, eGFR categories G1-G2) but microalbuminuria found no significant risk reduction associated with pravastatin treatment on the risk of although the number of events was small (n 47). A post hoc analysis of CARE participants with slightly more events (n 60) found a significant reduction in the risk of the primary outcome (CHD death or non-fatal MI) among the subset of CKD patients with eGFR categories G1-G2 (HR of pravastatin vs. placebo 0.48; 95% CI 0.28 0.83). Given these data, the high cardiovascular risk among people with CKD and eGFR categories G1-G2, the large body of evidence supporting the efficacy of statins in the general population, and the lack of an a priori reason why statins would be less effective in the presence of proteinuria (i.e., the lack of justification for a new trial done specifically in people with CKD and eGFR categories G1-G2), the Work Group judged that a strong recommendation was appropriate. 2.2: In adults aged 18-49 years with CKD but not treated with chronic dialysis or kidney transplantation, we suggest statin treatment in people with one or more of the following (2A): K known coronary disease (myocardial infarction or coronary revascularization) K diabetes mellitus K prior ischemic stroke K estimated 10-year incidence of coronary death or non-fatal myocardial infarction 410% RATIONALE As mentioned, the risk of coronary events is age-dependent in people with CKD, just as it is in the general population. Although the absolute rate of such events is lower among people with CKD who are less than 50 years of age, the co- existence of other risk factors increases the rate of coronary death or non-fatal MI substantially. 