Among 32,000 Medicare patients ($65 y) with myocardial infrac- tion who were treated with thrombolytic therapy, the following factors were independently associated with intracranial haemorrhage: age $75 y (OR, 1.6); black (OR, 1.6); female (OR, 1.4); previous stroke (OR, 1.5); systolic BP $160 mm Hg (OR, 1.8); women #65 kg or men # 80 kg (OR, 1.5); The rate of intracranial hemorrhage increased from 0.7% with 0 or 1 of these risk factors, to 4.1% with $5 risk factors. Among 32,000 patients with myocardial infraction who were treated with thrombolytic therapy in 5 clinical trials, the following factors were indepen- dently associated with moderate or severe bleeding: older age (OR, 1.04 per year); black (OR, 1.4); female (OR, 1.5); hypertension (OR, 1.2); lower weight We estimate that systemic thrombolytic therapy is associated with relative risk of major bleeding of 3.5 within 35 d (RR, approximately 7 for intracranial bleeding); about three-quarters of the excess of major bleeds with thrombolytic therapy occur in the rst 24 h.141 336 Evidence-Based Medicine [ 1 4 9 # 2 C H E S T F E B R U A R Y 2 0 1 6 ] the PREPIC and PREPIC 2 studies because of differences in the type of lter used, the duration of lter placement, and differences in the length of follow-up. 17. In patients with acute DVT or PE who are treated with anticoagulants, we recommend against the use of an IVC lter (Grade 1B). Compression Stocking to Prevent PTS Summary of the Evidence AT9 suggested routine use of graduated compression stockings for 2 years after DVT to reduce the risk of PTS. 