ISBN: Outcomes No of Participants (studies) Follow up Quality of the evidence (GRADE) Relative effect Anticipated absolute effects Risk with centre-based exercise training Risk difference with home-based exercise training (95% CI) Adherence to intervention VERY LOWa,b due to risk of bias, imprecision (from 102 more to 338 more) Adherence to intervention (Hwang MODERATEb due to imprecision f The mean adherence to intervention in the intervention group was (a) Downgraded by 1 increment if the majority of the evidence was at high risk of bias, and downgraded by 2 increments if the majority of the evidence was at very high risk of bias. (b) Downgraded by 1 increment if the confidence interval crossed one MID or by 2 increments if the confidence interval crossed both MIDs. (c) Heterogeneity, I2=54%, downgraded by 1 increment. (d) The outcome data for adherence to intervention was not meta-analysed as there was a significant degree of variation in the methods of obtaining this information across studies. (e) Unable to estimate as one of the studies included in the meta-analysis only reported the mean difference. The outcome has therefore been analysed using generic inverse variance. (f) Unable to calculate as the study only reported a mean difference. Chronic Heart Failure Rehabilitation in chronic heart failure NICE 2018. All rights reserved. Subject to Notice of rights. ISBN: 978-1-4731-3093-7 7.1.4 Economic evidence Published literature One health economic study was identified with the relevant comparison and has been included in This is summarised in the health economic evidence profile below (Table 77) and the health economic evidence table in appendix G. See also the health economic study selection flow chart in appendix D. Rehabilitation in chronic heart failure Chronic Heart Failure NICE 2018. All rights reserved. Subject to Notice of rights. 