The Cockcroft- Gault formula is commonly used as a surrogate marker for estimating creatinine clearance, which in turn estimates glomerular filtration rate.298,299,779,780 Medications that require dosage adjustments in patients with CKD include eptifibatide, tirofiban, bivalirudin, enoxaparin, and fondaparinux.781 5.9.5. Cardiac Allografts Cardiac allograft vasculopathy is a major cause of death in cardiac transplant recipients after their first year of sur- vival.782 In general, revascularization for cardiac allograft vasculopathy with PCI is only palliative, with no evidence supporting benefit in regard to long-term survival or avoid- ance of retransplantation. The restenosis rate after PCI in patients with cardiac allograft vasculopathy is high, although stent implantation reduces early and midterm restenosis compared with balloon angioplasty. DES have been shown to have a tendency to lower restenosis rates compared with BMS.783,784 Thus, many clinicians perform stenting with DES or BMS in cardiac transplant patients with discrete lesions who have an abnormal stress test or symptoms suggestive of myocardial ischemia. 5.10. Periprocedural MI Assessment: Recommendations Class I 1. In patients who have signs or symptoms suggestive of MI during or after PCI or in asymptomatic patients with significant persistent angiographic complications (eg, large side-branch occlusion, flow-limiting dissec- tion, no-reflow phenomenon, or coronary thrombosis), creatine kinase-MB and/or troponin I or T should be measured. (Level of Evidence: C) Class IIb 1. Routine measurement of cardiac biomarkers (crea- tine kinase-MB and/or troponin I or T) in all pa- tients after PCI may be reasonable. (Level of Evi- dence: C) Major events leading to ischemia or MI after PCI include acute closure, embolization and no-reflow, side-branch oc- clusion, and acute stent thrombosis. Issues surrounding the routine assessment of cardiac biomarkers after PCI are complex, especially given that the definition of PCI-related MI has evolved over the years and most events are asymp- tomatic. 