ISBN: 978-1-4731-3093-7 Study Intervention and comparison (in HF clinic unless stated otherwise) Population Outcomes Comments (Adlbrecht ) NP monitoring: Therapy intensified to meet or maintain target (NT-proBNP <2200pg/l), Clinical monitoring: Therapy intensified at clinician s discretion according to clinical assessment No protocol: Discharged to primary care Age mean: 71(12) Recently hospitalised with NYHA class III/IV and cardiothoracic ratio > 0.5 or LVEF Troughton IPD: Mortality Recruited from hospital Christchurch pilot Troughton NP monitoring: Treatment intensified to reach target (NT- Clinical monitoring: Therapy increased to reach target (Framingham score <2) Age mean: 70(10) LVEF < 40%, NYHA class II-IV Treatment with at least ACEi and loop diuretic Troughton IPD: Mortality Recruited in hospital or HF clinic PRIMA trial: NP monitoring: therapy increased to reach or maintain target (NT-proBNP at the lowest level recorded at discharge or two weeks following), 24 months Clinical monitoring: Therapy increased at clinician s discretion according to clinical assessment, 24 months Age mean: 72(12) Recent HF- admission, mainly NYHA III, Elevated NPs (NT- proBNP levels at admission 1700 pg/mL) that respond to treatment (decrease 10% at discharge) Troughton IPD: Mortality Primary paper: Admissions (as days in hospital) Recruited from hospital PROTECT trial: (Weiner , Mallick , Ibrahim , Bhardwaj ) NP monitoring: Therapy intensified to reach target (NT- months Clinical monitoring: Therapy intensified at clinician discretion according to clinical assessment, 6-12 months Age 21 years, NYHA class II-IV, LVEF 40%, destabilisation in (attended hospital or clinic for worsening HF) Troughton IPD: Mortality Recruited Chronic Heart Failure Monitoring NICE 2018. All rights reserved. Subject to Notice of rights. 