Delayed PCI of a significant stenosis in a patent infarct artery is reasonable in stable patients with STEMI af- ter fibrinolytic therapy. PCI can be performed as soon as logistically feasible at the receiving hospital, and ideally within 24 hours, but should not be performed within the first 2 to 3 hours after administration of fi- (Level of Evidence: B) Class IIb 1. Delayed PCI of a significant stenosis in a patent in- farct artery greater than 24 hours after STEMI may be considered as part of an invasive strategy in sta- (Level of Evidence: B) Class III: No Benefit 1. Delayed PCI of a totally occluded infarct artery greater than 24 hours after STEMI should not be performed in asymptomatic patients with 1- or 2-ves- sel disease if they are hemodynamically and electri- cally stable and do not have evidence of severe isch- (Level of Evidence: B) Delayed PCI of the infarct artery is performed in patients treated with an initial noninvasive strategy (ie, with fibrinolysis or without reperfusion therapy) who become unstable because of the development of cardiogenic shock, acute severe HF, or unstable postinfarction angina, provided that invasive manage- ment is not considered futile or inappropriate.215,379 Delayed PCI also encompasses interventions performed for fibrinolytic or infarct artery reocclusion, as part of an invasive strategy for patients after successful fibrinolysis,359 361 and for patients who did not receive reperfusion therapy but who did demonstrate significant residual ischemia during hospitaliza- tion. The benefits of routine, ie, non ischemia-driven, PCI of an angiographically significant stenosis in a patent infarct artery >24 hours after STEMI are less well established.232,233,378 Delayed PCI of a totally occluded infarct artery >24 hours after STEMI should not be undertaken in clinically stable patients without evidence of severe ischemia. 