Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers for adults with early (stage 1 to 3) non-diabetic chronic kidney disease. Cochrane Database of Systematic Reviews. 2011:10;CD007751.281 (Continued on following page) Table 2| (Continued) Clinical questions and systematic review topics in the PICOM format www.kidney-international.org methods for guideline development Guideline Chapter 3 Blood pressure management in patients with CKD, with or without diabetes, not receiving dialysis SoF table Supplementary Tables S31, S32, and S80 Clinical question In patients with CKD and chronic hyperkalemia, do potassium binders compared to placebo or standard of care improve clinically relevant outcomes, and decrease adverse effects? Population Adults with CKD (CKD G1 G5 without kidney transplant) with chronic hyperkalemia Intervention Potassium binders Comparator Placebo/standard of care Outcomes Critical and important harms listed in Table 1 Additional outcomes reported hospitalization, hypokalemia, SBP, and DBP Study design RCTs Cochrane review Natale P, et al. 2020. Potassium binders for chronic hyperkalaemia in people with chronic kidney disease. Cochrane Database of Systematic Reviews. 2020:6:CD013165.381 SoF table Supplementary Tables S73, S74, and S88 Guideline Chapter 4 Blood pressure management in kidney transplant recipients Clinical question In kidney transplant recipients, does reducing protein intake compared to usual protein intake improve clinically relevant outcomes and decrease adverse effects? Population Kidney transplant recipients Intervention Low-protein diet Comparator Usual protein diet Outcomes Outcomes listed in Table 1 Study design RCTs Cochrane review None relevant SoF table None Clinical question In kidney transplant recipients, does reducing dietary salt intake compared to usual salt intake improve clinically relevant outcomes and decrease adverse effect? 