KEY WORDS: antithrombotic therapy; evidence-based medicine; GRADE approach; venous thromboembolism FOR EDITORIAL COMMENT SEE PAGE 293 ABBREVIATIONS: AT9 = 9th Edition of the Antithrombotic Guideline; AT10 = 10th Edition of the Antithrombotic Guideline; CHEST = American College of Chest Physicians; CDT = catheter-directed thrombolysis; COI = con ict of interest; CTEPH = chronic thrombo- embolic pulmonary hypertension; CTPA = CT pulmonary angiogram; GOC = Guidelines Oversight Committee; INR = International Normalized Ratio; IVC = inferior vena cava; LMWH = low-molecular- weight heparin; NOAC = non-vitamin K oral anticoagulant; PE = pulmonary embolism; PTS = postthrombotic syndrome; RCT = ran- domized controlled trial; UEDVT = upper extremity deep vein thrombosis; US = ultrasound; VKA = vitamin K antagonist AFFILIATIONS: From McMaster University (Drs Kearon and Akl), Hamilton, ON; American University of Beirut (Dr Akl), Beirut, Lebanon; CHEST (Dr Ornelas), Glenview, IL; VA New Jersey Health Care System (Dr Blaivas), Newark, NJ; Hospital Ram n y Cajal and Instituto Ram n y Cajal de Investigaci n Sanitaria, Universidad de Alcala (Dr Jimenez), Madrid, Spain; University of Geneva (Dr Bou- nameaux), Geneva, Switzerland; Leiden University Medical Center (Dr Huisman), Leiden, Netherlands; Virginia Commonwealth University (Dr King), Falls Church, VA; University of California (Dr Morris), San Diego, CA; The Ohio State University (D. Sood), Columbus, OH; Intermountain Medical Center and the University of Utah (Drs Stevens and Woller), Murray, UT; Harbor-UCLA Medical Center (Dr Vintch), Torrance, CA; The University of Ottawa and Ottawa Hospital Research Institute (Dr Wells), Ottawa, ON; Uniformed Services University of the Health Sciences (Dr Moores), Bethesda, MD. [ Evidence-Based Medicine ] Note on Shaded Text: In this guideline, shaded text with an asterisk (shading appears in PDF only) indicates recommendations that are newly added or have been changed since the publication of Antithrombotic Therapy for VTE Disease: Antithrombotic Therapy and Prevention of Thrombosis (9th edition): American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. 