CLINICAL STATEMENTS AND GUIDELINES Abbreviation Meaning/Phrase ACS acute coronary syndromes AED automated external defibrillator AMI acute myocardial infarction BNP B-type natriuretic peptide CABG coronary artery bypass graft CKD chronic kidney disease CPR cardiopulmonary resuscitation CRT cardiac resynchronization therapy CT computed tomography ECG electrocardiogram ERC evidence review committee ESRD end-stage renal disease GDMT guideline-directed management and therapy HCM hypertrophic cardiomyopathy HF heart failure HFpEF heart failure with preserved ejection fraction HFrEF heart failure with reduced ejection fraction ICD implantable cardioverter-defibrillator LV left ventricular LVAD left ventricular assist device LVEF left ventricular ejection fraction MI myocardial infarction NICM nonischemic cardiomyopathy NSVT nonsustained ventricular tachycardia PET positron emission tomography PCI percutaneous coronary intervention PVC premature ventricular complex QoL quality of life RCT randomized controlled trial RV right ventricular RVOT right ventricular outflow tract SCA sudden cardiac arrest SCD sudden cardiac death SVT supraventricular tachycardia TOF tetralogy of Fallot VA ventricular arrhythmia VT ventricular tachycardia 2.1. General Concepts VA include a spectrum that ranges from premature ventricular complex (PVC) to ventricular fibrillation (VF), with a clinical presentation that ranges from a total lack of symptoms to cardiac arrest. Most life-threatening VA are associated with ischemic heart disease, particularly in older patients.S2.2.2-1 The risks of VA and SCD vary in specific populations with different underlying cardiac conditions, and with specific family history and genetic variants, and this variation has important implications for studying and applying therapies. 2.1.1. Premature Ventricular Complexes and Nonsustained VT PVCs are common and increase in frequency with age. 