For example, the available data are insufficient to determine if race, obesity, renal dysfunc- tion, PAD, or previous coronary revascularization af- fected the comparative outcomes of CABG and PCI. 2. Most of the patients enrolled in these trials were male, and most had 1- or 2-vessel CAD and normal LV systolic function (EF .50%) subjects known to be unlikely to derive a survival benefit and less likely to experience complications after CABG.412 3. The patients enrolled in these trials represented only a small fraction (generally ,5% to 10%) of those who were screened. For example, most screened patients with 1-vessel CAD and many with 3-vessel CAD were not considered for randomization. See Online Data Supplements 5 and 6 for additional data on CABG versus PCI. 5.6.2. CABG Versus DES Although the results of 9 observational studies comparing CABG and DES implantation have been published,964,1081 1088 most of them had short (12 to 24 months) follow-up periods. In a meta-analysis of 24 268 patients with multivessel CAD treated with CABG or DES,1089 the incidences of death and MI were similar for the 2 procedures, but the frequency with which repeat revascularization was performed was roughly 4 times higher after DES implantation. Only 1 large RCT comparing CABG and DES implantation has been published. The SYNTAX trial randomly assigned 1800 patients (of a total of 4337 who were screened) to receive DES or CABG.949,950,980 MACE, a composite of death, stroke, MI, or repeat revascularization during the 3 years after randomiza- tion, occurred in 20.2% of CABG patients and 28.0% of those undergoing DES implantation (P,0.001). 