Prevention of stroke with ticagrelor in patients with prior myocardial infarction: insights from PEGASUS-TIMI 54 (Prevention of Cardiovascular Events in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin-Thrombolysis in Myocardial Infarction 54). (1524-4539 (Electronic)). 279. Proietti M, Airaksinen KEJ, Rubboli A, et al. Time in therapeutic range and major adverse outcomes in atrial brillation patients undergoing percutaneous coronary intervention: the Atrial Fibrillation Undergoing Coronary Artery Stenting (AFCAS) registry. Am Heart J. 2017;190:86-93. 280. Chaudhary N, Bundhun PK, Yan H. Comparing the clinical outcomes in patients with atrial brillation receiving dual antiplatelet therapy and patients receiving an addition of an anticoagulant after coronary stent implantation: a systematic review and meta-analysis of observational studies. Medicine (Baltimore). 2016;95(50):e5581. 281. Zhu W, Guo L, Liu F, et al. Ef cacy and safety of triple versus dual antithrombotic therapy in atrial brillation and ischemic heart disease: a systematic review and meta-analysis. Oncotarget. 2017;8(46):81154-81166. 282. Bennaghmouch N, de Veer AJWM, Bode K, et al. Ef cacy and safety of the use of non-vitamin K antagonist oral anticoagulants in patients with nonvalvular atrial brillation and concomitant aspirin therapy: a meta-analysis of randomized trials. Circulation. 2018;137(11):1117-1129. 283. Lamberts M, Gislason GH, Olesen JB, et al. Oral anticoagulation and antiplatelets in atrial brillation patients after myocardial infarction and coronary intervention. J Am Coll Cardiol. 2013;62(11):981-989. 284. Dewilde WJ, Oirbans T, Verheugt FW, et al. Use of clopidogrel with or without aspirin in patients taking oral anticoagulant therapy and undergoing percutaneous coronary intervention: an open-label, randomised, controlled trial. Lancet. 2013;381(9872): 1107-1115. 285. Fiedler KA, Maeng M, Mehilli J, et al. Duration of triple therapy in patients requiring oral anticoagulation after drug-eluting stent implantation: the ISAR-TRIPLE Trial. J Am Coll Cardiol. 2015;65(16):1619-1629. 286. Gibson CM, Mehran R, Bode C, et al. 