The WHS also investigated the association between migraines and ICH. Although there was no increased risk of ICH in those who reported any history of migraine compared with those without a history of migraine (HR, 0.98; 95% CI, 0.56 1.71), there was an increased risk for ICH in women with active migraine with aura (HR, 2.25; 95% CI, 1.11 The age-adjusted increased risk was stronger for ICH (HR, 2.78; 95% CI, 1.09 7.07) and for fatal events (HR, 3.56; From this study, it is estimated that 4 additional ICH events are attributable to migraine with aura per 10000 women per year.598 Women who reported active migraine without aura had no increased risk for ICH. This increase in risk for ICH for women with migraine with aura, but not for women with migraine without aura, was similar to the increased risk found with ischemic strokes. The association of migraine in middle-aged to late-life infarct-like lesions on imaging was studied in a Reykjavik, Iceland, population-based cohort.599 After multivariable adjustment, midlife migraine with aura had an increased risk of late-life infarct-like lesions (OR, 1.4; 95% CI, 1.1 1.8).599 This was particularly reflected by an association with cerebel- lar lesions in women (OR, 1.9; 95% CI, 1.4 2.6), but not in men, with migraine with aura (OR, 1.0; 95% CI, 0.6 1.8).599 Migraine without aura and nonmigraine headache were not associated with an increased risk.599 Therefore, similar to the risk for ischemic stroke found in women with migraine with aura in the WHS, in this Icelandic population, women with migraine with aura had an increased risk for late-life isch- emic lesions as seen on brain MRI; however, this association was not appreciated in men or in those with migraine with- out aura or nonmigraine headaches. 