#8 Combine sets without outcomes of interest #9 Limit to RCTs Randomized controlled trials hedge [see Search Limits at the end of this table] #10 Limit to SRs/Meta- analysis Systematic review/meta-analysis hedge [see Search Limits at the end of this table] #11 Limit to cost studies (KQ 9) 'health care cost'/exp OR 'cost effectiveness analysis'/exp OR 'cost benefit analysis'/exp OR 'economic evaluation'/exp OR 'quality adjusted life year'/exp OR (cost OR costs OR costly OR costing OR price OR prices OR saving OR savings OR economi* OR financial OR finance* OR pharmacoeconomic* OR QALY or QALYs OR (quality NEXT/1 adjusted NEXT/1 life NEXT/1 year*) or (quality NEXT/1 adjusted life NEXT/1 expectanc*)):ti,ab #15 Apply limits See Search Limits at the end of this table Search Limits Applied to Each Search Limit to humans and items published since searches were conducted for AND [humans]/lim AND [english]/lim AND [9-12-2013]/sd NOT [2019]/sd Exclude conference publications, books, letters, editorials, case studies, etc. 