An additional dose of 0.3 mg/kg IV enoxaparin should be administered at the time of PCI to patients who have received fewer than 2 therapeutic subcu- taneous doses (eg, 1 mg/kg) or received the last subcutaneous enoxaparin dose 8 to 12 hours before PCI.649,661 664 (Level of Evidence: B) Class IIb 1. Performance of PCI with enoxaparin may be rea- sonable in patients either treated with upstream subcutaneous enoxaparin for UA/NSTEMI or who have not received prior antithrombin therapy and are administered IV enoxaparin at the time of PCI.646 650 (Level of Evidence: B) Class III: HARM 1. 