Once consensus is reached in a group meeting, the final grade for the quality of the evidence for an intervention outcome pair could be one of the following four grades: High , Moderate , Low or Very Low (Table 11). CKD subgroup analyses. The following criteria were devised to grade the quality of CKD-subgroup analyses of RCTs that were not specifically designed for or limited to individuals with CKD. CKD subgroups were graded only if they were of an acceptable size for the topic of interest (e.g., 50 per arm with CKD for lipid guideline). These criteria will be considered along with the assessment of whether the putative subgroup effect is plausible with regard to direction and size of effect. For the complete set of subgroup grading criteria, see Figure 3. 