Increased physical activity, preferably aerobic physical activity (eg, brisk walking) for 150 minutes/ week (equal to 30 minutes/day on most days of the week), is recommended for initial weight loss.S4.1-10 Higher levels of physical activity, approximately 200 to 300 minutes/week, are recommended to main- tain weight loss or minimize weight regain after 1 year. Adults with obesity are also typically prescribed a diet designed to reduce caloric intake by 500 kcal/ day from baseline, which often can be attained by limiting women to 1200 to 1500 kcal/day and men A very-low-calorie diet (defined as <800 kcal/day) should be prescribed only in limited circumstances and only by trained clinicians in a medical care setting with the patient under medical supervision.S4.1-10 Comprehensive life- style intervention has been shown to produce on average 8 kg of weight loss (5% to 10% of initial body weight) in the short term ( 6 months) and intermediate term (6 to 12 months), compared with However, longer interventions after 1 year are associated with gradual weight gain of 1 or 2 kg/year (on average), compared with usual care. Weight loss of 5% to 10% of initial weight, achieved through comprehensive lifestyle interven- tion, has been shown to improve BP, delay the onset of T2DM, improve glycemic control in T2DM, and improve lipid profile.S4.1-1,S4.1-2 3. Measures used to estimate body fat and quan- tify the associated health risks include BMI, waist CLINICAL STATEMENTS AND GUIDELINES circumference, waist hip ratio, bioimpedance, and dual-energy X-ray absorptiometry (DXA).S4.1-18 BMI, waist circumference, and waist hip ratio are easily measured and therefore are the most widely used in clinical practice. 