Premature menopause or early menopause and risk of ischemic stroke. Menopause. 2012;19:272 277. 239. Hu FB, Grodstein F, Hennekens CH, Colditz GA, Johnson M, Manson JE, Rosner B, Stampfer MJ.Age at natural menopause and risk of cardio- vascular disease. Arch Intern Med. 1999;159:1061 1066. 240. Choi SH, Lee SM, Kim Y, Choi NK, Cho YJ, Park BJ. Natural menopause and risk of stroke in elderly women. J Korean Med Sci. 2005;20:1053 1058. 241. Lisabeth LD, Beiser AS, Brown DL, Murabito JM, Kelly-Hayes M, Wolf PA. Age at natural menopause and risk of ischemic stroke: the Framingham heart study. Stroke. 2009;40:1044 1049. 242. Baba Y, Ishikawa S, Amagi Y, Kayaba K, Gotoh T, Kajii E. Premature menopause is associated with increased risk of cerebral infarction in Japanese women. Menopause. 2010;17:506 510. 243. de Leci ana MA, Egido JA, Fern ndez C, Mart nez-Vila E, Santos S, Morales A, Mart nez E, Pareja A, Alvarez-Sab n J, Casado I; PIVE Study Investigators of the Stroke Project of the Spanish Cerebrovascular Diseases Study Group. Risk of ischemic stroke and lifetime estrogen exposure. Neurology. 2007;68:33 38. 244. Rivera CM, Grossardt BR, Rhodes DJ, Brown RD Jr, Roger VL, Melton LJ 3rd, Rocca WA. Increased cardiovascular mortality after early bilat- eral oophorectomy. Menopause. 2009;16:15 23. 245. Parker WH, Broder MS, Chang E, Feskanich D, Farquhar C, Liu Z, Shoupe D, Berek JS, Hankinson S, Manson JE. Ovarian conservation at the time of hysterectomy and long-term health outcomes in the Nurses Health Study. Obstet Gynecol. 2009;113:1027 1037. 246. Ingelsson E, Lundholm C, Johansson AL, Altman D. Hysterectomy and risk of cardiovascular disease: a population-based cohort study. Eur Heart J. 2011;32:745 750. 247. 