Chronic Heart Failure Diagnosing heart failure NICE 2018. All rights reserved. Subject to Notice of rights. ISBN: 978-1-4731-3093-7 5.1.5 Economic evidence 5.1.5.1 Published literature No economic evaluations were identified comparing NT-proBNP thresholds and BNP thresholds. One relevant economic evaluation was identified and included in this review. This is summarised in the health economic profile below (Table 13) and the health economic tables in Appendix G. See also the economic article selection flow diagram in Appendix D. Diagnosing heart failure Chronic Heart Failure NICE 2018. All rights reserved. Subject to Notice of rights. ISBN: Table 13: Health economic evidence profile Study Applicabilit y Limitations Other comments Costs (c) Effects (QALYs) (c) Incrementa l cost (d) Incrementa l effects (d) Cost- effectiveness (d) Uncertainty Monahan [UK] Directly applicable(a ) Potentially serious limitations (b) Cost-utility analysis (health outcome: QALYs) Decision tree used to categorise patients according to diagnostic Population: Primary care patients aged 55years or over presenting to GP with symptoms suggestive of HF recruited across 28 central England practices in the UK. Interventions: 1. MICE clinical decision rule, upper cut-off 2. MICE clinical decision rule, lower cut-off guideline recommended strategy 4. Echo all sensitivity analysis showed that the probability that Intervention 3 is the optimal strategy at 99.9%. remains the most cost effective strategy in a number of scenario analyses. However, when proportion of HF-REF is the most cost effective strategy. When proportion of HF-REF is 100% became the most cost effective strategy. effects) is higher than for 2 vs 3) Diagnosing heart failure Chronic Heart Failure NICE 2018. All rights reserved. Subject to Notice of rights. ISBN: Study Applicabilit y Limitations Other comments Costs (c) Effects (QALYs) (c) Incrementa l cost (d) Incrementa l effects (d) Cost- effectiveness (d) Uncertainty 6. 