Costs (resource allocation) The higher the costs of an intervention that is, the more resources consumed the less likely a strong recommendation is warranted. Table 13 | Balance of benefits and harms When there was evidence to determine the balance of medical benefits and harms of an intervention to a patient, conclusions were categorized as follows: K For statistically significant benefit or harm, report as benefit [or harm] of drug X. K For non statistically significant benefit or harm, report as possible benefit [or harm] of drug X. K In instances where studies are inconsistent, report as possible benefit [or harm] of drug X. K No difference can only be reported if a study is not imprecise. K Insufficient evidence is reported if imprecision is a factor. Table 12 | Final grade for overall quality of evidence Grade Quality of Evidence Meaning A High We are confident that the true effect lies close to that of the estimate of the effect. B Moderate The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. C Low The true effect may be substantially different from the estimate of the effect. D Very low The estimate of effect is very uncertain, and often will be far from the truth. 