Despite general belief that a reduction in sedentary time results in lowering of blood pressure, there is a paucity of clinical data about optimal duration, frequency and specific type(s) of exercise that would result in improved patient outcomes. Clinical trials are required to address these research questions. F. Obesity and Hypertension Growing rates of obesity call for additional research on blood pressure lowering as well as cardiovascular benefits of weight loss interventions, including pharmacological therapy and bariatric surgery in obese hypertensive individuals. Trials with long-term follow up are especially important to evaluate sustainability and impact of weight-lowering interventions in patients with obesity and HTN. G. Pharmacotherapy Combination antihypertensive therapy may allow for use of lower doses of individual agents and, therefore, minimize adverse drug effects. However, clinical trials are needed to evaluate whether (and which specific) combination of antihypertensive agents and at what doses are more effective than a maximum-level dose of a single agent for blood pressure control and medication adherence. Clinical trials should also focus on comparative effectiveness of (1) equivalent doses of chlorthalidone and hydrochlorothiazide, and (2) newer antihypertensive agents, such as vasodilatory beta-blockers in essential HTN. Management of RHT is a rapidly expanding area and future studies with long-term follow-up that would allow evaluation of clinical outcomes are needed to establish optimal fourth-line antihypertensive agents in RHT and whether variations in patient characteristics may necessitate differential approaches to a fourth-line agents for RHT. H. Screening for Asymptomatic Hypertension-mediated Target Organ Damage Despite clinically sound concerns about target organ damage resulting from HTN and routine screening for asymptomatic CVD and kidney disease that is done by many general practitioners, there is a paucity of evidence to support this practice. 