Table 117: Clinical Evidence Summary: PRICE (Atienza 2004): Long MDT clinic (MDTc) vs Cardiology for high risk HF Outcomes No of Participants (studies) Follow up Quality of the evidence (GRADE) Relative effect Anticipated absolute effects Risk with cardiology clinic Risk difference with MDTc (95% CI) MODERATEa due to imprecision rate ratio (from 183 fewer to 526 fewer) HIGH (from 36 more to 290 more) Quality of life 220 The mean quality of life in The mean quality of life in the Referral and approach to care Chronic Heart Failure NICE 2018. All rights reserved. Subject to Notice of rights. ISBN: Outcomes No of Participants (studies) Follow up Quality of the evidence (GRADE) Relative effect Anticipated absolute effects Risk with cardiology clinic Risk difference with MDTc (95% CI) Minnesota LWHFQ, final score. lower=better. Scale from: 0 to 105. LOWa, b due to risk of bias, imprecision the control groups was intervention groups was 6.60 lower (better) Prescribed ACE-I 153 LOWa, b due to risk of bias, imprecision (from 151 fewer to 145 more) Prescribed beta-blocker 153 LOWa, b due to risk of bias, imprecision (from 66 more to 487 more) (a) Downgraded by 1 increment if the confidence interval crossed one MID or by 2 increments if the confidence interval crossed both MIDs. (b) Downgraded by 1 increment if the majority of the evidence was at high risk of bias, and downgraded by 2 increments if the majority of the evidence was at very high risk of bias. 9.2.3.2.1 High risk. 