It remains to be determined whether rFVIIa might benefit a particular subset of patients with ICH, but currently its benefits in ICH patients, whether or not they are taking an OAC, remain unproven. Thromboprophylaxis in ICH Patients Patients with ICH have a high risk of thromboembolic dis- Women and blacks may be at greater risk.110 112 In a randomized trial of 151 ICH patients, intermittent pneumatic compression together with elastic stockings reduced the occurrence of asymptomatic deep vein thrombosis (DVT) after ICH compared with elastic stockings alone (4.7% versus The CLOTS trials (Clots in Legs or Stockings After Stroke) consisted of 3 different randomized trials (CLOTS 1, 2, and 3) that assessed several different treatments, includ- ing graduated compression stockings versus none, thigh-high graduated compression stockings versus calf-high stockings, and intermittent pneumatic compression versus none.114 117 CLOTS 1 enrolled 2518 stroke patients (232 with ICH) and found that thigh-high compression stockings did not reduce DVT, pulmonary embolism (PE), or death.115 CLOTS 2 found that DVT was more common in patients who had below-knee graduated compression stockings than in those with thigh- high graduated compression stockings.114 Finally, CLOTS 3 enrolled 2876 patients (376 with ICH) and found that intermit- tent pneumatic compression begun as early as the day of hos- pital admission reduced the occurrence of proximal DVT, with Hemphill et al Management of Spontaneous ICH 2039 the effect being particularly prominent in patients with hem- orrhagic stroke (6.7% versus 17.0%, odds ratio [OR], 0.36; 95% confidence interval, [CI] 0.17 0.75).116 A meta-analysis of anticoagulant drugs for thromboprophylaxis that included 1000 ICH patients from 4 trials (2 randomized) and evalu- ated the early use of enoxaparin or heparin (from 1 to 6 days after admission) found a reduction in PE (1.7% versus 2.9%; relative risk [RR], 0.37; 95% CI, 0.17 0.80), a nonsignificant CI, 0.57 1.03), but no difference in DVT (4.2% versus 3.3%; RR, 0.77; 95% CI, 0.44 1.34) or hematoma enlargement ICH patients who develop DVT or PE may be consid- ered for full systemic anticoagulation or placement of an inferior vena cava (IVC) filter. 