The recommended maintenance dose of aspirin to be used with ticagrelor is 81 mg daily.290 Amsterdam et al 2014 AHA/ACC NSTE-ACS Guideline e365 Receptor Inhibitors receptor inhibitors are approved in the United States for treatment of ischemic myocardial disorders, including NSTE-ACS. For discontinuation before surgery, see Section 5. Clopidogrel Administration of clopidogrel with aspirin was superior to administration of aspirin alone in reducing the incidence of cardiovascular death and nonfatal MI or stroke both acutely and over the following 11 months.289,296 There was a slight increase in major bleeding events with clopidogrel, including a nonsignificant increase in life-threatening bleeding and fatal An initial loading dose of 300 mg to 600 mg is rec- A 600-mg loading dose results in a greater, more rapid, and more reliable platelet inhibition compared with a 300-mg loading dose.301 Use of clopidogrel for patients with NSTE-ACS who are aspirin intolerant is based on a study Table 7. 