Table A-1 provides a brief overview of the PICOTS typology. PICOTS Elements Description Patients, Population, or Problem Describes the patients of interest. It includes the condition(s), populations or sub-populations, disease severity or stage, co-occurring conditions, and other patient characteristics or demographics. Intervention or Exposure Refers to the specific treatments or approaches used with the patient or population. It includes doses, frequency, methods of administering treatments, etc. Comparison Describes the interventions or care that is being compared with the intervention(s) of interest described above. It includes alternatives such as placebo, drugs, surgery, lifestyle changes, standard of care, etc. Outcome Describes the specific results of interest. Outcomes can include short, intermediate, and long-term outcomes, or specific results such as quality of life, complications, mortality, morbidity, etc. Timing, if applicable Describes the duration of time that is of interest for the particular patient intervention and outcome, benefit, or harm to occur (or not occur). Setting, if applicable Describes the setting or context of interest. Setting can be a location (such as primary, specialty, or inpatient care). Abbreviations: PICOTS: population, intervention, comparison, outcome, timing, and setting The Champions, Work Group, and evidence review team carried out several iterations of this process, each time narrowing the CPG s scope and literature review by prioritizing topics of interest. As a result of resource constraints, all developed KQs were not able to be included in the systematic evidence review. Thus, the Champions and Work Group determined which questions were of highest priority and those were included in the review. Table A-2 contains the final set of KQs used to guide this CPG s systematic evidence review. Once the KQs were finalized, the Work Group prioritized the outcomes they had defined for each KQ based on how important the Work Group judged each outcome to be. 