a Included in evidence profile for other outcomes. methods for guideline development categorized by baseline proteinuria status in summary tables for the CKD with diabetes mellitus topic. For studies not exclusively examining CKD population, only those reporting analysis by CKD subgroups were tabulated. Studies including both diabetes mellitus and non-diabetes mellitus populations were included in summary tables for the CKD without diabetes mellitus topic unless results of subgroup analysis by diabetes mellitus status was provided. Work Group members proofed all summary table data and quality assessments. Summary tables are available at www.kdigo.org. Evidence profiles Evidence profiles were constructed to assess the quality and record quality grades and descriptions of effect for each outcome across studies, as well as the quality of overall evidence and description of net benefits or harms of the intervention or comparator across all outcomes. These profiles aim to make the evidence synthesis process transparent. Decisions in the evidence profiles were based on data from the primary studies listed in corresponding summary tables and on judgments of the ERT and the Work Group. When the body of evidence for a particular comparison of interest consisted of only one study, the summary table provided the final level of synthesis and an evidence profile was not generated. Evidence profiles were also not created for studies that did not exclusively examine CKD population. Each evidence profile was initially con- structed by the ERT and then reviewed, edited, and approved by the Work Group. The work products created by the ERT for summarizing the evidence base are listed in Table 9. Grading of quality of evidence for outcomes of individual studies Methodological quality. Methodological quality (internal validity) refers to the design, conduct, and reporting of outcomes of a clinical study. 