Comprehensive cardiac screening including 12-lead ECG, possible signal averaged ECG, echocardiogram, and ambulatory rhythm moni- toring or exercise testing of first-degree relatives of decedents with sudden unexpected death may identify a probable heritable cardiac cause of death in up to 30% of cases.S13-11 S13-13 Genetic testing should be targeted based on the results of Genetic testing in selected first-degree relatives may result in identification of inherited conditions including long QT syndrome, catecholaminergic polymorphic ventricular tachy- cardia, Brugada syndrome, arrhythmogenic right ventricular cardiomyopathy, and HCM in 4% to 3. For the purpose of family risk profiling, it is important to use the disease-specific genetic test panel that corresponds to the autopsy findings. Risk profiling of family members of an SCD victim suspected of having an inherited cardiomyopathy at autopsy is important. Although phenotyping of surviving family members is crucial, genotyp- ing of the SCD proband provides a mechanism for efficient follow-up evaluation of those rela- tives with the disease-causing mutation found CLINICAL STATEMENTS AND GUIDELINES in the proband. To be able to harvest quality DNA for such testing, medical examiners, hos- pital pathologists, and private pathologists need standards for harvesting and storing samples for later genetic testing. Family members of SCD probands who died suddenly (first cardiac event, death from natural causes, last seen alive and well within 12 hours), with autopsy findings showing structural abnormalities of uncertain significance (eg, ventricular hypertrophy, myocardial fibrosis, or minor ischemic heart disease [n=41]) had a 51% prevalence of genetic variants associated with sudden arrhythmic deaths, compared with 47% among a comparison group in which pro- band autopsies were completely negative.S13-15 4. Identification of the genotype can facilitate family 14. TERMINAL CARE Recommendations for Terminal Care References that support the recommendations are summarized in Online Data Supplement 59. 