Weak for Not reviewed, Deleted We recommend the use of thiazide-type diuretics for the treatment of hypertension. Strong for Reviewed, New- replaced We suggest the use of thiazide-type diuretics at recommended treatment doses as first-line therapy for drug treatment of hypertension either as monotherapy or in combination with other agents. (Modified from 2004 VA/DoD HTN CPG) Weak for Reviewed, Deleted To initiate treatment of hypertension with a thiazide-type diuretic, we suggest the use of chlorthalidone or indapamide over hydrochlorothiazide. Weak for Reviewed, Deleted We do not suggest switching from hydrochlorothiazide to chlorthalidone or indapamide if the patient is adequately controlled on and tolerating hydrochlorothiazide. Weak against Reviewed, Deleted We suggest considering a switch from hydrochlorothiazide to chlorthalidone for patients whose hypertension is inadequately controlled on 50mg/day of hydrochlorothiazide. Weak for Reviewed, Deleted We recommend a dosage of 12.5-25mg/day of chlorthalidone, 25-50mg/day of hydrochlorothiazide, or a dosage of 2.5mg/day immediate-release or 1.5- 2.5mg/day sustained-release (not currently available in the US) of indapamide. Strong for Reviewed, Deleted We recommend using the following as alternative therapies for patients who cannot tolerate thiazide-type diuretics, as supplementary therapies for patients who do not reach their hypertensive goals, or for those starting on combination therapy: a. Angiotensin-converting-enzyme inhibitors or angiotensin II receptor blockers (but not together) b. Long-acting dihydropyridine calcium channel blockers (Modified from 2004 VA/DoD HTN CPG) Strong for Reviewed, New- replaced 2014 Recommendation Text 2014 Strength of Recommendation Recommendation Category Recommendation Section Number Page We recommend against the use of more than one of the following three drug classes together in the same patient: angiotensin- converting-enzyme inhibitors, angiotensin II receptor blockers, or direct renin inhibitors. Strong against Not reviewed, Not changed We recommend additional therapy in refractory hypertension (for those who do not tolerate or are not adequately controlled with triple therapy [i.e.