Disclaimer: The views expressed do not represent those of the NHLBI, the National Institute of Diabetes and Digestive and Kidney Diseases, the National Institutes of Health, or the federal government. Additional Contributions: We thank Cory V. Evans, MPP, who at the time of the project was a senior research analyst and contract lead for JNC 8 with Leidos (formerly Science Applications International Corporation) and Linda J. Lux, MPA, RTI International, for their support. We also thank Lawrence J. Fine, MD, DrPH, NHLBI, for his work with the panel. Those named here were compensated in their roles as consultants on the project. REFERENCES 1. Staessen JA, Fagard R, Thijs L, et al; The Systolic Hypertension in Europe (Syst-Eur) Trial Investigators. Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension. Lancet. 1997;350(9080):757-764. 2. Beckett NS, Peters R, Fletcher AE, et al; HYVET Study Group. Treatment of hypertension in patients 80 years of age or older. N Engl J Med. 2008;358(18):1887-1898. 3. SHEP Cooperative Research Group. Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension: final results of the Systolic Hypertension in the Elderly Program (SHEP). JAMA. 1991;265(24):3255- 3264. 4. Institute of Medicine. Clinical Practice Guidelines We Can Trust. Washington, DC: National Academies /Clinical-Practice-Guidelines-We-Can-Trust.aspx. Accessed November 4, 2013. 5. Hsu CC, Sandford BA. The Delphi technique: making sense of consensus. Pract Assess Res Eval. 2007;12(10). http://pareonline.net/pdf/v12n10.pdf. Accessed October 28, 2013. 6. Institute of Medicine. Finding What Works in Health Care: Standards for Systematic Reviews. Washington, DC: National Academies Press; 2011. Works-in-Health-Care-Standards-for-systematic- Reviews.aspx. Accessed November 6, 2013. 7. Cushman WC, Evans GW, Byington RP, et al; ACCORD Study Group. Effects of intensive blood-pressure control in type 2 diabetes mellitus. N Engl J Med. 2010;362(17):1575-1585. 8. 