Both hyperglyce- mia and hypoglycemia should be avoided (Class I; Level of Evidence C). (Revised from the previous guideline) Temperature Management Fever worsens outcome in experimental models of brain Fever is common after ICH, especially in patients with intraventricular hemorrhage. In patients surviving the first 72 hours after hospital admission, the duration of fever is related to outcome and appears to be an independent prog- nostic factor in these patients.152 Fever may also be associated with hematoma growth, although a cause-effect relation- ship is unclear.153 Although these data provide a rationale for treatment of fever in ICH patients, maintenance of nor- mothermia has not been clearly demonstrated as beneficial Preliminary animal and human studies have suggested that therapeutic cooling may reduce perihemato- However, treatment with mild hypothermia should be considered investigational in ICH at this time.157 Temperature Management: Recommendation IIb; Level of Evidence C). (New recommendation) Seizures and Antiseizure Drugs The frequency of clinical seizures early (within 1 week) after ICH is as high as 16%, with the majority occurring at or near Cortical involvement of ICH is the most impor- tant risk factor for early seizures.158 160 In a large single-center study, prophylactic antiseizure drugs significantly reduced the number of clinical seizures after lobar ICH.161 Prospective and population-based studies, however, have shown no asso- ciation between clinical seizures and neurological outcome or Studies of continuous electroencephalography (EEG) report electrographic seizures in 28% to 31% of select cohorts of ICH patients, despite most having received prophylactic The clinical impact of subclini- cal seizures detected on EEG is unclear. 