Women with hyperten- sion and who smoked cigarettes were also at increased risk.221 In the Swedish Women s Lifestyle and Health Cohort, there was a significant decrease in hemorrhagic stroke among women who were parous (versus nulliparous; HR, 0.5; 95% CI, 0.2 0.8) and a nonsignificant increase in women who started OC use after 30 years of age (HR, 2.3; 95% CI, 0.8 6.8) and stopped using OCs based on doctor recommendation for medical reasons (adjusted HR, 2.1; 95% CI, 0.9 5.0).219 Hemorrhagic stroke in young women is relevant in Asia, where the risk of this type of stroke is disproportionately higher than in Europe and North America. A recent case- control study of Chinese women evaluated the association between the single-nucleotide polymorphisms rs10958409 GA/AA (located near SOX17, a transcription factor that modulates cardiovascular development and endothelial cell biology) and rs1333040 CT/TT (located near CDKN2A, CDKN2B, and ANRIL, which regulate p53 activity) and risk of ischemic and hemorrhagic stroke in OC users and nonus- Women with the rs10958409 GA/AA or rs1333040 CT/TT genotypes (associated with susceptibility of intracra- nial aneurysm) had an increased overall risk of stroke, which increased to an OR of 6.06 (95% CI, 1.69 21.81) and 14.48 (95% CI, 1.56 134.43), respectively, in OC users <50 years of age. 