Effect of intensive blood pressure lowering on kidney tubule injury: ndings from the ACCORD Trial study participants. Am J Kidney Dis. 2019;73:31 38. 134. Beddhu S, Rocco MV, Toto R, et al. Effects of intensive systolic blood pressure control on kidney and cardiovascular outcomes in persons without kidney disease: a secondary analysis of a randomized trial. Ann Intern Med. 2017;167:375 383. 135. Appel LJ, Wright JT Jr, Greene T, et al. Intensive blood-pressure control in hypertensive chronic kidney disease. N Engl J Med. 2010;363:918 929. 136. Beck GJ, Berg RL, Coggins CH, et al. Design and statistical issues of the Modi cation of Diet in Renal Disease Trial. The Modi cation of Diet in Renal Disease Study Group. Control Clin Trials. 1991;12:566 586. 137. Upadhyay A, Earley A, Haynes SM, et al. Systematic review: blood pressure target in chronic kidney disease and proteinuria as an effect modi er. Ann Intern Med. 2011;154:541 548. 138. Sarnak MJ, Greene T, Wang X, et al. The effect of a lower target blood pressure on the progression of kidney disease: long-term follow-up of the modi cation of diet in renal disease study. Ann Intern Med. 2005;142:342 351. 139. Modi cation of Diet in Renal Disease Study Group. Short-term effects of protein intake, blood pressure, and antihypertensive therapy on glomerular ltration rate in the Modi cation of Diet in Renal Disease Study. J Am Soc Nephrol. 1996;7:2097 2109. 140. Lv J, Ehteshami P, Sarnak MJ, et al. Effects of intensive blood pressure lowering on the progression of chronic kidney disease: a systematic review and meta-analysis. CMAJ. 2013;185:949 957. 141. Kidney Disease: Improving Global Outcomes (KDIGO) Blood Pressure Work Group. KDIGO Clinical Practice Guideline for the Management of Blood Pressure in Chronic Kidney Disease. Kidney Int Suppl. 2012;2: 337 414. 142. 