Moreover, it remains unclear whether high-intensity statin therapy early after CABG will improve graft patency or slow the process of vein graft disease compared with usual moderate statin doses, highlighting the need for further research on the subject. Statins are generally well tolerated and appear to be one of the safest classes of drugs ever developed.130,131 Although concerns had previously been raised about the safety of statins early after CABG,132 more recently, it has become clear that the perioperative risks associated with statin use are mark- edly less than originally anticipated.133,134 Furthermore, delay- ing statin reinitiation early after surgery may lead to greater Postoperative statin withdrawal may worsen endo- thelial function and result in a greater risk of postoperative Several studies in the cardiac and vascular surgery literature have reported a significantly greater risk of postoperative morbidity and mortality among patients whose statins are discontinued after surgery.122,136,137 Despite their benefits and low risk profile,134 statins remain underused after CABG,123,138 and long-term patient adherence to these medications remains a challenge.139 To maximize the benefits associated with their use and to potentially improve perioperative outcomes, statins should be administered pre- operatively when CAD is first documented and restarted early after CABG surgery. Postoperatively, statin use should be resumed when the patient is able to take oral medications and should be continued indefinitely. There is no evidence to support the use of one statin over another, either before or after CABG, although the administration of generic statins is appealing from a cost point of view because this may improve patient compliance.140 Essentially all patients under- going CABG are candidates for long-term statin therapy in the absence of contraindications such as liver disease. 