*CPD can guide dosing. 1 CPD is 1-2 mg of nicotine. Note: Use caution with all NRT products for patients with recent ( 2 wk) MI, serious arrhythmia, or angina; patients who are pregnant or breastfeeding; and adolescents. Timing of assessment relates to ICD-10 coding. Dose and duration can be titrated on the basis of response.S4.5-21 The FDA has issued a removal of black box warnings about neuropsychiatric events.S4.5-20,S4.5-21 am indicates morning; CPD, cigarettes smoked per day; FDA, US Food and Drug Administration; ICD-10, International Classification of Diseases, Tenth Revision; MAO, monoamine oxidase; NRT, nicotine replacement; and SR, sustained release. CLINICAL STATEMENTS AND GUIDELINES 6. Secondhand smoke exposure is known to cause in nonsmokers, and it can lead to immediate adverse events.S4.5-30 There is no safe lower limit of exposure to secondhand Even brief exposure to secondhand smoke can trigger an MI.S4.5-30,S4.5-32 Even though exposure to secondhand smoke has steadily decreased over time, certain subgroups remain exposed to secondhand smoke in homes, vehicles, public places, and workplaces. It is estimated that 41000 preventable deaths per year occur in adult nonsmokers as a result of exposure to second- The US Department of Housing and Urban Development prohibited the use of combustible tobacco products in all public hous- ing living units, indoor common areas, and public housing agency administrative office buildings, extending to all outdoor areas up to 25 feet from public housing buildings.S4.5-34 Therefore, the pres- ent writing committee recommends that clinicians advise patients to take precautions against expo- sure to secondhand smoke and aerosol from all tobacco products, such as by instituting smoking restrictions (including ENDS) inside all homes and vehicles and within 25 feet from all entryways, windows, and building vents. 4.6. 