed a clinically important increase in prescribed ACE-inhibitors or ARB. No difference was found for the outcomes of prescribed beta- blockers and renal function serum creatinine, which were of moderate to low quality. Quality of life was not reported. Pharmacist-led clinic Chronic Heart Failure Referral and approach to care NICE 2018. All rights reserved. Subject to Notice of rights. ISBN: 978-1-4731-3093-7 One study (n=83) with a long, pharmacist-led clinic for a low risk HF population was included in this category. The evidence for admissions was of very low quality and showed a clinical reduction for both. 