10.2.2 Review question: What is the effectiveness of domiciliary oxygen therapy in people with advanced heart failure For full details see review protocol in appendix A. Table 142: PICO characteristics of review question Review population Adults (aged 18 years and over) with advanced heart failure (whether living in a care home (community residential facility), at home or in a hospice). These patients may be approaching the end of their life and may be receiving other palliative care services. Trials of patients with heart failure and other co-morbidities such as sleep apnoea and COPD will be included (however, see exclusions). Interventions/co mparators Domiciliary oxygen therapy (repeated long term use (daily availability)) No oxygen therapy o Medical air o Handheld fan o No treatment Different doses of oxygen will be pooled in the analysis. Outcomes CRITICIAL Quality of life at 2 weeks (Continuous) Change in breathlessness at 2 weeks (Continuous) Unplanned hospitalization at 4 weeks (Count rate) Unplanned hospitalization at 4 weeks (number of bed days) Patient and carer satisfaction 2 weeks (Continuous) Chronic Heart Failure Domiciliary oxygen therapy in people with advanced heart failure NICE 2018. All rights reserved. Subject to Notice of rights. ISBN: 978-1-4731-3093-7 IMPORTANT Change in exercise capacity at 2 weeks (Continuous) Change in NYHA class at 2 weeks (Continuous) Shorter term time points will also be extracted if reported in the studies but may be downgraded for indirectness in consultation with the GC. Study design Systematic Review RCT 10.2.3 Clinical evidence A search was conducted for randomised trials comparing the effectiveness of domiciliary oxygen therapy versus no oxygen therapy or usual care as treatment for the symptoms (particularly breathlessness) of advanced heart failure. One study was included in the review63 which is summarised in Table 143 below. 