However, at levels of <130 mmHg, there was a 40% increase in serious adverse events with no benefit for other outcomes. In the second meta-analysis, 73913 patients with diabetes mellitus (295652 patient-years of exposure) were randomized Overall, more aggressive treatment reduced stroke incidence by 9% (P=0.006), and lower versus less aggressive BP control reduced the risk of stroke by 31% (RR, 0.61; 95% CI, 0.48 0.79). In a meta-regression analy- sis, the risk of stroke decreased by 13% (95% CI, 0.05 0.20; P=0.002) for each 5-mmHg reduction in SBP and by 11.5% in DBP. 