It is estimated that 41000 preventable deaths per year occur in adult nonsmokers as a result of exposure to second- The US Department of Housing and Urban Development prohibited the use of combustible tobacco products in all public hous- ing living units, indoor common areas, and public housing agency administrative office buildings, extending to all outdoor areas up to 25 feet from public housing buildings.S4.5-34 Therefore, the pres- ent writing committee recommends that clinicians advise patients to take precautions against expo- sure to secondhand smoke and aerosol from all tobacco products, such as by instituting smoking restrictions (including ENDS) inside all homes and vehicles and within 25 feet from all entryways, windows, and building vents. 4.6. Aspirin Use Recommendations for Aspirin Use Referenced studies that support recommendations are summarized in Online Data Supplements 17 and 18. COR LOE Recommendations IIb A Low-dose aspirin (75-100 mg orally daily) might be considered for the primary prevention of ASCVD among select adults 40 to 70 years of age who are at higher ASCVD risk but not at increased bleeding III: Harm B-R Low-dose aspirin (75-100 mg orally daily) should not be administered on a routine basis for the primary prevention of ASCVD among adults >70 years of age.S4.6-9 III: Harm C-LD Low-dose aspirin (75-100 mg orally daily) should not be administered for the primary prevention of ASCVD among adults of any age who are at increased risk of Synopsis For decades, aspirin has been widely administered for ASCVD prevention. By irreversibly inhibiting platelet function, aspirin reduces risk of atherothrombosis but also increases risk of bleeding, particularly in the gas- Aspirin is well established for secondary prevention of ASCVDS4.6-12 and is widely rec- ommended for this indication.S4.6-13 However, in primary prevention, aspirin use is more controversial. 