For a video with instructions on measuring blood pressure at home, please click on the Home Blood Pressure Monitoring video available at this link: https://www.healthquality.va.gov/guidelines/CD/htn/ Abbreviations: A1c: glycated hemoglobin; ABPM: ambulatory blood pressure monitoring; ACEI: angiotensin-converting enzyme inhibitor; AOBP: automated office blood pressure; ARB: angiotensin II receptor blockers; AV: atrioventricular; CCB: calcium channel blocker; CHF: chronic heart failure; CKD: chronic kidney disease; cm: centimeter; CPG: clinical practice guideline; CV: cardiovascular; DASH: Dietary Approaches to Stop Hypertension; DBP: diastolic blood pressure; DHP: dihydropyridine; DoD: Department of Defense; EKG: electrocardiogram; HBPM: home blood pressure monitoring; Hg: mercury; HTN: hypertension; IR: immediate release; K+: potassium; LV: left ventricular; LVH: left ventricular hypertrophy; mg: milligram; MI: myocardial infarction; ml: milliliter; mm: millimeter; NSAIDs: nonsteroidal anti-inflammatory drugs; OSA: obstructive sleep apnea; SBP: systolic blood pressure; SDM: shared decision making; SR: sustained release; tbsp: tablespoon; VA: Department of Veterans Affairs a Sofrito is a sauce made with tomato and onion, and often includes garlic, herbs, and olive oil b Recommended wine volume per glass: 100 mL for women, 150 mL for men c Commercial baked goods, sweets, and pastries included cakes, cookies, biscuits, and custard, and did not include those that are homemade Select Antihypertensive Therapyb Select Medicationb Usual Dosage Range Comments Thiazide- Type Diuretics Chlorthalidone 12.5 25 mg daily May cause hyperuricemia/ gout Monitor K+ levels Hydrochlorothiazide 25 50 mg dailyc ACEIs Lisinopril 10 40 mg daily Avoid in pregnancy Do not use if history of angioedema Monitor K+ and kidney function ARBs Losartan (daily or divided Avoid in pregnancy Monitor K+ and kidney function Valsartan 30 320 mg daily Long-acting CCBs: DHP CCBs Amlodipine 2.5 10 mg daily May cause ankle edema, dizziness, flushing, headache, constipation Nifedipine SR 30 120 mg daily Long-acting CCBs: Non- DHP CCBs Verapamil SR (daily or divided Verapamil may cause constipation; contraindicated in 2nd or 3rd degree AV block; severe LV dysfunction Diltiazem SR 120 540 mg daily Diltiazem may decrease sinus rate; contraindicated in 2nd or 3rd degree AV block; use with caution in LV dysfunction a For complete drug information, review the manufacturer s prescribing information b Drug classes recommended as primary pharmacologic therapy for HTN for reduction in composite CV outcomes; selected medications include those listed on the VA National Formulary and DoD Basic Core Formulary; refer to the full HTN CPG for treatment recommendations and additional medications information c Hydochlorothiazide 12.5 mg may be considered as an initial dose with titration recommended to 25 50 mg daily; refer to Recommendation 25 and associated discussion in the full HTN CPG for further information