K Physicians should be alert to the possibility of toxicity resulting from substances that increase blood levels of statins (e.g., grapefruit juice, certain medications). RESEARCH RECOMMENDATIONS K An extended observational study should be undertaken of the SHARP study cohort to determine whether the reduction in major atherosclerotic events resulting from 5 years of LDL-C lowering persists in the long-term, and whether LDL-C lowering significantly delays renal disease progression in people with non-dialysis-dependent CKD . K Given that the majority of early CKD is managed in primary care, audits of pharmacological cholesterol- lowering treatment should be undertaken in this setting. K Data from the AURORA, 4D and SHARP studies (dialysis cohort) should be pooled to undertake individual patient data meta-analysis to more comprehensively assess the benefits and risks of cholesterol-lowering treatment in people with dialysis-dependent CKD. DISCLAIMER While every effort is made by the publishers, editorial board, and ISN to see that no inaccurate or misleading data, opinion or statement appears in this Journal, they wish to make it clear that the data and opinions appearing in the articles and advertisements herein are the responsibility of the contributor, copyright holder, or advertiser concerned. Accordingly, the publishers and the ISN, the editorial board and their respective employers, office and agents accept no liability whatsoever for the consequences of any such inaccurate or misleading data, opinion or statement. While every effort is made to ensure that drug doses and other quantities are presented accurately, readers are advised that new methods and techniques involving drug usage, and described within this Journal, should only be followed in conjunction with the drug manufacturer s own published literature. 