The AHA/ ASA sponsor the development and publication of clinical practice guidelines without commercial support, and mem- bers volunteer their time to the writing and review efforts. Clinical practice guidelines for stroke provide rec- ommendations applicable to patients with or at risk of developing cerebrovascular disease. The focus is on medical practice in the United States, but many aspects are relevant to patients throughout the world. Although it must be acknowledged that guidelines may be used to inform regulatory or payer decisions, the core intent is to improve quality of care and to align with patients inter- ests. Guidelines are intended to define practices meeting the needs of patients in most, but not all, circumstances and should not replace clinical judgment; furthermore, the recommendations set forth should be considered in the context of individual patient values, preferences, and associated conditions. The AHA/ASA strive to ensure that guideline writing groups contain requisite expertise and are representative of the broader medical community by selecting experts from a broad array of backgrounds, representing differ- ent sexes, races, ethnicities, intellectual perspectives, geographic regions, and scopes of clinical practice and by inviting organizations and professional societies with related interests and expertise to participate as endors- ers. The AHA/ASA have rigorous policies and methods for development of guidelines that limit bias and prevent improper influence. The complete policy on relationships with industry and other entities can be found at https:// professional.heart.org/-/media/phd-files/guidelines-and- statements/policies-devolopment/aha-asa-disclosure- rwi-policy-5118.pdf?la=en. Beginning in 2017, numerous modifications to the guidelines have been implemented to make guidelines shorter and to enhance user friendliness. Guidelines are written and presented in a modular knowledge chunk format, in which each chunk includes a table of recom- mendations, a brief synopsis, recommendation-specific supportive text, and, when appropriate, flow diagrams or additional tables. 