For KQ 2, SRs of clinical or lab-based observational repeated measures studies, or individual studies of these designs not included in SRs were required. For KQ 3, SRs of RCTs and/or prognostic cohort studies and individual RCTs and prognostic cohort studies not included in SRs were required. For KQs 4 and 6, SRs of RCTs (for efficacy or long-term safety) and/or observational cohort/case- control studies (for long-term safety) and individual RCTs (for efficacy or long-term safety) and observational cohort/case-control studies (for long-term safety) not included in SRs were required. For KQs 5, 7, 8, 10, and 11, SRs of RCTs and individual RCTs not included in SRs were required. For KQ 9, SRs of cost-effectiveness studies and individual cost-effectiveness studies not included in SRs were required. For KQ 12, SRs of RCTs and comparative prospective cohort studies and individual RCTs and comparative prospective cohort studies not included in SRs were required. Information regarding the bibliographic databases, date limits, and platform/provider can be found in Table A-3, below. Additional information on the search strategies, including topic-specific search terms and search strategies, can be found in Appendix J. Table A-3. 