Although the quality of the evidence has improved, the overall quality is still low because of very serious imprecision. Unchanged from AT9, we propose that the patients who are most likely to bene t from CDT have iliofemoral DVT, symptoms for <14 days, good functional status, life expectancy of $1 year, and a low risk of bleeding (Tables 14 and 15, e-Table 15). Because the balance of risks and bene ts with CDT is TABLE 14 ] Summary of Findings: Catheter-Assisted Thrombus Removal vs Anticoagulation Alone for Acute Leg DVT Outcomes No. of Participants (Studies) Follow-up Quality of the Evidence (GRADE) Relative Effect Anticipated Absolute Effects Risk with Anticoagulation Alone Risk Difference with Catheter-Assisted Thrombus Removal (95% CI) All-cause mortality Lowa,b because of imprecision (from 43 fewer to 54 more) Recurrent VTE 189 Lowa,b because of imprecision Moderate-Risk Populatione (from 34 fewer to 12 more) Major bleeding 224 studies) Lowa,b because of imprecision Moderate-Risk Populatione,f (from 17 fewer to 1000 more) Moderatea because of imprecision Moderate-Risk Populationh (from 265 fewer to 0 more)i Moderateb because of imprecision (from 41 more to 386 more) Moderatek because of risk of bias The mean quality of life in the intervention groups was 0.2 higher (2.8 lower to 3 higher)l,m The basis for the assumed risk (eg, the median control group risk across studies) is provided in the footnotes. The corresponding risk (and its 95% CI) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CAVENT Catheter-Directed Venous Thrombolysis in Acute Iliofemoral Vein Thrombosis; EQ-5D EuroQol 5 Dimensions; PTS postthrombotic syndrome; QoL quality of life. See Table 1 and 4 legends for expansion of other abbreviations and GRADE Working Group grades of evidence. 