Structured professional psychological evaluation can identify up to 50% more patients with mood disorders.S3.7-1 3. Although there is limited evidence on neuro- developmental and neuropsychological issues in patients with ACHD, there is increasing evi- dence of the neurodevelopmental impact of CHD and surgery in childhood.S3.7-6,S3.7-8,S3.7-9 It is likely that this impact will persist into adulthood and may manifest in lower educational and occupa- tional achievement. This is particularly evident in patients with genetic conditions such as 22q11 deletion and trisomy 21. 3.8. Endocarditis Prevention Patients with ACHD have an increased risk of develop- ing infective endocarditis (IE).S3.8-1,S3.8-2 The most com- mon pathogens responsible for IE include Streptococ- cus viridans, Staphylococcus species, and Enterococcus species. Despite advances in antimicrobial therapy and surgical techniques, IE remains a condition associated with significant morbidity and mortality. Numerous guidelines are available with recommendations on the prevention and diagnosis of IE.S3.8-3 S3.8-5 These guidelines include consistent descriptions of the patients at high- est risk of adverse effects from endocarditis. Antibiotic prophylaxis continues to be recommended for patients with high-risk characteristics, which are often found in patients with ACHD.S3.8-2 These patients include: Those with previous IE; Patients with prosthetic valves (biological and me- chanical, surgical and transcatheter); Patients within 6 months of placement of pros- thetic material; Patients with residual intracardiac shunts at the site of or adjacent to previous repair with pros- thetic material or devices; or Patients with uncorrected cyanotic heart disease. See Online Data Supplement 15 for referenced studies. 3.9. Concomitant Syndromes Recommendation for Concomitant Syndromes Referenced studies that support the recommendation are summarized in Online Data Supplement 16. COR LOE Recommendation IIa B-NR Genetic testing for 22q11 deletions is reasonable for patients with conotruncal Synopsis Patients with genetic syndromes may have phenotypic manifestations and associated CHD as clinical features of the genetic abnormality. 