Safety of prothrombin complex concentrates for rapid anticoagulation reversal of vitamin K antagonists. A meta-analysis. Thromb Haemost. 2011;106(3):429-438. 194. Connolly SJ, Milling TJ Jr, Eikelboom JW, et al; ANNEXA-4 Investigators. Andexanet alfa for acute major bleeding associated with factor Xa inhibitors. N Engl J Med. 2016;375(12):1131-1141. 195. Pollack CV Jr, Reilly PA, Eikelboom J, et al. Idarucizumab for dabigatran reversal. N Engl J Med. 2015;373(6):511-520. 196. Held V, Eisele P, Eschenfelder CC, Szabo K. Idarucizumab as antidote to intracerebral hemorrhage under treatment with dabigatran. Case Rep Neurol. 2016;8(3):224-228. 197. Pollack CV Jr, Reilly PA, van Ryn J, et al. Idarucizumab for dabigatran reversal - full cohort analysis. N Engl J Med. 2017;377(5):431-441. 198. De Luca G, Parodi G, Antoniucci D. Safety and benefits of protamine administration to revert anticoagulation soon after coronary angioplasty. A meta- analysis. J Thromb Thrombolysis. 2010;30(4):452-458. 199. Newhall KA, Saunders EC, Larson RJ, Stone DH, Goodney PP. Use of protamine for anticoagulation during carotid endarterectomy: a meta-analysis. JAMA Surg. 2016;151(3):247-255. 200. Fearn SJ, Parry AD, Picton AJ, Mortimer AJ, McCollum CN. Should heparin be reversed after carotid endarterectomy? A randomised prospective trial. Eur J Vasc Endovasc Surg. 1997;13(4):394-397. 201. Pan M, Sua rez de Lezo J, Medina A, et al. In-laboratory removal of femoral sheath following protamine administration in patients having intracoronary stent implantation. Am J Cardiol. 1997;80(10):1336-1338. 202. Kaneda H, Suzuki J, Hosokawa G, Tanaka S, Hiroe Y, Saito S. Impact of heparin neutralization by protamine on restenosis after coronary stent implantation. Int J Cardiol. 2005;105(1):111-112. 203. Mauney MC, Buchanan SA, Lawrence WA, et al. Stroke rate is markedly reduced after carotid endarterectomy by avoidance of protamine. J Vasc Surg. 1995;22(3):264-269, discussion 269-270. 204. Levison JA, Faust GR, Halpern VJ, et al. Relationship of protamine dosing with postoperative complications of carotid endarterectomy. Ann Vasc Surg. 