[57] The largest individual study to date examining SBP targets, the Systolic Blood Pressure Intervention Trial (SPRINT), included HTN patients age 50 and over and demonstrated a 25% reduction in cardiovascular events in the intensive treatment group targeting an SBP of 120 mm Hg.[58] Only a small proportion of SPRINT participants (those with known CVD) would have been included in the SR by Saiz et al. (2018),[55] which could perhaps explain why Saiz et al. (2018) did not find benefits for reducing SBP below 150 mm Hg. Treating to a lower SBP goal of <130 mm Hg for older adults is also supported by evidence, but the research support this lower goal is weaker than the evidence for treating to a SBP goal of <150 mm Hg in patients 60 years and older. Thus, the current recommendation is specific to HTN in patients age 60 and over, which is supported by the large number of clinical trials that mostly included older people. Based on the SR by Weiss et al. (2017), there is strong and consistent evidence supporting lowering SBP to a target of 150 mm Hg.[56] Benefits clearly outweigh harms and burdens associated with this therapy. There is less consistency in the evidence supporting additional blood pressure reductions for patients with an SBP between 130 and 150 mm Hg. This more intensive or aggressive approach often requires additional medications which, in turn, require further resources and which some people might not prefer. Benefits of intensive therapy seem to outweigh harms.