The WHS, a primary prevention trial of women 45 years of age and free of CVD at enrollment, continues to inform the association between women with migraine and stroke. After a mean follow-up of 11.9 years, multivariable-adjusted analysis found that high migraine frequency (more than weekly) had an increased association with ischemic stroke (HR, 2.77; 95% CI, 1.03 7.46) but not in lower frequencies.596 When migraine aura status was taken into account, a significant association of migraine frequency was found only in the migraine with aura From this analysis, increased frequency of attacks in migraine with aura appears to increase the risk for ischemic stroke. However, caution in overly interpreting these results is needed because the incident numbers for these subgroup analyses were small. In a separate analysis of the WHS, the association of migraine with aura and ischemic stroke was found to be more pronounced in the absence (HR, 3.27; 95% CI, 1.93 5.51) than in the presence Overall, the WHS found that increased frequency in patients with migraine with aura increases ischemic stroke risk and that this increased risk is more pronounced in the absence of typical migraine features. The WHS also investigated the association between migraines and ICH. 