Yes 4.2 When systematic reviews are conducted specifically to inform particular guidelines, the GDG and systematic review team should interact regarding the scope, approach, and output of both processes. Yes 5. Establishing Evidence Foundations for and Rating Strength of Recommendations 5.1 For each recommendation, the following should be provided: An explanation of the reasoning underlying the recommendation, including Yes a clear description of potential benefits and harms; Yes a summary of relevant available evidence (and evidentiary gaps), description of the quality (including applicability), quantity (including completeness), and consistency of the aggregate available evidence; Yes IOM Standards for Developing Trustworthy Clinical Practice Guidelines Part of KDIGO Process? an explanation of the part played by values, opinion, theory, and clinical experience in deriving the recommendation. Yes A rating of the level of confidence in (certainty regarding) the evidence underpinning the recommendation Yes A rating of the strength of the recommendation in light of the preceding bullets Yes A description and explanation of any differences of opinion regarding the recommendation Yes 6. Articulation of Recommendations 6.1 Recommendations should be articulated in a standardized form detailing precisely what the recommended action is, and under what circumstances it should be performed. Yes 6.2 Strong recommendations should be worded so that compliance with the recommendation(s) can be evaluated. Yes 7. External Review 7.1 External reviewers should comprise a full spectrum of relevant stakeholders, including scientific and clinical experts, organizations (e.g., health care, specialty societies), agencies (e.g., federal government), patients, and representatives of the public. Yes 7.2 The authorship of external reviews submitted by individuals and/or organizations should be kept confidential unless that protection has been waived by the reviewer(s). 