The overall assessment of confidence was low, having been downgraded by two increments due to concerns over methodology and coherence. Review subfinding 2b: Knowledge and management Some patients did not want to know more about their diagnosis as it would cause them to worry, and they chose to put all their trust into healthcare professionals to make decisions for them. Yet, others described having received too little information about their diagnosis and some received contradicting information that caused them confusion. These patients felt that the lack of knowledge caused them panic attacks and anxiety about the practicalities of what to do in a crisis, for example. Methodological limitations were rated serious overall. Two studies were rated moderate limitations: one due to limitations in context, the role of researcher and data analysis, and another study due to missing information on the topic guide and the lack of data richness in sections relevant to this review. Three studies were rated serious limitations due to a lack of information on the role of the researcher, data richness as well as lack of rigour in research methods. Coherence was rated minor concerns overall. Agreement between papers was good in that they all reported a range of people s attitudes. Variability in people s attitudes is expected, hence the concerns were rated as minor overall. Relevance was rated no or very minor concerns. The relevance of the subfinding to the focus of the review was very high. The data stemmed from five studies from the UK in a relevant population. Adequacy was rated as no or very minor concerns. The subfinding was general and supported by numbers of studies; it was descriptive and supported by the richness of data. 