Endorsements: This guideline has been endorsed by the AF Association, American College of Clinical Pharmacy (ACCP), Arrhythmia Alliance, and StopA b.org. Other contributions: The authors would like to acknowledge Mellanie True Hills, founder of StopAFib.org, for her insights on patient values and preferences throughout the guideline development process and for contributing to the development of the patient education resources. Additional information: The e-Appendix, e-Figures, and e-Tables can be found in the Supplemental Materials section of the online article. References 1. Lip G, Freedman B, De Caterina R, Potpara TS. Stroke prevention in atrial brillation: past, present and future. Comparing the guidelines and practical decision-making. Thromb Haemost. 2017;117(7):1230-1239. 2. Lip GYH. The ABC pathway: an integrated approach to improve AF management. Nat Rev Cardiol. 2017;14(11):627-628. 3. You JJ, Singer DE, Howard PA, et al. Antithrombotic therapy for atrial brillation: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141(suppl 2):e531S-e575S. 4. Gomez-Outes A, Lagunar-Ruiz J, Terleira-Fernandez AI, Calvo- Rojas G, Suarez-Gea ML, Vargas-Castrillon E. Causes of death in anticoagulated patients with atrial brillation. J Am Coll Cardiol. 2016;68(23):2508-2521. 5. Higgins J, Altman D, Sterne J, (editors). Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org. 2011. 6. Sterne JA, Hern n MA, Reeves BC, et al. ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions. BMJ. 2016;355. 7. Diekemper RL, Ireland BK, Merz LR. Development of the Documentation and Appraisal Review Tool for systematic reviews. World J Meta-Anal. 2015;3(3):142-150. 8. Ozcan C, Strom JB, Newell JB, Mansour MC, Ruskin JN. 