d Study populations varied across studies: Pinede et al223 enrolled provoked and unprovoked proximal DVT and PE; Campbell et al,222 enrolled provoked and unprovoked isolated distal DVT, proximal DVT, and PE; Agnelli et al224 had separate randomizations for provoked PE (3 vs 6 mo) and unprovoked (3 vs 12 mo); Agnelli et al225 enrolled unprovoked proximal DVT; Eischer et al227 enrolled unprovoked isolated DVT, proximal DVT, and PE with high levels of factor VIII; and Couturaud et al60 enrolled unprovoked PE. e CIs include both values suggesting no effect and values suggesting either bene t or harm. Bibliography: Campbell et al,222 Pinede et al223 (DOTAVK), Agnelli (WODIT-PE Provoked and Unprovoked), Agnelli et al225 (WODIT-DVT), Couturaud et al60 (PADIS-PE), Siragusa et al226 (DACUS), Eischer et al227 (AUREC-FVIII) 330 Evidence-Based Medicine [ 1 4 9 # 2 C H E S T F E B R U A R Y 2 0 1 6 ] to use the same estimates for the reduction in recurrent VTE and the increase in bleeding with anticoagulation that we used in AT9, and that were based on VKA therapy. 