VERY LOWa,b,c due to risk of bias, indirectness, imprecision The mean quality of life at 6 months in the control groups was The mean quality of life at 6 months in the intervention groups was (24.96 lower to 7.6 higher) Oedema Congestion score. Scale from: 0 to 5. High is worse. VERY LOWa,c,d due to risk of bias, indirectness, imprecision The mean congestion sore in the control groups was The mean congestion score in the intervention groups was (1.1 lower to 1.24 higher) Treating Heart Failure Chronic Heart Failure NICE 2018. All rights reserved. Subject to Notice of rights. ISBN: (a) Downgraded by 1 increment if the majority of the evidence was at high risk of bias, and downgraded by 2 increments if the majority of the evidence was at very high risk of bias. (b) Downgraded by 1 or 2 increments because the majority of evidence was from an indirect population (people were already enrolled in a intrathoracic impedance monitoring device trial). (c) Downgraded by 1 increment if the confidence interval crossed 1 MID or by 2 increments if the confidence interval crossed both MIDs. (d) Downgraded by 2 increments because the majority of evidence was from an indirect population (people were already enrolled in a intrathoracic impedance monitoring device trial) and was looking at congestion, which includes things other than oedema (the protocol outcome). Chronic Heart Failure Beta-blockers in heart failure and concomitant atrial fibrillation NICE 2018. All rights reserved. Subject to Notice of rights. ISBN: 978-1-4731-3093-7 6.1.1.4 Economic evidence Published literature No relevant health economic studies were identified. See also the health economic study selection flow chart in Appendix D. 6.1.1.5 Evidence statements Clinical Two studies were identified for inclusion within the review. 