Now that multiple agents are available, a com- parison of their use in various settings within clinical practice is provided. This iteration replaces the sections in the 2007 ACC/AHA Guidelines for the Management of Patients With Unstable Angina/Non ST-Elevation Myo- that were updated by the 2011 ACCF/ AHA Focused Update of the Guidelines for the Manage- ment of Patients With Unstable Angina/Non ST-Elevation To provide clinicians with a comprehensive set of data, whenever deemed appropriate or when published, the abso- lute risk difference and number needed to treat or harm are provided in the guideline, along with confidence intervals (CI) and data related to the relative treatment effects such as odds ratio (OR), relative risk (RR), hazard ratio (HR), and incidence rate ratio. Consult the full-text version of the 2007 ACC/AHA Guidelines for the Management of Patients With Unstable Angina/Non ST-Elevation Myocardial Infarction4 for policy on clinical areas not covered by the current document. Individual recommendations updated in this focused update will be incorporated into future revisions and/or updates of the full-text guidelines. 1.2. Organization of the Writing Group For this focused update, members of the 2011 Unstable Angina/Non ST-Elevation Myocardial Infarction (UA/ NSTEMI) focused update writing group were invited and all agreed to participate (referred to as the 2012 focused update writing group). Members were required to disclose all RWI relevant to the data under consideration. The writing group included representatives from the ACCF, AHA, American Academy of Family Physicians, American College of Emer- gency Physicians, American College of Physicians, Society for Cardiovascular Angiography and Interventions, and So- ciety of Thoracic Surgeons. 1.3. 