OR (hyperten* OR atherosclero* OR arteriosclero* OR angina OR (Heart ADJ attack*) OR (myocardial ADJ infarct*) OR stroke* OR (cerebrovascular ADJ accident*)).ti. prediction/stratifica tion exp *risk factors/ OR exp*risk assessment/ OR ((risk or risks) ADJ4 (stratify or stratifying or stratification or define or defining or predict or prediction or assessment OR classif* OR prioritiz* OR category* OR tier* OR calculat* OR index OR indices OR score OR scores OR marker* OR biomarker* OR profile* OR algorithm* OR factor* OR characteristic*)).ti. OR (cardiovascular ADJ2 risk*).ti. #4 Risk stratification tools Lipids/an,bl OR exp Cholesterol/an,bl OR exp Ankle Brachial Index/ OR exp Galectin 3/ OR C-Reactive Protein/ OR exp Apolipoproteins B/ OR exp Carotid Intima-Media Thickness/ OR c-reactive protein/ or exp Troponin I/ OR ((framingham ADJ2 risk*) OR 'ankle brachial index' OR (coronary ADJ2 calcium) OR ('c reactive' ADJ2 protein*) OR 'hs-crp' OR 'hs crp' OR 'hscrp' OR 'ntprobnp' OR 'nt-probnp' OR 'hs-tnl' OR 'hs tnl' OR 'galecton 3' OR 'galecton-3' OR 'pooled cohort' OR (particle ADJ2 size*) OR (high ADJ sensitiv* ADJ troponin*) OR apolipoprotein* OR lipoprotein* OR (carotid ADJ1 intima* ADJ3 thickness*)).ti,ab. OR ((cholesteryl* OR cholesterol* OR lipid* OR lipoprotein* OR tryglycer* OR triaclyglycer* OR "HDL-C" OR "LDL-C" OR "HDL C" OR "LDL C" OR "non HDL C" OR "non-HDL C" OR "non-HDL-C") ADJ5 (level OR levels)).ti. #5 Outcomes of interest exp *Cardiovascular Diseases/pc OR exp primary prevention/ OR exp mortality/ OR exp morbidity/ OR exp death/ OR exp myocardial infarction/ OR cerebrovascular accident/ OR stroke/ OR exp Angina, Unstable/ OR (stroke* OR (cerebrovascular ADJ accident*) OR morbidity OR mortality OR death OR (heart ADJ attack*) OR (myocardial ADJ infarct*) OR ((vascular OR cardiac OR coronary OR cerebrovascular) ADJ2 event*) OR (heart ADJ infarct*)).ti,ab. OR (morbidity OR mortality OR prevent* OR outcome*).ti,ab. OR (secondary ADJ prevention).ti,ab. OR (primary ADJ prevention).ti,ab. 