Fihn et al 2014 Stable Ischemic Heart Disease Focused Update 1757 published. The SYNTAX (Synergy Between Percutaneous Coronary Intervention With TAXUS and Cardiac Surgery) trial randomly assigned 1800 patients (of a total of 4337 who were screened) to receive DES or CABG.66,81,82 Major adverse cardiac and cerebrovascular events (MACCE) a composite of death, stroke, MI, or repeat revascularization during the 3 years after randomization occurred in 20.2% of patients who had received CABG and 28.0% of those who had under- gone DES implantation (P<0.001). The rates of death and stroke were not significantly different; however, MI (3.6% for CABG, 7.1% for DES) and repeat revascularization (10.7% for CABG, 19.7% for DES) were more likely to occur with DES At 5 years of follow-up,83 MACCE occurred in 26.9% of patients who had received CABG and 37.3% of those who had undergone DES implantation (P<0.0001). The combined endpoint of death, stroke, or MI was also lower in CABG-treated patients than in DES-treated patients (16.7% In SYNTAX, the extent of CAD was assessed using the SYNTAX score, which is based on the location, severity, and extent of coronary stenoses, with a low score indicating less complicated anatomic CAD. In post hoc analyses, a low score was defined as 22; intermediate, 23 to 32; and high, 33. The occurrence of MACCE correlated with the SYNTAX score for DES patients but not for those who had undergone CABG. At 12-month follow-up, the primary endpoint was similar for CABG and DES in those with a low SYNTAX score. 