[2008] 1.4.4 Ensure that protocols are in place for delivering and managing intravenous thrombolysis, including post-thrombolysis complications. Thrombectomy for people with acute ischaemic stroke 1.4.5 Offer thrombectomy as soon as possible and within 6 hours of symptom onset, together with intravenous thrombolysis (if not contraindicated and within the licensed time window), to people who have: acute ischaemic stroke and confirmed occlusion of the proximal anterior circulation demonstrated by computed tomographic angiography (CTA) or magnetic resonance angiography (MRA) taking into account the factors in recommendation 1.4.8 (see additional 1.4.6 Offer thrombectomy as soon as possible to people who were last known to be well between 6 hours and 24 hours previously (including wake-up strokes): who have acute ischaemic stroke and confirmed occlusion of the proximal anterior circulation demonstrated by CTA or MRA and 2022 if there is the potential to salvage brain tissue, as shown by imaging such as CT perfusion or diffusion-weighted MRI sequences showing limited infarct core volume taking into account the factors in recommendation 1.4.8 (see additional 1.4.7 Consider thrombectomy together with intravenous thrombolysis (where not contraindicated and within the licensed time window) as soon as possible for people last known to be well up to 24 hours previously (including wake-up strokes): who have acute ischaemic stroke and confirmed occlusion of the proximal posterior circulation (that is, basilar or posterior cerebral artery) demonstrated by CTA or MRA and if there is the potential to salvage brain tissue, as shown by imaging such as CT perfusion or diffusion-weighted MRI sequences showing limited infarct core volume taking into account the factors in recommendation 1.4.8 (see additional 1.4.8 Take into account the person's overall clinical status and the extent of established infarction on initial brain imaging to inform decisions about thrombectomy. 