An acute fall in estimated glomerular filtration rate during treatment with losartan predicts a slower decrease in long-term renal function. Kidney Int 2011; 80: 282 287. 88. Weir MR. Acute fall in glomerular filtration rate with renin-angiotensin system inhibition: a biomeasure of therapeutic success? Kidney Int 2011; 80: 235 237. 89. Bomback AS, Klemmer PJ. The incidence and implications of aldosterone breakthrough. Nat Clin Pract Nephrol 2007; 3: 486 492. 90. Palmer BF. Renal dysfunction complicating the treatment of hyperten- sion. N Engl J Med 2002; 347: 1256 1261. 91. Bridoux F, Hazzan M, Pallot JL et al. Acute renal failure after the use of angiotensin-converting-enzyme inhibitors in patients without renal artery stenosis. Nephrol Dial Transplant 1992; 7: 100 104. 92. Kohli HS, Bhaskaran MC, Muthukumar T et al. Treatment-related acute renal failure in the elderly: a hospital-based prospective study. Nephrol Dial Transplant 2000; 15: 212 217. 93. Wynckel A, Ebikili B, Melin JP et al. Long-term follow-up of acute renal failure caused by angiotensin converting enzyme inhibitors. Am J Hypertens 1998; 11: 1080 1086. 94. Adhiyaman V, Asghar M, Oke A et al. Nephrotoxicity in the elderly due to co-prescription of angiotensin converting enzyme inhibitors and nonsteroidal anti-inflammatory drugs. J R Soc Med 2001; 94: 512 514. 95. Loboz KK, Shenfield GM. Drug combinations and impaired renal function the triple whammy . Br J Clin Pharmacol 2005; 59: 239 243. 96. Jafar TH, Stark PC, Schmid CH et al. Progression of chronic kidney disease: the role of blood pressure control, proteinuria, and angiotensin- converting enzyme inhibition: a patient-level meta-analysis. Ann Intern Med 2003; 139: 244 252. 97. Balamuthusamy S, Srinivasan L, Verma M et al. Renin angiotensin system blockade and cardiovascular outcomes in patients with chronic kidney disease and proteinuria: a meta-analysis. Am Heart J 2008; 155: 791 805. 