See Table XCV in online Data Supplement 1 for original wording. Mechanical thrombectomy aims to achieve reperfusion, not simply recanalization. A variety of reperfusion scores exist, but the mTICI score is the current assessment tool of choice, with proven value in predicting clinical outcomes.196,197 All recent endovascular trials used the mTICI grade 2b/3 threshold for adequate reperfusion, with high rates achieved. In HERMES, 402 of 570 patients (71%) were successfully reperfused to mTICI grade 2b/3.189 Earlier trials with less efficient devices showed lower recanalization rates, a factor in their inability to demonstrate benefit from the procedure (IMS III, 41%; MR RESCUE, 25%). The additional benefit of pursuing mTICI of grade 3 rather than grade 2b deserves further investigation. To ensure benefit, reperfusion to mTICI grade 2b/3 should be achieved as early as possible within the therapeutic window. I A Recommendation revised from 2015 Endovascular. In the 6- to 24-hour thombectomy window evaluation and treatment should proceed as rapidly as possible to ensure access to treatment for the greatest proportion of patients. I B-R New recommendation. 