The GRADE system uses these four domains to assess the strength of each Balance of desirable and undesirable outcomes Confidence in the quality of the evidence Values and preferences Other implications, as appropriate, e.g.,: Resource use Equity Acceptability Feasibility Subgroup considerations Using these four domains, the Work Group determined the relative strength of each recommendation ( Strong or Weak ). A Strong recommendation generally indicates high confidence in the quality of the available scientific evidence, a clear difference in magnitude between the benefits and harms of an intervention, similar values and preferences, and understood influence of other implications (e.g., resource use, feasibility). If the Work Group has less confidence after the assessment across these domains and believes that additional evidence may change the recommendation, it generally assigns a Weak recommendation. It is important to distinguish GRADE terminology (i.e., Strong versus Weak ) from a recommendation s clinical importance. For instance, a Weak recommendation indicates the Work Group s assessment of the four domains outlined above. Despite the Weak strength supporting the recommendation, it may still be important to the clinical care of a patient with dyslipidemia. Occasionally, there is insufficient evidence to make a recommendation for or against a particular therapy or preventive measure, such as when there is an absence of studies that met evidence review inclusion criteria, or when studies included in the evidence review report had conflicting or inconclusive results. 