A Primer on Stroke Prevention and Treatment: an Overview Based on AHA/ASA Guidelines. Oxford, UK: Wiley- Blackwell; 2009:152 169. 827. Pezzini A, Del Zotto E, Magoni M, Costa A, Archetti S, Grassi M, Akkawi NM, Albertini A, Assanelli D, Vignolo LA, Padovani A. Inherited thrombophilic disorders in young adults with ischemic stroke and patent foramen ovale. Stroke. 2003;34:28 33. 828. Bank I, Libourel EJ, Middeldorp S, Van Pampus EC, Koopman MM, Hamulyak K, Prins MH, Van Der Meer J, Buller HR. Prothrombin 20210A mutation: a mild risk factor for venous thromboembolism but not for arterial thrombotic disease and pregnancy-related complications in a family study. Arch Intern Med. 2004;164:1932 1937. 829. Barnes C, Deveber G. Prothrombotic abnormalities in childhood isch- aemic stroke. Thromb Res. 2006;118:67 74. 830. Dalen JE. Should patients with venous thromboembolism be screened for thrombophilia? Am J Med. 2008;121:458 463. 831. Hamedani AG, Cole JW, Mitchell BD, Kittner SJ. Meta-analysis of fac- tor V Leiden and ischemic stroke in young adults: the importance of case ascertainment. Stroke. 2010;41:1599 1603. 832. Wasay M, Bakshi R, Bobustuc G, Kojan S, Sheikh Z, Dai A, Cheema Z. Cerebral venous thrombosis: analysis of a multicenter cohort from the United States. J Stroke Cerebrovasc Dis. 2008;17:49 54. 833. Wu O, Robertson L, Twaddle S, Lowe GD, Clark P, Greaves M, Walker ID, Langhorne P, Brenkel I, Regan L, Greer I. Screening for throm- bophilia in high-risk situations: systematic review and cost-effective- ness analysis: the Thrombosis: Risk and Economic Assessment of Thrombophilia Screening (TREATS) study. Health Technol Assess. 2006;10:1 110. 834. Wells PS, Louzada ML, Taljaard M, Anderson DR, Kahn SR, Langlois NJ, Rutberg J, Kovacs MJ, Rodger MA. A pilot study to assess the feasibility of a multicenter cluster randomized trial for the manage- ment of asymptomatic persons with a thrombophilia. 