The association of migraine in middle-aged to late-life infarct-like lesions on imaging was studied in a Reykjavik, Iceland, population-based cohort.599 After multivariable adjustment, midlife migraine with aura had an increased risk of late-life infarct-like lesions (OR, 1.4; 95% CI, 1.1 1.8).599 This was particularly reflected by an association with cerebel- lar lesions in women (OR, 1.9; 95% CI, 1.4 2.6), but not in men, with migraine with aura (OR, 1.0; 95% CI, 0.6 1.8).599 Migraine without aura and nonmigraine headache were not associated with an increased risk.599 Therefore, similar to the risk for ischemic stroke found in women with migraine with aura in the WHS, in this Icelandic population, women with migraine with aura had an increased risk for late-life isch- emic lesions as seen on brain MRI; however, this association was not appreciated in men or in those with migraine with- out aura or nonmigraine headaches. Overall, the Icelandic study is in agreement with the previous studies, including the Cerebral Abnormalities in Migraine, an Epidemiological Risk Meschia et al Guidelines for the Primary Prevention of Stroke 3787 Analysis (MRI CAMERA) study, which found that, on the basis of MRI, migraineurs with aura had higher prevalence of subclinical infarcts in the posterior circulation (OR, 13.7; 95% CI, 1.7 112), with female migraineurs at an indepen- dent increased risk of white matter lesions (OR, 2.1; 95% CI, The mechanism and relevance of the migraine brain lesion association are unclear. 