All patients who are post NSTE-ACS should be giv- en sublingual or spray nitroglycerin with verbal and written instructions for its use.429 (Level of Evidence: C) 3. Before hospital discharge, patients with NSTE-ACS should be informed about symptoms of worsening myocardial ischemia and MI and should be given verbal and written instructions about how and when to seek emergency care for such symptoms.429 (Level of Evidence: C) 4. Before hospital discharge, patients who are post NSTE-ACS and/or designated responsible caregiv- ers should be provided with easily understood and culturally sensitive verbal and written instructions about medication type, purpose, dose, frequency, side effects, and duration of use.429 (Level of Evidence: C) 5. For patients who are post NSTE-ACS and have ini- tial angina lasting more than 1 minute, nitroglycerin (1 dose sublingual or spray) is recommended if an- gina does not subside within 3 to 5 minutes; call 9-1-1 immediately to access emergency medical services.429 (Level of Evidence: C) 6. If the pattern or severity of angina changes, suggest- ing worsening myocardial ischemia (eg, pain is more frequent or severe or is precipitated by less effort or occurs at rest), patients should contact their clinician without delay to assess the need for additional treat- ment or testing.429 (Level of Evidence: C) 7. Before discharge, patients should be educated about modification of cardiovascular risk factors.428 (Level of Evidence: C) 6.2.1. Late Hospital and Posthospital Oral Antiplatelet Therapy: Recommendations Class I 1. Aspirin should be continued indefinitely. The mainte- nance dose should be 81 mg daily in patients treated with ticagrelor and 81 mg to 325 mg daily in all other (Level of Evidence: A) 2. 