When a non-UK study was included in the profile, the results were converted into pounds sterling using the appropriate purchasing power parity.249 Table 8: Content of NICE health economic evidence profile Item Description Study Surname of first author, date of study publication and country perspective with a reference to full information on the study. Applicability An assessment of applicability of the study to this guideline, the current NHS situation and NICE decision-making:(a) Directly applicable the study meets all applicability criteria, or fails to meet 1 or more applicability criteria but this is unlikely to change the conclusions about cost effectiveness. Partially applicable the study fails to meet 1 or more applicability criteria, and this could change the conclusions about cost effectiveness. Not applicable the study fails to meet 1 or more of the applicability criteria, and this is likely to change the conclusions about cost effectiveness. Such studies would usually be excluded from the review. Limitations An assessment of methodological quality of the study:(a) Minor limitations the study meets all quality criteria, or fails to meet 1 or more quality criteria, but this is unlikely to change the conclusions about cost effectiveness. Potentially serious limitations the study fails to meet 1 or more quality criteria, and this could change the conclusions about cost effectiveness. Very serious limitations the study fails to meet 1 or more quality criteria, and this is highly likely to change the conclusions about cost effectiveness. Such studies would usually be excluded from the review. Other comments Information about the design of the study and particular issues that should be considered when interpreting it. Incremental cost The mean cost associated with one strategy minus the mean cost of a comparator strategy. 