We suggest offering nurse-led interventions as an option for patients treated for hypertension. (Weak for | Reviewed, New-replaced) Discussion Nurse-led interventions for the management of HTN encompass a wide variety of treatment approaches including cardiovascular risk assessment, education, counseling on lifestyle modification, goal setting, action planning, and the initiation and titration of antihypertensive medications using established protocols. When compared with usual care, nurse-led interventions have been found to reduce SBP and DBP, improve adherence to medication therapy, and improve quality of life metrics in patients with HTN.[82-88] All studies reviewed by the Work Group contained multiple components of nurse-led intervention, some paired with other co-interventions. Our evidence review found one SR, by Parappilly et al. (2018), that compared nurse-led interventions to usual care.[88] It was based on 16 RCTS and enrolled a total of 3,568 participants diagnosed with a previous stroke or transient ischemic attack. The researchers observed no statistically significant difference in SBP and DBP changes between nurse-led interventions and usual care. However, the authors indicated that one RCT was found to be an outlier. After removing this study from the meta-analysis, the models demonstrated a statistically significant effect on reducing SBP and DBP in favor of nurse-led interventions when compared to usual care. The authors reported a mean difference in SBP reduction of 2.84 mm Hg and a MD in DBP reduction of 2 mm Hg, favoring nurse-led intervention. All studies included in the SR contained multiple nurse-led components including education, lifestyle changes, providing feedback, appointment scheduling, and medication review and compliance.[88] The Work Group identified two additional RCTs that had results consistent with the SR by Parappilly et al. (2018) (i.e., favoring the nurse- led intervention group).[82,84] One found a reduction in DBP similar to the SR by Parappilly et al. 