Houpikian P, Raoult D. Blood culture-negative endocarditis in a refer- ence center: etiologic diagnosis of 348 cases. Medicine (Baltimore). 2005;84:162 73. 12.3. Medical Therapy 1. Gould FK, Denning DW, Elliott TSJ, et al. Guidelines for the diagnosis and antibiotic treatment of endocarditis in adults: a report of the Working Party of the British Society for Antimicrobial Chemotherapy. J Antimicrob Chemother. 2012;67:269 89. 2. Baddour LM, Wilson WR, Bayer AS, et al. Infective endocarditis: diagnosis, antimicrobial therapy, and management of complications: a statement for healthcare professionals from the Committee on Rheumatic Fever, Endo- carditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, and the Councils on Clinical Cardiology, Stroke, and Cardiovas- cular Surgery and Anesthesia, American Heart Association. Circulation. 2005;111:e394 e434. 3. L pez J, Sevilla T, Vilacosta I, et al. Prognostic role of persistent positive blood cultures after initiation of antibiotic therapy in left-sided infective endocarditis. Eur Heart J. 2013;34:1749 54. 4. Partridge DG, O Brien E, Chapman ALN. Outpatient parenteral antibiotic therapy for infective endocarditis: a review of 4 years experience at a UK centre. Postgrad Med J. 2012;88:377 81. 5. Leekha S, Terrell CL, Edson RS. General principles of antimicrobial therapy. Mayo Clin Proc. 2011;86:156 67. 6. DiNubile MJ. Short-course antibiotic therapy for right-sided endocarditis caused by Staphylococcus aureus in injection drug users. Ann Intern Med. 1994;121:873 6. 7. Mart -Carvajal AJ, Dayer M, Conterno LO, et al. A comparison of different antibiotic regimens for the treatment of infective endocarditis. Cochrane Database Syst Rev. 2016;4:CD009880. 8. Liebschutz JM, Crooks D, Herman D, et al. Buprenorphine treatment for hospitalized, opioid-dependent patients: a randomized clinical trial. JAMA Intern Med. 2014;174:1369 76. 9. Englander H, Weimer M, Solotaroff R, et al. Planning and designing the Improving Addiction Care Team (IMPACT) for hospitalized adults with sub- stance use disorder. 