, diabetes, CKD) Note: Although evidence on pregnant women was included in the search, no evidence in this population was identified in the evidence review; see the VA/DoD Clinical Practice Guideline for the Management of Pregnancy for additional information regarding HTN in Excluding children, adolescents, and patients with unusual causes of secondary HTN (e.g., pheochromocytoma, aldosteronism) b. Interventions Key Question 1 Interventions to diagnose and manage HTN, including white coat HTN, masked HTN, undiagnosed masked HTN Home measure (self-measure), 24-hour ambulatory monitoring (daytime, nighttime, and Different approaches to physician office manual blood pressure measurement Key Question 2 Home measure (self-measure), 24-hour ambulatory monitoring (daytime, nighttime, and 24-hour), telemonitoring, night-time home measurement Key Question 3 Bariatric surgery Obesity medications approved for chronic weight management (phentermine/topiramate, lorcaserin, orlistat, naltrexone/bupropion, liraglutide) Lifestyle interventions to reduce weight (only weight loss diet studies designed to reduce HTN), including dietary changes, physical activity, decrease in sedentary activities, and including intervention using behavioral modification methods Key Question 4 Lifestyle modification that involves exercise Aerobic exercise, non-aerobic exercise Interventions intended to reduce sedentary time Weight training/ resistance (e.g., hand grip) 14 See the VA/DoD Clinical Practice Guideline for the Management of Pregnancy. Available at: https://www.healthquality.va.gov/guidelines/WH/up/ Tai Chi, Qigong, yoga Key Question 5 Antihypertensive pharmacologic therapy to a specific systolic blood pressure goal or range or with the goal of reduction in blood pressure Key Question 6 Antihypertensive pharmacologic therapy to a specific diastolic blood pressure goal or range or with the goal of blood pressure reduction Key Question 7 Initial therapy: thiazide-type diuretics, ACEIs, ARBs, CCBs, beta blockers Add-on therapy: a drug/class from list above that is other than the initial therapy, or other drugs/classes (e.g., spironolactone, a MRA, aka aldosterone antagonist [AA], etc.) 