2011:10;CD00323.380 SoF table Supplementary Table S91 Clinical question In kidney transplant recipients does lower (intensive) BP target compared to standard BP targets improve clinical ef cacy outcomes and reduce adverse effects? Population Kidney transplant recipients, adult and children Intervention Lower BP target Comparator Standard BP target Outcomes Critical and important outcomes listed in Table 1 Study design RCTs Table 2| (Continued) Clinical questions and systematic review topics in the PICOM format methods for guideline development www.kidney-international.org  Repeating the analysis, excluding unpublished studies  Repeating the analysis taking account of the risk of bias, as speci ed  Repeating the analysis, excluding any very long or large studies to establish how much they dominate the results  Repeating the analysis, excluding studies using the following l- ters: language of publication, source of funding (industry vs. other), and country in which the study was conducted. However, the available data were insuf cient to determine the in u- ence of these factors on the effect size of critical and important outcomes. Grading the quality of the evidence and the strength of a guideline recommendation. GRADING the quality of the evidence for each outcome across studies. The overall quality of the evidence related to each critical and important outcome was assessed using the GRADE approach,384,388 which assesses the quality of the evidence for each outcome. For outcomes that are based on data from RCTs, the initial grade for the quality of the evidence is considered to be high. For observational studies, the initial quality of the evidence is low. 