2019 ACC/AHA guideline on the primary prevention of cardiovascular disease: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 2019;140:e563 e595. DOI: 10.1161/CIR.0000000000000677. Key Words: AHA Scientific Statements guidelines antihypertensive agents aspirin atherosclerosis atherosclerotic cardiovascular disease atrial fibrillation behavior modification behavior therapy blood cholesterol blood pressure body mass index cardiovascular team-based care cardiovascular cardiovascular disease cholesterol chronic kidney disease coronary artery calcium score coronary disease coronary heart disease cost diet dietary patterns dietary fats dietary sodium dyslipidemia e-cigarettes exercise healthcare disparities health services accessibility heart failure hypertension LDL cholesterol diabetes mellitus lifestyle lipids measurement myocardial infarction nicotine nonpharmacological treatment nutrition physical activity prejudice primary prevention psychosocial deprivation public health quality indicators quality measurement risk assessment risk- enhancing factors risk factors risk reduction risk reduction discussion risk treatment discussion secondhand smoke sleep smoking smoking cessation social determinants of health socioeconomic factors statin therapy systems of care tobacco tobacco smoke pollution treatment adherence treatment outcomes type 2 diabetes mellitus waist circumference weight loss Endorsed by the American Associa- tion of Cardiovascular and Pulmo- nary Rehabilitation, the American Geriatrics Society, the American Society of Preventive Cardiology, and the Preventive Cardiovascular Nurses Association ACC/AHA Task Force Members, see page e577 CLINICAL STATEMENTS AND GUIDELINES TABLE OF CONTENTS Top 10 Take-Home Messages for the Primary Prevention of Cardiovascular Disease e564 Preamble e564 1. Introduction e565 1.1. Methodology and Evidence Review e566 1.2. Organization of the Writing Committee e566 1.3. Document Review and Approval e566 1.4. Scope of the Guideline e567 1.5. Class of Recommendation and Level of Evidence e567 1.6. Abbreviations e568 2. Overarching Recommendations for ASCVD Prevention Efforts e568 2.1. Patient-Centered Approaches to Comprehensive ASCVD Prevention e568 2.2. Assessment of Cardiovascular Risk e569 3. Lifestyle Factors Affecting Cardiovascular Risk e570 3.1. 