A link to the Copyright Permissions Request Form appears on the right side of the page. 2011 by the American College of Cardiology Foundation and the American Heart Association, Inc. Circulation is available at http://circ.ahajournals.org DOI: 10.1161/CIR.0b013e31823ba622 Table of Contents Preamble e576 1. Introduction e578 1.1. Methodology and Evidence Review e578 1.2. Organization of the Writing Committee e579 1.3. Document Review and Approval e579 1.4. PCI Guidelines: History and Evolution e579 2. CAD Revascularization e580 2.1. Heart Team Approach to Revascularization Decisions: Recommendations e580 2.2. Revascularization to Improve Survival: Recommendations e582 2.3. Revascularization to Improve Symptoms: Recommendations e583 2.4. CABG Versus Contemporaneous Medical Therapy e583 2.5. PCI Versus Medical Therapy e584 2.6. CABG Versus PCI e584 2.6.1. CABG Versus Balloon Angioplasty or BMS e584 2.6.2. CABG Versus DES e585 2.7. Left Main CAD e585 2.7.1. CABG or PCI Versus Medical Therapy for Left Main CAD e585 2.7.2. Studies Comparing PCI Versus CABG for Left Main CAD e586 2.7.3. Revascularization Considerations for Left Main CAD e586 2.8. Proximal LAD Artery Disease e587 2.9. Clinical Factors That May Influence the Choice of Revascularization e587 2.9.1. Diabetes Mellitus e587 2.9.2. Chronic Kidney Disease e587 2.9.3. Completeness of Revascularization e587 2.9.4. LV Systolic Dysfunction e588 2.9.5. Previous CABG e588 2.9.6. Unstable Angina/Non ST-Elevation Myocardial Infarction e588 2.9.7. DAPT Compliance and Stent Thrombosis: Recommendation e588 2.10. TMR as an Adjunct to CABG e588 2.11. Hybrid Coronary Revascularization: Recommendations e589 3. PCI Outcomes e589 3.1. Definitions of PCI Success e589 3.1.1. Angiographic Success e589 3.1.2. Procedural Success e589 3.1.3. Clinical Success e589 3.2. Predictors of Clinical Outcome After PCI e590 3.3. PCI Complications e590 4. Preprocedural Considerations e591 4.1. Cardiac Catheterization Laboratory Requirements e591 4.1.1. Equipment e591 4.1.2. Staffing e591 4.1.3. Time-Out Procedures e592 4.2. Ethical Aspects e592 4.2.1. Informed Consent e592 4.2.2. 