Describe the following: Yes Research protocol No Eligibility criteria (criteria for including and excluding studies in the systematic review) Yes Analytic framework and key questions No Databases and other information sources used to identify relevant studies Yes Search strategy Yes Study selection process Yes Data extraction process Yes Methods for handling missing information No Information to be extracted from included studies Yes IOM Standards for Systematic Reviews Part of KDIGO Process? Methods to appraise the quality of individual studies Yes Summary measures of effect size (e.g., risk ratio, difference in means) No Rationale for pooling (or not pooling) results of included studies No Methods of synthesizing the evidence (qualitative and meta-analysis) Yes Additional analyses, if done, indicating which were prespecified N/A 5.1.7 Include a results section; organize the presentation of results around key questions; describe the following (repeat for each key question): N/A 5.1.8 Include a discussion section. Include the following: N/A1 Summary of the evidence Mostly Strengths and limitations of the systematic review No Conclusions for each key question No Gaps in evidence Yes 5.1.9 Include a section describing funding sources and COI Yes 5.2 Peer review the draft report N/A 5.2.1 Use a third party to manage the peer review process N/A 5.2.2 Provide a public comment period for the report and publicly report on disposition of comments N/A2 5.3 Publish the final report in a manner that ensures free public access N/A3 1 The systematic review is not written up as a separate report. There is no stand-alone discussion section. The evidence is summarized in individual rationale sections of the guideline as needed to support the recommendations. There are no key questions, per se, for which to write conclusions, beyond what is summarized as needed in the rationale for the recommendations. 