, systems biology), or effective treatment interventions that reduce the progression from stage A to stage B is an urgent need. Presidents and Staff American College of Cardiology Foundation John Gordon Harold, MD, MACC, President Shalom Jacobovitz, Chief Executive Of cer William J. Oetgen, MD, MBA, FACC, Senior Vice President, Science and Quality Charlene L. May, Senior Director, Science and Clinical Policy American College of Cardiology Foundation/ American Heart Association Lisa Brad eld, CAE, Director, Science and Clinical Policy Debjani Mukherjee, MPH, Associate Director, Evidence- Based Medicine Ezaldeen Ramadhan III, Specialist, Science and Clinical Policy Sarah Jackson, MPH, Specialist, Science and Clinical Policy American Heart Association Donna K. Arnett, PhD, MD, FAHA, President Nancy Brown, Chief Executive Of cer Rose Marie Robertson, MD, FAHA, Chief Science Of cer Gayle R. Whitman, PhD, RN, FAHA, FAAN, Senior Vice President, Of ce of Science Operations Judy Bezanson, DSN, RN, CNS-MS, FAHA, Science and Medicine Advisor Jody Hundley, Production Manager, Scienti c Publications, Of ce of Science Operations References 1. ACCF/AHA Task Force on Practice Guidelines. Methodology Manual and Policies From the ACCF/AHA Task Force on Practice Guidelines. Available at: http://assets.cardiosource.com/Methodology_Manual_for_ ACC_AHA_Writing_Committees.pdf and http://my.americanheart.org/ idc/groups/ahamah-public/@wcm/sop/documents/downloadable/ ucm_319826.pdf. American College of Cardiology Foundation and American Heart Association. Accessed May 16, 2012. 2. Committee on Standards for Developing Trustworthy Clinical Practice Guidelines, Institute of Medicine: Clinical Practice Guidelines We Can Trust. Washington, DC: The National Academies Press; 2011. 3. Committee on Standards for Systematic Reviews of Comparative Effectiveness Research, Institute of Medicine: Finding What Works in Health Care: Standards for Systematic Reviews. Washington, DC: The National Academies Press; 2011. 4. Yancy C, Jessup M, Bozkurt B, et al. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. 