PCI of a hemodynamically significant stenosis in a patent infarct artery greater than 24 hours after STEMI may be considered as part of an invasive strategy.413 417 (Level of Evidence: B) Class III: NO BENEFIT 1. PCI of a totally occluded infarct artery greater than 24 hours after STEMI should not be performed in asymptomatic patients with 1- or 2-vessel disease if patients are hemodynamically and electrically stable and do not have evidence of severe ischemia.418 420 (Level of Evidence: B) Studies and meta-analyses suggest potential benefit for PCI in fibrinolytic failure.385,386 In stable patients treated with fi- brinolytic therapy and clinical evidence for successful reper- fusion, an early invasive strategy with cardiac catheterization performed within 24 hours decreases reinfarction and recur- rent ischemic events.388,390,391 Table 10. 