Neuroendocrine activation in rela- tion to left ventricular function in chronic severe congestive heart failure: a subgroup analysis from the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS). Clin Cardiol. 1994;17:603 6. 3. Granger CB, McMurray JJV, Yusuf S, et al. Effects of candesartan in pa- tients with chronic heart failure and reduced left-ventricular systolic func- tion intolerant to angiotensin-converting-enzyme inhibitors: the CHARM- Alternative trial. Lancet. 2003;362:772 6. 4. Krum H, Roecker EB, Mohacsi P, et al. Effects of initiating carvedilol in patients with severe chronic heart failure: results from the COPERNICUS Study. JAMA. 2003;289:712 8. 5. Pitt B, Zannad F, Remme WJ, et al. The effect of spironolactone on morbid- ity and mortality in patients with severe heart failure. Randomized Aldac- tone Evaluation Study Investigators. N Engl J Med. 1999;341:709 17. 6. St John Sutton MG, Plappert T, Abraham WT, et al. Effect of cardiac resyn- chronization therapy on left ventricular size and function in chronic heart failure. Circulation. 2003;107:1985 90. 7. van Bommel RJ, Marsan NA, Delgado V, et al. Cardiac resynchroniza- tion therapy as a therapeutic option in patients with moderate-severe functional mitral regurgitation and high operative risk. Circulation. 2011;124:912 9. 8. Kang D-H, Park S-J, Shin S-H, et al. Angiotensin receptor neprilysin inhibi- tor for functional mitral regurgitation. Circulation. 2019;139:1354 65. 9. Yancy CW, Jessup M, Bozkurt B, et al. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of CLINICAL STATEMENTS AND GUIDELINES Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2013;128:e240 327. 10. Mullens W, Martens P. Sacubitril/valsartan to reduce secondary mitral re- gurgitation. Circulation. 2019;139:1366 70. 11. Abraham WT, Fisher WG, Smith AL, et al. Cardiac resynchronization in chronic heart failure. N Engl J Med. 2002;346:1845 53. 12. Stone GW, Lindenfeld J, Abraham WT, et al. 