This predisposition to thrombosis has raised concerns that hormone therapy may cause adverse events at the time of CABG. A prospective RCT comparing hormone therapy to placebo in postmenopausal women after CABG was initiated in 1998 but was stopped when the Women s Health Initiative trial results were reported.589 Eighty-three subjects were enrolled, and 45 underwent angiographic follow-up at 42 months. Angiographic progression of CAD in nonbypassed coronary arteries was greater in patients receiving hormone therapy, although less progression of disease was observed in SVGs. Postoperative angioplasty was performed in 8 hor- mone therapy patients and only 1 placebo subject (P 0.05). On the basis of these data, it is not recommended that post-menopausal hormone therapy be initiated in women undergoing CABG, and it may be reasonable to discontinue it in those scheduled for elective CABG. 4.4.3. CABG in Patients With Hypothyroidism Subclinical hypothyroidism (thyroid-stimulating hormone concentration, 4.50 mIU/L to 19.9 mIU/L) occurs commonly in patients with CAD. In a meta-analysis of 55 000 subjects with CAD, those with subclinical hypothyroidism did not have an increase in total deaths, but the CAD mortality rate was increased, particularly in those with thyroid-stimulating The risks of CABG in hypothyroid patients are poorly defined. 