Epicardial adipose tissue: anatomic, biomolecular and clinical relationships with the heart. Nat Clin Pract Cardiovasc Med. 2005;2:536 543. doi: 10.1038/ ncpcardio0319. 214. Mahabadi AA, Massaro JM, Rosito GA, Levy D, Murabito JM, Wolf PA, O Donnell CJ, Fox CS, Hoffmann U. Association of pericardial fat, intrathoracic fat, and visceral abdominal fat with cardiovas- cular disease burden: the Framingham Heart Study. Eur Heart J. 2009;30:850 856. doi: 10.1093/eurheartj/ehn573. 215. Khawaja T, Greer C, Chokshi A, Chavarria N, Thadani S, Jones M, Schaefle K, Bhatia K, Collado JE, Shimbo D, Einstein AJ, Schulze PC. Epicardial fat volume in patients with left ventricular systolic dysfunction. Am J Cardiol. 2011;108:397 401. doi: 10.1016/j. amjcard.2011.03.058. 216. Doesch C, Suselbeck T, Leweling H, Fluechter S, Haghi D, Schoenberg SO, Borggrefe M, Papavassiliu T. Bioimpedance analy- sis parameters and epicardial adipose tissue assessed by cardiac magnetic resonance imaging in patients with heart failure. Obesity (Silver Spring). 2010;18:2326 2332. doi: 10.1038/oby.2010.65. 217. Lavie CJ, Milani RV, Ventura HO. Obesity and cardiovascular disease: risk factor, paradox, and impact of weight loss. J Am Coll Cardiol. 2009;53:1925 1932. doi: 10.1016/j.jacc.2008.12.068. 218. von Haehling S, Horwich TB, Fonarow GC, Anker SD. Tipping the scale: heart failure, body mass index, and prognosis. Circulation. 2007;116:588 590. doi: 10.1161/CIRCULATIONAHA. 107.716662. 219. Aquilani R, Opasich C, Verri M, Boschi F, Febo O, Pasini E, Pastoris O. Is nutritional intake adequate in chronic heart failure patients? J Am Coll Cardiol. 2003;42:1218 1223. 220. Anker SD, Ponikowski P, Varney S, Chua TP, Clark AL, Webb- Peploe KM, Harrington D, Kox WJ, Poole-Wilson PA, Coats AJ. Wasting as independent risk factor for mortality in chron- ic heart failure [published correction appears in Lancet. S0140-6736(96)07015-8. 221. Kalantar-Zadeh K, Block G, Horwich T, Fonarow GC. Reverse epi- demiology of conventional cardiovascular risk factors in patients with chronic heart failure. 