Secondary analysis of APPLE study suggests atorvastatin may reduce atherosclerosis pro- gression in pubertal lupus patients with higher C reactive protein. Ann Rheum Dis. 2014;73:557 66. S4.4.4.3-33. Perak AM, Ning H, de Ferranti SD, et al. Long-term risk of ath- erosclerotic cardiovascular disease in US adults with the familial hypercholesterolemia phenotype. Circulation. 2016;134:9 19. S4.4.4.3-34. Neil HA, Hawkins MM, Durrington PN, et al. Non-coronary heart disease mortality and risk of fatal cancer in patients with treated heterozygous familial hypercholesterolaemia: a prospective regis- try study. Atherosclerosis. 2005;179:293 7. S4.4.4.3-35. Sniderman AD, Tsimikas S, Fazio S. The severe hypercholesterol- emia phenotype: clinical diagnosis, management, and emerging therapies. J Am Coll Cardiol. 2014;63:1935 47. S4.4.4.3-36. Smith AJ, Turner EL, Kinra S. Universal cholesterol screening in childhood: a systematic review. Acad Pediatr. 2016;16:716 25. S4.4.4.3-37. Kerr M, Pears R, Miedzybrodzka Z, et al. Cost effectiveness of cascade testing for familial hypercholesterolaemia, based on data from familial hypercholesterolaemia services in the UK. Eur Heart J. 2017;38:1832 9. CLINICAL STATEMENTS AND GUIDELINES S4.4.4.3-38. Berenson GS. Childhood risk factors predict adult risk associated with subclinical cardiovascular disease. The Bogalusa Heart Study. Am J Cardiol. 2002;90:3L 7L. S4.4.4.3-39. Juonala M, Magnussen CG, Venn A, et al. Influence of age on associations between childhood risk factors and carotid intima- media thickness in adulthood: the Cardiovascular Risk in Young Finns Study, the Childhood Determinants of Adult Health Study, the Bogalusa Heart Study, and the Muscatine Study for the International Childhood Cardiovascular Cohort (i3C) Consortium. Circulation. 2010;122:2514 20. S4.4.4.3-40. Juhola J, Magnussen CG, Viikari JS, et al. Tracking of serum lipid levels, blood pressure, and body mass index from childhood to adulthood: the Cardiovascular Risk in Young Finns Study. J Pediatr. 2011;159:584 90. S4.4.4.3-41. 