Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med. 2011;365:883 891. doi: 10.1056/NEJMoa1009638. 73. Connolly SJ, Eikelboom J, Joyner C, Diener HC, Hart R, Golitsyn S, Flaker G, Avezum A, Hohnloser SH, Diaz R, Talajic M, Zhu J, Pais P, Budaj A, Parkhomenko A, Jansky P, Commerford P, Tan RS, Sim KH, Lewis BS,Van Mieghem W, Lip GY, Kim JH, Lanas-Zanetti F, Gonzalez- Hermosillo A, Dans AL, Munawar M, O Donnell M, Lawrence J, Lewis G, Afzal R, Yusuf S; AVERROES Steering Committee and Investigators. Apixaban in patients with atrial fibrillation. N Engl J Med. 2011;364:806 817. doi: 10.1056/NEJMoa1007432. 74. Chatterjee S, Sardar P, Biondi-Zoccai G, Kumbhani DJ. New oral anticoagulants and the risk of intracranial hemorrhage: traditional and Bayesian meta-analysis and mixed treatment comparison of random- ized trials of new oral anticoagulants in atrial fibrillation. JAMA Neurol. 2013;70:1486 1490. doi: 10.1001/jamaneurol.2013.4021. 75. Schulman S, Bijsterveld NR. Anticoagulants and their reversal. Transfus Med Rev. 2007;21:37 48. doi: 10.1016/j.tmrv.2006.08.002. 76. Holbrook A, Schulman S, Witt DM, Vandvik PO, Fish J, Kovacs MJ, Svensson PJ, Veenstra DL, Crowther M, Guyatt GH; American College of Chest Physicians. Evidence-based management of anticoagulant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice chest.11-2295. 77. Hanley JP. Warfarin reversal. J Clin Pathol. 2004;57:1132 1139. doi: 10.1136/jcp.2003.008904. 78. Dentali F, Ageno W, Crowther M. Treatment of coumarin-associated coag- ulopathy: a systematic review and proposed treatment algorithms. J Thromb Haemost. 2006;4:1853 1863. doi: 10.1111/j.1538-7836.2006.01986.x. 79. Goldstein JN, Thomas SH, Frontiero V, Joseph A, Engel C, Snider R, Smith EE, Greenberg SM, Rosand J. Timing of fresh frozen plasma administration and rapid correction of coagulopathy in warfarin-related intracerebral hemorrhage. Stroke. 2006;37:151 155. doi: 10.1161/01. STR.0000195047.21562.23. 80. Leissinger CA, Blatt PM, Hoots WK, Ewenstein B. 