Heerspink HL, de Zeeuw D. Composite renal endpoints: was ACCOM- PLISH accomplished? Lancet 2010; 375: 1140 1142. 194. Caramori ML, Fioretto P, Mauer M. Low glomerular filtration rate in normoalbuminuric type 1 diabetic patients: an indicator of more advanced glomerular lesions. Diabetes 2003; 52: 1036 1040. 195. Kramer HJ, Nguyen QD, Curhan G et al. Renal insufficiency in the absence of albuminuria and retinopathy among adults with type 2 diabetes mellitus. JAMA 2003; 289: 3273 3277. 196. MacIsaac RJ, Panagiotopoulos S, McNeil KJ et al. Is nonalbuminuric renal insufficiency in type 2 diabetes related to an increase in intrarenal vascular disease? Diabetes Care 2006; 29: 1560 1566. 197. Perkins BA, Ficociello LH, Roshan B et al. In patients with type 1 diabetes and new-onset microalbuminuria the development of advanced chronic kidney disease may not require progression to proteinuria. Kidney Int 2010; 77: 57 64. 198. Law MR, Morris JK, Wald NJ. Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies. BMJ 2009; 338: b1665. 199. Czernichow S, Zanchetti A, Turnbull F et al. The effects of blood pressure reduction and of different blood pressure-lowering regimens on major cardiovascular events according to baseline blood pressure: meta- analysis of randomized trials. J Hypertens 2011; 29: 4 16. 200. O Seaghdha CM, Perkovic V, Lam TH et al. Blood pressure is a major risk factor for renal death: an analysis of 560 352 participants from the Asia-Pacific region. Hypertension 2009; 54: 509 515. references 201. Stamler J, Vaccaro O, Neaton JD et al. Diabetes, other risk factors, and 12- yr cardiovascular mortality for men screened in the Multiple Risk Factor Intervention Trial. Diabetes Care 1993; 16: 434 444. 202. 