Synopsis In the United States, hypertension accounts for more ASCVD deaths than any other modifiable ASCVD risk The prevalence of hypertension (defined as systolic blood pressure [SBP] 130 mm Hg or diastolic blood pressure [DBP] 80 mm Hg) among US adults is 46%; is higher in blacks than in whites, Asians, and Hispanic Americans; and increases dramatically with In a meta-analysis of 61 prospec- tive studies, a log-linear association was observed be- tween SBP levels <115 to >180 mm Hg and DBP lev- els <75 to 105 mm Hg and risk of ASCVD.S4.4-55 In that analysis, 20 mm Hg higher SBP and 10 mm Hg higher DBP were each associated with a doubling in the risk of death from stroke, heart disease, or other vascular disease. An increased risk of ASCVD associated with higher SBP and DBP has been reported across a broad age spectrum, from 30 to >80 years of age. Although the relative risk of incident CVD associated with higher SBP and DBP is smaller at older ages, the correspond- ing high BP-related increase in absolute risk is larger in older persons ( 65 years) given the higher absolute risk of CVD at an older age.S4.4-55 See Figure 4 for the BP thresholds and treatment recommendations algorithm and refer to the 2017 Hypertension Clinical Practice Guidelines for comprehensive details.S4.4-1 Recommendation-Specific Supportive Text 1. 