The HAS-BLED score has better prediction accuracy for major bleeding than CHADS2 or CHA2DS2-VASc scores in anticoagulated patients with atrial brillation. J Am Coll Cardiol. 2013;62(23):2199-2204. 106. Zhu W, He W, Guo L, Wang X, Hong K. The HAS-BLED score for predicting major bleeding risk in anticoagulated patients with atrial brillation: a systematic review and meta-analysis. Clin Cardiol. 2015;38(9):555-561. 107. Lip GY, Lane DA, Buller H, Apostolakis S. Development of a novel composite stroke and bleeding risk score in patients with atrial brillation: the AMADEUS Study. Chest. 2013;144(6):1839-1847. 108. Banerjee A, Fauchier L, Bernard-Brunet A, Clementy N, Lip GY. Composite risk scores and composite endpoints in the risk prediction of outcomes in anticoagulated patients with atrial brillation. The Loire Valley Atrial Fibrillation Project. Thromb Haemost. 2014;111(3):549-556. 109. Smith JG, Wieloch M, Koul S, et al. Triple antithrombotic therapy following an acute coronary syndrome: prevalence, outcomes and prognostic utility of the HAS-BLED score. EuroIntervention. 2012;8(6):672-678. 110. Thomas MR, Lip GY. Novel Risk Markers and Risk Assessments for Cardiovascular Disease. Circ Res. 2017;120(1):133-149. 111. Ban N, Siegfried CJ, Lin JB, et al. GDF15 is elevated in mice following retinal ganglion cell death and in glaucoma patients. JCI Insight. 2017;2(9). 112. Rivera-Caravaca JM, Roldan V, Esteve-Pastor MA, et al. Long-term stroke risk prediction in patients with atrial brillation: comparison of the ABC-Stroke and CHA2DS2-VASc scores. J Am Heart Assoc. 2017;6(7). 113. Esteve-Pastor MA, Rivera-Caravaca JM, Roldan V, et al. Long-term bleeding risk prediction in real world patients with atrial brillation: comparison of the HAS-BLED and ABC-Bleeding risk scores. The Murcia Atrial Fibrillation Project. Thromb Haemost. 2017;117(10):1848-1858. 114. Lip GY, Lane DA. Bleeding risk assessment in atrial brillation: observations on the use and misuse of bleeding risk scores. J Thromb Haemost. 2016;14(9):1711-1714. 115. Caldeira D, Costa J, Fernandes RM, Pinto FJ, Ferreira JJ. 