Comparative performance of the CKD Epidemiology Collaboration (CKD-EPI) and the Modification of Diet in Renal Disease (MDRD) Study equations for estimating GFR levels . Am J Kidney Dis 2010; 56: 486 495. 382. Nakamura T, Kanno Y, Takenaka T et al. An angiotensin receptor blocker reduces the risk of congestive heart failure in elderly hypertensive patients with renal insufficiency. Hypertens Res 2005; 28: 415 423. 383. Dulin BR, Haas SJ, Abraham WT et al. Do elderly systolic heart failure patients benefit from beta blockers to the same extent as the non- elderly? Meta-analysis of 412,000 patients in large-scale clinical trials. Am J Cardiol 2005; 95: 896 898. 384. Aymanns C, Keller F, Maus S et al. Review on pharmacokinetics and pharmacodynamics and the aging kidney. Clin J Am Soc Nephrol 2010; 5: 314 327. 385. O Hare AM. The management of older adults with a low eGFR: moving toward an individualized approach. Am J Kidney Dis 2009; 53: 925 927. 386. Eriksen BO, Ingebretsen OC. The progression of chronic kidney disease: a 10-year population-based study of the effects of gender and age. Kidney Int 2006; 69: 375 382. 387. Roderick PJ, Atkins RJ, Smeeth L et al. CKD and mortality risk in older people: a community-based population study in the United Kingdom. Am J Kidney Dis 2009; 53: 950 960. 388. Fogari R, Zoppi A. Effect of antihypertensive agents on quality of life in the elderly. Drugs Aging 2004; 21: 377 393. 389. Musini VM, Tejani AM, Bassett K et al. Pharmacotherapy for hypertension in the elderly. Cochrane Database Syst Rev 2009: CD000028. 390. Bejan-Angoulvant T, Saadatian-Elahi M, Wright JM et al. Treatment of hypertension in patients 80 years and older: the lower the better? A meta-analysis of randomized controlled trials. J Hypertens 2010; 28: 1366 1372. references 391. 