Improved prediction rules and validated treatment rec- ommendations are urgently needed.646 12.8. Prevention of HF Much progress has been made to limit LV remodeling, though there remains substantial room for improvement, beginning with the timeliness of reperfusion and initiation of ACE inhib- The superimposition of ischemic mitral regurgitation adds further to the risks of HF and death. Contin- ued exploration of the roles of cell- and gene-based therapies after STEMI is encouraged.647 656 Presidents and Staff American College of Cardiology Foundation William A. Zoghbi, MD, FACC, President Thomas E. Arend, Jr, Esq, CAE, Interim Chief Staff Officer William J. Oetgen, MD, MBA, FACC, Senior Vice President, Science and Quality Charlene L. May, Senior Director, Science and Clinical Policy American College of Cardiology Foundation/ American Heart Association Lisa Bradfield, CAE, Director, Science and Clinical Policy Debjani Mukherjee, MPH, Associate Director, Evidence- Based Medicine Sarah Jackson, MPH, Specialist, Science and Clinical Policy American Heart Association Donna K. Arnett, PhD, MSPH, BSN, FAHA, President Nancy Brown, Chief Executive Officer Rose Marie Robertson, MD, FAHA, Chief Science Officer Gayle R. Whitman, PhD, RN, FAHA, FAAN, Senior Vice President, Office of Science Operations Judy Bezanson, DSN, RN, CNSMS, FAHA, Science and Medicine Advisor, Office of Science Operations Jody Hundley, Production Manager, Scientific Publications, Office of Science Operations References 1. ACCF/AHA Task Force on Practice Guidelines. Manual for ACCF/AHA Guideline Writing Committees: Methodologies and Policies from theACCF/ AHA Task Force on Practice Guidelines. American College of Cardiology and American Heart Association. 2006. Available at: http://assets.cardio- source.com/Methodology_Manual_for_ACC_AHA_Writing_Committees. pdf and http://my.americanheart.org/professional/StatementsGuidelines/ PoliciesDevelopment/Development/Methodologies-and-Policies-from-the- ACCAHA-Task-Force-on-Practice-Guidelines_UCM_320470_Article.jsp. Accessed July 26, 2012. 2. Eden J, Levit L, Berg A, et al, eds; Committee on Standards for Systematic Reviews of Comparative Effectiveness Research; Institute of Medicine. Finding What Works in Health Care: Standards for Systematic Reviews. Washington, DC: The National Academies Press; 2011. 3. 