The TIMI risk index is useful in predicting 30-day and 1-year mortality in patients with NSTE-ACS.134 For patients with a TIMI risk score of 0 and normal high-sen- sitivity cardiac troponin 2 hours after presentation, accelerated diagnostic protocols have been developed that predict a very low rate of 30-day MACE (Section 3.4.3).65 The GRACE risk model predicts in-hospital and post- discharge mortality or MI.44,78,79,81 The GRACE tool was developed from 11389 patients in GRACE and validated in subsequent GRACE and GUSTO (Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries) IIb cohorts. The sum of scores is applied to a reference nomogram to determine all-cause mortality from hospital discharge to 6 months. 