Lysis of intraventricular blood clot with urokinase in a canine model: part 3. effects of intraventricular uro- kinase on clot lysis and posthemorrhagic hydrocephalus. Neurosurgery. 1986;19:553 572. 214. King NK, Lai JL, Tan LB, Lee KK, Pang BC, Ng I, Wang E. A ran- domized, placebo-controlled pilot study of patients with spontaneous intraventricular haemorrhage treated with intraventricular thrombolysis. J Clin Neurosci. 2012;19:961 964. doi: 10.1016/j.jocn.2011.09.030. 215. Staykov D, Huttner HB, Struffert T, Ganslandt O, Doerfler A, Schwab S, Bardutzky J. Intraventricular fibrinolysis and lumbar drainage for ventricular hemorrhage. Stroke. 2009;40:3275 3280. doi: 10.1161/ STROKEAHA.109.551945. 216. Staykov D, Wagner I, Volbers B, Huttner HB, Doerfler A, Schwab S, Bardutzky J. Dose effect of intraventricular fibrinolysis in ven- tricular hemorrhage. Stroke. 2011;42:2061 2064. doi: 10.1161/ STROKEAHA.110.608190. 217. Morgan T, Awad I, Keyl P, Lane K, Hanley D. Preliminary report of the clot lysis evaluating accelerated resolution of intraventricular hemorrhage (CLEAR-IVH) clinical trial. Acta Neurochir Suppl. 2008;105:217 220. 218. Naff N, Williams MA, Keyl PM, Tuhrim S, Bullock MR, Mayer SA, Coplin W, Narayan R, Haines S, Cruz-Flores S, Zuccarello M, Brock D, Awad I, Ziai WC, Marmarou A, Rhoney D, McBee N, Lane K, Hanley DF Jr. Low-dose recombinant tissue-type plasminogen activa- tor enhances clot resolution in brain hemorrhage: the Intraventricular Hemorrhage Thrombolysis Trial. Stroke. 2011;42:3009 3016. doi: 10.1161/STROKEAHA.110.610949. 219. Webb AJ, Ullman NL, Mann S, Muschelli J, Awad IA, Hanley DF. Resolution of intraventricular hemorrhage varies by ventricular region and dose of intraventricular thrombolytic: the Clot Lysis: Evaluating Accelerated Resolution of IVH (CLEAR IVH) program. Stroke. 2012;43:1666 1668. doi: 10.1161/STROKEAHA.112.650523. 220. Basaldella L, Marton E, Fiorindi A, Scarpa B, Badreddine H, Longatti P. External ventricular drainage alone versus endoscopic surgery for severe intraventricular hemorrhage: a comparative retrospective analysis on outcome and shunt dependency. Neurosurg Focus. 2012;32:E4. doi: 10.3171/2012.1.FOCUS11349. 221. 