The yield of genetic testing in phenotype positive patients is approximately 20% to 30% in Brugada SCN5A variants account for most of this subset of genotype positive Brugada syndrome. However, 2% to 10% of other- wise healthy individuals host a rare variant of Anegativegenetictestdoes not exclude the diagnosis of Brugada syndrome, which is usually based on electrocardiographic and clinical characteristics. Risk stratification is based on symptoms and clinical findingsS7.9.1.3-32 ; genotype status is not correlated with the risk of adverse events.S7.9.1.3-5,S7.9.1.3-18,S7.9.1.3-19,S7.9.1.3-33 Identification of a pathogenetic mutation may help facilitate recognition of carrier status in fam- ily members, allowing for lifestyle modification and potential treatment. 8. Factors identified as potential triggers of VF and SCA in Brugada syndrome include some psy- chotropic medications, and anesthetic agents, cocaine, excessive alcohol intake, and fever These agents should be avoided and fever warrants early and aggressive measures to reduce tempera CLINICAL STATEMENTS AND GUIDELINES 7.9.1.4. Early Repolarization J-wave Syndrome Recommendations for Early Repolarization Syndrome References that support the recommendations are summarized in Online Data Supplement 43. COR LOE Recommendations I B-NR In asymptomatic patients with an early repolarization pattern on ECG, observation without treatment is I B-NR In patients with early repolarization pattern on ECG and cardiac arrest or sustained VA, an ICD is recommended if meaningful survival greater than 1 year is III: No Benefit B-NR In patients with early repolarization pattern on ECG, genetic testing is not Recommendation-Specific Supportive Text 1. The prevalence of an early repolarization pattern on ECG with J point elevation in the inferior or lateral leads of at least 0.1 mV has been reported to be as high as 5.8% in adultsS7.9.1.4-1 and is more common in males. 