2008;358: 2319 31. 1045. Greilich PE, Jessen ME, Satyanarayana N, et al. The effect of epsilon- aminocaproic acid and aprotinin on fibrinolysis and blood loss in patients undergoing primary, isolated coronary artery bypass surgery: a randomized, double-blind, placebo-controlled, noninferiority trial. Anesth Analg. 2009;109:15 24. 1046. Kikura M, Levy JH, Tanaka KA, et al. A double-blind, placebo- controlled trial of epsilon-aminocaproic acid for reducing blood loss in coronary artery bypass grafting surgery. J Am Coll Surg. 2006;202: 216 22. 1047. Mehr-Aein A, Sadeghi M, Madani-civi M. Does tranexamic acid reduce blood loss in off-pump coronary artery bypass? Asian Car- diovasc Thorac Ann. 2007;15:285 9. 1048. Mehr-Aein A, Davoodi S, Madani-civi M. Effects of tranexamic acid and autotransfusion in coronary artery bypass. Asian Cardiovasc Thorac Ann. 2007;15:49 53. 1049. Murphy GJ, Mango E, Lucchetti V, et al. A randomized trial of tranexamic acid in combination with cell salvage plus a meta-analysis of randomized trials evaluating tranexamic acid in off-pump coronary artery bypass grafting. J Thorac Cardiovasc Surg. 2006;132:475 80, e1 8. 1050. Santos AT, Kalil RA, Bauemann C, et al. A randomized, double-blind, and placebo-controlled study with tranexamic acid of bleeding and fibrinolytic activity after primary coronary artery bypass grafting. Braz J Med Biol Res. 2006;39:63 9. 1051. Taghaddomi RJ, Mirzaee A, Attar AS, et al. Tranexamic acid reduces blood loss in off-pump coronary artery bypass surgery. J Cardiothorac Vasc Anesth. 2009;23:312 5. 1052. Paone G, Spencer T, Silverman NA. Blood conservation in coronary artery surgery. Surgery. 1994;116:672 7. 1053. Nuttall GA, Oliver WC, Santrach PJ, et al. efficacy of a simple intraoperative transfusion algorithm for nonerythrocyte component uti- lization after cardiopulmonary bypass. Anesthesiology. 2001;94: 773 81. 1054. Royston D, von Kier S. Reduced haemostatic factor transfusion using heparinase-modified thrombelastography during cardiopulmonary bypass. Br J Anaesth. 2001;86:575 8. 1055. 