Incidence of heparin-PF4 complex antibody formation and heparin-induced thrombocytopenia in acute cor- onary syndrome. Thromb Res. 2005;115:475 81. 530. Ohman EM, Granger CB, Rice L, et al. Identification, diagnosis and treatment of heparin-induced thrombocytopenia and thrombosis: a reg- istry of prolonged heparin use and thrombocytopenia among hospital- ized patients with and without cardiovascular disease: the Complication After Thrombocytopenia Caused by Heparin (CATCH) Registry Steering Committee. J Thromb Thrombolysis. 2005;19:11 9. 531. Crespo EM, Oliveira GBF, Honeycutt EF, et al. Evaluation and manage- ment of thrombocytopenia and suspected heparin-induced thrombocyto- penia in hospitalized patients: the ComplicationsAfterThrombocytopenia Caused by Heparin (CATCH) Registry. Am Heart J. 2009;157:651 7. 532. Beyth RJ, Quinn LM, Landefeld CS. Prospective evaluation of an index for predicting the risk of major bleeding in outpatients treated with war- farin. Am J Med. 1998;105:91 9. 533. S rensen R, Hansen ML,Abildstrom SZ, et al. Risk of bleeding in patients with acute myocardial infarction treated with different combinations of aspirin, clopidogrel, and vitamin K antagonists in Denmark: a retrospec- tive analysis of nationwide registry data. Lancet. 2009;374:1967 74. arin-induced thrombocytopenia: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence- Based Clinical Practice Guidelines. Chest. 2012;141:e495S e530S. 535. Rao SV, O Grady K, Pieper KS, et al. Impact of bleeding severity on clinical outcomes among patients with acute coronary syndromes. Am J Cardiol. 2005;96:1200 6. 536. Spencer FA, Moscucci M, Granger CB, et al. Does comorbidity account for the excess mortality in patients with major bleeding in acute myocar- dial infarction? Circulation. 2007;116:2793 801. 537. Giugliano RP, Giraldez RR, Morrow DA, et al. Relations between bleed- ing and outcomes in patients with ST-elevation myocardial infarction in the ExTRACT-TIMI 25 trial. Eur Heart J. 2010;31:2103 10. 538. Ho PM, Peterson ED, Wang L, et al. 