2004;6:636 42. S6-4. Whelton PK, Appel LJ, Espeland MA, et al. Sodium reduction and weight loss in the treatment of hypertension in older persons: a randomized controlled trial of nonpharmacologic interventions in the elderly (TONE). TONE Collaborative Research Group. JAMA. 1998;279:839 46. S6-5. Whelton PK. The elusiveness of population-wide high blood pres- sure control. Annu Rev Public Health. 2015;36:109 30. S6.1-1. National High Blood Pressure Education Program Working Group report on primary prevention of hypertension. Arch Intern Med. 1993;153:186 208. S6.1-2. Cook NR, Cutler JA, Obarzanek E, et al. Long term effects of dietary sodium reduction on cardiovascular disease outcomes: observational follow-up of the Trials of Hypertension Prevention (TOHP). BMJ. 2007;334:885 8. S6.1-3. Rodgers A, MacMahon S. Blood pressure and the global bur- den of cardiovascular disease. Clin Exp Hypertens. 1999;21: 543 52. S6.1-4. Qin X, Jackson R, Marshall R, et al. Modelling the potential impact of population-wide and targeted high-risk blood pressure-lowering strategies on cardiovascular disease in China. Eur J Cardiovasc Prev Rehabil. 2009;16:96 101. S6.1-5. Zulman DM, Vijan S, Omenn GS, et al. The relative merits of population-based and targeted prevention strategies. Milbank Q. 2008;86:557 80. 6.2. Nonpharmacological Interventions S6.2-1. Neter JE, Stam BE, Kok FJ, et al. Influence of weight reduction on blood pressure: a meta-analysis of randomized controlled trials. Hypertension. 2003;42:878 84. S6.2-2. Whelton PK, Kumanyika SK, Cook NR, et al. Efficacy of nonphar- macologic interventions in adults with high-normal blood pres- sure: results from phase 1 of the Trials of Hypertension Prevention. Trials of Hypertension Prevention Collaborative Research Group. Am J Clin Nutr. 1997;65:652S 60S. S6.2-3. The effects of nonpharmacologic interventions on blood pres- sure of persons with high normal levels. Results of the Trials of Hypertension Prevention, Phase I. JAMA. 1992;267:1213 20. S6.2-4. 