For example, if a high quality, directly Chronic Heart Failure Methods NICE 2018. All rights reserved. Subject to Notice of rights. ISBN: 978-1-4731-3093-7 applicable UK analysis was available, then other less relevant studies may not have been included. Where exclusions occurred on this basis, this is noted in the relevant section. For more details about the assessment of applicability and methodological quality see Table 8 below and the economic evaluation checklist (appendix H of the NICE guidelines manual236 ) and the health economics review protocol in appendix B. When no relevant health economic studies were found from the economic literature review, relevant UK NHS unit costs related to the compared interventions were presented to the committee to inform the possible economic implications of the recommendations. 4.4.1.2 NICE health economic evidence profiles NICE health economic evidence profile tables were used to summarise cost and cost-effectiveness estimates for the included health economic studies in each review chapter. The health economic evidence profile shows an assessment of applicability and methodological quality for each economic study, with footnotes indicating the reasons for the assessment. These assessments were made by the health economist using the economic evaluation checklist from the NICE guidelines manual.236 It also shows the incremental costs, incremental effects (for example, quality-adjusted life years [QALYs]) and incremental cost-effectiveness ratio (ICER) for the base case analysis in the study, as well as information about the assessment of uncertainty in the analysis. See Table 8 for more details. When a non-UK study was included in the profile, the results were converted into pounds sterling using the appropriate purchasing power parity.249 Table 8: Content of NICE health economic evidence profile Item Description Study Surname of first author, date of study publication and country perspective with a reference to full information on the study. 