Of note, the SPRINT protocol did not specify whether AOBP should be performed while attended or unattended. A post hoc analysis of SPRINT data found that while a majority of sites did perform unattended AOBP, many performed attended AOBP or some combination of Study Method/device Type of study Year Framingham MDRD UKPDS AASK ADVANCE CRIC ACCORD ONTARGET CKD JAC SPRINT Population General ) ) ) Recent lacunar stroke (baseline eGFR 80 ; 16% CKD) CVD or T2D (baseline SCr 1.05 mg/dl [93 mol/l]; ) ) High CVD risk (baseline SCr 1.07 mg/dl [95 mol/l]; ) Observational Clinical trial Clinical trial Clinical trial Clinical trial Observational Clinical trial Clinical trial Clinical trial Observational Clinical trial Manual Manual Automated Manual Manual Manual and automated Automated/Omron Automated/Colin electronic device Automated/Omron Manual Automated/Omron Figure 3 | Blood pressure measurement method and device used in select RCTs and prospective observational studies. AASK, African American Study of Kidney Disease and Hypertension; ACCORD, Action to Control Cardiovascular Risk in Diabetes; ADVANCE, Action in Diabetes and Vascular Disease: Preterax and Diamicron Modi ed Release Controlled Evaluation; CKD-JAC, Chronic Kidney Disease Japan Cohort; CRIC, Chronic Renal Insuf ciency Cohort; MDRD, Modi cation of Diet in Renal Disease; ONTARGET, Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial; SPRINT, Systolic Blood Pressure Intervention Trial; SPS3, Secondary Prevention of Small Subcortical Strokes Trial; UKPDS, United Kingdom Prospective Diabetes Study. Adapted with modi cations with permission of the American Society of Nephrology from BP measurement in clinical practice: time to SPRINT to guideline-recommended protocols. Drawz PE, Ix JH, volume 29, Copyright 2018, permission conveyed through Copyright Clearance Center, Inc.10 ONTARGET was published in 2008.11 The BP measurement approach used in the trial was subsequently published in the 2012 article referenced above. 