A number of expert panels have reviewed the existing literature and made similar recommendations. The National High Blood Pressure Education Program Working Group on High BP in Children and Adolescents has recommended initiating pharmacologic therapy for BP above the 90th percentile if a compelling indication such as CKD is In 2004, the NKF KDOQI Clinical Practice Guidelines on Hypertension and Antihypertensive Agents in Chronic Kidney Disease1 recommended that the target BP in children with CKD should be lower than the 90th percentile for normal values adjusted for age, sex, and height or o130/ 80 mm Hg, whichever is lower. Similarly, the Cardiovascular Risk Reduction in High-Risk Pediatric Patients report330 listed children with CKD or kidney failure as a pediatric population at high risk for CVD, for which a target BP below percentile for age, sex, and height is suggested. According to that consensus statement, CKD is considered a coronary heart disease equivalent for which the treatment recommendations are similar to those in secondary preven- tion guidelines for adults with established coronary disease. Among children with CKD, observational data have shown that those with hypertension (i.e.