Women at high risk are those with any of the following: hypertensive disease during a previous pregnancy chronic kidney disease autoimmune disease such as systemic lupus erythematosus or antiphospholipid syndrome type 1 or type 2 diabetes chronic hypertension. [2010, amended 2019] 1.1.3 Advise pregnant women with more than 1 moderate risk factor for pre- eclampsia to take 75 150 mg of aspirin[1] daily from 12 weeks until the birth of the baby. Factors indicating moderate risk are: nulliparity age 40 years or older pregnancy interval of more than 10 years body mass index (BMI) of 35 kg/m2 or more at first visit family history of pre-eclampsia multi-fetal pregnancy. [2010, amended 2019] Other pharmaceutical agents 1.1.4 Do not use the following to prevent hypertensive disorders during pregnancy: nitric oxide donors progesterone diuretics low molecular weight heparin. [2010] Nutritional supplements 1.1.5 Do not recommend the following supplements solely with the aim of preventing hypertensive disorders during pregnancy: magnesium folic acid antioxidants (vitamins C and E) fish oils or algal oils garlic. [2010] Diet 1.1.6 Do not recommend salt restriction during pregnancy solely to prevent gestational hypertension or pre-eclampsia. [2010] Lifestyle 1.1.7 Give the same advice on rest, exercise and work to women with chronic hypertension or at risk of hypertensive disorders during pregnancy as healthy pregnant women. See the NICE guideline on antenatal care. Diabetes 1.1.8 For women with pre-existing diabetes or gestational diabetes, see the NICE guideline on diabetes in pregnancy. [2019] 1.2 Assessment of proteinuria in hypertensive disorders of pregnancy 1.2.1 Interpret proteinuria measurements for pregnant women in the context of a full clinical review of symptoms, signs and other investigations for pre- 1.2.2 Use an automated reagent-strip reading device for dipstick screening for proteinuria in pregnant women in secondary care settings. 