The proband with arrhythmogenic right ven- tricular cardiomyopathy is usually diagnosed by the presence of clinical symptoms along with the presence of arrhythmogenic right ventricu- lar cardiomyopathy Task Force criteria including: abnormalities on ECG, structural and functional changes of either ventricle, arrhythmias, and arrhythmogenic right ventricular cardiomyopathy in first-degree relatives.S7.3-6 A pathogenic genetic mutation was added to the major Task Force criteria in 2010.S7.3-44 The yield of genetic test- ing in probands with suspected arrhythmogenic right ventricular cardiomyopathy is generally 30% to 54%, and is up to 58% among patients with a strong family history of SCD in multiple A negative genetic test for arrhythmogenic right ventricular cardiomyop- athy does not exclude the disease, and a positive genetic test currently does not guide therapy.S7.3-22 For the proband with a clinical diagnosis of arrhythmogenic right ventricular cardiomyopathy, identification of pathogenic mutations provides limited prognostic information relative to the risk or development of HF.S7.3-22 In a large multicenter study, the presence of posi- tive mutations among probands was not asso- ciated with a difference in mortality or cardiac CLINICAL STATEMENTS AND GUIDELINES However, the identification of a pathogenic mutation facilitates targeted genetic screening for that mutation in first- degree relatives, that may identify approximately highest among siblings, and those with symptoms.S7.3-4 Screening for the specific mutation can identify some gene positive family members prior to disease expres- sion, while relieving others from the need for life- style changes and long-term monitoring.S7.3-2,S7.3-3 7. Syncope is reported in 16% to 39% of arrhythmo- genic right ventricular cardiomyopathy patients at the time of diagnosis,S7.3-13,S7.3-14,S7.3-16,S7.3-41,S7.3-43 is frequently exercise-related, and has been associated with high arrhythmic risk in some Among patients with arrhyth- mogenic right ventricular cardiomyopathy and implanted ICDs, syncope was an important pre- dictor of appropriate shocks in 1 study,S7.3-10 but not in other studies.S7.3-9,S7.3-12,S7.3-13,S7.3-43 Studies have not provided information about ventricular function or abnormalities on ECG in patients with syncope, limiting its assessment as an indepen- dent risk factor. 