(c) Downgraded due to indirectness as a proxy measure of quality of life was reported by the study. 9.2.3.1.8 High risk, Mid-length, Case-management Table 111: Clinical Evidence Summary: J-HOMECARE (Tsuchihashi-Makaya 2013): Mid-length Case management (MDTcm) vs Cardiology clinic for high risk HF Outcomes No of Participants (studies) Follow up Quality of the evidence (GRADE) Relative effect Anticipated absolute effects Risk with cardiology clinic Risk difference with MDTcm VERY LOWa,b,c estimated risk: (from 4 fewer to 148 fewer) Referral and approach to care Chronic Heart Failure NICE 2018. All rights reserved. Subject to Notice of rights. ISBN: Outcomes No of Participants (studies) Follow up Quality of the evidence (GRADE) Relative effect Anticipated absolute effects Risk with cardiology clinic Risk difference with MDTcm 12 months due to risk of bias, indirectness, imprecision VERY LOWa, c due to risk of bias, imprecision (from 58 fewer to 159 more) Quality of life (physical) SF-8 physical component, final score. higher=better. Scale from: 0 to 100. VERY LOWa,c due to risk of bias, imprecision The mean SF-8 physical in the control groups was The mean in the intervention groups was 2.00 higher (better) (1.18 lower to 5.18 higher) Quality of life (mental) SF-8 mental health component, final score. higher=better. Scale from: 0 to 100. LOWa due to risk of bias The mean SF-8 mental in the control groups was The mean quality of life (mental) in the intervention groups was 2.00 higher (better) (0.67 lower to 4.67 higher) (a) Downgraded by 1 increment if the majority of the evidence was at high risk of bias, and downgraded by 2 increments if the majority of the evidence was at very high risk of bias. (b) Downgraded for indirectness as not protocol outcome of count rates for hospitalisations. 