A suggestion for assessing CVD risk is pro- vided in Section 8. 7. Although both ABPM and HBPM are better predictors of CVD risk than are office BP readings, ABPM confir- mation of elevated BP by HBPM might be reasonable because of the more extensive documentation of CVD risk with ABPM. However, unlike the documentation of a significant white coat effect to justify the decision to not treat an elevated clinic BP, it is not mandatory to confirm masked uncontrolled hypertension determined by HBPM. Figure 1. Detection of white coat hypertension or masked hypertension in patients not on drug therapy. Colors correspond to Class of Recommendation in Table 1. ABPM indicates ambulatory blood pressure monitoring; BP, blood pressure; and HBPM, home blood pressure monitoring. 5. Causes of Hypertension 5.1. Genetic Predisposition Hypertension is a complex polygenic disorder in which many genes or gene combinations influence BP.S5.1-1,S5.1-2 Although several monogenic forms of hypertension have been identified, such as glucocorticoid-remediable aldosteronism, Liddle s syndrome, Gordon s syndrome, and others in which single- gene mutations fully explain the pathophysiology of hyper- tension, these disorders are rare.S5.1-3 The current tabulation of known genetic variants contributing to BP and hypertension includes more than 25 rare mutations and 120 single-nucleo- However, even with the discov- ery of multiple single-nucleotide polymorphisms influencing control of BP since completion of the Human Genome Project in 2003, the associated variants have only small effects. 