Key Question 10: Placebo or different dietary supplement(s) Key Question 11: Different dietary therapy or no dietary therapy Different health professional other than an RD Key Question 12: No exercise No routine exercise Different type of exercise d. Outcomes Key Question 1: Critical outcomes CV mortality Important outcomes Composite CV outcomes (as defined as the a priori outcome by individual studies) that could include any of the following: unstable angina, AMI, revascularization, stroke, CV mortality, all-cause mortality AMI fatal or non-fatal Stroke fatal or non-fatal All-cause mortality Changing risk stratification, reclassification of CV risk Time to crossing to a different treatment threshold Key Question 2: Critical outcomes Change in lab value over time Key Question 3: Critical outcomes Test characteristics (AUC, specificity, sensitivity, positive predictive value, negative predictive value, etc.) Important outcomes Changing risk stratification, reclassification of CV risk Critical outcomes CV mortality Important outcomes Composite CV outcomes (as defined as the a priori outcome by individual studies) that could include any of the following: unstable angina, AMI, revascularization, stroke, CV mortality, all-cause mortality AMI fatal or non-fatal Stroke fatal or non-fatal All-cause mortality Key Question 7: Critical outcomes Adherence to lipid therapy medication >85% @ 1 year Important outcomes Changes in lipid levels (total-, LDL-, HDL-cholesterol, non-HDL cholesterol, TGs) Key Question 9: Critical outcomes Marginal cost-effectiveness Important outcomes Thresholds of cost-effectiveness for cost, effectiveness, utilities Sensitivity of cost-effectiveness to cost and effectiveness (ARR, RRR) e. Timing Key Question 1: 3 years follow-up No minimum follow-up Key Questions 4 6: 1 year follow-up Key Questions 8, 9: Lifetime horizon f. Settings Outpatient primary care (Key Question 2 also includes laboratory setting) B. 