Metabolic Syndrome Metabolic syndrome is a state of metabolic dysregulation characterized by visceral fat accumulation, insulin resis- tance, hyperinsulinemia, and hyperlipidemia, as well as pre- disposition to type 2 DM, hypertension, and atherosclerotic According to data from the NHANES III and the prevalence of metabolic syndrome in the United States was 34.2% in 2006 and has likely increased substantially since that time. The metabolic syndrome is linked to several other disorders, including non- alcoholic steatohepatitis, polycystic ovary syndrome, certain cancers, CKD, Alzheimer s disease, Cushing s syndrome, lipodystrophy, and hyperalimentation.S9.7-5,S9.7-6 Lifestyle modification, with an emphasis on improv- ing insulin sensitivity by means of dietary modification, weight reduction, and exercise, is the foundation of treat- ment of the metabolic syndrome. 