While every effort is made to ensure that drug doses and other quantities are presented accurately, readers are advised that new methods and techniques involving drug usage, and described within this Journal, should only be followed in conjunction with the drug manufacturer s own published literature. SUPPLEMENTARY MATERIAL Supplementary Table 63. RCTs examining the effect of intensified vs. conventional BP control on children with CKD without DM [categorical outcome]. Supplementary Table 64. RCTs examining the effect of intensified vs. conventional BP control on children with CKD without DM [continuous outcome]. Supplementary material is linked to the online version of the paper at http://www.kdigo.org/clinical_practice_guidelines/bp.php Chapter 7: Blood pressure management in elderly persons with CKD ND INTRODUCTION This chapter specifically addresses the BP management of older patients with CKD that is non-dialysis-dependent (i.e., CKD ND), many of whom have accumulated co-morbidities associated with aging, including vascular disease, osteoporo- sis, and general frailty. The term elderly is used for persons whereas very elderly is reserved for persons 480 years of age, consistent with the terminology used in the literature reviewed in this chapter.43,149,355,356 In using these definitions, we recognize that chronological age is used as a surrogate for biological age, although this relationship is highly variable. The elderly comprise the most rapidly growing proportion of the population in most parts of the world.357 From 30 to 40 years of age, the GFR generally (but not invariably) declines, and in the older person, tubular and endocrine dysfunction in the kidney are common.358,359 Combine this with the increased prevalence of type 2 diabetes mellitus and high BP among older persons, it is not surprising that the elderly constitute the most rapidly growing population of CKD patients. In population health surveys, a large proportion of the elderly have a reduced GFR. 