*Patients are candidates for exercise testing if they are capable of performing at least moderate physical functioning (ie, moderate household, yard, or recreational work and most activities of daily living) and have no disabling comorbidity. Patients should be able to achieve 85% of age-predicted maximum heart rate. IHD who require testing and are incapable of at least moderate physical functioning or have disabling comorbidity. (Level of Evidence: C) 2. CCTA is reasonable for patients with a low to intermediate pretest probability of IHD who are incapable of at least moderate physical functioning or have disabling comorbidity.158 166 (Level of Evi- dence: B) 3. Pharmacological stress CMR is reasonable for pa- tients with an intermediate to high pretest probabil- ity of IHD who are incapable of at least moderate physical functioning or have disabling comorbid- ity.153,157,158,169 172 (Level of Evidence: B) Class III: No Benefit 1. Standard exercise ECG testing is not recommended for patients who have an uninterpretable ECG or are incapable of at least moderate physical function- ing or have disabling comorbidity.91,132,148 156,161 (Level of Evidence: C) Class IIa 1. CCTA is reasonable for patients with an intermedi- ate pretest probability of IHD who a) have continued symptoms with prior normal test findings, or b) have inconclusive results from prior exercise or pharma- cological stress testing, or c) are unable to undergo stress with nuclear MPI or echocardiography.173 (Level of Evidence: C) Class IIb 1. For patients with a low to intermediate pretest probability of obstructive IHD, noncontrast cardiac CT to determine the CAC score may be consid- ered.174 (Level of Evidence: C) See Online Data Supplement 1 for additional data on diag- nostic accuracy of stress testing and advanced imaging for the diagnosis of suspected SIHD. 2.2.3. 