Overell J, Bone I, Lees K. Interatrial septal abnormalities and stroke: a meta-analysis of case-control studies. Neurology. 2000;55:1172 1179. 487. O Gara PT, Messe SR, Tuzcu EM, Catha G, Ring JC; American Heart Association; American Stroke Association; American College of Cardiology Foundation. Percutaneous device closure of patent fora- men ovale for secondary stroke prevention: a call for completion of randomized clinical trials: a science advisory from theAmerican Heart Association/American Stroke Association and the American College of Cardiology Foundation. Circulation. 2009;119:2743 2747. 488. Handke M, Harloff A, Olschewski M, Hetzel A, Geibel A. Patent fora- men ovale and cryptogenic stroke in older patients. N Engl J Med. 2007;357:2262 2268. 489. Meissner I, Khandheria BK, Heit JA, Petty GW, Sheps SG, Schwartz GL, Whisnant JP, Wiebers DO, Covalt JL, Petterson TM, Christianson TJ, AgmonY. Patent foramen ovale: innocent or guilty? Evidence from a pro- spective population-based study. J Am Coll Cardiol. 2006;47:440 445. 490. Goel SS, Tuzcu EM, Shishehbor MH, de Oliveira EI, Borek PP, Krasuski RA, Rodriguez LL, Kapadia SR. Morphology of the patent foramen ovale in asymptomatic versus symptomatic (stroke or transient ischemic attack) patients. Am J Cardiol. 2009;103:124 129. 491. Mas JL, Arquizan C, Lamy C, Zuber M, Cabanes L, Derumeaux G, Coste J; Patent Foramen Ovale and Atrial Septal Aneurysm Study Group. Recurrent cerebrovascular events associated with patent foramen ovale, atrial septal aneurysm, or both. N Engl J Med. 2001;345:1740 1746. 492. Di Tullio MR, Jin Z, Russo C, Elkind MS, Rundek T,Yoshita M, DeCarli C, Wright CB, Homma S, Sacco RL. Patent foramen ovale, subclini- cal cerebrovascular disease, and ischemic stroke in a population-based cohort. J Am Coll Cardiol. 2013;62:35 41. 493. 