analyses Randomized controlled trials/systematic review/meta-analysis hedge [see Search Limits at the end of this table] #10 Apply limits See Search Limits at the end of the table Question Strategies to improve patient tolerance to statins Dyslipidemia dyslipidemia/exp OR 'hypercholesterolemia'/exp OR cholesterol/exp OR lipid/de OR (dyslipidemia* OR dyslipidaemia* OR dyslipidproteinemia* OR dyslipidproteinaemia* OR hyperlipidemia* OR hyperlipidaemia* OR hypercholesterolemia* OR hypercholesterolaemia* OR hyperlipoproteinemia* OR hyperlipoproteinaemia* OR hypertriglyceridemia* OR hypertriglyceridaemia* OR hyperlipemia OR hyperlipaemia):ti,ab OR ((high OR elevated OR low) NEAR/5 (cholesteryl* OR cholesterol* OR lipid* OR lipoprotein* OR tryglycer* OR triaclyglycer* OR "HDL-C" OR "LDL-C" OR "HDL C" OR "LDL C")):ti,ab #2 CVD 'cardiovascular disease'/exp/mj/dm_pc OR 'cardiovascular disease'/de OR 'hypertension'/exp OR 'ischemic heart disease'/exp OR 'heart disease'/de OR 'coronary artery disease'/exp OR 'peripheral vascular disease'/exp OR 'cerebral artery disease'/exp OR 'brain ischemia'/exp OR 'cerebrovascular accident'/exp OR 'cerebrovascular disease'/exp OR 'heart infarction'/exp OR ((heart* OR cardio* OR cardiac* OR coronary OR vascular OR cerebrovascular OR artery OR arteries) NEAR/5 (disease* OR syndrome* OR event* OR ischem* OR ischaem* OR plaque*)):ti,de OR (hyperten* OR atherosclero* OR arteriosclero* OR angina OR (Heart NEXT/1 attack*) OR (myocardial NEXT/1 infarct*) OR stroke* OR (cerebrovascular tolerance/adheren ce/ substitution (controlled terms) ('hydroxymethylglutaryl coenzyme A reductase inhibitor'/exp OR 'hypocholesterolemic agent'/exp) AND ('medication compliance'/exp OR 'patient compliance'/exp OR 'drug substitution'/exp OR 'drug dose intensification'/exp OR 'drug dose reduction'/exp) #4 Statin tolerance/ adherence/ substitution (keywords) ((hydroxymethylglutaryl or hydroxy-methylglutaryl) NEAR/5 reductase*) OR "HMG CoA" or statin* or lovastatin or meglutol or pravastatin or atorvastatin or simvastatin):ti,ab AND (tolerate* or tolerance or adher* or nonadherence* or non-adherence or ((alternat* or low or lower or high or higher or increase or decrease) NEXT/3 dose or dosing or dosag*)):ti,ab analyses Randomized controlled trials/systematic review/meta-analysis hedge [see Search Limits at the end of this table] #8 Apply limits See Search Limits at the end of this table Question Set # Concept Strategy Questions Pertaining to non-pharmacologic treatment including cost #1 Dyslipidemia dyslipidemia/exp OR 'hypercholesterolemia'/exp OR cholesterol/exp OR lipid/de OR (dyslipidemia* OR dyslipidaemia* OR dyslipidproteinemia* OR dyslipidproteinaemia* OR hyperlipidemia* OR hyperlipidaemia* OR hypercholesterolemia* OR hypercholesterolaemia* OR hyperlipoproteinemia* OR hyperlipoproteinaemia* OR hypertriglyceridemia* OR hypertriglyceridaemia* OR hyperlipemia OR hyperlipaemia):ti,ab OR ((high OR elevated OR low) NEAR/5 (cholesteryl* OR cholesterol* OR lipid* OR lipoprotein* OR tryglycer* OR triaclyglycer* OR "HDL-C" OR "LDL-C" OR "HDL C" OR "LDL C")):ti,ab #2 CV risk ('cardiovascular disease'/exp/mj OR 'hypertension'/exp/mj OR 'ischemic heart disease'/exp/mj OR 'heart disease'/mj OR 'coronary artery disease'/exp/mj OR 'peripheral vascular disease'/exp/mj OR 'cerebral artery disease'/exp/mj OR 'brain ischemia'/exp/mj OR 'cerebrovascular accident'/exp/mj OR 'cerebrovascular disease'/exp/mj OR 'heart infarction'/exp/mj OR ((heart* OR cardio* OR cardiac* OR coronary OR vascular OR cerebrovascular OR artery OR arteries) NEAR/5 (disease* OR syndrome* OR event* OR ischem* OR ischaem* OR plaque*)):ti OR (hyperten* OR atherosclero* OR arteriosclero* OR angina OR (Heart NEXT/1 attack*) OR (myocardial NEXT/1 infarct*) OR stroke* OR (cerebrovascular NEXT/1 accident*)):ti) AND (risk* OR prevent*):ti supplements/ neutraceuticals 'dietary supplement'/exp OR 'plant medicinal product'/exp OR 'omega 3 fatty acid'/exp OR 'vitamin'/de OR garlic/exp OR 'dietary fiber'/exp OR 'ginger'/exp OR 'phytosterol'/exp OR 'ispagula'/exp OR 'tea'/exp OR (((diet OR dietary) NEAR/5 supplement*) OR neutraceutical* OR ((omega* OR marine) NEXT/3 fatty) or "fish oil" OR ((eicosapentaenoic OR docosahexaenoic) NEXT/1 acid*) OR icosapent ethyl OR ((diet* OR soluable) NEAR/5 fiber) OR garlic OR ginger OR phytosterol* OR (plant NEXT/2 sterol*) OR (green NEXT/1 tea*) OR niacin* OR psyllium):ti #4 Diet therapy 'diet therapy'/exp OR ((Diet or diets or dietary or nutrition) and ("low sodium" or "low fat" or (gluten next/2 free) or "low gluten" or "low carb" or "low carbohydrate" or "low calorie" or vegetarian or vegan or macrobiotic or Mediterranean or DASH)):ti or "diabetic diet":ti or (dietary next/1 approach* NEXT/1 stop NEXT/1 hypertension):ti or diet*:ti #5 Exercise 'exercise'/exp OR (aerobics OR dance OR dancing OR exercise* OR fitness OR kinesiotherapy OR "muscle strengthening" OR "physical activity" OR "physical conditioning" OR "plyometric training" OR "resistance training" OR "strength training" OR "tai chi" OR "tai-chi" OR walk* OR "weight lifting" OR yoga OR swim OR swimming OR run OR running OR "weight training"):ti #6 Outcomes of interest 'secondary prevention'/exp OR 'primary prevention'/exp OR 'prevention and control'/exp OR 'treatment outcome'/exp OR 'morbidity'/exp OR 'mortality'/exp OR 'all cause mortality'/exp OR 'cerebrovascular accident'/exp OR 'heart infarction'/exp OR 'unstable angina pectoris'/exp OR (stroke* OR (cerebrovascular NEXT/1 accident*) OR morbidity OR mortality OR death OR (heart NEXT/1 attack*) OR (myocardial NEXT/1 infarct*) OR ((vascular OR cardiac OR coronary OR cerebrovascular) NEXT/2 event*) OR (heart NEXT/1 infarct*)):ti,ab OR (morbidity OR mortality OR prevent* OR outcome*):ti,ab OR (secondary NEXT/1 prevention):ti,ab OR (primary NEXT/1 prevention):ti,ab OR angina:ti,ab OR ((cholesteryl* OR cholesterol* OR lipid* OR lipoprotein* OR tryglycer* OR triaclyglycer* OR "HDL-C" OR "LDL-C" OR "HDL C" OR "LDL C") AND (level OR levels OR lower OR low OR reduce OR reduction OR profile*)):ti,ab OR ('adverse event'/exp OR 'side effect'/exp OR 'safety'/de OR ((side NEXT/1 effect*) OR (adverse NEXT/1 event*) OR safe OR safety):ti,ab #7 Combine sets including outcomes of interest Question Set # Concept Strategy Questions Pertaining to non-pharmacologic treatment including cost (cont.) 