analyses Randomized controlled trials/systematic review/meta-analysis hedge [see Search Limits at the end of this table] #10 Apply limits See Search Limits at the end of the table Question Set # Concept Strategy Question Strategies to improve patient tolerance to statins #1 Dyslipidemia exp dyslipidemias/ OR exp cholesterol/ OR exp lipids/ OR (dyslipidemia* OR dyslipidaemia* OR dyslipidproteinemia* OR dyslipidproteinaemia* OR hyperlipidemia* OR hyperlipidaemia* OR hypercholesterolemia* OR hypercholesterolaemia* OR hyperlipoproteinemia* OR hyperlipoproteinaemia* OR hypertriglyceridemia* OR hypertriglyceridaemia* OR hyperlipemia OR hyperlipaemia OR cholesteryl* OR cholesterol* OR lipid* OR lipoprotein* OR tryglycer* OR triaclyglycer* OR "HDL-C" OR "LDL-C" OR "HDL C" OR "LDL C").ti,ab. #2 CVD exp *Cardiovascular Diseases/pc OR cardiovascular diseases/ or heart diseases/ or vascular diseases/ or exp arterial occlusive diseases/ or cerebrovascular disorders/ OR exp brain ischemia/ or exp stroke/ or exp myocardial ischemia/ OR exp myocardial Infarction/ OR exp heart arrest/ OR exp hypertension/ OR exp peripheral vascular diseases/ OR ((heart* OR cardio* OR cardiac* OR coronary OR vascular OR cerebrovascular OR artery OR arteries) ADJ5 (disease* OR syndrome* OR event* OR ischem* OR ischaem* OR plaque*)).ti,ab. OR (hyperten* OR atherosclero* OR arteriosclero* OR angina OR (Heart ADJ attack*) OR (myocardial ADJ infarct*) OR stroke* OR (cerebrovascular ADJ accident*)).ti,ab. tolerance/adherenc e/ substitution (controlled terms) (exp Hypolipidemic Agents/ or exp Ezetimibe, Simvastatin Drug Combination/ or exp Anticholesteremic Agents/ or exp Hydroxymethylglutaryl-CoA Reductase Inhibitors/) AND (exp Medication Adherence/ or exp "Treatment Adherence and Compliance"/ OR exp Drug Substitution/ OR exp Drug Administration Schedule/) tolerance/adherenc e/ substitution (keywords) (((hydroxymethylglutaryl or hydroxy-methylglutaryl) ADJ5 (reductase ADJ inhibitor*)) OR "HMG CoA" or statin* or lovastatin or meglutol or pravastatin or atorvastatin or simvastatin).ti,ab. AND (tolerate* or tolerance or adher* or nonadherence* or non-adherence or ((alternat* or low or lower or high or higher or increase or decrease) ADJ3 dose or dosing or dosag*)).ti,ab. 