(3) What is the impact on mortality, recurrent VTE risk, and recurrent bleeding risk associated with resumption of anticoagulation therapy following extracranial bleeding from sites other than the gastrointestinal tract? (4) Is resuming anticoagulation therapy following major bleeding a cost-effective strategy? Good practice statements: renal function monitoring For patients with creatinine clearance of $50 mL/min receiving DOAC therapy for treatment of VTE, the ASH guideline panel agrees that good practice includes renal function monitoring every 6 to 12 months (ungraded good practice statement). For patients with creatinine clearance of ,50 mL/min receiving DOAC therapy for treatment of VTE, the ASH guideline panel agrees that good practice includes renal function monitoring approximately every 3 months (ungraded good practice statement). What are others saying and what is new in these ASH guidelines? One other recent set of guidelines on the optimal management of anticoagulation therapy is available, issued by the 2012 American College of Chest Physicians (ACCP).234 Major differences between the ASH guidelines and the ACCP guidelines include the consistent use of systematic reviews and EtD frameworks, which increase transparency, and the use of marker states to estimate the relative importance to patients of key outcomes of treatment. Both ASH and ACCP guidelines suggest using longer INR recall intervals for patients receiving VKA therapy during periods of stable INR control. The ASH guidelines make a graded recommendation in favor of using AMS, whereas ACCP provided an ungraded best practice statement suggesting that health care providers who manage oral anticoagulation therapy should do so in a systematic and coordinated fashion, incorporating patient education, system- atic INR testing, tracking, follow-up, and good patient communica- tion of results and dosing decisions. 