#7 Combine sets including outcomes of interest Question Set # Concept Strategy Questions Pertaining to non-pharmacologic treatment including cost (cont.) #8 Combine sets without outcomes of interest #9 Limit to RCTs Randomized controlled trials hedge [see Search Limits at the end of this table] #10 Limit to SRs/Meta- analysis Systematic review/meta-analysis hedge [see Search Limits at the end of this table] #11 Limit to cost studies 'health care cost'/exp OR 'cost effectiveness analysis'/exp OR 'cost benefit analysis'/exp OR 'economic evaluation'/exp OR 'quality adjusted life year'/exp OR (cost OR costs OR costly OR costing OR price OR prices OR saving OR savings OR economi* OR financial OR finance* OR pharmacoeconomic* OR QALY or QALYs OR (quality NEXT/1 adjusted NEXT/1 life NEXT/1 year*) or (quality NEXT/1 adjusted life NEXT/1 expectanc*)):ti,ab #15 Apply limits See Search Limits at the end of this table Search Limits Applied to Each Search Limit to humans and items published since searches were conducted for 2014 CPG AND (english language and humans); limit 18 to ed=20131209-2019 Exclude conference publications, books, letters, editorials, case studies, etc. NOT ("column/opinion" OR "comment/reply" OR dissertation OR editorial OR letter OR book).dt. OR book.pt. OR letter/ or editorial/ or news/ or comment/ or case report or case reports/ or note/ or conference paper/ or (letter or editorial or news or comment or case reports or conference abstract*).pt. OR (child* or teen* or adolescen* or school* or baby or babies or infant* or neonat* or pediatric* or kid or kids or preschool*).ti. Limit to meta- analyses and SRs AND ('systematic review'/exp OR 'systematic review' OR 'meta analysis'/exp OR 'meta analysis') Limit to RCTs AND (Randomized controlled trials or random allocation or double-blind method or single-blind method or placebos or cross-over studies).de. or placebo*.mp. or random*.ti. or randomized controlled trial.pt. OR crossover*.mp. or cross over.mp. 