treatments: non- statins Gemfibrozil/ or fenofibrate/ or niacin/ or exp Fatty Acids, Omega-3/ or exp Ezetimibe/ or exp Proprotein Convertase 9/tu or exp "Bile Acids and Salts"/tu OR (fibrate* or gemfibrozil or fenofibrate or bezafibrate or (nicotinic adj acid*) or niacin or (bile ADJ acid ADJ sequestrant*) or (bile ADJ acid ADJ resin*) or ezetimibe or (omega* ADJ3 fatty adj acid*) or "fish oil" or pcsk9 or pcsk-9 or "pcsk 9" or ((eicosapentaenoic or docosahexaenoic) ADJ acid*)).ti,ab. Question Set # Concept Strategy Questions Pertaining to pharmacologic treatment including cost (cont.) #5 Outcomes of interest Exp secondary prevention/ OR exp primary prevention/ OR exp mortality/ OR exp morbidity/ OR exp death/ OR exp myocardial infarction/ OR cerebrovascular accident/ OR stroke/ OR exp Angina, Unstable/ OR (stroke* OR (cerebrovascular ADJ accident*) OR morbidity OR mortality OR death OR (heart ADJ attack*) OR (myocardial ADJ infarct*) OR ((vascular OR cardiac OR coronary OR cerebrovascular) ADJ2 event*) OR (heart ADJ infarct*)).ti,ab. OR (morbidity OR mortality OR prevent* OR outcome*).ti,ab. OR (secondary ADJ prevention).ti,ab. OR (primary ADJ prevention).ti,ab. OR angina.ti,ab. OR ae.fs.OR to.fs. OR safety/ or exp patient harm/ OR ((side ADJ effect*) OR (adverse ADJ event*) OR safe OR safety).ti,ab. Additional outcome of interest for KQ 8 [change in lipid levels] ((cholesteryl* OR cholesterol* OR lipid* OR lipoprotein* OR tryglycer* OR triaclyglycer* OR "HDL-C" OR "LDL-C" OR "HDL C" OR "LDL C") AND (level OR levels OR lower OR low OR reduce OR reduction OR profile* OR target*)).ti,ab. 