SEARCH CRITERIA The rapid review conducted by the Evidence-based Practice Center to complete this literature search, in the limited timeframe provided, built on existing systematic reviews conducted on behalf of the USPSTF. Medical Subject Headings (MeSH) Terms Key Words Nutrition and Diet Search since the 2017 review1 exp Diet/ diet* exp Diet Therapy/ cardiovascular Healthy Diet coronary Primary Prevention/ heart myocardial infarction MI CVD CHD cerebrovascular stroke microvascular mortality prevent* Obesity and Weight Loss Search since the 2018 review2 exp Obesity/ obes* exp Weight Loss overweight Primary Prevention/ weight cardiovascular coronary heart myocardial infarction MI CVD CHD cerebrovascular stroke microvascular mortality prevent* Type 2 Diabetes Mellitus Search since the 2015 review3 exp Diabetes Mellitus, Type 2/ impaired fasting glucose Prediabetic State/ impaired glucose tolerance Glucose Intolerance/ Ifg Primary Prevention/ Igt prediabetes* type 2 diabet* DM cardiovascular coronary heart myocardial infarction MI CVD CHD cerebrovascular stroke microvascular mortality prevent* Tobacco Use Search since the 2015 review4 Smoking/ smoking exp "Tobacco Use Cessation"/ cigarette* "Tobacco Use Disorder"/ tobacco Electronic Cigarettes/ nicotine Primary Prevention/ vape vaping e-cigarette electronic cigarette electronic nicotine delivery system* ENDS cardiovascular coronary heart myocardial infarction MI CVD CHD cerebrovascular stroke microvascular mortality prevent* Aspirin Use Search since the 2016 review5 Aspirin aspirin exp Cerebrovascular Disorders/ acetylsalicylic acid exp Cardiovascular Diseases/ clopidogrel Primary Prevention/ cardiovascular coronary heart myocardial infarction Appendix 1. Continued Medical Subject Headings (MeSH) Terms Key Words (Continued) (Continued) CLINICAL STATEMENTS AND GUIDELINES Primary Prevention/ MI CVD CHD cerebrovascular stroke microvascular mortality prevent* Social Determinants of Health Search limited to English. 