Other considerations regarding this recommendation included the benefits (e.g., improved CV mortality, all-cause mortality, and non-fatal MI). Although data on safety endpoints were not reported, the Work Group determined these benefits outweighed the risk of harm anticipated with exercise interventions, most of which would be minor musculoskeletal injuries. Although variation in patient preference and feasibility is a concern in some settings, the Work Group determined that given the highly favorable risk-benefit ratio for CV mortality, providers and healthcare systems should make strong efforts to motivate their patients and invest in the resources required to provide a cardiac rehabilitation program for their patients. Thus, the Work Group decided upon a Strong for recommendation. More research involving head-to-head comparisons between different exercise components is needed to better ascertain the optimal form of cardiac rehabilitation to improve CV outcomes in patients with CHD and other forms of CVD. VII. Knowledge Gaps and Recommended Research Despite the breadth of research on dyslipidemia and the prevention of CVD, the Work Group noted that many patient-oriented questions have not been specifically addressed. In looking towards the next iteration of these guidelines, the Work Group created a ranked list of research priorities. A. Comparison of Medical Therapies in Primary and Secondary Prevention a. Primary Prevention The pool of primary prevention studies using statins almost exclusively employed moderate-dose statins. The JUPITER trial was the only study that employed a high-dose statin.[47] The CV benefit of higher dose statins in JUPITER is consistent with benefits found in other primary prevention trials of moderate-dose statins. Prospective comparisons of different statin intensities might demonstrate an additional benefit of higher statin doses in patients treated for primary prevention. Similarly, studies of ezetimibe monotherapy and ezetimibe and statin combination therapy showing patient-oriented outcomes in primary prevention are lacking. 