(b) Downgraded by one increment as confidence interval crosses one MID or two increments as confidence interval crosses both MID. 9.2.3.3 Low risk, Long, Case-management Referral and approach to care Chronic Heart Failure NICE 2018. All rights reserved. Subject to Notice of rights. ISBN: Table 124: Clinical Evidence Summary: HICMann (Peters-Klimm 2010): Non-specialist case management (MDTcm) vs Primary care (1 control) >6 months for HFREF Outcomes No of Participant s (studies) Follow up Quality of the evidence (GRADE) Relative effect Anticipated absolute effects Risk with primary care Risk difference with MDTcm VERY LOWa, b due to risk of bias, imprecision rate ratio (from 82 fewer to 351 more) VERY LOWa, b due to risk of bias, imprecision (from 35 fewer to 131 more) Quality of life Kansas City Cardiomyopathy Questionnaire, final score. higher=better. Scale from: 0 to 100. VERY LOWa, b due to risk of bias, imprecision The KCCQ final score in the control groups was The mean KCCQ in the intervention groups was 1.70 higher (better) (3.28 lower to 6.68 higher) Quality of life (physical) SF-36 physical health composite, final score. higher=better. Scale from: 0 to 100. LOWa due to risk of bias The mean SF-physical in the control groups was The mean SF-physical in the intervention groups was 0.3 lower (worse) (3.25 lower to 2.65 higher) Quality of life (mental) SF-36 mental health composite, final score. higher=better. Scale from: 0 to 100. LOWa due to risk of bias The mean SF-mental in the control groups was The mean SF-mental in the intervention groups was 0.1 lower (worse) (3.5 lower to 3.5 higher) Prescribed double therapy of ACE-I/ARB and B- blocker LOWa due to risk of bias (from 115 fewer to 144 more) Referral and approach to care Chronic Heart Failure NICE 2018. All rights reserved. 