A clear, detailed, and evidence-based plan of care that promotes medication adherence, timely follow- up with the healthcare team, appropriate dietary and physical activities, and compliance with interven- tions for secondary prevention should be provided to patients with STEMI. (Level of Evidence: C) 4. Encouragement and advice to stop smoking and to avoid secondhand smoke should be provided to pa- tients with STEMI.602 605 (Level of Evidence: A) 11.1.1. The Plan of Care for Patients With STEMI Education of patients with STEMI and their families is criti- cal and often challenging, especially when transitions of care occur. Failure to understand and comply with a plan of care may account for the high rate of STEMI rehospitalization rates seen in the United States.19,606 One key intervention to ensure effective coordination is to provide to patients and caregiv- ers, during the hospital stay, a comprehensive plan of care and educational materials that promote compliance with recom- mended evidence-based therapies.607 609 The posthospitaliza- tion plan of care for patients with STEMI should address in detail several complex issues, including medication adherence and titration, timely follow-up, dietary interventions, physical and sexual activities, cardiac rehabilitation, compliance with interventions for secondary prevention (Table 14), and reas- sessment of arrhythmic and HF risks. In addition, providers should pay close attention to psychosocial and socioeconomic issues, including access to care, risk of depression, social iso- lation, and healthcare disparities.610 612 11.1.2. Smoking Cessation The value of smoking cessation for the secondary prevention of cardiovascular disease has been demonstrated in several prospective observational studies. 