(Weak for | Reviewed, New-added) Discussion Although the benefits of regular physical activity involve many health domains, its effects on CV risk reduction are commonly cited by clinicians when advocating for lifestyle change to their patients. The biological plausibility that physical activity could improve CV outcomes by positively altering lipid profiles has been well established. Lipids and their various subtypes are established independent CV risk factors and observational data indicate associations between regular physical activity and the main components of lipids (i.e., reductions in TC and LDL, and increases in HDL).[132] Whether these changes in lipids are mediating the association between physical activity and lower CVD risk is unknown. However, a biological connection is plausible and although this evidence did not restrict inclusion to patients meeting the traditional definition of dyslipidemia based on lipid levels, we think it is reasonable to extrapolate these data to patients with dyslipidemia defined by CV risk, as we do with statins (see Dyslipidemia is Defined by Risk for Cardiovascular Disease). This broader definition of dyslipidemia and the biological plausibility connection warrant consideration of physical activity as a strategy in managing dyslipidemia. The Work Group recognized that both the 2008 Physical Activity Guidelines for Americans (PAGA) (referenced in the 2014 VA/DoD Dyslipidemia CPG) and the updated 2018 PAGA guideline recommend at least 150 minutes of moderate intensity or 75 minutes of vigorous intensity aerobic exercise per week.[133] Although randomized trial data are lacking, this CPG s systematic evidence review yielded an expansive body of observational data whose findings align with the established federal PAGA recommendations. 