ISBN: Risk tool No of studie s n Strata Risk of bias a Inconsistency b Indirectne ssc Imprecisi ond Sensitivi ty (%) Specifici ty (%) AUC(or C- statistic)/NPV/ PPV Calibration Quality te cohort s) Outpatien t mixed LO W No inconsistency No indirectne ss Not estimable HIGH At any threshold Outpatien t mixed LO W Serious No indirectne ss Not estimable AUC: 0.66 Hosmer-Lemeshow: MODERA TE t mixed LO W Serious Unclear No imprecisio n : 0.99 LOW t mixed LO W Serious Unclear No imprecisio n t HFREF LO W Serious Serious Not estimable t HFREF LO W Serious No indirectne ss Not estimable MODERA TE t HFREF LO W Serious Serious No imprecisio n : 0.97 LOW t HFREF LO W Serious Serious No imprecisio n : 0.97 LOW t HFREF LO W Serious Serious No imprecisio n : 0.98 LOW Advanced heart failure and palliative care Chronic Heart Failure NICE 2018. All rights reserved. Subject to Notice of rights. ISBN: Risk tool No of studie s n Strata Risk of bias a Inconsistency b Indirectne ssc Imprecisi ond Sensitivi ty (%) Specifici ty (%) AUC(or C- statistic)/NPV/ PPV Calibration Quality hy LO W Serious Serious No imprecisio n : 0.99 LOW 1139 CRT LO W Serious No indirectne ss Not estimable AUC: 0.66 MODERA TE MAGGIC project heart failure risk score 2 At threshold 50% predicted mortality Outpatien t mixed HIG H No inconsistency No indirectne ss Not estimable MODERA TE At threshold 20% predicted mortality Outpatien t mixed HIG H No inconsistency No indirectne ss Not estimable MODERA TE At any threshold Outpatien t mixed HIG H Serious No indirectne ss Not estimable AUC: 0.69 Hosmer-Lemeshow: LOW Outpatien t mixed HIG H Serious Unclear Not estimable LOW Untitled risk tool + NT- proBNP) t HFREF HIG H No inconsistency No indirectne ss Not estimable AUC: 0.68 MODERA TE Advanced heart failure and palliative care Chronic Heart Failure NICE 2018. 