2012;10:33. S10.1.1-20. Jafar TH, Stark PC, Schmid CH, et al. Progression of chronic kid- ney disease: the role of blood pressure control, proteinuria, and angiotensin-converting enzyme inhibition: a patient-level meta- analysis. Ann Intern Med. 2003;139:244 52. S10.1.1-21. Law MR, Morris JK, Wald NJ. Use of blood pressure lower- ing drugs in the prevention of cardiovascular disease: meta- analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies. BMJ. 2009;338: b1665. 10.2. Sex-Related Issues S10.2-1. Benjamin EJ, Blaha MJ, Chiuve SE, et al. Heart disease and stroke statistics 2017 update: a report from the American Heart Association. Circulation. 2017;135:e146 603. S10.2-2. Gueyffier F, Boutitie F, Boissel JP, et al. Effect of antihyperten- sive drug treatment on cardiovascular outcomes in women and men. A meta-analysis of individual patient data from randomized, controlled trials. The INDANA Investigators. Ann Intern Med. 1997;126:761 7. S10.2-3. Turnbull F, Woodward M, Neal B, et al. Do men and women respond differently to blood pressure-lowering treatment? Results of prospectively designed overviews of randomized trials. Eur Heart J. 2008;29:2669 80. S10.2.1-1. Turnbull F, Woodward M, Neal B, et al. Do men and women respond differently to blood pressure-lowering treatment? Results of prospectively designed overviews of randomized trials. Eur Heart J. 2008;29:2669 80. S10.2.1-2. Wenger NK, Ferdinand KC, Bairey Merz CN, et al. Women, hypertension, and the Systolic Blood Pressure Intervention Trial. Am J Med. 2016;129:1030 6. S10.2.1-3. FletcherA, Beevers DG, Bulpitt C, et al. Beta adrenoceptor block- ade is associated with increased survival in male but not female hypertensive patients: a report from the DHSS Hypertension Care Computing Project (DHCCP). J Hum Hypertens. 1988;2:219 27. S10.2.1-4. Jansen J, Bonner C, McKinn S, et al. General practitioners' use of absolute risk versus individual risk factors in cardiovas- cular disease prevention: an experimental study. BMJ OPEN. 2014;4:e004812. 