Comparison of different antithrombotic regimens for patients with atrial brilla- tion undergoing drug-eluting stent implantation. Circ J. 2010;74(4):701-708. 121. Rothberg MB, Celestin C, Fiore LD, Lawler E, Cook JR. Warfarin plus aspirin after myocardial infarction or the acute coronary syndrome: meta-analysis with estimates of risk and bene t. Ann Intern Med. 2005;143(4):241-250. therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical prac- tice guidelines. Chest. 2012;141(2)(suppl):e152S-e184S. 92. Bloom eld HE, Krause A, Greer N, et al. Meta-analysis: effect of patient self-testing and self-management of long- term anticoagulation on major clinical outcomes. Ann Intern Med. 2011;154(7):472-482. 93. Freeman JV, Zhu RP, Owens DK, et al. Cost-effectiveness of dabigatran compared with warfarin for stroke preven- tion in atrial brillation. Ann Intern Med. 2011;154(1):1-11. 94. Hughes M, Lip GY; Guideline Development Group for the NICE national clinical guideline for management of atrial brillation in primary and secondary care. Risk fac- tors for anticoagulation-related bleeding complications in patients with atrial brillation: a systematic review. QJM. 2007;100(10):599-607. 95. Beyth RJ, Quinn LM, Landefeld CS. Prospective evalua- tion of an index for predicting the risk of major bleeding in outpatients treated with warfarin. Am J Med. 1998;105(2): 91-99. 96. Landefeld CS, Goldman L. Major bleeding in outpatients treated with warfarin: incidence and prediction by fac- tors known at the start of outpatient therapy. Am J Med. 1989;87(2):144-152. 97. Shireman TI, Mahnken JD, Howard PA, Kresowik TF, Hou Q, Ellerbeck EF. Development of a contemporary bleeding risk model for elderly warfarin recipients. Chest. 2006;130(5):1390-1396. 98. Gage BF, Yan Y, Milligan PE, et al. Clinical classi cation schemes for predicting hemorrhage: results from the National Registry of Atrial Fibrillation (NRAF). Am Heart J. 2006;151(3):713-719. 99. Lip GY, Frison L, Halperin JL, Lane DA. 