Renin angiotensin system blockade and cardiovascular outcomes in patients with chronic kidney disease and proteinuria: a meta-analysis. Am Heart J 2008; 155: 791 805. 98. Oregon Health Resources Commission. Direct Renin Inhibitors, Angioten- sin Converting Enzyme Inhibitors, and Angiotensin II Receptor Blockers Draft. January 2010. references 99. Oregon Health Resources Commission. Angiotensin-Converting Enzyme Inhibitors (ACEIs) Subcommittee Report Update. July 2005. 100. Oregon Health Resources Commission. Angiotensin II Receptor Antago- nists (AIIRA) Subcommittee Report. March 2006. 101. Bakris GL, Sarafidis PA, Weir MR et al. Renal outcomes with different fixed-dose combination therapies in patients with hypertension at high risk for cardiovascular events (ACCOMPLISH): a prespecified secondary analysis of a randomised controlled trial. Lancet 2010; 375: 1173 1181. 102. Batterink J, Stabler SN, Tejani AM et al. Spironolactone for hypertension. Cochrane Database Syst Rev 2010: CD008169. 103. Becker GJ, Hewitson TD, Chrysostomou A. Aldosterone in clinical nephrology old hormone, new questions. Nephrol Dial Transplant 2009; 24: 2316 2321. 104. Epstein M. Aldosterone as a mediator of progressive renal disease: pathogenetic and clinical implications. Am J Kidney Dis 2001; 37: 677 688. 105. Goodfriend TL. Treating resistant hypertension with a neglected old drug. Hypertension 2007; 49: 763 764. 106. Epstein M, Williams GH, Weinberger M et al. Selective aldosterone blockade with eplerenone reduces albuminuria in patients with type 2 diabetes. Clin J Am Soc Nephrol 2006; 1: 940 951. 107. Bomback AS, Kshirsagar AV, Amamoo MA et al. Change in proteinuria after adding aldosterone blockers to ACE inhibitors or angiotensin receptor blockers in CKD: a systematic review. Am J Kidney Dis 2008; 51: 199 211. 108. Mehdi UF, Adams-Huet B, Raskin P et al. Addition of angiotensin receptor blockade or mineralocorticoid antagonism to maximal angiotensin- converting enzyme inhibition in diabetic nephropathy. J Am Soc Nephrol 2009; 20: 2641 2650. 109. 