2004;27:699 703. S8.1.6-8. Ogedegbe G, Shah NR, Phillips C, et al. Comparative effective- ness of angiotensin-converting enzyme inhibitor-based treatment on cardiovascular outcomes in hypertensive blacks versus whites. J Am Coll Cardiol. 2015;66:1224 33. S8.1.6-9. Leenen FHH, Nwachuku CE, Black HR, et al. Clinical events in high-risk hypertensive patients randomly assigned to calcium channel blocker versus angiotensin-converting enzyme inhibitor in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial. Hypertension. 2006;48:374 84. S8.1.6-10. Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial Collaborative Research Group. Diuretic versus alpha- blocker as first-step antihypertensive therapy: final results from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). Hypertension. 2003;42:239 46. S8.1.6-11. Law MR, Morris JK, Wald NJ. Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospec- tive epidemiological studies. BMJ. 2009;338:b1665. S8.1.6-12. Thomopoulos C, Parati G, Zanchetti A. Effects of blood pressure- lowering on outcome incidence in hypertension: 5. Head-to-head comparisons of various classes of antihypertensive drugs-over- view and meta-analyses. J Hypertens. 2015;33:1321 41. S8.1.6-13. ZhangY, Sun N, Jiang X, et al. Comparative efficacy of -blockers on mortality and cardiovascular outcomes in patients with hyper- tension: a systematic review and network meta-analysis. J Am Soc. Hypertens. 2017;11:394 401. S8.1.6-14. Larochelle P, Tobe SW, Lacourciere Y. -Blockers in hyperten- sion: studies and meta-analyses over the years. Can J Cardiol. 2014;30:S16 22. 8.1.6.1. Choice of Initial Monotherapy Versus Initial Combination Drug Therapy S8.1.6.1-1. Chobanian AV, Bakris GL, Black HR, et al; the National High Blood Pressure Education Program Coordinating Committee. Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension. 2003;42:1206 52. S8.1.6.1-2. Law MR, Wald NJ, Morris JK, et al. 