Occur- rence and characteristics of stroke events in the Atrial Fibrillation Follow-up Investigation of Sinus Rhythm Management (AFFIRM) study. Arch Intern Med. 2005; 165(10):1185-1191. 126. Krittayaphong R, Raungrattanaamporn O, Bhuripanyo K, et al. A randomized clinical trial of the ef cacy of radio- frequency catheter ablation and amiodarone in the treat- ment of symptomatic atrial brillation. J Med Assoc Thai. 2003;86(suppl 1):S8-S16. 127. Wazni OM, Marrouche NF, Martin DO, et al. Radiofre- quency ablation vs antiarrhythmic drugs as rst-line treat- ment of symptomatic atrial brillation: a randomized trial. JAMA. 2005;293(21):2634-2640. 128. Oral H, Pappone C, Chugh A, et al. Circumferential pul- monary-vein ablation for chronic atrial brillation. N Engl J Med. 2006;354(9):934-941. 129. Pappone C, Augello G, Sala S, et al. A randomized trial of circumferential pulmonary vein ablation versus antiar- rhythmic drug therapy in paroxysmal atrial brillation: the APAF Study. J Am Coll Cardiol. 2006;48(11):2340-2347. 130. Stabile G, Bertaglia E, Senatore G, et al. Catheter ablation treatment in patients with drug-refractory atrial brillation: a prospective, multi-centre, randomized, controlled study (Catheter Ablation For The Cure Of Atrial Fibrillation Study). Eur Heart J. 2006;27(2):216-221. 131. Ja s P, Cauchemez B, Macle L, et al. Catheter ablation ver- sus antiarrhythmic drugs for atrial brillation: the A4 study. Circulation. 2008;118(24):2498-2505. 132. Wilber DJ, Pappone C, Neuzil P, et al; ThermoCool AF Trial Investigators. Comparison of antiarrhythmic drug therapy and radiofrequency catheter ablation in patients with paroxysmal atrial brillation: a randomized controlled trial. JAMA. 2010;303(4):333-340. 133. Omran H, Jung W, Rabahieh R, et al. Left atrial appendage function in patients with atrial utter. Heart. 1997;78(3): 250-254. 134. Seidl K, Hauer B, Schwick NG, Zellner D, Zahn R, Senges J. Risk of thromboembolic events in patients with atrial utter. Am J Cardiol. 1998;82(5):580-583. 135. Corrado G, Sgalambro A, Mantero A, et al. 