could be used as add-on therapy Key Question 8 Initial therapy various combinations of: thiazide-type diuretic + ACEI, thiazide-type diuretic + ARB, thiazide-type diuretic + ARB, thiazide-type diuretic + beta blocker, thiazide-type diuretic + CCB, ACEI + CCB, ARB + CCB Note: Interventions were not limited to combination within one tablet Key Question 9 Addition of a fourth drug (any) Initial three medications should include (all in maximum tolerated doses): long-acting dihydropyridine CCB, renin-angiotensin system blocker (ACEI or ARB), thiazide-type diuretic Key Question 10 Telehealth visit with primary care or sub-specialty Telehealth monitoring Mobile apps Instead of or in addition to usual care (in-person visits) Key Question 11 Clinical provider other than prescribers, such as clinical pharmacists, nurses, etc. (In-person or via telehealth) Instead or in addition to usual care (in-person visits) Key Question 12 Screening for asymptomatic CKD with eGFR and urine protein (albumin) measurement Screening for asymptomatic CAD with electrocardiogram (ECG) and calcium score Screening for asymptomatic left ventricular hypertrophy (LVH) with ECG and echocardiogram (ECHO) Screening for asymptomatic peripheral vascular disease (PVD) with carotid ultrasound (US) and ankle-brachial index (ABI) At diagnosis and whether should be repeated at certain intervals c. Comparators Key Question 1 Other method of blood pressure measurement Key Question 2 No monitoring Standard of care office blood pressure Other forms of monitoring listed in intervention Key Question 3 Standard care No intervention Wait list Active intervention unrelated to weight or blood pressure Other intervention listed in intervention column Placebo Sham surgery Different frequency or amount Key Question 4 Standard of care No intervention Wait list Active intervention unrelated to blood pressure Other intervention listed in intervention column Different frequency or amount Key Question 5 Comparator group has a different systolic blood pressure goal or range (i.e.