SCD-HeFT included 792 NICM Total mortality at 5 years was 27% in the placebo group and 21% in the ICD group (P=0.06). A pooled analysis of these studies dem- onstrated a significant 31% reduction in all-cause mortality for ICD relative to medical therapy.S7.2.2-4 The DANISH (Danish Study to Assess the Efficacy of ICDs in Patients with Non-ischemic Systolic Heart Failure on Mortality) trialS7.2.2-11 raised ques- tions about the role of primary pevention ICDs in patients with NICM. This trial randomized 1116 patients with NICM LVEF <35% and class II, III, or IV (if CRT was planned) HF to an ICD or no ICD. CRT (either ICD or pacemaker) was pres- ent in 58% of patients in the ICD and medical CLINICAL STATEMENTS AND GUIDELINES therapy arms. Therefore, the results of DANISH should not be generalized to patients with NICM who are ineligible for CRT. During a median follow-up of 5.6 years, ICD reduced SCD from 8.4% to 4.3%, but there was no difference in Several meta-analyses have been published.S7.2.2-12,S7.2.2-13 One provided data on ICDs with and without CRT and showed survival benefit from the ICD.S7.2.2-13 The second used patient level data from 2 trials and adopted a more robust approach to reducing heterogene- ity by excluding patients with CRT and those ran- domized to antiarrhythmic medications; a 25% relative risk reduction in mortality with an ICD 2. Laminopathies are diseases caused by mutations mainly in the Lamin A/C gene that produce various inherited diseases including subtypes of muscular dystrophy and progeria. Isolated cardiac involve- ment is also observed and is an important cause of familial cardiomyopathy.S7.2.2-9 The disease is highly penetrant such that all affected individu- als have evidence of disease by 60 years of age. Cardiac manifestations may include atrial fibril- lation, conduction disturbances, VA, and NICM. 