For patients with hypertension and overweight/obesity, we suggest offering a diet directed at weight loss for the treatment of hypertension. (Weak for | Reviewed, New-added) Discussion The Work Group reviewed evidence on the effects of various weight loss interventions, including diet directed at weight loss which has been found to improve blood pressure in patients with HTN. One SR [108] and two RCTs [106,107] comprised the evidence base for diets directed at weight loss therapy. One SR, by Semlitsch et al. (2016), assessed the long-term effects of weight-reducing diets in people with HTN.[108] Three of the studies included in the SR by Semlitsch et al. (2016) examined the impact of diet versus no diet on SBP and DBP reduction (n=731);[108] there was further blood pressure reduction in the diet intervention group. One study included in the SR by Semlitsch et al. (2016) demonstrated significantly reduced cardiovascular morbidity in the diet intervention group. While the study was small, there was a large effect.[110] An RCT, by Kucharska et al. (2018), found that the Dietary Approaches to Stop Hypertension (DASH) diet reduced blood pressure in patients with overweight/obesity and HTN.[107] Another RCT, by Tay et al. (2014), studied the effects of a low-carbohydrate, high-unsaturated/low- saturated fat diet (LC) versus a high unrefined carbohydrate, low-fat diet (HC) on blood pressure reduction in patients with type 2 diabetes; results were inconclusive.[106] Confidence in the quality of the evidence is very low due to serious study limitations and imprecision. 