2011;342:d3527. 11. Mahaffey KW, Wojdyla DM, Carroll K, et al. Ticagrelor compared with clopidogrel by geographic region in the Platelet Inhibition and Patient Outcomes (PLATO) trial. Circulation. 2011;124:544 54. 12. AstraZeneca. Brilinta REMS Document. NDA 22-433. 2011. Available at: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ ucm263964.htm. Accessed May 2, 2012. 13. Yusuf S, Zhao F, Mehta SR, et al. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med. 2001;345:494 502. 13a.Connolly SJ, Pogue J, Hart RG, et al. Effect of clopidogrel added to aspirin in patients with atrial fibrillation. N Engl J Med. 2009;360:2066 78. 13b.Diener HC, Bogousslavsky J, Brass LM, et al. Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial. Lancet. 2004;364:331 7. 13c.Sacco RL, Diener HC, Yusuf S, et al. Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke. N Engl J Med. 2008;359:1238 51. 13d.James SK, Storey RF, Khurmi N, et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes and a history of stroke or transient ischemic attack. Circulation. 2012 May 9. [Epub ahead of print], doi:10.1161/CIRCULATIONAHA.111.082727. 13e.Sabatine M. Prevention of cardiovascular events (eg, death from heart or vascular disease, heart attack, or stroke) in patients with prior heart attack using ticagrelor compared to placebo on a background of aspirin (PEGASUS). 2012. Available at: http://clinicaltrials.gov/ct2/show/ NCT01225562. Accessed May 16, 2012. 13f.Verheugt FW. Beware of novel antiplatelet therapy in ACS patients with previous stroke. Circulation. 2012 May 9. [Epub ahead of print], doi: 10.1161/CIRCULATIONAHA.112.111930. 14. Food and Drug Administration. Early communication about an ongoing safety review of clopidogrel bisulfate (marketed as Plavix). fda.gov. 2009. Available at: http://www.fda.gov/cder/drug/early_comm/clopidogrel_ bisulfate.htm. Accessed April 6, 2009. 15. Grines CL, Bonow RO, Casey DE Jr, et al. 