The Work Group took the primary role of writing the recommendation statements and rationales and retained final responsibility for their content. The Work Group Co-Chairs and the ERT prepared the first draft of the scope of work document as a series of open-ended questions to be considered by Work Group members. Formulating Questions of Interest Questions of interest were formulated according to the PICODD (Population, Intervention, Comparator, Outcome, study Design and Duration of follow-up) criteria. Details of the PICODD criteria are presented in Table 6. http://www.kidney-international.org methods for guideline development & 2013 KDIGO Table 6 | Systematic review topics and screening criteria Lipid-lowering agents Population Adults and children with CKD of any severity, with or without dyslipidemia and diabetes; kidney transplant recipients; CKD subgroups in large studies of the general population Intervention Z1 lipid-lowering agent (typically statin, niacin, colestipol, or cholestyramine). Excluded dietary supplements, phosphate binders, apheresis, stanols, and sterols. 