Intensity of statin therapy and response to LDL- Clowering Japanese patients may be sensitive to statin dosing. In an open-label, randomized primaryprevention trial, Japanese participants had a reduction in CVD events with low- intensity doses of pravastatin as compared with placebo.S4.5.1-33 In a secondary-prevention trial, Japanese participants with CAD benefitted from a moderate-intensity dose of No sensitivity to statin dosage is seen, as compared with non-Hispanic white or black individuals. No sensitivity to statin dosage is seen, as compared with non-Hispanic white individuals. Using a lower statin intensity in Japanese patients may give results similar to those seen with higher intensities in non-Japanese patients. Safety Higher rosuvastatin plasma levels are seen in Japanese, Chinese, Malay, and Asian Indians as compared FDA recommends a lower starting dose (5 mg of rosuvastatin in Asians vs. 10 mg in whites). Caution is urged as dose is uptitrated There are no specific safety issues with statins related to Hispanic/Latino Baseline serum CK values are higher in blacks than in The 95th percentile race/ ethnicity- specific and sexspecific serum CK normal levels are available for assessing changes in serum CK. Clinicians should take Asian race into account when prescribing dose of rosuvastatin (See package insert). In adults of East Asian descent, other statins should be used preferentially over *The term Asian characterizes a diverse portion of the world s population. Individuals from Bangladesh, India, Nepal, Pakistan, and Sri Lanka make up most of the South Asian group.S4.5.1-26 Individuals from Japan, Korea, and China make up most of the East Asian group. The term Hispanics/Latinos in the United States characterizes a diverse population group. This includes white, black, and Native American races. Their ancestry goes from Europe to America, including among these, individuals from the Caribbean, Mexico, Central and South America. 