This is the approach taken in the following KDIGO recommendations. Chapter 1 | Assessment of lipid status in adults with CKD Grade 1C 1.1: In adults with newly identified CKD (including those treated with chronic dialysis or kidney transplantation), we recommend evaluation with a lipid profile (total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides) Not graded 1.2: In adults with CKD (including those treated with chronic dialysis or kidney transplantation), follow-up measurement of lipid levels is not required for the majority of patients Within each recommendation, the strength of recommendation is indicated as Level 1, Level 2, or Not graded, and the quality of the supporting evidence is shown as A, B, C, or D (see also Supplementary Appendix Tables S1 and S2 online). GRADE criteria were used for grade levels and letters in this guideline (2). Level 1, We recommend . Most patients should receive the recommended course of action. Level 2, We suggest . Different choices will be appropriate for different patients. Each patient needs help to arrive at a management decision consistent with her or his values and preferences. Not graded was used, typically, to provide guidance based on common sense or where the topic does not allow adequate application of evidence. Grade A quality of evidence is high, and we are confident that the true effect lies close to that of the estimate of the effect. Grade B is moderate, and the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. Grade C is low and the true effect may be substantially different from the estimate of the effect. Grade D is very low. The estimate of effect is very uncertain, and often will be far from the truth. 