It includes alternatives such as placebo, drugs, surgery, lifestyle changes, standard of care, etc. Outcome Describes the specific results of interest. Outcomes can include short, intermediate, and long-term outcomes, or specific results such as quality of life, complications, mortality, morbidity, etc. Timing, if applicable Describes the duration of time that is of interest for the particular patient intervention and outcome, benefit, or harm to occur (or not occur). Setting, if applicable Describes the setting or context of interest. Setting can be a location (such as primary, specialty, or inpatient care). Abbreviation: PICOTS: population, intervention, comparison, outcome, timing and setting The Champions, Work Group, and evidence review team carried out several iterations of this process, each time narrowing the scope of the CPG and the literature review by prioritizing the topics of interest. Due to resource constraints, all developed KQs were not able to be included in the systematic evidence review. Thus, the Champions and Work Group determined which questions were of highest priority, and those were included in the review. Table A-2 contains the final set of KQs used to guide the SR for this CPG. Once the KQs were finalized, the Work Group rated and prioritized the outcomes they had defined for each KQ based on how important the Work Group judged each outcome to be. Rating outcomes by their relative importance can help focus attention on those outcomes that are considered most important for clinical decision making when making judgements regarding the overall quality of the evidence to support Using GRADE methodology, the Work Group rated each outcome on a 1-9 scale (7-9, critical for decision making; 4-6, important, but not critical, for decision making; and 1-3, of limited importance for decision making). 