Nitroprusside infusion in hypertensive patients with severe aortic ste- nosis lowers pulmonary and systemic resistance, with improvements in stroke volume and LV end-diastolic Thus, careful use of antihypertensive agents to achieve BP control in patients with hypertension and aortic stenosis is beneficial. Although there are no spe- cific trials comparing various classes of antihypertensive agents, RAS blockade may be advantageous because of the potentially beneficial effects on LV fibrosis,S9.9-3 con- trol of hypertension, reduction of dyspnea, and improved Diuretics should be used sparingly in patients with small LV chamber dimensions. Beta blockers may be appropriate for patients with aortic stenosis who have reduced ejection fraction, prior MI, arrhythmias, or angina pectoris. In patients with mod- erate or severe aortic stenosis, consultation or co-man- agement with a cardiologist is preferred for hypertension management. 2. Vasodilator therapy can reduce the LV volume and mass and improve LV performance in patients with aortic but improvement of long-term clinical outcomes, such as time to valve replacement, have been Beta blockers may result in increased diastolic filling period because of bradycardia, poten- tially causing increased aortic insufficiency. Marked reduction in DBP may lower coronary perfusion pres- sure in patients with chronic severe aortic regurgitation (stage B [progressive asymptomatic aortic regurgita- tion] and stage C [asymptomatic severe AR]). However, there are no outcomes data to support these theoretical concerns. 9.10. Aortic Disease Recommendation for Management of Hypertension in Patients With Aortic Disease COR LOE Recommendation I C-EO 1. 