ISBN: Outcomes No of Participants (studies) Follow up Quality of the evidence (GRADE) Relative effect Anticipated absolute effects Risk with Clinical monitoring Risk difference with NP monitoring (95% CI) Hypotension - Age 75 and over VERY LOWb,c due to risk of bias, imprecision (from 51 more to 341 more) Hypotension - All ages 1114 LOWb due to risk of bias Peto odds (from 4 more to 65 more) Bradycardia - Age <75 years 210 LOWc due to imprecision (from 27 fewer to 200 more) Bradycardia - Age 75 and over 289 VERY LOWb,c due to risk of bias, imprecision (from 42 fewer to 141 more) Symptomatic bradycardia All ages MODERATEb due to risk of bias - j j Significant Ventricular Arrhythmia - All ages VERY LOWb,c due to risk of bias, imprecision (from 25 fewer to 249 more) New Atrial Fibrillation - All ages LOWc due to imprecision (from 61 fewer to 64 more) a The age-specific control risk was calculated from TIME-CHF and BATTLESCARRED b Downgraded by 1 increment if the majority of the evidence was at high risk of bias, and downgraded by 2 increments if the majority of the evidence was at very high risk of bias c Downgraded by 1 increment if the confidence interval crossed one MID or by 2 increments if the confidence interval crossed both MIDs d Downgraded by 1 increment because due to indirectness of the outcome e The age-specific control risk was taken from TIME-CHF Monitoring Chronic Heart Failure NICE 2018. All rights reserved. Subject to Notice of rights. ISBN: Outcomes No of Participants (studies) Follow up Quality of the evidence (GRADE) Relative effect Anticipated absolute effects Risk with Clinical monitoring Risk difference with NP monitoring (95% CI) f The control rate refers to the overall control risk in the Troughton meta-analysis (11 studies) g Heterogeneity could not be formally assessed due to use of pooled data, which comprised seven of the nine included studies for the outcome. 