Evidence in secondary pre- vention is drawn from the Lyon Diet Heart trial of the Mediterranean diet with supplemental canola compared with a usual post-MI prudent diet, producing low-quality evidence of reduced CVD mortality and total mortality (adjusted HR, 0.21 0.92], respectively) in a coronary heart One study in first stroke and matched control cases108 shows each unit (1 of 55) in MedDietScore is associated with a 17% lower likelihood of ischemic stroke in participants without hypercholesterolemia (95% CI, 0.72 0.96) and 10% lower likelihood in par- ticipants with hypercholesterolemia (95% CI, 0.81 0.99). 2. A meta-analysis of 13 prospective studies and follow-up, 3.5 19 years) identified that higher levels of habitual salt intake are associated with greater stroke risk (relative risk [RR], 1.23 [95% A Japanese population-based study identified that in men the highest compared with the lowest tertile of sodium intake recorded was significantly positively associated with death resulting from ischemic stroke (adjusted HR, 3.22 Meta-analysis in those with established CVD identified through long- term follow-up of participants in 5 salt-reducing reported a reduction of 1 g/d sodium (2.5 g/d salt) is associated with a 20% reduction in further cardiovascular events (RR, 0.80 [95% CI, identified that for a typical US diet in the 1990s (the con- trol diet), a reduction in sodium intake from 3.3 to 2.4 g/d reduced systolic BP (SBP) by 2.1 mmHg (P<0.001), and further reducing sodium intake from 2.4 to 1.5 g/d yielded additional reductions of 4.6 mmHg (P<0.001). The DASH diet was associated with a significantly lower SBP at each sodium level than the control diet. Table 4. 