Percutaneous closure of patent foramen ovale in crypto- genic embolism. N Engl J Med. 2013;368:1083 1091. doi: 10.1056/ 561. Turc G, Calvet D, Guerin P, Sroussi M, Chatellier G, Mas JL; CLOSE Investigators. Closure, anticoagulation, or antiplatelet therapy for crypto- genic stroke with patent foramen ovale: systematic review of randomized trials, sequential meta-analysis, and new insights from the CLOSE study. J Am Heart Assoc. 2018;7:e008356. doi: 10.1161/JAHA.117.008356 562. Merkler AE, Gialdini G, Yaghi S, Okin PM, Iadecola C, Navi BB, Kamel H. Safety outcomes after percutaneous transcatheter closure of pat- ent foramen ovale. Stroke. 2017;48:3073 3077. doi: 10.1161/ 563. Mas JL, Derex L, Gu rin P, Guillon B, Habib G, Juliard JM, Marijon E, Massardier E, Meneveau N, Vuillier F. Transcatheter closure of patent fora- men ovale to prevent stroke recurrence in patients with otherwise unex- plained ischaemic stroke: expert consensus of the French Neurovascular Society and the French Society of Cardiology. Arch Cardiovasc Dis. 564. Pristipino C, Sievert H, D Ascenzo F, Louis Mas J, Meier B, Scacciatella P, Hildick-Smith D, Gaita F, Toni D, Kyrle P, et al; Evidence Synthesis Team; EAPCI Scientific Documents and Initiatives Committee; International Experts. European position paper on the management of patients with pat- ent foramen ovale. General approach and left circulation thromboembolism. Eur Heart J. 2019;40:3182 3195. doi: 10.1093/eurheartj/ehy649 CLINICAL STATEMENTS AND GUIDELINES Kleindorfer 565. Kamel H, Merkler AE, Iadecola C, Gupta A, Navi BB. Tailoring the ap- proach to embolic stroke of undetermined source: a review. JAMA Neurol. 566. Kent DM, Ruthazer R, Weimar C, Mas JL, Serena J, Homma S, Di Angelantonio E, Di Tullio MR, Lutz JS, Elkind MS, et al. An index to identify stroke-related vs incidental patent foramen ovale in cryp- togenic stroke. Neurology. 2013;81:619 625. doi: 10.1212/WNL. 567. 