In general, there is more knowledge on the risk for SCD in patients with aortic stenosis than other valvular lesions with a risk of 1% to 1.5% per year.S10.6-2 Most patients who die suddenly have been symptomatic from their Although recurrent NSVT may place a patient with severe aortic stenosis at risk for syncope, the management of such a patient is guided by the severity of the valvular lesion. Mitral valve prolapse has been implicated as a cause of SCD, although a study of 18786 patients found no increased risk of SCA for patients with bileaflet mitral valve prolapse versus single leaflet mitral valve prolapse or no mitral valve prolapse.S10.6-5 LV fibrosis in the papil- lary muscles has been described in some mitral valve prolapse patients with VA or SCD.S10.6-6 Further, a possi- ble syndrome for SCD has been described that includes bileaflet mitral valve prolapse, female sex, T wave ab- normality, and complex ventricular ectopy.S10.6-7 Guid- ance for treatment of patients with NICM, whether val- vular or otherwise in origin, is provided in the current guideline (see Sections 7.2.1 and 7.2.2 for primary and secondary prevention). 10.6. Sex-Related Differences in the Risk of SCD The information on associations between sex and VA and SCD is largely limited to epidemiological, cohort, and observational studies. Various population studies, primarily focused on SCD due to ischemic heart disease, have demonstrated age gradients in SCD risk among men and women.S10.6-8 S10.6-10 These include a 10-year lag in SCD incidence in women compared with men. 