Urgent CABG within 5 days of clopidogrel or ti- cagrelor administration or within 7 days of prasu- grel administration might be considered, especially if the benefits of prompt revascularization outweigh the risks of bleeding. (Level of Evidence: C) In contrast to previous observations410 412 of markedly increased rates of major bleeding and mediastinal reex- ploration after CABG in patients exposed to clopidogrel within 5 to 7 days before CABG, several reports have sug- gested that it might be reasonable to proceed with urgent surgery within a shorter time frame, especially when the benefits of revascularization outweigh the risks of bleeding, as often may be the case among patients with Shorter delays to urgent surgery may also be pos- sible when off-pump revascularization is planned. Among the 136 patients in CLARITY-TIMI 28 who underwent CABG within 5 days of clopidogrel exposure, there was no differ- ence in the rates of major bleeding through 30 days of follow- up between the clopidogrel and placebo groups (7.5% versus In a prospective RCT exam- ining the effect of the timing of clopidogrel discontinuation before CABG, 3 groups were studied: clopidogrel continued to the day of surgery, clopidogrel discontinued 3 days before surgery, and clopidogrel discontinued 5 days before surgery. 