HF indicates heart failure; IV, intravenous; and N/A, not applicable. * In the absence of contraindications to anticoagulation. Yancy et al. JACC Vol. 62, No. 16, 2013 2013 ACCF/AHA Heart Failure Guidelines: Executive Summary October 15, 2013:1495 539 6.3.2.9. DRUGS OF UNPROVEN VALUE OR THAT MAY WORSEN HF CLASS III: NO BENEFIT 1. Nutritional supplements as treatment for HF are not rec- ommended in patients with current or prior symptoms of HFrEF (231,232). (Level of Evidence: B) 2. Hormonal therapies other than to correct de ciencies are not recommended for patients with current or prior symp- toms of HFrEF. (Level of Evidence: C) CLASS III: HARM 1. Drugs known to adversely affect the clinical status of patients with current or prior symptoms of HFrEF are potentially harmful and should be avoided or withdrawn Table 11. 