(Class 1, Level of Evidence: C-EO) Use of combination pills rather than free individual components can be useful to improve adherence to antihypertensive therapy.129 132 (Class 2a, Level of Evidence: B-NR) Initiation of antihypertensive drug therapy with a single antihypertensive drug is reasonable in adults with stage 1 hypertension and BP goal <130/80 mmHg with dosage titration and sequential addition of other agents to achieve the BP target. (Class 2a, Level of Evidence: C-EO) *We encourage stratification by clinically relevant subsets, such as stage 1 with ASCVD risk 10, or stage 2, for quality improvement efforts. ACC indicates American College of Cardiology; AHA, American Heart Association; ASCVD, atherosclerotic cardiovascular disease; BP, blood pressure; CVD, cardiovascular disease; DBP, diastolic blood pressure; HBP, high blood pressure; PDC, proportion of days covered; PQA, Pharmacy Quality Alliance; and SBP, systolic blood pressure. 30 Appendix A. 