Bushnell et al Guidelines for Prevention of Stroke in Women 1573 risk of IS (RR, 0.70; 95% CI, 0.49 1.00; P=0.05); how- ever, the benefit was reduced when the combination of IS and hemorrhagic stroke was considered (RR, 0.78; 95% CI, 0.57 1.08; P=0.13). On the basis of the WHS results, aspirin is recommended for primary prevention for women after con- sideration of the 10-year risk of CVD and whether this and age outweigh the risk of hemorrhage.21 A large, sex-specific meta-analysis of aspirin for primary prevention of IS (separate from other cardiovascular events) showed that women appeared to benefit from aspirin (OR, 0.76; 95% CI, 0.63 0.93), whereas men showed no benefit For heart disease, however, men benefited from aspirin for prevention against coronary heart disease, whereas women did not. As in men, aspirin allocation in primary prevention trials increased the risk of hemorrhagic stroke and major gastrointestinal and extracra- nial bleeds among women and resulted in uncertain net value. 