EXPERT CONSENSUS DECISION PATHWAY 2021 Update to the 2017 ACC Expert Consensus Decision Pathway for Optimization of Heart Failure Treatment: Answers to 10 Pivotal Issues About Heart Failure With Reduced Ejection Fraction A Report of the American College of Cardiology Solution Set Oversight Committee Writing Committee Thomas M. Maddox, MD, MSC, FACC, Chair James L. Januzzi, JR, MD, FACC, Vice Chair Larry A. Allen, MD, MHS, FACC Khadijah Breathett, MD, MS, FACC Javed Butler, MD, MBA, MPH, FACC Leslie L. Davis, PHD, RN, ANP-BC, FACC Gregg C. Fonarow, MD, FACC Nasrien E. Ibrahim, MD, FACC JoAnn Lindenfeld, MD, FACC Frederick A. Masoudi, MD, MSPH, FACC Shweta R. Motiwala, MD, MPH Estefania Oliveros, MD, MSC J. Herbert Patterson, PHARMD Mary Norine Walsh, MD, MACC Alan Wasserman, MD, FACC Clyde W. Yancy, MD, MSC, MACC Quentin R. Youmans, MD Solution Set Oversight Committee Ty J. Gluckman, MD, FACC, Chair Niti R. Aggarwal, MD, FACC Nicole M. Bhave, MD, FACC Gregory J. Dehmer, MD, MACC Olivia N. Gilbert, MD, MSc, FACC Chayakrit Krittanawong, MD Dharam J. Kumbhani, MD, SM, FACC Javier A. Sala-Mercado, MD, PhD David E. Winchester, MD, MS, FACC Martha Gulati, MD, MS, FACC Ex Of cio This document was approved by the American College of Cardiology Clinical Policy Approval Committee in November 2020. The American College of Cardiology requests that this document be cited as follows: Maddox TM, Januzzi JL Jr., Allen LA, Breathett K, Butler J, Davis LL, Fonarow GC, Ibrahim NE, Lindenfeld J, Masoudi FA, Motiwala SR, Oliveros E, Patterson JH, Walsh MN, Wasserman A, Yancy CW, Youmans QR. 