2002;347:1309 17. 520. Berger JS, Frye CB, Harshaw Q, et al. Impact of clopidogrel in patients with acute coronary syndromes requiring coronary artery bypass sur- gery: a multicenter analysis. J Am Coll Cardiol. 2008;52:1693 701. 521. Held C, Asenblad N, Bassand JP, et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes undergoing coronary artery bypass surgery. Results from the PLATO (Platelet Inhibition and Patient Outcomes) trial. J Am Coll Cardiol. 2010;57:672 84. 522. Hongo RH, Ley J, Dick SE, et al. The effect of clopidogrel in combi- nation with aspirin when given before coronary artery bypass grafting. J Am Coll Cardiol. 2002;40:231 7. 523. Firanescu CE, Martens EJ, Schonberger JP, et al. Postoperative blood loss in patients undergoing coronary artery bypass surgery after pre- operative treatment with clopidogrel. A prospective randomised con- trolled study. Eur J Cardiothorac Surg. 2009;36:856 62. 524. Herman CR, Buth KJ, Kent BA, et al. Clopidogrel increases blood transfusion and hemorrhagic complications in patients undergoing cardiac surgery. Ann Thorac Surg. 2010;89:397 402. 525. Mehta RH, Sheng S, O Brien SM, et al. Reoperation for bleeding in patients undergoing coronary artery bypass surgery: incidence, risk factors, time trends, and outcomes. Circ Cardiovasc Qual Outcomes. 2009;2:583 90. 526. Bizzarri F, Scolletta S, Tucci E, et al. Perioperative use of tirofiban hydrochloride (Aggrastat) does not increase surgical bleeding after emergency or urgent coronary artery bypass grafting. J Thorac Car- diovasc Surg. 2001;122:1181 5. 527. Dyke CM, Bhatia D, Lorenz TJ, et al. Immediate coronary artery bypass surgery after platelet inhibition with eptifibatide: results from PURSUIT. Platelet Glycoprotein IIb/IIIa in Unstable Angina: Receptor Suppression Using Integrelin Therapy. Ann Thorac Surg. 2000;70: 866 71. 528. Lincoff AM, LeNarz LA, Despotis GJ, et al. Abciximab and bleeding during coronary surgery: results from the EPILOG and EPISTENT trials. 