PCI to improve survival is reasonable in patients with acute STEMI when an unprotected left main coronary artery is the culprit lesion, distal coronary flow is less than TIMI (Thrombolysis In Myocardial Infarction) grade 3, and PCI can be performed more rapidly and safely than CABG.965,982,983 (Level of Evidence: C) Class IIb 1. PCI to improve survival may be reasonable as an alternative to CABG in selected stable patients with significant (>50% diameter stenosis) unprotected left main CAD with: a) anatomic conditions associ- ated with a low to intermediate risk of PCI proce- dural complications and an intermediate to high likelihood of good long-term outcome (eg, low intermediate SYNTAX score of <33, bifurcation left main CAD); and b) clinical characteristics that predict an increased risk of adverse surgical out- comes (eg, moderate severe chronic obstructive pul- monary disease, disability from previous stroke, or previous cardiac surgery; STS-predicted risk of operative mortality >2%).949,953,955,958,963 979,984 (Level of Evidence: B) Class III: Harm 1. PCI to improve survival should not be performed in stable patients with significant (>50% diameter stenosis) unprotected left main CAD who have un- favorable anatomy for PCI and who are good can- didates for CABG.73,381,412,949,953,955,959 964 (Level of Evidence: B) Non Left Main CAD Revascularization Class I 1. CABG to improve survival is beneficial in patients with significant (>70% diameter) stenoses in 3 major coronary arteries (with or without involve- ment of the proximal LAD artery) or in the proximal LAD artery plus 1 other major coronary ar- tery.353,412,959,985 987 (Level of Evidence: B) 2. CABG or PCI to improve survival is beneficial in survivors of sudden cardiac death with presumed ischemia-mediated ventricular tachycardia caused by significant (>70% diameter) stenosis in a major coronary artery. (CABG Level of Evidence: B350,1003,1004; PCI Level of Evidence: C1003) Class IIa 1. 