1) Little interest or pleasure in doing things 2) Feeling down, depressed, or hopeless 3) Trouble falling asleep, staying asleep, or sleeping too much 4) Feeling tired or having little energy 5) Poor appetite or overeating 6) Feeling bad about yourself, feeling that you are a failure, or feeling that you have let yourself or your family down 7) Trouble concentrating on things such as reading the newspaper or watching television 8) Moving or speaking so slowly that other people could have noticed. Or being so fidgety or restless that you have been moving around a lot more than usual 9) Thinking that you would be better off dead or that you want to hurt yourself in some way Reproduced from Kroenke et al.702 fects, as reflected by a reduction in C-reactive protein.709,710 Alternatively, the apparent cardioprotective effects of modest alcohol consumption reported in observational studies could represent uncontrolled confounding, as many coronary risk factors are more prevalent in nondrinkers than in light to There are no RCTs in either healthy individuals or in patients with SIHD demonstrating improved clinical out- comes with alcohol consumption. Because of the many health and societal consequences of alcohol abuse, patients who do not already drink alcohol should not be encouraged to start. Patients who do consume alcoholic beverages should be counseled to do so in moderation: no more than 1 drink (4 ounces of wine or 1 ounce of spirits) per day for women and no more than 2 drinks per day for men. 4.4.1.9. Avoiding Exposure to Air Pollution Class IIa 1. 