Treatment of isolated systolic hypertension is most effective in older patients with high-risk profile. Circulation. Oct 16 2001;104(16):1923-1926. PMID: 11602495. 32. Ogden LG, He J, Lydick E, Whelton PK. Long-term absolute benefit of lowering blood pressure in hypertensive patients according to the JNC VI risk stratification. Hypertension. Feb 2000;35(2):539-543. PMID: 10679494. 33. Staessen JA, Gasowski J, Wang JG, et al. Risks of untreated and treated isolated systolic hypertension in the elderly: Meta-analysis of outcome trials. Lancet. Mar 11 2000;355(9207):865-872. PMID: 10752701. 34. Vasan RS, Larson MG, Leip EP, Kannel WB, Levy D. Assessment of frequency of progression to hypertension in non-hypertensive participants in the Framingham Heart Study: A cohort study. Lancet. Nov 17 2001; 358(9294):1682-1686. PMID: 11728544. 35. Piper MA, Evans CV, Burda BU, Margolis KL, O'Connor E, Whitlock EP. Diagnostic and predictive accuracy of blood pressure screening methods with consideration of rescreening intervals: A systematic review for the U.S. Preventive Services Task Force. Ann Intern Med. Feb 3 2015;162(3):192-204. PMID: 25531400. 36. Muntner P, Shimbo D, Carey RM, et al. Measurement of blood pressure in humans: A Scientific Statement From the American Heart Association. Hypertension. May 2019;73(5):e35-e66. PMID: 30827125. 37. Pappaccogli M, Di Monaco S, Perlo E, et al. Comparison of automated office blood pressure with office and out-off-office measurement techniques. Hypertension. Feb 2019;73(2):481-490. PMID: 30624994. 38. Roerecke M, Kaczorowski J, Myers MG. Comparing automated office blood pressure readings with other methods of blood pressure measurement for identifying patients with possible hypertension: A systematic review and meta-analysis. JAMA Intern Med. Feb 4 2019. PMID: 30715088. 39. Kollias A, Stambolliu E, Kyriakoulis KG, Gravvani A, Stergiou GS. Unattended versus attended automated office blood pressure: Systematic review and meta-analysis of studies using the same methodology for both methods. J Clin Hypertens (Greenwich). Feb 2019;21(2):148-155. PMID: 30585383. 40. 