The committee acknowledged the BHF funded pilot study Report-IV-Diuretics-August-2014.pdf) which consisted of a 2 year project in 10 NHS organisations across the UK in both urban and rural areas to assess Chronic Heart Failure Domiciliary oxygen therapy in people with advanced heart failure NICE 2018. All rights reserved. Subject to Notice of rights. ISBN: 978-1-4731-3093-7 Recommendations No recommendation Research recommendation In people with advanced heart failure and significant peripheral fluid overload, what is the clinical and cost effectiveness of oral, subcutaneous and intravenous diuretic therapy in the community? whether funding a home or community based IV diuretics service was safe, clinically effective, cost effective and well received by patients and carers. The committee noted that this study was not randomised and therefore did not meet the methodological threshold for inclusion within this review. 10.2 Domiciliary oxygen therapy in people with advanced heart failure Breathlessness is a common symptom in advanced heart failure even with optimal pharmacological and non pharmacological treatments and the absence of clinical pulmonary oedema. Current British Thoracic Society guidelines (2015)142 .for home oxygen state that only hypoxaemic patients with PO2 below 7.3kpa or 8 (with peripheral oedema, polycythaemia or pulmonary hypertension) should receive any form of home oxygen therapy except for a specific group with sleep disordered breathing. They specifically state that palliative oxygen therapy should not be provided to non hypoxaemic or mildly hypoxaemic patients. However, the evidence base for these recommendations was limited Therefore an up-to date review of the literature in this area is warranted. 10.2.2 Review question: What is the effectiveness of domiciliary oxygen therapy in people with advanced heart failure For full details see review protocol in appendix A. 