Thus, when weighing the risks and benefits of a lower BP goal for people aged 70 years or older with estimated GFR less than 60 mL/min/ , antihypertensive treatment should be individualized, tak- ing into consideration factors such as frailty, comorbidities, and albuminuria. macologic treatment to lower BP at SBP of 140 mm Hg or higher or DBP of 90 mm Hg or higher and treat to a goal SBP of lower than 140 mm Hg and goal DBP lower than 90 mm Hg. Expert Opinion Grade E Syst-Eur, and UKPDS) that treatment to an SBP goal of lower than in adults with diabetes and hypertension.23-25 No RCTs addressed whether treatment to an SBP goal of lower than 140 mm Hg com- outcomesinadultswithdiabetesandhypertension.Intheabsence of such evidence, the panel recommends an SBP goal of lower than based on expert opinion, consistent with the BP goals in recom- hypertension.UseofaconsistentBPgoalinthegeneralpopulation younger than 60 years and in adults with diabetes of any age may facilitateguidelineimplementation.ThisrecommendationforanSBP goal of lower than 140 mm Hg in patients with diabetes is also sup- portedbytheACCORD-BPtrial,inwhichthecontrolgroupusedthis goal and had similar outcomes compared with a lower goal.7 The panel recognizes that the ADVANCE trial tested the ef- fects of treatment to lower BP on major macrovascular and micro- vascular events in adults with diabetes who were at increased risk of CVD, but the study did not meet the panel s inclusion criteria be- causeparticipantswereeligibleirrespectiveofbaselineBP,andthere were no randomized BP treatment thresholds or goals.26 The panel also recognizes that an SBP goal of lower than 130 mmHgiscommonlyrecommendedforadultswithdiabetesandhy- pertension. 