Use of more objective methods (eg, pill counts, data on medication refills) to assess adherence along with self-report methods is optimal. Recommendation-Specific Supportive Text 1. Remembering to take medication is often challenging, particularly for regimens that must be dosed several times daily. Taking medications several times through- out the day requires greater attention to scheduling, as well as additional issues such as transportation or stor- age, which can be challenging for some patients. The impact of once-daily dosing of antihypertensive drugs versus dosing multiple times daily has been evaluated in several meta-analyses.S12.1.1-1 S12.1.1-3 Medication ad- herence was greatest with once-daily dosing (range 71% to 94%) and declined as dosing frequency 2. Assessment and possible modification of drug therapy regimens can improve suboptimal adherence. Simplifying medication regimens, either by less frequent dosing (ie, once daily versus multiple times daily) or use of com- bination drug therapy, improves adherence. Available fixed-dose combination drug therapy is listed in Online Data Supplement D. 12.1.2. Strategies to Promote Lifestyle Modification Recommendation for Strategies to Promote Lifestyle Modification References that support the recommendation are summarized in Online Data Supplement 61. COR LOE Recommendation I C-EO 1. Effective behavioral and motivational strategies to achieve a healthy lifestyle (ie, tobacco cessation, weight loss, moderation in alcohol intake, increased physical activity, reduced sodium intake, and consumption of a healthy diet) are recommended for adults with Synopsis The primary lifestyle modification interventions that can help reduce high BP are outlined in Section 6 (healthy diet, weight loss, exercise and moderate alcohol intake). In addi- tion, tobacco cessation is crucial for CVD risk reduction. These modifications are central to good health and require specific motivational and cognitive intervention strategies designed to promote adherence to these healthy behaviors. 