2.6.10 Describe and justify any planned analyses of differential treatment effects according to patient subgroups, how an intervention is delivered, or how an outcome is measured Yes 2.6.11 Describe the proposed timetable for conducting the review Yes 2.7 Submit the protocol for peer review No 2.7.1 Provide a public comment period for the protocol and publicly report on disposition of comments No 2.8 Make the final protocol publicly available, and add any amendments to the protocol in a timely fashion No 3.1 Conduct a comprehensive systematic search for evidence Yes 3.1.1 Work with a librarian or other information specialist trained in performing systematic reviews to plan the search strategy No 3.1.2 Design the search strategy to address each key research question Yes 3.1.3 Use an independent librarian or other information specialist to peer review the search strategy No 3.1.4 Search bibliographic databases Yes 3.1.5 Search citation indexes No 3.1.6 Search literature cited by eligible studies No 3.1.7 Update the search at intervals appropriate to the pace of generation of new information for the research question being addressed Yes 3.1.8 Search subject-specific databases if other databases are unlikely to provide all relevant evidence N/A 3.1.9 Search regional bibliographic databases if other databases are unlikely to provide all relevant evidence N/A 3.2 Take action to address potentially biased reporting of research results No 3.2.1 Search grey-literature databases, clinical trial registries, and other sources of unpublished information about studies No 3.2.2 Invite researchers to clarify information about study eligibility, study characteristics, and risk of bias No 3.2.3 Invite all study sponsors and researchers to submit unpublished data, including unreported outcomes, for possible inclusion in the systematic review No 3.2.4 Handsearch selected journals and conference abstracts No 3.2.5 Conduct a web search No 3.2.6 Search for studies reported in languages other than English if appropriate Yes 3.3 Screen and select studies Yes 3.3.1 Include or exclude studies based on the protocol s prespecified criteria Yes 3.3.2 Use observational studies in addition to randomized clinical trials to evaluate harms of interventions No 3.3.3 Use two or more members of the review team, working independently, to screen and select studies No 3.3.4 Train screeners using written documentation; test and retest screeners to improve accuracy and consistency Yes 3.3.5 Use one of two strategies to select studies: (1) read all fulltext articles identified in the search or (2) screen titles and abstracts of all articles and then read the full texts of articles identified in initial screening 3.3.6 Taking account of the risk of bias, consider using observational studies to address gaps in the evidence from randomized clinical trials on the benefits of interventions No 3.4 Document the search Yes 3.4.1 Provide a line-by-line description of the search strategy, including the date of every search for each database, web browser, etc. 