(b) Downgraded by 1 increment if the confidence interval crossed 1 MID or by 2 increments if the confidence interval crossed both MID. (c) Downgraded by 1 increment as the outcome is indirect. (d) Mean control group rate per 100 patient-years. Table 53: Clinical evidence summary: oral iron versus placebo Outcomes No of Participants (studies) Follow up Quality of the evidence (GRADE) Relative effect Anticipated absolute effects Risk with Placebo Risk difference with Oral iron (95% CI) VERY LOWa, b,e due to risk of bias, imprecision, Peto Odds ratio Moderate (from 13 fewer to 128 more) Treating Heart Failure Chronic Heart Failure NICE 2018. All rights reserved. Subject to Notice of rights. ISBN: Outcomes No of Participants (studies) Follow up Quality of the evidence (GRADE) Relative effect Anticipated absolute effects Risk with Placebo Risk difference with Oral iron (95% CI) inconsistency Improvement in NYHA class Data on improvement in NYHA has only been extracted where quality of life data is not reported in a trial. 