With proper education, it is expected that most patients will be amenable to a change in statin or an intermittent dosing schedule. Since statins have the most robust safety and clinical outcome databases of any treatment for dyslipidemia, the Work Group determined any measures that continue statin therapy were preferred over other, less robust interventions. There appeared to be no harms to re-challenging nor intermittent nondaily dosing and statins are associated with improved clinical outcomes. Thus, the Work Group decided upon a Weak for recommendation. Randomized clinical trials that evaluate the relationship between vitamin D replacement or supplementation and statin-induced myopathy are needed. Recommendation 24. We suggest offering intensified patient care (e.g., phone calls, emails, patient education, drug regimen simplification) to improve adherence to lipid-lowering medications. (Weak for | Reviewed, New-added) Discussion In a systematic review of 35 RCTs (n=925,171), Van Driel et al. (2016) examined strategies to improve patient adherence to lipid-lowering medications.[121] The systematic review found adherence to lipid- lowering medication was improved after intensified patient care. When compared to standard care, these interventions demonstrated significantly better adherence rates and a decrease in cholesterol levels in both the short term (<6 months) and long term (>6 months). Overall, patients in the intensified care group were twice as likely to be adherent to statin treatment short term, and almost three times as likely to continue treatment long term. Intensified care included drug regimen simplification, patient education and information, intensified patient follow-up with reminders via mail, telephone, and hand-held pill devices, complex behavioral approaches, group sessions, decision support systems, administrative improvements, or large-scale pharmacy-led automated telephone sessions. Intensified care was delivered by different healthcare providers, including pharmacists, nurses, and physicians. Not all interventions among studies included in Van Driel et al. (2016) resulted in positive outcomes. 