[75,80] The benefits of pharmacist- led care outweighed the harms due to the low number of adverse events reported with the interventions in the barbershop trial.[80] The SR by Greer et al. (2016) had only limited information regarding patient satisfaction or drug-related problems.[75] This strong recommendation will have implications for resource use, as utilization of pharmacist-led interventions for the treatment of HTN could have significant system implications. As this is a Reviewed, New-replaced recommendation, the Work Group systematically reviewed evidence related to blood pressure management using pharmacist-led care either through in-person interactions, via telehealth, or a combination of the two, and that specifically discussed studies related to pharmacist- led interventions.[75-81] The evidence reviewed included two SRs and five RCTs. The confidence in the quality of evidence was moderate. The recommendation focuses on clinical pharmacists, in contrast to the recommendation in the 2014 VA/DoD HTN CPG, which grouped nurses, pharmacists, and social workers together and centered on adherence in addition to blood pressure control. Although there were variations in the quality of the evidence for the five RCTs, the moderate quality SRs by Greer et al. (2016) and Santschi et al. (2014) with the large effect sizes and the evidence for improved adherence led to the overall confidence in the quality of evidence to be assessed as moderate. Other factors considered by the Work Group for this recommendation included the improved outcomes of blood pressure reduction and blood pressure goal attainment, which outweighed the small risk of adverse events. There was some variation in patient values and preferences. Overall, the strength of the evidence and substantial effect sizes within the two SRs contributed to the Strong for recommendation.[75,76] Recommendation 11. We suggest offering nurse-led interventions as an option for patients treated for hypertension. 