LOE amended to conform with ACC/AHA 2015 Recommendation Classification System. It is recommended to minimize or eliminate skin friction, to minimize skin pressure, to provide appropriate support surfaces, to avoid excessive moisture, and to maintain adequate nutrition and hydration to prevent skin breakdown. Regular turning, good skin hygiene, and use of specialized mattresses, wheelchair cushions, and seating are recommended until mobility returns. I C-LD Recommendation and COR unchanged from 2016 Rehab Guidelines. LOE amended to conform with ACC/AHA 2015 Recommendation Classification System. It is reasonable for patients and families with stroke to be directed to palliative care resources as appropriate. IIa C-EO New recommendation. It is reasonable for healthcare providers to ascertain and include patient-centered preferences in decision-making, especially during prognosis formation and considering interventions or limitations in care. Healthcare providers should ascertain and include patient-centered preferences in decision-making, especially during prognosis formation and considering interventions or limitations in care. See 2014 Palliative Care for additional information.9 4. Routine use of prophylactic antibiotics has not been shown to be beneficial. III: No Benefit A Recommendation revised from 2013 AIS Guidelines. Two large RCTs demonstrated no effect of preventive antimicrobial therapy on functional outcome. 