In another study of 309 subjects followed up for 1 year after CABG, those with diagnostic criteria for a major depressive disorder before discharge were nearly 3 times as likely to have a cardiac event, such as heart failure requiring hospitalization, MI, cardiac arrest, PCI, repeat CABG, or cardiac death.666 Fi- nally, depression after CABG is an important predictor of the recurrence of angina during the first 5 postoperative 4.8.2. Interventions to Treat Depression in CABG Patients The Bypassing the Blues investigators identified 302 patients who were depressed before CABG and 2 weeks after dis- charge.668 They were randomly assigned to 8 months of telephone-delivered collaborative care (150 patients) or usual care (152 patients). The 2 groups were compared with each other and also to another group of 151 randomly selected nondepressed post-CABG patients. At 8 month follow-up, the collaborative care group showed an improve- ment in quality of life and physical functioning and were more likely to report a 50% decline in the Hamilton Rating Score for Depression than the usual care group (50.0% versus 29.6%; P 0.001). Men were more likely to benefit from the intervention.668,669 In another study, 123 patients who met the Diagnostic and Statistical Manual of Mental Disorders, 4th edition, criteria for major or minor depression within 1 year of CABG were randomly assigned to 12 weeks of cognitive behavior therapy, 12 weeks of supportive stress management, or usual care.667 Both interventions were efficacious for treating depression after CABG, and cognitive behavior therapy had the most durable effects on depression and several secondary psychological outcome variables.667 Thus, both collaborative intervention and cognitive behavior ther- apy are effective for treating depression in patients after CABG. 