Composite outcomes that include both prevention of events and surrogates, such as prevention of decline in renal function or amelioration of measures of subclinical atheroscle- rosis, vascular stiffness, or LV structure and function, should be considered. Otherwise, these younger individuals may be undertreated and experience mortality or CVD events before being old enough to enter hard outcome driven trials such as SPRINT. Replication of SPRINT, especially in younger patients with DM and in countries where nonischemic stroke is the predominant cause of CVD, is highly desirable. Likewise, implementation studies that demonstrate the practicality of SPRINT-like interventions in resource-constrained practice settings are needed. More information is urgently needed relating hypertensive target organ damage to CVD risk and outcomes. Should the identification of target organ damage and hypertensive heart disease prompt more aggressive BP management (ie, increase the rationale for instituting pharmacological therapy earlier or more intensively? Should all patients with hypertension be screened with echocardiogram for LVH? Should echocardiog- raphy be repeated once LVH is noted? Is it important to docu- ment LVH regression? At present, there are no RCT data to inform guideline recommendations. ABPM and HBPM provide enhanced ability to both diag- nose hypertension and monitor treatment. Although evidence is sufficient to recommend incorporating these tools into clini- cal practice, more knowledge about them is required. Areas of inquiry include closer mapping of the relationship of out- comes to ambulatory and home BP measurements, so that definitions of hypertension and hypertension severity based on Clinician follow-up, monitoring, and care coordination Follow-up visits Sections 8.1.3, Team-based care Section 12.2 Electronic health record Section 12.3.1 Health information technology tools for remote and self-monitoring Socioeconomic and cultural factors Health literacy Section 13.1.3 Access to health insurance and medication assistance plans Social services Section 13.1.3 Community services Section 13.1.3 BP indicates blood pressure. 