Airway, Breathing, and Oxygenation COR LOE New, Revised, or Unchanged Airway support and ventilatory assistance are recommended for the treatment of patients with acute stroke who have decreased consciousness or who have bulbar dysfunction that causes compromise of the airway. I C-EO Recommendation and COR unchanged from 2013 AIS Guidelines. LOE amended to conform with ACC/AHA 2015 Recommendation Classification System. Supplemental oxygen should be provided to maintain oxygen saturation >94%. I C-LD Recommendation and COR unchanged from 2013 AIS Guidelines. LOE amended to conform with ACC/AHA 2015 Recommendation Classification System. 3. Supplemental oxygen is not recommended in nonhypoxic patients with AIS. III: No Benefit B-R Recommendation unchanged from 2013 AIS Guidelines. COR and LOE amended to conform with ACC/AHA 2015 Recommendation Classification System. Additional support for this unchanged recommendation from the 2013 AIS Guidelines is provided by an RCT of 8003 participants randomized within 24 hours of admission. There was no benefit on functional outcome at 90 days of oxygen by nasal cannula at 2 L/min (baseline O2 continuously for 72 hours or nocturnally for 3 nights.112 See Table XXVII in online Data Supplement 1. Hyperbaric oxygen (HBO) is not recommended for patients with AIS except when caused by air embolization. III: No Benefit B-NR Recommendation revised from 2013 AIS Guidelines. The limited data available on the utility of HBO therapy for AIS (not related to cerebral air embolism) show no HBO therapy is associated with claustrophobia and middle ear barotrauma,114 as well as an increased risk of seizures.115 Given the confines of HBO chambers, the ability to closely/adequately monitor patients may also be compromised. HBO thus should be offered only in the context of a clinical trial or to individuals with cerebral air embolism. See Table XXVIII in online Data Supplement 1. 3.2. Blood Pressure 3.2. 