ISBN: Index Test (Threshold) No of studies n Quality Sensitivity % Specificity % Positive Predictive Value (PPV) % Negative Predictive Value (NPV) % AUC NT-pro BNP Men 50 years due to serious risk of bias, serious indirectness NT-pro BNP Men 50 years due to serious risk of bias, serious indirectness NT-pro BNP due to serious inconsistency, serious imprecision Pooledf: Pooledf: NT-pro BNP Women 50 years due to serious risk of bias, serious indirectness NT-pro BNP Men 50 years due to serious risk of bias, serious indirectness NT-pro BNP NT-pro BNP Women 50 years due to serious risk of bias, serious indirectness, serious imprecision NT-pro BNP due to serious inconsistency, very serious imprecision Pooledf: Pooledf: Diagnosing heart failure Chronic Heart Failure NICE 2018. All rights reserved. Subject to Notice of rights. ISBN: Index Test (Threshold) No of studies n Quality Sensitivity % Specificity % Positive Predictive Value (PPV) % Negative Predictive Value (NPV) % AUC NT-pro BNP g VERY LOWb,d due to serious inconsistency, very serious imprecision Pooledf: Pooledf: NT-pro BNP [Threshold data not accurately reported] due to serious risk of bias, serious indirectness - - 0.74 The assessment was conducted with an emphasis on test sensitivity as this was identified by the GC as the primary measure in guiding decision making (except for the very high rule in thresholds of 400 ng/mL BNP and 2000 ng/mL NT-proBNP where specificity was the emphasis). The GC set the sensitivity threshold of 95% as an acceptable level to recommend a test. (a) Risk of bias was assessed using the QUADAS-2 checklist. The evidence was downgraded by 1 increment if the majority of studies were rated at high risk of bias, and downgraded by 2 increments if the majority of studies were rated at very high risk of bias. 