Of these, 217 were ultimately excluded and reasons for their exclusion are presented in Figure A-1. Overall, 97 studies addressed one or more of the KQs and were considered as evidence in this review. Table A-2 indicates the number of studies that addressed each of the questions. Figure A-1. Study Flow Diagram Abbreviations: KQ: key question; SR: systematic review Alternative Text Description of Study Flow Diagram Figure A-1. Study Flow Diagram is a flow chart with nine labeled boxes linked by arrows that describe the literature review inclusion/exclusion process. Arrows point down to boxes that describe the next literature review step and arrows point right to boxes that describe the excluded citations at each step (including the reasons for exclusion and the numbers of excluded citations). 1. Box 1: 16,492 citations identified by searches a. Right to Box 2: 11,050 citations excluded at the title level i. Citations excluded at this level were off-topic, not published in English, or published prior to inclusion date b. Down to Box 3 a. Right to Box 4: 4,723 citations excluded at the abstract level i. Citations excluded at this level were not an SR or clinical study, clearly did not address a KQ, did not report on an outcome of interest, or were outside cutoff publication dates b. Down to Box 5 a. Right to Box 6: 405 citations excluded at 1st pass full article level i. Articles excluded at this level did not: address a key question of interest, enroll the population of interest, meet inclusion criteria for clinical study or SR, meet inclusion criteria for any key question, or were a duplicate b. Down to Box 7 a. Right to Box 8: 217 citations excluded at 2nd pass KQ level i. 