Study details and results were taken from the first available source in the following hierarchy. The choice of source was based on utilising the advantages of individual patient data analysis while being able to present results for each study separately, stratified by age, wherever possible: individual patient-level data (IPD) from the meta-analysis in an NIHR funded HTA (Pufulete ) aggregate data from the same meta-analysis (Pufulete 2017273 ) based on the Troughton IPD meta-analysis IPD data from analysis of the Troughton 2014 meta-analysis55, 338 aggregate data from a Cochrane meta-analysis (McLellan 2016219 ) individual study reports A single study was included in the 2010 update (CG108) of this question30 . This paper has been excluded in the current review as it no longer matches the protocol. For further explanation please see the Recommendations and link to evidence. Table 79: Summary of systematic reviews included in the review Study Intervention and comparison (in HF clinic unless stated otherwise) Population Primary studies included McLellan, Cochrane systematic review NP guided therapy versus Usual care (review refers to as Health plan alone) Range of intervention times: 1- Anguita 2010, BATTLESCARRED, Berger 2010, Christchurch pilot, NorthStar, OPTIMA, PRIMA, PROTECT, Shochat 2012, SIGNAL- HF, STARS-BNP, TIME-CHF, UPSTEP Pufulete NIHR HTA NP guided therapy versus Usual care (review refers to as Symptom-guided therapy ) Stratified by age or over) analysis As IPD: Anguita 2010, NorthStar, Shochat Chronic Heart Failure Monitoring NICE 2018. All rights reserved. Subject to Notice of rights. 