Table 79: Summary of systematic reviews included in the review Study Intervention and comparison (in HF clinic unless stated otherwise) Population Primary studies included McLellan, Cochrane systematic review NP guided therapy versus Usual care (review refers to as Health plan alone) Range of intervention times: 1- Anguita 2010, BATTLESCARRED, Berger 2010, Christchurch pilot, NorthStar, OPTIMA, PRIMA, PROTECT, Shochat 2012, SIGNAL- HF, STARS-BNP, TIME-CHF, UPSTEP Pufulete NIHR HTA NP guided therapy versus Usual care (review refers to as Symptom-guided therapy ) Stratified by age or over) analysis As IPD: Anguita 2010, NorthStar, Shochat Chronic Heart Failure Monitoring NICE 2018. All rights reserved. Subject to Notice of rights. ISBN: 978-1-4731-3093-7 Study Intervention and comparison (in HF clinic unless stated otherwise) Population Primary studies included Range of intervention times: 3- available As aggregate data: BATTLESCARRED, Berger 2010, Christchurch pilot, PRIMA, PROTECT, Shochat 2012, SIGNAL- HF, STARS-BNP, TIME-CHF Troughton (Brunner-la ) Troughton review NP-guided therapy versus Usual care (review refers to as Clinically-guided therapy ) Range of intervention times: 3- Subgroups for age, and others including CKD As IPD: BATTLESCARRED, Berger 2010 (labelled Vienna ), Christchurch pilot, PRIMA, PROTECT, SIGNAL-HF, TIME-CHF, UPSTEP NP: natriuretic peptides including BNP and NT-proBNP Table 80: Summary of primary studies included in the review Study Intervention and comparison (in HF clinic unless stated otherwise) Population Outcomes Comments NP monitoring: Therapy increased to target (BNP level < Clinical monitoring: Therapy intensified to reach target (congestion score and months Age mean: 69(10) Recently hospitalised and NYHA II/III HTA IPD: Mortality by age All-cause admission by age Recruited on discharge BATTLESCARRE D trial: Lainchbury (Lainchbury ) NP monitoring: Therapy increased to achieve clinical and NP target (congestion score<2 Clinical monitoring: Therapy increased to meet target months No protocol: Discharged to primary care Age > 18 mean: Recently hospitalised HF- admission Elevated NP (NT- proBNP > 50 pmol/L) HTA aggregate: Mortality by age Troughton IPD: HF admission Study papers: Quality of life renal function, no monitoring arm Recruited from hospital Chronic Heart Failure Monitoring NICE 2018. 