Brugada Syndrome Recommendations for Brugada Syndrome References that support the recommendations are summarized in Online Data Supplement 42 and Systematic Review Report. COR LOE Recommendations I B-NR In asymptomatic patients with only inducible type 1 Brugada electrocardiographic pattern, observation without therapy is I B-NR In patients with Brugada syndrome with spontaneous type 1 Brugada electrocardiographic pattern and cardiac arrest, sustained VA or a recent history of syncope presumed due to VA, an ICD is recommended if meaningful survival of greater than 1 year is I B-NR In patients with Brugada syndrome experiencing recurrent ICD shocks for polymorphic VT, intensification of therapy with quinidine or catheter ablation is I B-NR In patients with spontaneous type 1 Brugada electrocardiographic pattern and symptomatic VA who either are not candidates for or decline an ICD, quinidine or catheter ablation is IIa B-NR In patients with suspected Brugada syndrome in the absence of a spontaneous type 1 Brugada electrocardiographic pattern, a pharmacological challenge using a sodium channel blocker can be useful for IIb B-NRSR In patients with asymptomatic Brugada syndrome and a spontaneous type 1 Brugada electrocardiographic pattern, an electrophysiological study with programmed ventricular stimulation using single and double extrastimuli may be considered for further risk IIb C-EO In patients with suspected or established Brugada syndrome, genetic counseling and genetic testing may be useful to facilitate cascade screening of SR indicated systematic review. Synopsis Refer to the Systematic Review for the 2017 ACC/ AHA/HRS Guideline for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death for the complete systematic evidence review for additional data and analyses.S7.9.1.3-15 The results from the question For asymptomatic patients with Brugada syndrome, what is the association be- tween an abnormal EP study and SCD and other ar- rhythmia endpoints? 