In addition, clinicians may encounter clinical questions that were not included among those prioritized by the panel. Revision or adaptation of the guidelines Plans for updating these guidelines After publication of these guidelines, ASH will maintain them through surveillance for new evidence, ongoing review by experts, and regular revisions. Updating or adapting recommendations locally Adaptation of these guidelines will be necessary in many circum- stances. These adaptations should be based on the associated EtD Acknowledgments The authors acknowledge Ann Wittkowski for her participation on the guideline panel. The authors acknowledge Miney Paquette, Gian Paolo Morgano, Sara Balduzzi, Meng Zhu, Samantha Craigie, Angela Barbara, Maja Ludwikowska, Piotr Stankowicz, Anna Starok, Siavash Piran, Reza Mirza, Itziar Etxeandia, Rachel Couban, Laura Fullerton, and Laura Charry for supporting the systematic reviews and Robby Nieuwlaat, Wojtek Wiercioch, and Holger Schu nemann for cocoordi- nation of the systematic review team. Holger Schu nemann prepared a template of these guidelines for all panels that was critically reviewed by Adam Cuker, Rob Kunkle, the Guideline Oversight Subcommittee, the Methods Group supporting the guidelines, and Blood Advances editors. Authorship Contribution: D.M.W. prepared the first draft of this manuscript and revised the manuscript based on authors suggestions; G.G. and R.N. contributed to drafting and critical revisions of the manuscript and contributed to further drafts; Guideline Panel members (J.A., N.P.C., M.A.C., F.D., A.H., J.M., T.M., N.S., J.S.) critically reviewed the manuscript and provided suggestions for improvement; members of the Knowledge Synthesis Team (A.A., M.B., R.K., J.J.R., Y.Z.) contributed evi- dence summaries to the guidelines; R.N. cocoordinated the systematic review team; D.M.W. and G.G. were the chair and vice chair of the panel and led the panel meeting; and all au- thors approved the content. 