A meta-analysis of studies assessing poststroke depression screening tools (24 studies, N=2907) found several inventories with high sensitivity for detecting poststroke depression.270 Two of these studies evaluated patients in the acute phase 2 weeks after onset and found that depression screening tools showed good accuracy compared with the reference standard diagnosis by the American Psychiatric Association Diagnostic and Statistical Manual of However, further studies are needed to determine the optimal timing, setting, and follow-up for See Tables LXIII and LXIV in online Data Supplement 1. Patients diagnosed with poststroke depression should be treated with antidepressants in the absence of contraindications and closely monitored to verify effectiveness. I B-R Recommendation and COR unchanged from 2016 Rehab Guidelines. LOE amended to conform with ACC/AHA 2015 Recommendation Classification System. Clinical trials of antidepressants in individuals with poststroke depression have shown a beneficial effect on depression remission and response, but trials were limited by small samples, variable criteria for poststroke depression, and vague definitions for remission and response.16 Several trials have indicated a benefit of psychosocial therapies for treatment.16 In an RCT, participants who underwent screening in the early subacute period 1 to 2 months after stroke followed by treatment with counseling antidepressant medication showed significantly lower 12-week depression scores than those who received usual care.273 See Tables LXV and LXVI in online Data Supplement 1. 4.9. Deep Vein Thrombosis Prophylaxis (Continued) COR LOE New, Revised, or Unchanged Powers et al 2019 Guidelines for Management of AIS e385 4.11. Other COR LOE New, Revised, or Unchanged During hospitalization and inpatient rehabilitation, regular skin assessments are recommended with objective scales of risk such as the Braden scale. I C-LD Recommendation and COR unchanged from 2016 Rehab Guidelines. LOE amended to conform with ACC/AHA 2015 Recommendation Classification System. 