Furthermore, little is known about the impact of age, gender, and comorbidities like diabetes, CKD, CAD, or prior stroke on the response to specific medications in patients with RHT. VIII. Research Priorities During the development of the 2020 VA/DoD HTN CPG, the Work Group identified numerous areas for future research, including areas requiring stronger evidence to support current recommendations as well as research exploring new areas to guide future CPGs. A. Automated Office Blood Pressure and Out-of-office Blood Pressure Out-of-office blood pressure measurements were shown to be superior to routine office blood pressure measurements in predicting cardiovascular events; therefore, future studies should focus on impact of blood pressure management based on out-of-office blood pressure measurements on clinically relevant outcomes in hypertensive individuals. Further research is also needed to evaluate whether patient-related outcomes can be improved with management of HTN in the general population based on blood pressure targets obtained with AOBP that is being increasingly recognized as equivalent to out-of-office blood pressure. Additionally, variation in appropriate management for blood pressure variation by time of day and season should be included in future studies to determine the clinical significance. B. Self-monitoring of Blood Pressure Areas of research include the development of protocols allowing for self-management and self-adjustment of antihypertensive medications by hypertensive individuals, based on home self-monitoring of blood pressure and provider guidance. Furthermore, it is important to identify what specific hypertensive populations (demographic characteristics and comorbidities) would benefit the most from self-monitoring of blood pressure and what outcomes (blood pressure control, adherence, cardiovascular outcomes) may be improved with self-monitoring of blood pressure. 