Pirmohamed M, Burnside G, Eriksson N, Jorgensen AL, Toh CH, Nicholson T, Kesteven P, Christersson C, Wahlstrom B, Stafberg C, Zhang JE, Leathart JB, Kohnke H, Maitland-van der ZeeAH, Williamson PR, Daly AK, Avery P, Kamali F, Wadelius M; EU-PACT Group. A ran- domized trial of genotype-guided dosing of warfarin. N Engl J Med. 2013;369:2294 2303. 80. Kimmel SE, French B, Kasner SE, Johnson JA, Anderson JL, Gage BF, Rosenberg YD, Eby CS, Madigan RA, McBane RB, Abdel-Rahman SZ, Stevens SM, Yale S, Mohler ER 3rd, Fang MC, Shah V, Horenstein RB, Limdi NA, Muldowney JA 3rd, Gujral J, Delafontaine P, Desnick RJ, Ortel TL, Billett HH, Pendleton RC, Geller NL, Halperin JL, Goldhaber SZ, Caldwell MD, Califf RM, Ellenberg JH; COAG Investigators. A pharmacogenetic versus a clinical algorithm for warfarin dosing. N Engl J Med. 2013;369:2283 2293. 81. Verhoef TI, Ragia G, de Boer A, Barallon R, Kolovou G, Kolovou V, Konstantinides S, Le Cessie S, Maltezos E, van der Meer FJ, Redekop WK, Remkes M, Rosendaal FR, van Schie RM, Tavridou A, Tziakas D, Wadelius M, Manolopoulos VG, Maitland-van der Zee AH; EU-PACT Group. A randomized trial of genotype-guided dosing of acenocoumarol and phenprocoumon. N Engl J Med. 2013;369:2304 2312. 82. SEARCH Collaborative Group, Link E, Parish S, Armitage J, Bowman L, Heath S, Matsuda F, Gut I, Lathrop M, Collins R. SLCO1B1 vari- ants and statin-induced myopathy: a genomewide study. N Engl J Med. 2008;359:789 799. 83. Tournier-Lasserve E, Joutel A, Chabriat H, Vahedi K, Nagy T, Ducros A, Nibbio A, Verin M, Mas JL, Davous P, Ducrocq X, Levasseur M, Dubois B, Lyoncaen O, Ragno M, Hutchinson M, Burkhard P, Julien J, Viader F, Burgunder JM, Iba-Zizen MT, Bousser MG. CADASIL Clinical phe- notypes and genetic data in 15 unrelated families. Neurology. 1995;45(4 Suppl 4):A273. 84. 