The most recent and comprehensive meta-analysis comparing LMWH or heparinoid with UFH for venous thromboembolism prophylaxis in AIS included 1 large trial (N=1762) and 2 smaller trials comparing LMWH with UFH and 4 small trials comparing heparinoids with UFH. There were no significant effects on death or disability for LMWH/heparinoids compared with UFH.269 The use of LMWH/heparinoid was associated with a statistically significant reduction in DVTs (OR, 0.55 [95% CI, 0.44 0.70]), which were mostly asymptomatic, at the expense of a greater risk of major extracranial hemorrhages (OR, 3.79 [95% CI, 1.30 11.03]). LMWH can be administered once a day and thus is more convenient for nurses and comfortable for patients. Higher cost and increased bleeding risk in elderly patients with renal impairment are disadvantages of LMWH that should be kept in mind. See Table LXII in online Data Supplement 1. 4. In ischemic stroke, elastic compression stockings should not be used. III: Harm B-R Recommendation wording modified from 2016 Rehab Guidelines to match COR III stratifications. COR and LOE amended to conform with ACC/AHA 2015 Recommendation Classification System. 4.10. Depression Screening 4.10. Depression Screening COR LOE New, Revised, or Unchanged Administration of a structured depression inventory is recommended to routinely screen for poststroke depression. I B-NR Recommendation revised from 2016 Rehab Guidelines. A meta-analysis of studies assessing poststroke depression screening tools (24 studies, N=2907) found several inventories with high sensitivity for detecting poststroke depression.270 Two of these studies evaluated patients in the acute phase 2 weeks after onset and found that depression screening tools showed good accuracy compared with the reference standard diagnosis by the American Psychiatric Association Diagnostic and Statistical Manual of However, further studies are needed to determine the optimal timing, setting, and follow-up for See Tables LXIII and LXIV in online Data Supplement 1. 