Class III Conditions for which there is evidence and/or general agreement that the procedure or treatment is not useful/ effective and in some cases may be harmful. Therapeutic recommendations Level of Evidence A Data derived from multiple randomized clinical trials or meta-analyses Level of Evidence B Data derived from a single randomized trial or nonrandomized studies Level of Evidence C Consensus opinion of experts, case studies, or standard of care Diagnostic recommendations Level of Evidence A Data derived from multiple prospective cohort studies using a reference standard applied by a masked evaluator Level of Evidence B Data derived from a single grade A study or one or more case-control studies, or studies using a reference standard applied by an unmasked evaluator Level of Evidence C Consensus opinion of experts AHA/ASA indicates American Heart Association/American Stroke Association individuals between 20 to 54 years of age.28 The Nationwide Inpatient Sample showed that the rates of stroke hospitaliza- tion increased for individuals between 25 and 34 years of age and between 35 and 44 years of age from 1998 to 2007.29 Stroke occurring at younger ages has the potential to cause greater lifetime impairment and disability. The Framingham Heart Study estimated the lifetime risk of stroke to be 1 in 6 or more for middle-aged adults.30 Low Birth Weight Low birth weight has been associated in several populations with risk of stroke in later life. 