Skyler JS, Bergenstal R, Bonow RO, Buse J, Deedwania P, Gale EA, Howard BV, Kirkman MS, Kosiborod M, Reaven P, Sherwin RS. Intensive glycemic control and the preven- tion of cardiovascular events: implications of the ACCORD, ADVANCE, and VA diabetes trials: a position statement of the American Diabetes Association and a scientific statement of the American College of Cardiology Foundation and the American Heart Association [published correction appears in Circulation. 2009;119:e605]. Circulation. 2009;119:351 357. doi: 10.1161/CIRCULATIONAHA.108.191305. 182. Effect of intensive blood-glucose control with metformin on com- plications in overweight patients with type 2 diabetes (UKPDS 34): UK Prospective Diabetes Study (UKPDS) Group [published correction appears in Lancet. 1998;352:1558]. Lancet. 1998;352:854 865. 183. ACCORD Study Group, Gerstein HC, Miller ME, Genuth S, Ismail- Beigi F, Buse JB, Goff DC Jr, Probstfield JL, Cushman WC, Ginsberg HN, Bigger JT, Grimm RH Jr, Byington RP, Rosenberg YD, Friedewald WT. Long-term effects of intensive glucose lower- ing on cardiovascular outcomes. N Engl J Med. 2011;364:818 828. doi: 10.1056/NEJMoa1006524. 184. Riddle MC, Ambrosius WT, Brillon DJ, Buse JB, Byington RP, Cohen RM, Goff DC Jr, Malozowski S, Margolis KL, Probstfield JL, Schnall A, Seaquist ER; Action to Control Cardiovascular Risk in Diabetes Investigators. Epidemiologic relationships be- tween A1C and all-cause mortality during a median 3.4-year Management of Comorbidities in Chronic Heart Failure CLINICAL STATEMENTS AND GUIDELINES follow-up of glycemic treatment in the ACCORD trial. Diabetes Care. 2010;33:983 990. doi: 10.2337/dc09-1278. 185. Bonds DE, Miller ME, Bergenstal RM, Buse JB, Byington RP, Cutler JA, Dudl RJ, Ismail-Beigi F, Kimel AR, Hoogwerf B, Horowitz KR, Savage PJ, Seaquist ER, Simmons DL, Sivitz WI, Speril-Hillen JM, Sweeney ME. The association between symptomatic, severe hypo- glycaemia and mortality in type 2 diabetes: retrospective epidemio- logical analysis of the ACCORD study. BMJ. 2010;340:b4909. 186. 