Although a low proportion of patients treated with PCI received DES (35%) and a low proportion of patients treated with CABG received internal mammary grafts (72%), the outcomes at 30 days and 1 year were similar between the groups. In the PRECOMBAT (Premier of Randomized Comparison of Bypass Surgery Versus Angioplasty Using Sirolimus-Eluting Stent in Patients With Left Main Coronary Artery Disease) trial of 600 patients with left main disease, the composite endpoint of death, MI, or stroke at 2 years occurred in 4.4% of patients treated with DES and 4.7% of patients treated with CABG, but ischemia-driven target-vessel revascularization was required more often in the patients treated with PCI (9.0% versus 4.2%).88 The results from these 3 RCTs suggest (but do not defini- tively prove) that major clinical outcomes in selected patients with left main CAD are similar with CABG and PCI at 1- to 2-year follow-up but that repeat revascularization rates are higher after PCI than after CABG. RCTs with extended follow-up of 5 years are required to provide definitive con- clusions about the optimal treatment of left main CAD; 2 such studies are under way. In a meta-analysis of 8 cohort stud- death, MI, and stroke occurred with similar frequency in the PCI- and CABG-treated patients at 1, 2, and 3 years of follow-up. Target-vessel revascularization was per- formed more often in the PCI group at 1 year (OR: 4.36), 2 years (OR: 4.20), and 3 years (OR: 3.30). 