See Table XCV in online Data Supplement 1 for original wording. See also the text of these guidelines for additional information on these recommendations. LOE amended to conform with American College of Cardiology/AHA 2015 Recommendation Classification System. COR amended to conform with American College of Cardiology/AHA 2015 Recommendation Classification System. Table 8. Continued Table 9. Treatment of AIS: IV Administration of Alteplase Infuse 0.9 mg/kg (maximum dose 90 mg) over 60 min, with 10% of the dose given as a bolus over 1 min. Admit the patient to an intensive care or stroke unit for monitoring. If the patient develops severe headache, acute hypertension, nausea, or vomiting or has a worsening neurological examination, discontinue the infusion (if IV alteplase is being administered) and obtain emergency head CT scan. Measure BP and perform neurological assessments every 15 min during and after IV alteplase infusion for 2 h, then every 30 min for 6 h, then hourly until 24 h after IV alteplase treatment. Increase the frequency of BP measurements if SBP is >180 mmHg or if DBP is >105 mmHg; administer antihypertensive medications to maintain BP at or below these levels (Table 5). Delay placement of nasogastric tubes, indwelling bladder catheters, or intra- arterial pressure catheters if the patient can be safely managed without them. Obtain a follow-up CT or MRI scan at 24 h after IV alteplase before starting anticoagulants or antiplatelet agents. AIS indicates acute ischemic stroke; BP, blood pressure; CT, computed tomography; DBP, diastolic blood pressure; IV, intravenous; MRI, magnetic resonance imaging; and SBP, systolic blood pressure. Reprinted from Jauch et al.1 Copyright 2013, American Heart Association, Inc. Powers et al 2019 Guidelines for Management of AIS e371 3.6. Other IV Fibrinolytics and Sonothrombolysis 3.6. 