All compared to each other Thiazides are limited to: Bendroflumethiazide (Bendrofluazide) Cyclopenthiazide Chlorthalidone / Chlortalidone Indapamide Xipamide Metolazone Outcomes CRITICAL Quality of life Unplanned hospitalization Chronic Heart Failure Domiciliary oxygen therapy in people with advanced heart failure NICE 2018. All rights reserved. Subject to Notice of rights. ISBN: 978-1-4731-3093-7 IMPORTANT Change in dyspnoea Weight change / change in oedema Change in NYHA class Patient and carer satisfaction Time to death (survival) Successful administration of intervention Study design Systematic Review RCT 10.1.3 Clinical evidence A search was conducted for randomised trials and systematic reviews of randomised trials comparing the effectiveness of different modes of administration of diuretics in people with advanced heart failure in the community. No relevant studies were identified. See appendix I for the excluded studies table. 10.1.4 Economic evidence Published literature No relevant health economic studies were identified. See also the health economic study selection flow chart in appendix D. 10.1.5 Evidence statements Clinical No relevant published evidence was identified. Economic No relevant economic evaluations were identified. 10.1.6 Recommendations and link to evidence Recommendations No recommendation Research recommendation In people with advanced heart failure and significant peripheral fluid overload, what is the clinical and cost effectiveness of oral, subcutaneous and intravenous diuretic therapy in the community? Relative values of different outcomes The committee agreed that the outcomes critical for decision making were quality of life, unplanned hospitalisations (count rate) and unplanned hospitalisations (number of bed days), while the outcomes change in dyspnoea, weight change/change in oedema, change in NYHA class, patient and carer satisfaction, time to death or survival and successful administration of the intervention were important for decision making. Quality of the clinical evidence No clinical evidence was identified for inclusion within the review. 