Sep 2019;37(9):1768-1774. PMID: 30986788. 150. Liu L, Xu B, Ju Y. Addition of spironolactone in patients with resistant hypertension: A meta-analysis of randomized controlled trials. Clin Exp Hypertens. 2017;39(3):257-263. PMID: 28448185. 151. Wang C, Xiong B, Huang J. Efficacy and safety of spironolactone in patients with resistant hypertension: A meta-analysis of randomised controlled trials. Heart Lung Circ. Oct 2016;25(10):1021-1030. PMID: 27118266. 152. Makai P, IntHout J, Deinum J, Jenniskens K, Wilt GJV. A network meta-analysis of clinical management strategies for treatment-resistant hypertension: Making optimal use of the evidence. J Gen Intern Med. Aug 2017;32(8):921-930. PMID: 28275946. 153. Williams B, MacDonald TM, Morant SV, et al. Endocrine and haemodynamic changes in resistant hypertension, and blood pressure responses to spironolactone or amiloride: The PATHWAY-2 mechanisms substudies. Lancet Diabetes Endocrinol. Jun 2018;6(6):464-475. PMID: 29655877. 154. Krieger EM, Drager LF, Giorgi DMA, et al. Spironolactone versus clonidine as a fourth-drug therapy for resistant hypertension: The ReHOT randomized study (Resistant Hypertension Optimal Treatment). Hypertension. Apr 2018;71(4):681-690. PMID: 29463627. 155. Rossignol P, Claggett BL, Liu J, et al. Spironolactone and resistant hypertension in heart failure with preserved ejection fraction. Am J Hypertens. Mar 10 2018;31(4):407-414. PMID: 29228101. 156. Agency for Health Research and Quality. The effective health care program stakeholder guide appendix d: Research questions & PICO(TS) 2011. https://www.ahrq.gov/research/findings/evidence-based- reports/stakeholderguide/appendixc.html. 157. Guyatt GH, Oxman AD, Kunz R, et al. GRADE guidelines: 2. Framing the question and deciding on important outcomes. J Clin Epidemiol. Apr 2011;64(4):395-400. PMID: 21194891. 158. Andrews J, Guyatt G, Oxman AD, et al. GRADE guidelines: 14. Going from evidence to recommendations: The significance and presentation of recommendations. J Clin Epidemiol. Jul 2013;66(7):719-725. PMID: 23312392. 159. National Heart Lung and Blood Institute. Your guide to lowering your blood pressure with DASH: DASH eating plan: Lower your blood pressure. Bethesda, Md. U.S. Dept. 