Local resources and expertise, specific clinical circumstances and patient preferences, and evidence published since the issuance of these guidelines are some of the additional factors that should be considered when making individual patient care decisions. In many instances, only limited data exist demonstrating the urgent need for con- tinued research on treatment of AIS. A focused update addressing data from additional relevant recent RCTs is in process. Powers et al 2019 Guidelines for Management of AIS e347 Table 2. 