One study was included in the review63 which is summarised in Table 143 below. The study was a HTA report which was stopped early due to poor adherence to the prescribed oxygen therapy in the intervention arm of the trial. Evidence from this study is summarised in the clinical evidence summary below (Table 144). See also the study selection flow chart in appendix C, forest plots in appendix E, study evidence tables in appendix F, GRADE tables in appendix H and excluded studies list in appendix I. The study originally included a third arm which comprised nocturnal oxygen therapy (assumed to be 8 hours per night). This arm of the trial was dropped before trial completion due to problems with both centre and patient recruitment. The study authors reported data for this arm of the trial for several outcomes including quality of life. The study authors conducted an exploratory analysis, including all 3 treatment arms and found no significant difference between the nocturnal therapy (NOT) and long term oxygen therapy (LTOT) arms, therefore the authors combined these arms and compared them against the best medical therapy (BMT) arm for participants recruited up until 30 April 2013. To avoid double counting and maximise the number of participants analysed in either arm we have not included this comparison and included only the data reported for LTOT versus BMT at 3 months for this outcome. Table 143: Summary of studies included in the review Study Intervention and comparison Population Outcomes Comments Intervention 1: Long term oxygen therapy (LTOT) prescribed for 15 hours per day including overnight hours. 