Their ancestry goes from Europe to America, including among these, individuals from the Caribbean, Mexico, Central and South America. ASCVD indicates atherosclerotic cardiovascular disease; BP, blood pressure; CAC, coronary artery calcium; CAD, coronary artery disease; CK, creatine kinase; CVD, cardiovascular disease; DASH, Dietary Approaches to Stop Hypertension; DM, type 2 diabetes mellitus; FDA, US Food and Drug Administration; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; MESA, Multi-Ethnic Study of Atherosclerosis; MetS, metabolic syndrome; and PCE, pooled cohort equations. Table 10. Continued Racial/Ethnic Groupings Asian * Hispanic/Latino Blacks/African Comments CLINICAL STATEMENTS AND GUIDELINES IIa B-R In adults 40 to 75 years of age with moderate or severe hypertriglyceridemia and ASCVD risk of 7.5% or higher, it is reasonable to reevaluate ASCVD risk after lifestyle and secondary factors are addressed and to consider a persistently elevated triglyceride level as a factor favoring initiation or intensification of statin therapy (see Section 4.4.2.).S4.5.2-2 S4.5.2-6 IIa B-R In adults 40 to 75 years of age with severe hypertriglyceridemia (fasting triglycerides 500 mg/dL [ 5.6 mmol/L]) and ASCVD risk of 7.5% or higher, it is reasonable to address reversible causes of high triglyceride and to initiate statin therapy.S4.5.2-3 S4.5.2-5,S4.5.2-7,S4.5.2-8 IIa B-NR In adults with severe hypertriglyceridemia (fasting triglycerides 500 mg/dL [ 5.7 mmol/L]), and especially fasting triglycerides 1000 mg/dL (11.3 mmol/L)), it is reasonable to identify and address other causes of hypertriglyceridemia), and if triglycerides are persistently elevated or increasing, to further reduce triglycerides by implementation of a very low-fat diet, avoidance of refined carbohydrates and alcohol, consumption of omega-3 fatty acids, and, if necessary to prevent acute pancreatitis, fibrate Synopsis Two categories of hypertriglyceridemia consist of moder- ate hypertriglyceridemia (fasting or nonfasting triglycer- ides 175-499 mg/dL [2.0-5.6 mmol/L]) and severe hyper- triglyceridemia (fasting triglycerides 500 mg/dL [ 5.6 mmol/L]). 