McFarlane SI, Muniyappa R, Francisco R, Sowers JR. Clinical review 145: pleiotropic effects of statins: lipid reduction and beyond. J Clin Endocrinol Metab. 2002;87:1451 1458. doi: 10.1210/jcem.87.4.8412. 96. Werba JP, Tremoli E, Massironi P, Camera M, Cannata A, Alamanni F, Biglioli P, Parolari A. Statins in coronary bypass surgery: rationale and clinical use. Ann Thorac Surg. 2003;76:2132 2140. 97. Cimino M, Gelosa P, Gianella A, Nobili E, Tremoli E, Sironi L. Statins: multiple mechanisms of action in the ischemic brain. Neuroscientist. 2007;13:208 213. doi: 10.1177/1073858406297121. 98. Merla R, Daher IN, Ye Y, Uretsky BF, Birnbaum Y. Pretreatment with statins may reduce cardiovascular morbidity and mortality after elective surgery and percutaneous coronary intervention: clinical evidence and possible underlying mechanisms. Am Heart J. 2007;154:391 402. doi: 10.1016/j.ahj.2007.04.029. 99. Chello M, Patti G, Candura D, Mastrobuoni S, Di Sciascio G, Agr F, Carassiti M, Covino E. Effects of atorvastatin on systemic inflammatory response after coronary bypass surgery. Crit Care Med. 2006;34:660 667. doi: 10.1097/01.CCM.0000201407.89977.EA. 100. Chello M, Anselmi A, Spadaccio C, Patti G, Goffredo C, Di Sciascio G, Covino E. Simvastatin increases neutrophil apoptosis and reduces inflammatory reaction after coronary surgery. Ann Thorac Surg. 2007;83:1374 1380. doi: 10.1016/j.athoracsur.2006.10.065. 101. Nakamura K, Masuda H, Kariyazono H, Arima J, Iguro Y, Yamada K, Sakata R. Effects of atorvastatin and aspirin combined therapy on inflammatory responses in patients undergoing coronary artery bypass grafting. Cytokine. 2006;36:201 210. doi: 10.1016/j.cyto.2006.11.001. 102. Dereli Y, Ege E, Kurban S, Narin C, Sarig l A, Yeniterzi M. Pre- operative atorvastatin therapy to decrease the systemic inflamma- tory response after coronary artery bypass grafting. J Int Med Res. 2008;36:1248 1254. 103. Pound EM, Kang JX, LeafA. Partitioning of polyunsaturated fatty acids, which prevent cardiac arrhythmias, into phospholipid cell membranes. J Lipid Res. 2001;42:346 351. 104. 