Establish a fair procedure for resolving discrepancies do not simply give final decision-making power to the senior reviewer Single extraction 3.5.2 Link publications from the same study to avoid including data from the same study more than once Yes IOM Standards for Systematic Reviews Part of KDIGO Process? 3.5.3 Use standard data extraction forms developed for the specific SR Yes 3.5.4 Pilot-test the data extraction forms and process Yes 3.6 Critically appraise each study Yes 3.6.1 Systematically assess the risk of bias, using predefined criteria Yes 3.6.2 Assess the relevance of the study s populations, interventions, and outcome measures Yes 3.6.3 Assess the fidelity of the implementation of interventions Yes 4.1 Use a prespecified method to evaluate the body of evidence Yes 4.1.1 For each outcome, systematically assess the following characteristics of the body of evidence: Risk of bias; Consistency; Precision; Directness; Reporting bias Yes 4.1.2 For bodies of evidence that include observational research, also systematically assess the following characteristics for each outcome: Dose response association; Plausible confounding that would change the observed effect; Strength of association Yes 4.1.3 For each outcome specified in the protocol, use consistent language to characterize the level of confidence in the estimates of the effect of an intervention Yes 4.2 Conduct a qualitative synthesis Yes 4.2.1 Describe the clinical and methodological characteristics of the included studies, including their size, inclusion or exclusion of important subgroups, timeliness, and other relevant factors Yes 4.2.2 Describe the strengths and limitations of individual studies and patterns across studies Yes 4.2.3 Describe, in plain terms, how flaws in the design or execution of the study (or groups of studies) could bias the results, explaining the reasoning behind these judgments No 4.2.4 Describe the relationships between the characteristics of the individual studies and their reported findings and patterns across studies No 4.2.5 Discuss the relevance of individual studies to the populations, comparisons, cointerventions, settings, and outcomes or measures of interest No 4.3 Decide if, in addition to a qualitative analysis, the systematic review will include a quantitative analysis (meta-analysis) No 4.3.1 Explain why a pooled estimate might be useful to decision makers No 4.4 If conducting a meta-analysis, then do the following: Use expert methodologists to develop, execute, and peer review the meta-analyses Address the heterogeneity among study effects Accompany all estimates with measures of statistical uncertainty Assess the sensitivity of conclusions to changes in the protocol, assumptions N/A 5.1 Prepare final report using a structured format N/A 5.1.1 Include a report title N/A 5.1.2 Include an abstract N/A 5.1.3 Include an executive summary N/A 5.1.4 Include a summary written for the lay public N/A 5.1.5 Include an introduction (rationale and objectives) N/A 5.1.6 Include a methods section. 