Gomez-Outes A, Terleira-Fernandez AI, Lecumberri R, Suarez- Gea ML, Vargas-Castrillon E. Direct oral anticoagulants in the treatment of acute venous thromboembolism: a systematic review and meta-analysis. Thromb Res. 2014;134(4):774-782. 30. Fox BD, Kahn SR, Langleben D, Eisenberg MJ, Shimony A. Ef cacy and safety of novel oral anticoagulants for treatment of acute venous thromboembolism: direct and adjusted indirect meta- analysis of randomised controlled trials. BMJ. 2012;345:e7498. 31. van der Hulle T, Kooiman J, den Exter PL, Dekkers OM, Klok FA, Huisman MV. Effectiveness and safety of novel oral anticoagulants as compared with vitamin K antagonists in the treatment of acute symptomatic venous thromboembolism: a systematic review and meta-analysis. J Thromb Haemost. 2014;12(3):320-328. 32. Mantha S, Ansell J. Indirect comparison of dabigatran, rivaroxaban, apixaban and edoxaban for the treatment of acute venous thromboembolism. J Thromb Thrombolysis. 2015;39(2):155-165. 33. Chai-Adisaksopha C, Crowther M, Isayama T, Lim W. The impact of bleeding complications in patients receiving target-speci c oral anticoagulants: a systematic review and meta-analysis. Blood. 2014;124(15):2450-2458. 34. Wu C, Alotaibi GS, Alsaleh K, Linkins LA, Sean McMurtry M. Case- fatality of recurrent venous thromboembolism and major bleeding associated with aspirin, warfarin, and direct oral anticoagulants for secondary prevention. Thromb Res. 2015;135(2):243-248. 35. Castellucci LA, Cameron C, Le Gal G, et al. Clinical and safety outcomes associated with treatment of acute venous thromboembolism: a systematic review and meta-analysis. JAMA. 2014;312(11):1122-1135. 36. Carrier M, Cameron C, Delluc A, Castellucci L, Khorana AA, Lee AY. Ef cacy and safety of anticoagulant therapy for the treatment of acute cancer-associated thrombosis: a systematic review and meta-analysis. Thromb Res. 2014;134(6):1214-1219. 37. Vedovati MC, Germini F, Agnelli G, Becattini C. Direct oral anticoagulants in patients with vte and cancer: a systematic review and meta-analysis. Chest. 2015;147(2):475-483. 38. 