In obese patients receiving low-molecular- weight heparin (LMWH) therapy for treatment of acute VTE, the American Society of Hematology (ASH) guideline panel suggests initial LMWH dose selection according to actual body weight rather than dose selection based on a fixed maximum daily dose (ie, capped dose) (conditional recommendation based on very low certainty in the evidence about effects ). Drug-interaction management Recommendation 2. For patients requiring administration of inhibitors or inducers of P-glycoprotein (P-gp) or strong inhibitors or inducers of cytochrome P450 (CYP) enzymes, the ASH guideline panel suggests using an alternative anticoagulant (such as vitamin K antagonist [VKA] or LMWH) rather than a direct oral anticoagulant (DOAC) for the treatment of VTE (conditional recommendation based on very low certainty in the evidence about effects ). Point-of-care INR testing Recommendation 3. For patients receiving maintenance VKA therapy for treatment of VTE, the ASH guideline panel suggests using home point-of-care INR testing (patient self-testing [PST]) over any other INR testing approach except patient self- management (PSM) (see recommendation 4) in suitable patients (those who have demonstrated competency to perform PST and who can afford this option) (conditional recommendation based on low certainty in the evidence about effects ). Recommendation 4. For patients receiving maintenance VKA therapy for treatment of VTE, the ASH guideline panel recom- mends using point-of-care INR testing by the patient at home and self-adjustment of VKA dose (PSM) over any other management approach, including PST in suitable patients (those who have demonstrated competency to perform PSM and who can afford this option) (strong recommendation based on low certainty in the evidence about effects ). Selecting the timing between INR measurements (INR recall interval) Recommendation 5. 