Arrows point down to boxes that describe the next literature review step and arrows point right to boxes that describe the excluded citations at each step (including the reasons for exclusion and the numbers of excluded citations). 1. Box 1: 16,836 citations identified by searches a. Right to Box 2: 4,831 citations excluded at the title level i. Citations excluded at this level were off-topic, not published in English, or published prior to inclusion date b. Down to Box 3 a. Right to Box 4: 11,142 citations excluded at the abstract level i. Citations excluded at this level were not an SR or clinical study, clearly did not address a KQ, did not report on an outcome of interest, or were outside cutoff publication dates b. Down to Box 5 a. Right to Box 6: 439 citations excluded at 1st pass full article level i. Articles excluded at this level did not: address a key question of interest, enroll the population of interest, meet inclusion criteria for clinical study or SR, meet inclusion criteria for any key question, or were a duplicate b. Down to Box 7 a. Right to Box 8: 283 citations excluded at 2nd pass KQ level i. 175 not a study design, setting, or population of interest ii. 71 superseded by more comprehensive review or included in an SR iii. 33 not a comparison of interest iv. 4 other (e.g., not published in English, not a clinical trial or SR, published outside date range) b. Down to Box 9 Table A-2. 