Dipyridamole and warfarin add nothing to the effect of aspirin on SVG patency,544,545 and use of the latter may be associated with an increased risk for bleeding compared with Clopidogrel is associated with fewer adverse effects than ticlopidine. Severe leukopenia occurs very rarely.546,547 A subset analysis of CABG patients from the CURE (Clopi- dogrel in Unstable Angina to Prevent Recurrent Ischemic Events) trial suggested that clopidogrel reduced the occur- rence of cardiovascular death, MI, and stroke (14.5%) com- pared with placebo (16.2%). This benefit occurred primarily before surgery, however, and after CABG a difference in primary endpoints between groups was not demonstrable. Clopidogrel was stopped a median of 10 days before surgery and was restarted postoperatively in 75.3% of patients as- signed to receive it. All patients received aspirin, 75 mg to 325 mg daily, but the details of aspirin administration in the study groups were not described.530 4.3. Management of Hyperlipidemia: Recommendations Class I 1. All patients undergoing CABG should receive statin therapy, unless contraindicated.545,548 559 (Level of Evidence: A) 2. In patients undergoing CABG, an adequate dose of statin should be used to reduce LDL cholesterol to less than 100 mg/dL and to achieve at least a 30% lowering of LDL cholesterol.548 552 (Level of Evi- dence: C) Class IIa 1. In patients undergoing CABG, it is reasonable to treat with statin therapy to lower the LDL choles- terol to less than 70 mg/dL in very high-risk* patients.549 551,561 563 (Level of Evidence: C) 2. For patients undergoing urgent or emergency CABG who are not taking a statin, it is reasonable to initiate high-dose statin therapy immediately.564 (Level of Evidence: C) Class III: HARM 1. 