ISBN: 978-1-4731-3093-7 Study Population Target condition Index test Reference standard Comments Switzerland Diagnosing heart failure Chronic Heart Failure NICE 2018. All rights reserved. Subject to Notice of rights. ISBN: Table 12: Clinical evidence summary: diagnostic test accuracy for index test(s) BNP and NT-proBNP Index Test (Threshold) No of studies n Quality Sensitivity % Specificity % Positive Predictive Value (PPV) % Negative Predictive Value (NPV) % AUC Plasma BNP BNP - 100 pg/mL 2e Axsym Centaur BNP - 178 pg/mL 1 105 VERY LOWa,c,d due to serious risk of bias, serious indirectness, serious imprecision BNP - 400 pg/mL 1e Axsym Centaur [Threshold data not accurately reported] due to serious risk of bias, serious indirectness - - - - 0.69 Plasma NT-proBNP NT-pro BNP Age specific thresholds NT-pro BNP Women 50 years due to serious risk of bias, serious indirectness Diagnosing heart failure Chronic Heart Failure NICE 2018. All rights reserved. Subject to Notice of rights. ISBN: Index Test (Threshold) No of studies n Quality Sensitivity % Specificity % Positive Predictive Value (PPV) % Negative Predictive Value (NPV) % AUC NT-pro BNP Men 50 years due to serious risk of bias, serious indirectness NT-pro BNP Men 50 years due to serious risk of bias, serious indirectness NT-pro BNP due to serious inconsistency, serious imprecision Pooledf: Pooledf: NT-pro BNP Women 50 years due to serious risk of bias, serious indirectness NT-pro BNP Men 50 years due to serious risk of bias, serious indirectness NT-pro BNP NT-pro BNP Women 50 years due to serious risk of bias, serious indirectness, serious imprecision NT-pro BNP due to serious inconsistency, very serious imprecision Pooledf: Pooledf: Diagnosing heart failure Chronic Heart Failure NICE 2018. All rights reserved. Subject to Notice of rights. 