ISBN: Outcomes No of Participants (studies) Follow up Quality of the evidence (GRADE) Relative effect Anticipated absolute effects Risk with Placebo Risk difference with Intravenous iron (95% CI) Improvement in NYHA class Data on improvement in NYHA has only been extracted where quality of life data is not reported in a trial. VERY LOWa, b, c due to risk of bias, indirectness, imprecision (from 144 fewer to 1000 more) Hospitalisation due to HF 40 LOWa,c due to risk of bias, indirectness Peto Odds (from 450 fewer to 50 more) Hospitalisation all cause 760 months LOWa, b due to risk of bias, imprecision Rate Ratio Moderated (from 57 fewer to 191 fewer) Exercise tolerance months MODERATE b due to imprecision The mean exercise tolerance in the control groups was The mean exercise tolerance in the intervention groups was Haemoglobin in anaemic patients (anaemia defined as <12.5g/dL for men and <11.5g/dL for women) HIGH The mean haemoglobin in anaemic patients in the control groups was The mean haemoglobin in anaemic patients in the intervention groups was Treating Heart Failure Chronic Heart Failure NICE 2018. All rights reserved. Subject to Notice of rights. 